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公开(公告)号:KR1020170003000A
公开(公告)日:2017-01-09
申请号:KR1020150093049
申请日:2015-06-30
Applicant: (주)아모레퍼시픽
IPC: A61K31/4178 , A61K31/18 , A61K8/49 , A61K8/46 , A61K8/42 , A61K9/20 , A61K9/48 , A61K47/38 , A61Q19/02 , G01N33/50
CPC classification number: A61K8/494 , A61K8/42 , A61K8/46 , A61K8/49 , A61K9/20 , A61K9/48 , A61K31/18 , A61K31/4178 , A61K47/38 , A61Q19/02 , G01N33/50 , G01N33/5044
Abstract: 본명세서에는멜라닌형성세포에서분비되는엑소좀의분비제어를통해피부미백에효능이있는피부미백용조성물및 피부미백효능물질을스크리닝하는방법이개시된다. 상기피부미백용조성물은멜라닌형성세포에서분비되는엑소좀의분비량을억제시킴으로써멜라닌형성세포의세포사멸을증가시킬수 있고, 이러한멜라닌형성세포의세포사멸로인해결과적으로멜라닌생성을저해하여미백효능이발휘되는효과가있다.
Abstract translation: 在本说明书中公开的是:通过控制从黑素细胞分泌的外来体的分泌而具有皮肤美白效果的皮肤美白组合物; 以及用于筛选具有皮肤美白效果的材料的方法。 皮肤美白组合物可以通过抑制从黑素细胞分泌的外来体的分泌量来促进黑素细胞的凋亡,从而通过黑素细胞的凋亡抑制黑色素的产生,从而呈现皮肤美白效果。
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公开(公告)号:KR1020160116800A
公开(公告)日:2016-10-10
申请号:KR1020150045066
申请日:2015-03-31
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K8/44 , A61K36/899 , A61K31/205 , A61Q19/00 , A23L1/30
CPC classification number: A61K36/899 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K8/44 , A61K8/97 , A61K9/0014 , A61K9/0053 , A61K9/0095 , A61K9/06 , A61K9/1652 , A61K9/2018 , A61K9/4858 , A61K31/205 , A61K47/10 , A61K47/26 , A61K47/44 , A61Q19/00 , A61Q19/007 , A61K8/442 , A61K2300/00
Abstract: 본명세서의일측면에서는, 대나무수액과베타인(Betaine)을유효성분으로포함하는피부보습용조성물이제공되며, 구체적으로상기조성물은천연보습인자(Natural Moisturizing Factors, NMFs)를조절하여피부보습효과를나타내며, 피부보습에효과가있는화장료조성물, 약학조성물또는건강식품조성물을제공하고자한다.
Abstract translation: 在一方面,本公开提供了一种用于保湿皮肤的组合物,其含有竹汁和甜菜碱作为活性成分。 具体地,该组合物通过调节天然保湿因子(NMF)表现出皮肤保湿效果,并且可用作有效保湿皮肤的化妆品组合物,药物组合物或保健食品组合物。
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公开(公告)号:KR1020160015745A
公开(公告)日:2016-02-15
申请号:KR1020140098395
申请日:2014-07-31
Applicant: (주)아모레퍼시픽
Abstract: 본발명은케모카인, 특히 ITAC(interferon-inducible T-cell alpha chemoattractant; 인터페론유도성 T 세포알파화학주성인자)를함유함으로써멜라닌형성세포에서멜라닌색소생성관련인자의유전자발현을감소시켜피부미백효과를가져올수 있는조성물에관한것이다.
