公开(公告)号：US11411551B2

公开(公告)日：2022-08-09

申请号：US16473630

申请日：2017-12-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.

Inventor： Reshef Tenne ,  Ernesto Joselevich ,  Yiftach Divon ,  Roi Levi ,  Assaf Yaakobovitz ,  Dan Yudilevich

IPC: H03B5/30 ,  H03H9/24 ,  B82B1/00 ,  H03H9/02

Abstract: This invention provides electromechanical resonators based on metal chalcogenide nanotubes. The invention further provides methods of fabrication of electromechanical resonators and methods of use of such electromechanical resonators.

公开(公告)号：US20220217934A1

公开(公告)日：2022-07-14

申请号：US17272685

申请日：2019-09-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Maxim ITKIN ,  Adam JOZWlAK

IPC: A01H6/82 ,  C12N15/82 ,  C12N9/10

Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.

公开(公告)号：US20220175807A1

公开(公告)日：2022-06-09

申请号：US17442198

申请日：2020-03-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rotem SOREK ,  Auda BERNHEIM ,  Adl Jenny MILLMAN DAYAN

IPC: A61K31/708 ,  A61K31/7068 ,  C07K14/195 ,  A61K31/7072 ,  A61P31/12

Abstract: Disclosed herein are prokaryotic homologs of viperin (pVips), and nucleotide and nucleoside analogs produced from pVips. These nucleotide and nucleoside analogs stop nucleotide chain synthesis and provide host cells with resistance to viral infections by targeting actively replicating viral genome. Further, these nucleotide and nucleoside analogs decrease DNA replication in malignant cells. Further disclosed are methods of identifying pVips, and nucleotide and nucleoside analogs produced thereof.

公开(公告)号：US20220133701A1

公开(公告)日：2022-05-05

申请号：US17576954

申请日：2022-01-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael FAINZILBER ,  Letizia MARVALDI

IPC: A61K31/437 ,  A61K31/496 ,  A61P25/04

Abstract: Methods of treating pain are provided. Accordingly, there is provided a method of treating nociceptive or neuropathic pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an agent which binds importin alpha3 or a polynucleotide encoding same and inhibits expression and/or activity of said importin α3.

公开(公告)号：US20220080034A1

公开(公告)日：2022-03-17

申请号：US17531897

申请日：2021-11-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/00 ,  A61K35/17 ,  C12N5/078 ,  C12N5/0783 ,  A61P31/00 ,  A61P35/04 ,  A61K39/395 ,  C07K16/28

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20220031776A1

公开(公告)日：2022-02-03

申请号：US16644641

申请日：2018-09-07

Applicant: Keio University ,  BiomX Ltd. ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

Inventor： Kenya Honda ,  Koji Atarashi ,  Seiko Narushima ,  Eran Elinav ,  Rotem Sorek ,  Efrat Khabra ,  Hava Ben David ,  Eyal Weinstock ,  Sarah Pollock ,  Yulia Matiuhin ,  Naomi Zak

IPC: A61K35/76 ,  C12N7/00

Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.

公开(公告)号：US20210369761A1

公开(公告)日：2021-12-02

申请号：US17391125

申请日：2021-08-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

IPC: A61K31/7105 ,  C12N15/113 ,  A61K45/06 ,  A61P25/00

Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

公开(公告)号：US11174561B2

公开(公告)日：2021-11-16

申请号：US16771243

申请日：2018-12-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny Neumann ,  Alexander Khenkin ,  Miriam Somekh

IPC: C25B3/23 ,  C25B3/07 ,  B01J23/78 ,  C25B1/02

Abstract: The invention relates to electrocatalytic processes for the formation of formate esters using at least one catalyst or pre-catalyst; wherein the formate ester can be further hydrolyzed.

公开(公告)号：US11167005B2

公开(公告)日：2021-11-09

申请号：US16474831

申请日：2018-01-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Edna Mozes

IPC: A61K38/04 ,  A61K38/10 ,  A61P11/00 ,  A61P15/00 ,  A61P17/00 ,  A61P17/16 ,  A61P19/02 ,  A61P1/02 ,  A61P27/02 ,  A61P37/02 ,  A61P43/00 ,  C07K7/08

Abstract: Compositions and methods for the treatment of Sjogren's syndrome (SS) and SS-related symptoms in human subjects are described. The compositions comprise synthetic peptides based on the sequence of CDR1 of an anti-DNA monoclonal antibody.

公开(公告)号：US20210332024A1

公开(公告)日：2021-10-28

申请号：US17370216

申请日：2021-07-08

Applicant: Yeda Research and Development Co. Ltd. ,  Dana-Farber Cancer Institute, Inc. ,  Beth Israel Deaconess Medical Center, Inc.

Inventor： Nir LONDON ,  Daniel ZAIDMAN ,  Christian DUBIELLA ,  Nathanael S. GRAY ,  Benika Joan PINCH ,  Kun Ping LU ,  Alfred Thomas LOOK ,  Shuning HE ,  Xiao Zhen ZHOU ,  Xiaolan LIAN

IPC: C07D333/16

Abstract: Disclosed herein are compounds comprising an electrophilic moiety and rigid moiety for use in modulating an activity of Pin1. The rigid moiety comprises at least one functional group that is capable of forming hydrogen bonds with hydrogen atoms, wherein the electrophilic moiety and the rigid moiety are arranged such that the electrophilic moiety is capable of covalently binding to the Cys113 residue of Pin1, and the rigid moiety is capable of forming hydrogen bonds with the Gln131 and His 157 residues of Pin1. Further disclosed are novel compounds having Formula Id: wherein the dashed line, W, X, Y, Z, Ra-Rc, R1, R2, L1, L2 and n are as defined herein, and libraries comprising such compounds. Further disclosed are methods of identifying a compound capable of modulating an activity of Pin1, by screening a library of compounds.