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公开(公告)号：KR1020070095709A
公开(公告)日：2007-10-01
申请号：KR1020060026238
申请日：2006-03-22
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K8/97 , A61K2800/782 , A61Q19/00
Abstract: A cosmetic composition is provided to inhibit the amount of sebum produced from sebocytes by inhibiting the formation and activity of SREBP-1(Sterol Regulatory Element Binding Protein-1), thereby capable of effectively improving sebum metabolism and acne. A cosmetic composition comprises 0.001-30 wt.% of at least one selected from the group consisting of catechin such as epigallocatechin gallate(EGCG), gallocatechin gallate(GCG) and a mixture thereof and flavonols such as quercetin, kaempferol and myricetin as effective ingredients and is characterized in that it inhibit the formation and activity of SREBP-1 which is a transcription factor.
Abstract translation: 提供化妆品组合物，通过抑制SREBP-1（甾醇调节元件结合蛋白-1）的形成和活性来抑制由皮脂细胞产生的皮脂的量，从而能够有效地改善皮脂代谢和痤疮。 化妆品组合物包含0.001-30重量％的选自儿茶素如表没食子儿茶素没食子酸酯（EGCG），没食子儿茶素没食子儿茶素（GCG）及其混合物中的至少一种，和黄酮醇如槲皮素，山奈酚和杨梅素作为有效成分 其特征在于它抑制作为转录因子的SREBP-1的形成和活性。
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公开(公告)号：KR1020070091964A
公开(公告)日：2007-09-12
申请号：KR1020060021797
申请日：2006-03-08
Applicant: (주)아모레퍼시픽
Abstract: A skin external composition is provided to inhibit TNF-alpha(Tumor Necrosis Factor-alpha) and the expression of MMP-1 through activation of PPAR-alpha(Peroxisome Proliferator Activated Receptor-alpha), thereby inhibiting skin aging. A skin external composition comprises 0.001-10 wt.% of at least one kind selected from the group consisting of epigallocatechin(EGCG), gallocatechingallate(GCG), epicatechin gallate(ECG), catechin gallate(CG), catechin(C), gallic acid, quercetin, kaempferol, theobromine, theophylline, theanine, quinic acid, an ethanol extract of green tea leaves, an aqueous extract of green tea leaves, an extract of catechin 1 including 70% of catechin and an extract of catechin 2 including 50% of EGCG as an effective ingredient.
Abstract translation: 提供皮肤外用组合物以通过激活PPAR-α（过氧化物酶体增殖剂活化受体-α）抑制TNF-α（肿瘤坏死因子-α）和MMP-1的表达，从而抑制皮肤老化。 皮肤外用组合物包含0.001-10重量％的选自下组的至少一种：表没食子儿茶素（EGCG），gallocatechingallate（GCG），表儿茶素没食子酸酯（ECG），儿茶素没食子酸酯（CG），儿茶素（C） 酸，槲皮素，山奈酚，可可碱，茶碱，茶氨酸，奎尼酸，绿茶叶的乙醇提取物，绿茶叶的水提物，儿茶素1的提取物，其中儿茶素含量为70％，儿茶素2提取物含50％ 的EGCG作为有效成分。
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公开(公告)号：KR100706279B1
公开(公告)日：2007-04-12
申请号：KR1020050108080
申请日：2005-11-11
Applicant: (주)아모레퍼시픽
IPC: A61K31/352 , A61K31/366 , A61P3/04
Abstract: 본 발명은 쿠메스트롤을 함유하여 카르니틴 팔미토일트랜스퍼라아제1A(Carnitine Palmitoyl Transferase1A) 유전자 발현을 촉진시킴으로써 지방산 베타 산화를 증가시키는 비만 개선 및 예방용 의약 조성물과 비만 개선 및 예방용 식품 조성물에 관한 것이다. 본 발명에 의한 비만 개선 및 예방용 의약 조성물과 비만 개선 및 예방용 식품 조성물은 쿠메스트롤을 함유하여 카르니틴 팔미토일트랜스퍼라아제1A의 발현을 세포 독성 없이 효과적으로 증가시킴으로써, 세포질 내 지방산이 미토콘드리아 내로 이동하는 것을 촉진하여 결과적으로 지방산의 베타 산화 증가에 도움이 된다. 따라서 본 발명에 의한 쿠메스트롤을 함유한 비만 개선용 조성물은 체지방의 과도한 축적을 예방 또는 개선하는데 도움이 된다.