Abstract translation: 本发明涉及包含趋化因子,特别是干扰素诱导型T细胞α化学引诱物(ITAC)的组合物。 此外,本发明的组合物降低与黑素细胞中黑色素的生成相关因素的遗传表达,从而显示出皮肤美白效果,其中ITAC的含量相对于总量为0.0001-0.955重量% 组合物的重量。
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公开(公告)号:KR1020150125241A
公开(公告)日:2015-11-09
申请号:KR1020140052273
申请日:2014-04-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/23 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K9/0014 , A61K9/0019 , A61K9/0056 , A61K9/0095 , A61K9/107 , A61K9/14 , A61K9/20 , A61K9/48 , A61K2236/333 , A61Q19/00 , A61Q19/08
Abstract: 본명세서에는산형화(Masterwort)() 추출물을유효성분으로포함하는조성물이개시된다. 본명세서에개시된조성물은산형화(Masterwort)() 추출물을포함하는것에의해엔도셀린 1의양의감소, NK1R 및 EDN1 유전자의과발현감소효과를나타낸다. 따라서, 이러한효과로인해본 명세서의산형화(Masterwort)() 추출물은피부항상성유지및 항스트레스효과를나타낼수 있으며, 그러므로피부항상성유지용조성물로서약학또는화장료분야에서널리사용될수 있다.
Abstract translation: 公开了含有Pe ium(益母草)提取物作为活性成分的组合物。 本发明公开的组合物通过含有豌豆ium(母菊)提取物,减少内皮素-1的量和减少NK1R和EDN1基因的过表达。 因此,由于这些效果,本发明的Peucedanum ostruthium(益母草)提取物可以表现出维持皮肤稳态和抗应激作用的效果,因此被广泛用于药物或化妆品领域,作为用于保持皮肤的组合物 动态平衡。
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公开(公告)号:KR1020140055401A
公开(公告)日:2014-05-09
申请号:KR1020120122155
申请日:2012-10-31
Abstract: The present invention relates to a method for screening skin whitening substances, and more specifically, to a method for screening skin whitening substances comprising a step of treating a test substance on a melanin-producing cell; and a step of checking relative expression level of one or more proteins selected from a group consisting of tyrosinase, integrin alpha 6, and MITF in a cell treated with the test substance of the step.
Abstract translation: 本发明涉及一种用于筛选皮肤美白物质的方法,更具体地,涉及一种用于筛选皮肤美白物质的方法,包括在黑色素产生细胞上处理测试物质的步骤; 以及在用该步骤的测试物质处理的细胞中检查选自由酪氨酸酶,整联蛋白α6和MITF组成的组中的一种或多种蛋白质的相对表达水平的步骤。
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公开(公告)号:KR1020140034594A
公开(公告)日:2014-03-20
申请号:KR1020120101125
申请日:2012-09-12
Applicant: (주)아모레퍼시픽
IPC: A61K31/19 , A61K31/192 , A61K8/36 , A61Q19/02
Abstract: A composition for external skin application which comprises trans-communic acid as an active ingredient for skin whitening of the present invention can be usefully applied as a composition for external skin application with a purpose of skin whitening since effects of tyrosinase activity reduction and melanin generation reduction are excellent. The composition for external skin application contains 0.0025-0.025 wt% of the trans-communic acid compared to a total weight of the composition. [Reference numerals] (AA) Comparative example 1; (BB) Example 1; (CC) Example 2; (DD) Example 3
Abstract translation: 作为外用皮肤应用的组合物,其含有作为本发明的皮肤美白的活性成分的反式交联酸可有效地用作皮肤美白用的外用皮肤用组合物,因为酪氨酸酶活性降低和黑色素生成降低的作用 很好 与组合物的总重量相比,用于外部皮肤应用的组合物含有0.0025-0.025wt%的反式连通酸。 (附图标记)(AA)比较例1; (BB)实施例1; (CC)实施例2; (DD)实施例3
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57.
