公开(公告)号：AU1319502A

公开(公告)日：2002-04-22

申请号：AU1319502

申请日：2001-10-12

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： REDL HEINZ ,  SPAETHE REINER ,  SIMUNEK MANUELA

IPC: A61K38/36 ,  A61P41/00 ,  A61K38/00

公开(公告)号：AU9305501A

公开(公告)日：2002-04-08

申请号：AU9305501

申请日：2001-09-25

Applicant: BAXTER AG ,  BAXTER INT

Inventor： REDL HEINZ ,  FURST WALTER ,  KNEIDINGER RUDOLF ,  HELGERSON SAM L ,  LOOKER DOUGLAS L ,  INMAN ELISABETH M ,  RICHARDS JANE P ,  WONG CATALINA

IPC: A61K47/42 ,  A61K38/00 ,  A61K47/48 ,  C07K14/475 ,  C07K14/50 ,  C07K14/705 ,  C07K14/745 ,  C07K14/75 ,  C07K14/78 ,  C07K16/00 ,  C07K19/00 ,  C12N15/12 ,  C07K14/00

公开(公告)号：CA2423492A1

公开(公告)日：2002-04-04

申请号：CA2423492

申请日：2001-09-25

Applicant: BAXTER AG ,  BAXTER INT

Inventor： HELGERSON SAM L ,  KNEIDINGER RUDOLF ,  FURST WALTER ,  INMAN ELISABETH M ,  LOOKER DOUGLAS L ,  REDL HEINZ ,  WONG CATALINA ,  RICHARDS JANE P

IPC: A61K47/42 ,  A61K38/00 ,  A61K47/48 ,  C07K14/475 ,  C07K14/50 ,  C07K14/705 ,  C07K14/745 ,  C07K14/75 ,  C07K14/78 ,  C07K16/00 ,  C07K19/00 ,  C12N15/12 ,  C07K14/00

Abstract: A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substacne from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety suc h as VEGF185 C-terminal domain fused to a wound-healing substance such as lept in.