公开(公告)号：US09957320B2

公开(公告)日：2018-05-01

申请号：US15180916

申请日：2016-06-13

Applicant: UCB BIOPHARMA SPRL

Inventor： Neil Gozzard ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Roger Thomas Palframan ,  Bryan John Smith ,  Kerry Louise Tyson

IPC: C07K16/24 ,  A61K39/395 ,  A61K9/00 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K9/0078 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/544 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing antibody molecules.

公开(公告)号：US20180100007A1

公开(公告)日：2018-04-12

申请号：US15566231

申请日：2016-04-20

Applicant: UCB BIOPHARMA SPRL

Inventor： SAM PHILIP HEYWOOD ,  GAVIN BARRY WILD

IPC: C07K16/06 ,  C07K1/22 ,  C07K16/18 ,  C07K16/28

CPC classification number: C07K16/065 ,  C07K1/22 ,  C07K16/18 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/624

Abstract: The present invention provides a method for recovering a human VH3 domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human VH3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.

公开(公告)号：US20180028652A1

公开(公告)日：2018-02-01

申请号：US15549528

申请日：2016-02-05

Applicant: UCB Biopharma SPRL

Inventor： Michael Joseph Edouard BOONEN ,  Claude PEERBOOM

IPC: A61K39/395 ,  A61K47/12 ,  A61K47/26 ,  C07K16/28 ,  A61K47/18

CPC classification number: A61K39/39591 ,  A61K9/0019 ,  A61K9/08 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  C07K16/2866 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: The current invention relates to a new pharmaceutical formulation, in particular to a pharmaceutical formulation comprising a protein, more particularly an antibody as an active ingredient.

公开(公告)号：US20180022748A1

公开(公告)日：2018-01-25

申请号：US15547980

申请日：2016-01-29

Applicant: UCB Biopharma SPRL

Inventor： Joel Mercier ,  Laurent Provins ,  Celine Vermeiren ,  Yogesh Anil Sabnis

IPC: C07D471/14 ,  A61K51/04 ,  C07B59/00

CPC classification number: C07D471/14 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07B59/002 ,  C07B2200/05

Abstract: The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.

公开(公告)号：US09868749B2

公开(公告)日：2018-01-16

申请号：US15100825

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Rikki Peter Alexander ,  Jonathan Mark Bentley ,  Gareth Neil Brace ,  Daniel Christopher Brookings ,  Prafulkumar Tulshibhai Chovatia ,  Hervé Jean Claude Deboves ,  Craig Johnstone ,  Elizabeth Pearl Jones ,  Boris Kroeplien ,  Fabien Claude Lecomte ,  James Madden ,  Craig Miller ,  John Robert Porter ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Darshan Gunvant Vaidya ,  Ian Andrew Yule

IPC: C07D519/00 ,  C07D471/04 ,  A61K31/4355 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/5383

CPC classification number: C07D519/00 ,  A61K31/4355 ,  A61K31/4709 ,  A61K31/538 ,  A61K31/5383 ,  C07D471/04

Abstract: A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US09850240B2

公开(公告)日：2017-12-26

申请号：US15101044

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Daniel Christopher Brookings ,  Victoria Elizabeth Jackson

IPC: C07D471/04 ,  A61K31/506 ,  A61K31/437 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/5377

Abstract: A series of substituted [1,2,4]triazolo[4,3-a]pyridine derivatives, being potent modulators of human TNF activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US09815797B2

公开(公告)日：2017-11-14

申请号：US15101283

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Rikki Peter Alexander ,  Gregory Foulkes ,  Martin Clive Hutchings ,  Victoria Elizabeth Jackson ,  Boris Kroeplien ,  James Thomas Reuberson ,  Sarah Margaret Rook ,  Zhaoning Zhu

IPC: C07D239/74 ,  A61K31/47 ,  A61K31/472 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  C07D215/14 ,  C07D237/28 ,  A61K31/502 ,  C07D215/06 ,  C07D237/32 ,  C07D241/44 ,  A61K45/06 ,  C07D217/16 ,  C07D241/42 ,  C07D403/04

CPC classification number: C07D239/74 ,  A61K31/47 ,  A61K31/472 ,  A61K31/498 ,  A61K31/502 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  C07D215/06 ,  C07D215/14 ,  C07D217/16 ,  C07D237/28 ,  C07D237/32 ,  C07D241/42 ,  C07D241/44 ,  C07D403/04 ,  A61K2300/00

Abstract: A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20170305932A1

公开(公告)日：2017-10-26

申请号：US15513357

申请日：2015-10-02

Applicant: UCB Biopharma SPRL ,  Sanofi

Inventor： Teresa De Haro Garcia ,  Michael Deligny ,  Jag Paul Heer ,  Joanna Rachel Quincey ,  Mengyang Xuan ,  Zhaoning Zhu ,  Daniel Christopher Brookings ,  Mark Daniel Calmiano ,  Yves Evrard ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Sophie Jadot ,  Jean Keyaerts ,  Malcolm Mac Coss ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Dominique Louis Leon Swinnen ,  Laurent Schio ,  Yann Foricher ,  Bruno Filoche-Romme

IPC: C07D519/00 ,  C07D495/18 ,  C07D487/18 ,  C07D491/18 ,  C07F7/18 ,  C07D513/18

CPC classification number: C07D519/00 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/55 ,  C07D471/18 ,  C07D487/08 ,  C07D487/18 ,  C07D491/08 ,  C07D491/18 ,  C07D493/18 ,  C07D495/08 ,  C07D495/18 ,  C07D513/18 ,  C07F7/1804

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

公开(公告)号：US20170275355A1

公开(公告)日：2017-09-28

申请号：US15476279

申请日：2017-03-31

Applicant: UCB BIOPHARMA SPRL

Inventor： Ralph Adams ,  Andrew George Popplewell ,  Stephen Edward Rapecki ,  Simon Peter Tickle

IPC: C07K16/24 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/464 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.

公开(公告)号：US20170239419A1

公开(公告)日：2017-08-24

申请号：US15513771

申请日：2015-09-21

Applicant: UCB BIOPHARMA SPRL ,  BESPAK EUROPE LIMITED

Inventor： Martin John McLoughlin ,  Barry Alan Knight ,  Matt Ekman ,  Deborah Jane Norris

IPC: A61M5/20 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32

CPC classification number: A61M5/2033 ,  A61M5/3137 ,  A61M5/31576 ,  A61M5/3202 ,  A61M5/3243 ,  A61M2005/3125 ,  A61M2205/0216 ,  A61M2205/0238

Abstract: Provided is a housing part for an auto-injector comprising a shell form body defining inner and outer shell surfaces and comprising a relatively hard or generally incompressible material; an over-coating formed of a relatively softer or more compressible material, the over-coating covering at least part of the outer shell surface of the shell form body; and at least one window defined in the shell form body, wherein the over-coating extends into the at least one window. Also provided is a housing comprising the housing part, and an auto-injector comprising the housing.