公开(公告)号:KR1020140027782A
公开(公告)日:2014-03-07
申请号:KR1020120093805
申请日:2012-08-27
Applicant: (주)아모레퍼시픽
Abstract: Novel melanoblast is disclosed in the present invention. A production method of the novel melanoblast is also disclosed in the present invention. Specifically, the present invention provides the novel melanoblast which has different gene expression, melanin content, tyrosinase activity, and protein expression compare to existing melanocyte. The present invention also provides the production method of the novel melanoblast for producing melanoblast from the culturing of keratinocyte. [Reference numerals] (AA) After the separation of cultured epithelial cells; (BB) In a PMA- medium; (CC) In a PMA+ medium
Abstract translation: 本发明公开了新型黑素细胞。 本发明还公开了新型黑色素细胞的制造方法。 具体地说,本发明提供与现有黑素细胞相比,具有不同基因表达,黑色素含量,酪氨酸酶活性和蛋白质表达的新型黑素细胞。 本发明还提供了用于从培养角化细胞产生黑素细胞的新型黑素细胞的制备方法。 (附图标记)(AA)培养的上皮细胞分离后; (BB)在PMA-介质中; (CC)在PMA +培养基中
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公开(公告)号:KR1020130131628A
公开(公告)日:2013-12-04
申请号:KR1020120055319
申请日:2012-05-24
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/4926 , A61K9/0014 , A61K31/445 , A61Q19/02
Abstract: The present invention relates to a composition for skin whitening, wherein the composition contains Plumarol as an active ingredient. The composition for skin whitening according to the present invention suppresses the protein expression of tyrosinase, which is a melanogenic enzyme, and inhibits melanogenesis, by containing Plumarol as an active ingredient, thereby exhibiting a whitening effect. [Reference numerals] (AA) Comparative example 1;(BB) Example 1;(CC) Example 2
Abstract translation: 本发明涉及一种用于皮肤美白的组合物,其中该组合物含有Plumarol作为活性成分。 根据本发明的皮肤美白组合物通过含有Plumarol作为活性成分抑制作为黑素生成酶的酪氨酸酶的蛋白质表达并抑制黑素生成,从而表现出美白效果。 (AA)比较例1(BB)实施例1(CC)实施例2
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公开(公告)号:KR1020130128907A
公开(公告)日:2013-11-27
申请号:KR1020120053095
申请日:2012-05-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/133 , A23L29/035 , A23L29/045 , A23V2200/318 , A61K8/41 , A61Q19/02
Abstract: The present invention relates to a whitening composition which suppresses or prevents melanogenesis and, particularly, to a composition containing valiolamine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 本发明涉及抑制或预防黑素生成的增白组合物,特别涉及包含化学式1的缬草烯胺衍生物或其药学上可接受的盐作为活性成分的组合物。
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公开(公告)号:KR1020120128774A
公开(公告)日:2012-11-28
申请号:KR1020110046619
申请日:2011-05-18
Applicant: (주)아모레퍼시픽
CPC classification number: C12N5/0629 , C12N2500/14 , C12N2509/10
Abstract: PURPOSE: A method for sorting a cultured epithelial cell layer is provided to control calcium concentration by calcium pulse and to maximize skin regeneration. CONSTITUTION: A method for sorting a cultured epithelial cell layer comprises: a step of culturing keratinocytes in a basal medium; a step of changing the medium into a calcium medium of high content; a step of changing the medium into a basal medium; a step of removing basal medium and washing with a buffer solution; a step of exposing the washed keratinocytes to the air; and a step of adding a fresh buffer solution. The calcium medium contains 1.2-1.4 mM of CaCl_2. [Reference numerals] (AA) Basal medium 6 days(comparative embodiment 1); (BB) Basal medium 10 days(comparative embodiment 2); (CC) MRNA relative value
Abstract translation: 目的:提供一种用于分选培养的上皮细胞层的方法,以通过钙脉冲控制钙浓度并使皮肤再生最大化。 构成:用于分选培养的上皮细胞层的方法包括:在基础培养基中培养角质形成细胞的步骤; 将培养基更换成高含量的钙培养基的步骤; 将培养基更换为基础培养基的步骤; 除去基础培养基并用缓冲溶液洗涤的步骤; 将洗涤的角质形成细胞暴露于空气的步骤; 以及添加新鲜缓冲溶液的步骤。 钙介质含有1.2-1.4mM CaCl 2。 (AA)基础培养基6天(比较例1); (BB)基础培养基10天(比较例2); (CC)MRNA相对值
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