쿠메스트롤, 제니스테인, 다이드제인, CPT1A, 지방산, 베타 산화Abstract translation: 本发明ク手术刀包含拖网肉碱棕榈酰基转移酶1A氮杂促进（肉碱棕榈酰Transferase1A）基因表达通过涉及肥胖，改善和预防食品组合物的药物组合物和肥胖改善和预防用于增加脂肪酸β-氧化 。 肥胖改善和预防肥胖改善和预防食品组合物用于根据本发明通过将含区手术刀拖网肉碱棕榈酰转移酶的增加氮杂有效细胞1A表达而没有毒性的药物组合物，此举是脂肪细胞质内进入线粒体 因此有助于增加脂肪酸的β氧化。 因此，根据本发明的用于改善含有cumestrol的肥胖症的组合物有助于预防或改善体脂过度积聚。
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公开(公告)号：KR1020070028901A
公开(公告)日：2007-03-13
申请号：KR1020050083665
申请日：2005-09-08
Applicant: (주)아모레퍼시픽
Abstract: A skin external composition comprising optimal concentration of catechins and theanine is provided to increase biosynthesis of collagen in the inner skin, restore elasticity of the skin, and improve wrinkles in the skin by containing low concentration of catechins and theanine at a fixed ingredient rate. The skin external composition for promoting biosynthesis of collagen and improving skin aging and elasticity comprises 0.0004-0.025 wt.% of catechins and 0.008-2.5 wt.% of theanine based on the total weight of the composition, wherein the weight ratio of catechins to theanine is 1:20 to 1:100, and the catechin is EGCG(epigallocatechin gallate), GCG(gallocatechin gallate), ECG(epicatechin gallate) or CG(catechin gallate).
Abstract translation: 提供包含最佳浓度的儿茶素和茶氨酸的皮肤外用组合物以增加内皮中胶原的生物合成，恢复皮肤的弹性，并通过以固定的成分速率含有低浓度的儿茶素和茶氨酸来改善皮肤的皱纹。 用于促进胶原蛋白的生物合成和改善皮肤老化和弹性的皮肤外用组合物包含基于组合物总重量的0.0004-0.025重量％的儿茶素和0.008-2.5重量％的茶氨酸，其中儿茶素与茶氨酸的重量比 是1:20至1:100，儿茶素是EGCG（表没食子儿茶素没食子酸酯），GCG（没食子儿茶素没食子酸酯），ECG（表儿茶素没食子酸酯）或CG（儿茶素没食子酸酯）。
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公开(公告)号：KR100619437B1
公开(公告)日：2006-09-28
申请号：KR1020030081033
申请日：2003-11-17
Applicant: (주)아모레퍼시픽
IPC: A61K36/9064 , A61P5/06
Abstract: 본 발명은 인슐린 유사 성장인자-1(Insulin-like Growth Factor-1; IGF-1)의 생체내 분비를 촉진하는 조성물에 관한 것이다. 보다 상세하게는 생약재인 사인(Amomi Semen)으로부터 추출된 사인추출물을 함유하여 IGF-1의 생체내 분비를 촉진하는 피부 외용제 및 건강보조식품에 관한 것이다. 본 발명을 통해 얻어지는 조성물은 식품 생약재로 알려진 사인추출물을 유효성분으로 함유하고 있으므로, 인체에 안전성을 가지며, 피부노화와 관련된 여러 인자들을 증진 혹은 억제하여 피부 두께 강화, 주름 개선, 및 탄력 개선 효과를 나타내어 궁극적으로 피부 노화를 지연시킬 수 있고 부작용이 없는 조성물을 제공할 수 있다.
