케모카인을 함유하는 피부 미백용 조성물
    53.
    发明公开
    케모카인을 함유하는 피부 미백용 조성물 审中-实审
    含白蛋白的皮肤组合物

    公开(公告)号:KR1020160015745A

    公开(公告)日:2016-02-15

    申请号:KR1020140098395

    申请日:2014-07-31

    CPC classification number: A61K8/64 A61K38/19 A61Q19/02

    Abstract: 본발명은케모카인, 특히 ITAC(interferon-inducible T-cell alpha chemoattractant; 인터페론유도성 T 세포알파화학주성인자)를함유함으로써멜라닌형성세포에서멜라닌색소생성관련인자의유전자발현을감소시켜피부미백효과를가져올수 있는조성물에관한것이다.

    Abstract translation: 本发明涉及包含趋化因子,特别是干扰素诱导型T细胞α化学引诱物(ITAC)的组合物。 此外,本发明的组合物降低与黑素细胞中黑色素的生成相关因素的遗传表达,从而显示出皮肤美白效果,其中ITAC的含量相对于总量为0.0001-0.955重量% 组合物的重量。

    산형화 추출물을 포함하는 조성물
    54.
    发明公开
    산형화 추출물을 포함하는 조성물 审中-实审
    包含芍药(MASTERWORT)提取物的组合物

    公开(公告)号:KR1020150125241A

    公开(公告)日:2015-11-09

    申请号:KR1020140052273

    申请日:2014-04-30

    Abstract: 본명세서에는산형화(Masterwort)() 추출물을유효성분으로포함하는조성물이개시된다. 본명세서에개시된조성물은산형화(Masterwort)() 추출물을포함하는것에의해엔도셀린 1의양의감소, NK1R 및 EDN1 유전자의과발현감소효과를나타낸다. 따라서, 이러한효과로인해본 명세서의산형화(Masterwort)() 추출물은피부항상성유지및 항스트레스효과를나타낼수 있으며, 그러므로피부항상성유지용조성물로서약학또는화장료분야에서널리사용될수 있다.

    Abstract translation: 公开了含有Pe ium(益母草)提取物作为活性成分的组合物。 本发明公开的组合物通过含有豌豆ium(母菊)提取物,减少内皮素-1的量和减少NK1R和EDN1基因的过表达。 因此,由于这些效果,本发明的Peucedanum ostruthium(益母草)提取物可以表现出维持皮肤稳态和抗应激作用的效果,因此被广泛用于药物或化妆品领域,作为用于保持皮肤的组合物 动态平衡。

    피부 미백 물질 스크리닝 방법
    55.
    发明公开
    피부 미백 물질 스크리닝 방법 审中-实审
    用于皮肤白化的候选材料的筛选方法

    公开(公告)号:KR1020140055401A

    公开(公告)日:2014-05-09

    申请号:KR1020120122155

    申请日:2012-10-31

    Abstract: The present invention relates to a method for screening skin whitening substances, and more specifically, to a method for screening skin whitening substances comprising a step of treating a test substance on a melanin-producing cell; and a step of checking relative expression level of one or more proteins selected from a group consisting of tyrosinase, integrin alpha 6, and MITF in a cell treated with the test substance of the step.

    Abstract translation: 本发明涉及一种用于筛选皮肤美白物质的方法,更具体地,涉及一种用于筛选皮肤美白物质的方法,包括在黑色素产生细胞上处理测试物质的步骤; 以及在用该步骤的测试物质处理的细胞中检查选自由酪氨酸酶,整联蛋白α6和MITF组成的组中的一种或多种蛋白质的相对表达水平的步骤。

    트랜스코뮤닉산을 유효성분으로 함유하는 피부 미백용 조성물
    56.
    发明公开
    트랜스코뮤닉산을 유효성분으로 함유하는 피부 미백용 조성물 审中-实审
    含有透皮酸的组合物用于皮肤白化

    公开(公告)号:KR1020140034594A

    公开(公告)日:2014-03-20

    申请号:KR1020120101125

    申请日:2012-09-12

    Abstract: A composition for external skin application which comprises trans-communic acid as an active ingredient for skin whitening of the present invention can be usefully applied as a composition for external skin application with a purpose of skin whitening since effects of tyrosinase activity reduction and melanin generation reduction are excellent. The composition for external skin application contains 0.0025-0.025 wt% of the trans-communic acid compared to a total weight of the composition. [Reference numerals] (AA) Comparative example 1; (BB) Example 1; (CC) Example 2; (DD) Example 3

    Abstract translation: 作为外用皮肤应用的组合物,其含有作为本发明的皮肤美白的活性成分的反式交联酸可有效地用作皮肤美白用的外用皮肤用组合物,因为酪氨酸酶活性降低和黑色素生成降低的作用 很好 与组合物的总重量相比,用于外部皮肤应用的组合物含有0.0025-0.025wt%的反式连通酸。 (附图标记)(AA)比较例1; (BB)实施例1; (CC)实施例2; (DD)实施例3