사인*IGF-1*피부두께강화*피부노화방지*주름개선*탄력개선*건강보조식품-
Patent Agency Ranking
公开(公告)号：KR1020050099839A
公开(公告)日：2005-10-17
申请号：KR1020040025053
申请日：2004-04-12
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 방선균(
Actinomycetes ) 균주 또는 방선균(
Actinomycetes ) 배양물 추출물을 유효성분으로 함유하는 피부 미백용 조성물에 관한 것으로서, 본 발명에 의한 조성물은 멜라닌 생합성에 관여하는 효소인 타이로시네이즈(tyrosinase)를 합성하는 글라이코실레이션(glycosylation)의 과정에 관여하는 중요한 효소인 베타-글루코시다제(beta-glucosidase)의 효소 활성을 억제함으로써, 타이로시네이즈의 글라이코실레이션을 억제하여 멜라닌 생성을 저해함으로써 미백 효과를 나타내므로, 본 발명에 의한 피부 미백용 조성물을 이용하면, 방선균 균주 또는 방선균 배양물 추출물의 효능으로 인해 부작용 없이 멜라닌 생성을 효과적으로 억제할 수 있다.-
公开(公告)号：KR1020050052839A
公开(公告)日：2005-06-07
申请号：KR1020030086405
申请日：2003-12-01
Applicant: (주)아모레퍼시픽
IPC: A61K36/26 , A61K36/535 , A61P17/00
CPC classification number: A61K36/268 , A61K9/06 , A61K36/36 , A61K36/535 , A61K36/71 , A61K36/81 , A61K2300/00 , Y10S514/861 , Y10S514/863
Abstract: 본 발명은 생약재 추출물을 함유하는 피부 외용제 조성물에 관한 것으로, 더욱 상세하게는, 세신(
Asiasari Radix ), 소엽(
Perillae Herba ), 소자(
Perillae Semen ), 승마(
Cimicifugae Rhizoma ), 왕불유행(
Melandrii Herba ), 용규(
Solani Nigri Herba ), 우방자(
Arctii Semen ), 위릉채(
Potentillae Radix ), 육계(
Cinnamomi Cortex Spissus ), 적복령(
Hoelen rubra ), 적소두(
Phaseoli angularis Semen ), 초과(
Ammomi Tsao-ko Frucuts ), 초두구(
Alpiniae Katsumadaii Semen ), 메밀(
Fagopyrum esculentum ), 명아주(
Chenopodium album var. centrorubrum ), 범꼬리(
Bistorta manshuriensis ), 상사화(
Lycoris squamigera ), 섬백리향(
Thymus quinquecostatus var. japonica ), 쑥방망이(
Senecio argunensis ) 및 참나물(
Pimpinella brachycarpa ) 중에서 선택된1종 이상의 생약재 추출물을 유효성분으로 함유하는 피부 외용제로서, T 임파구 매개성 면역반응 억제능력에 의해 아토피성 피� �염, 접촉성 피부염, 건선 등의 피부질환을 치료 또는 예방하기 위해 사용될 수 있다.-
公开(公告)号：KR1020040071963A
公开(公告)日：2004-08-16
申请号：KR1020030007885
申请日：2003-02-07
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/981 , A61K2800/75 , A61Q19/00 , Y10S514/857
Abstract: PURPOSE: A composition containing musk having effects of strengthening the formation and maintenance of a natural moisturizing factor present in the stratum corneum of the skin and naturally increasing synthesis of lipid between cells is provided. It can be used as a therapeutic agent for preventing skin diseases such as atopic contact dermatitis as well as xeroderma or improving its symptoms. CONSTITUTION: The composition for external for improving the drying of the skin is characterized in that it contains 0.0001 to 20% by weight of musk as an effective ingredient, based on the total weight of the composition. The musk is musk 781 or musk T. The improvement in drying of the skin contains inducing the cell growth of keratinocyte, recovering a skin barrier, promoting the expression of filaggrin, activating PPAR(Peroxisome Proliferator Activated Receptor)-α, increasing biosynthesis of ceramide, improving skin moisturization, preventing atopic, contact dermatitis or improving its symptoms.