    각질형성세포에 적응이 된 멜라노블라스트 및 그 제조방법
    57.
    发明公开
    각질형성세포에 적응이 된 멜라노블라스트 및 그 제조방법 审中-实审
    适用于生产适合KERATINOCYTE的适应性乳清蛋白的乳清蛋白和方法

    公开(公告)号:KR1020140027782A

    公开(公告)日:2014-03-07

    申请号:KR1020120093805

    申请日:2012-08-27

    Abstract: Novel melanoblast is disclosed in the present invention. A production method of the novel melanoblast is also disclosed in the present invention. Specifically, the present invention provides the novel melanoblast which has different gene expression, melanin content, tyrosinase activity, and protein expression compare to existing melanocyte. The present invention also provides the production method of the novel melanoblast for producing melanoblast from the culturing of keratinocyte. [Reference numerals] (AA) After the separation of cultured epithelial cells; (BB) In a PMA- medium; (CC) In a PMA+ medium

    Abstract translation: 本发明公开了新型黑素细胞。 本发明还公开了新型黑色素细胞的制造方法。 具体地说,本发明提供与现有黑素细胞相比,具有不同基因表达,黑色素含量,酪氨酸酶活性和蛋白质表达的新型黑素细胞。 本发明还提供了用于从培养角化细胞产生黑素细胞的新型黑素细胞的制备方法。 (附图标记)(AA)培养的上皮细胞分离后; (BB)在PMA-介质中; (CC)在PMA +培养基中

    플루마롤을 함유하는 피부 미백용 조성물
    58.
    发明公开
    플루마롤을 함유하는 피부 미백용 조성물 审中-实审
    用于包含PLUMAROL的皮肤组合物

    公开(公告)号:KR1020130131628A

    公开(公告)日:2013-12-04

    申请号:KR1020120055319

    申请日:2012-05-24

    CPC classification number: A61K8/4926 A61K9/0014 A61K31/445 A61Q19/02

    Abstract: The present invention relates to a composition for skin whitening, wherein the composition contains Plumarol as an active ingredient. The composition for skin whitening according to the present invention suppresses the protein expression of tyrosinase, which is a melanogenic enzyme, and inhibits melanogenesis, by containing Plumarol as an active ingredient, thereby exhibiting a whitening effect. [Reference numerals] (AA) Comparative example 1;(BB) Example 1;(CC) Example 2

    Abstract translation: 本发明涉及一种用于皮肤美白的组合物,其中该组合物含有Plumarol作为活性成分。 根据本发明的皮肤美白组合物通过含有Plumarol作为活性成分抑制作为黑素生成酶的酪氨酸酶的蛋白质表达并抑制黑素生成,从而表现出美白效果。 (AA)比较例1(BB)实施例1(CC)实施例2

    칼슘 펄스를 통한 배양상피세포층의 분리방법
    60.
    发明公开
    칼슘 펄스를 통한 배양상피세포층의 분리방법 有权
    通过钙脉冲分离培养的上皮片的方法

    公开(公告)号:KR1020120128774A

    公开(公告)日:2012-11-28

    申请号:KR1020110046619

    申请日:2011-05-18

    Inventor: 조은경 이태룡

    CPC classification number: C12N5/0629 C12N2500/14 C12N2509/10

    Abstract: PURPOSE: A method for sorting a cultured epithelial cell layer is provided to control calcium concentration by calcium pulse and to maximize skin regeneration. CONSTITUTION: A method for sorting a cultured epithelial cell layer comprises: a step of culturing keratinocytes in a basal medium; a step of changing the medium into a calcium medium of high content; a step of changing the medium into a basal medium; a step of removing basal medium and washing with a buffer solution; a step of exposing the washed keratinocytes to the air; and a step of adding a fresh buffer solution. The calcium medium contains 1.2-1.4 mM of CaCl_2. [Reference numerals] (AA) Basal medium 6 days(comparative embodiment 1); (BB) Basal medium 10 days(comparative embodiment 2); (CC) MRNA relative value

    Abstract translation: 目的:提供一种用于分选培养的上皮细胞层的方法,以通过钙脉冲控制钙浓度并使皮肤再生最大化。 构成:用于分选培养的上皮细胞层的方法包括:在基础培养基中培养角质形成细胞的步骤; 将培养基更换成高含量的钙培养基的步骤; 将培养基更换为基础培养基的步骤; 除去基础培养基并用缓冲溶液洗涤的步骤; 将洗涤的角质形成细胞暴露于空气的步骤; 以及添加新鲜缓冲溶液的步骤。 钙介质含有1.2-1.4mM CaCl 2。 (AA)基础培养基6天(比较例1); (BB)基础培养基10天(比较例2); (CC)MRNA相对值

Patent Agency Ranking