Abstract translation: 目的：提供一种含有麝香的组合物，其具有加强皮肤角质层中天然保湿因子的形成和维持的作用，并且天然增加细胞之间的脂质合成。 它可以用作预防皮肤疾病如特应性接触性皮炎以及干性皮炎或改善其症状的治疗剂。 构成：用于改善皮肤干燥的外用组合物的特征在于，基于组合物的总重量，其含有0.0001至20重量％的麝香作为有效成分。 麝香是麝香781或麝香T.皮肤干燥的改善包括诱导角质形成细胞的细胞生长，恢复皮肤屏障，促进丝聚蛋白的表达，激活PPAR（过氧化物酶体增殖物激活受体）-α，增加神经酰胺的生物合成 改善皮肤保湿，预防特应性，接触性皮炎或改善其症状。
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59.发明公开
公开(公告)号：KR1020040058851A
公开(公告)日：2004-07-05
申请号：KR1020020085364
申请日：2002-12-27
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: Provided is a composition for inhibiting phagocytosis containing Saururus Chinesis(Lour) Bail extract that effectively inhibits the phagocytosis of the keratinocyte activated by exposure to ultraviolet rays. Further, provided is a pharmaceutical composition which prevents and treats various kinds of diseases associated with phagocytosis. CONSTITUTION: A phagocytosis inhibiting composition is characterized by containing, as an active ingredient, Saururus Chinesis(Lour) Bail extract in the amount of 0.0001-10 wt.%. It is used for prevention and treatment of phagocytosis related diseases.
Abstract translation: 目的：提供一种用于抑制吞噬作用的组合物，其含有SaururusChinesis（Lour）保释提取物，其有效抑制通过暴露于紫外线而活化的角质形成细胞的吞噬作用。 此外，提供了防止和治疗与吞噬作用相关的各种疾病的药物组合物。 构成：吞噬抑制组合物的特征在于以0.0001-10重量％的量含有SaururusChinesis（Lour）保释提取物作为活性成分。 用于预防和治疗吞噬相关疾病。
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公开(公告)号：KR1020040058848A
公开(公告)日：2004-07-05
申请号：KR1020020085361
申请日：2002-12-27
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/342 , A61K9/0014 , A61K2236/331 , A61K2236/51 , Y10S514/857
Abstract: PURPOSE: Provided is a composition of external application to the skin containing extract of Adenophorea radix, thereby preventing dryness of the skin, improving moisture retaining property of the skin, and preventing and treating atopic dermatitis and skin inflammation. CONSTITUTION: A composition of external application to the skin is characterized by containing, as an active ingredient, 0.0001-60 wt.% of extract of Adenophorea radix. The composition moisturizes the skin, improves atopic dermatitis or skin inflammation, facilitates the differentiation of keratinocyte and expression of filaggrin, promotes the generation of ceramide, and activates PPAR-alpha.
Abstract translation: 目的：提供外用于含有Adenophorea根的提取物的皮肤的组合物，从而防止皮肤干燥，改善皮肤的保湿性，以及预防和治疗特应性皮炎和皮肤炎症。 构成：外用于皮肤的组合物的特征在于含有0.0001-60重量％的Adenophorea根的提取物作为活性成分。 组合物润湿皮肤，改善特应性皮炎或皮肤炎症，促进角质形成细胞的分化和丝聚蛋白的表达，促进神经酰胺的产生，并激活PPAR-α。
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