公开(公告)号：EP3316852A1

公开(公告)日：2018-05-09

申请号：EP15745667.4

申请日：2015-07-17

Applicant: Colgate-Palmolive Company

Inventor： KINSCHERF, Kevin ,  SCHAEFFER-KORBYLO, Lyndsay ,  SZEWCZYK, Gregory ,  MYERS, Carl ,  TRIVEDI, Harsh

IPC: A61K8/27 ,  A61K8/30 ,  A61K8/46 ,  A61Q11/00 ,  A61K33/30

CPC classification number: A61K8/58 ,  A61K8/21 ,  A61K8/25 ,  A61K8/27 ,  A61K8/30 ,  A61K8/463 ,  A61K9/08 ,  A61K33/00 ,  A61K33/30 ,  A61K45/06 ,  A61K47/34 ,  A61K2800/58 ,  A61P1/02 ,  A61Q11/00 ,  A61K2300/00

Abstract: An oral care composition comprising a surfactant having formula [R(OC2H4)xOSO3]2M wherein R is a saturated or unsaturated alkyl group with an alkyl chain length of 8 to 30 carbon atoms; x is from 0 to 10; and M is a divalent metal cation selected from zinc cations, copper cations and stannous cations is provided.

公开(公告)号：EP3223914A1

公开(公告)日：2017-10-04

申请号：EP14821476.0

申请日：2014-12-26

Applicant: Colgate-Palmolive Company

Inventor： QIAO, Baohua ,  PAN, Long ,  SZEWCZYK, Gregory ,  SUBRAMANYAM, Ravi ,  NAWROCKI, Shiri ,  DUBOVOY, Viktor

IPC: A61Q11/00 ,  A61K8/27 ,  A61K8/24 ,  A61Q15/00

Abstract: A soluble zinc polyphosphate complex made by combining ingredients which include an organic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the organic zinc salt and long chain polyphosphates being mixed in amounts that provide a phosphorus to zinc mole ratio of 15:1 to about 55:1. Further provided is a method of making this soluble zinc polyphosphate.

Abstract translation: 一种可溶性多磷酸锌络合物，其特征在于，将含有有机锌盐和多个磷酸酯聚合物单元的长链多磷酸盐的多种成分混合而成，所述有机锌盐和长链多磷酸盐的混合量使磷/锌的摩尔比 为15：1至约55：1。 还提供了制备这种可溶性聚磷酸锌的方法。

公开(公告)号：EP3198021A1

公开(公告)日：2017-08-02

申请号：EP14781402.4

申请日：2014-09-24

Applicant: Colgate-Palmolive Company

Inventor： SCHAEFFER-KORBYLO, Lyndsay ,  WON, Betty ,  MALONEY, Venda ,  SZEWCZYK, Gregory

IPC: C12Q1/18 ,  A61L2/16 ,  A61K49/00

CPC classification number: C12Q1/18 ,  C12Q2304/22 ,  C12Q2304/24

Abstract: Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.

Abstract translation: 本文提供了用于测定包含金属离子源的组合物中金属离子的生物利用度的方法，其中所述金属离子具有抗微生物活性，并且其中所述方法包括：a）将组合物样品与细菌细胞， 和b）确定孵育后细菌细胞的生存力。 该方法可用于确定试剂对组合物中金属离子生物利用度的影响。

公开(公告)号：EP2790649B1

公开(公告)日：2017-02-15

申请号：EP11808759.2

申请日：2011-12-16

Applicant: Colgate-Palmolive Company

Inventor： SZEWCZYK, Gregory ,  PATEL, Neeta Atul ,  JOGUN, Suzanne ,  PRENCIPE, Michael

IPC: A61Q11/00 ,  A61Q17/00 ,  A61K8/34 ,  A61K8/46 ,  A61K8/73 ,  A61K8/81 ,  A61K8/02

CPC classification number: A61K8/731 ,  A61K8/0216 ,  A61K8/345 ,  A61K8/347 ,  A61K8/463 ,  A61K8/4973 ,  A61K8/8164 ,  A61K2800/43 ,  A61K2800/5424 ,  A61Q11/00 ,  A61Q17/005

公开(公告)号：EP2925410B1

公开(公告)日：2016-11-16

申请号：EP12798542.2

申请日：2012-11-27

Applicant: Colgate-Palmolive Company

Inventor： PAN, Guisheng ,  PATEL, Dipak ,  SZEWCZYK, Gregory ,  LIN, Nora C.

IPC: A61Q11/00 ,  A61K8/73 ,  A61K8/81 ,  A61K8/02 ,  A61K8/29

CPC classification number: A61K8/29 ,  A61K8/0216 ,  A61K8/731 ,  A61K8/8176 ,  A61K2800/43 ,  A61Q11/00

公开(公告)号：EP2934453A1

公开(公告)日：2015-10-28

申请号：EP12824835.8

申请日：2012-12-21

Applicant: Colgate-Palmolive Company

Inventor： SZEWCZYK, Gregory ,  PATEL, Neeta Atul ,  JOGUN, Suzanne

IPC: A61K8/29 ,  A61Q11/00 ,  A61K8/49 ,  A61K8/19 ,  A61K8/81

CPC classification number: A61K8/29 ,  A61K8/19 ,  A61K8/21 ,  A61K8/25 ,  A61K8/345 ,  A61K8/347 ,  A61K8/463 ,  A61K8/494 ,  A61K8/73 ,  A61K8/8164 ,  A61K2800/43 ,  A61K2800/58 ,  A61Q11/00

Abstract: The present invention relates to a dentifrice which does not excessively stain toothbrush bristles, for example, a pigmented toothpaste formulations having a pigment system which comprises (i) a dissolvable or disintegratable film comprising one or more releasable pigments which are released during brushing, and (ii) titanium dioxide, wherein the level of titanium dioxide is 0.01-0.375% by weight of the toothpaste; together with methods of making and using the same.

Abstract translation: 本发明涉及不会过度污染牙刷刷毛的洁齿剂，例如，具有颜料体系的着色牙膏制剂，其包含（i）包含在刷洗过程中释放的一种或多种可释放颜料的可溶解或可分解的膜，和 ii）二氧化钛，其中二氧化钛的含量为牙膏重量的0.01-0.375％; 以及制作和使用方法。

公开(公告)号：EP2637634A1

公开(公告)日：2013-09-18

申请号：EP10782111.8

申请日：2010-11-12

Applicant: Colgate-Palmolive Company

Inventor： LEWUS, Catherine ,  SZEWCZYK, Gregory ,  MELLO, Sarita ,  SMITH-WEBSTER, Kimdra ,  NESTA, Jason ,  DILLON, Rensl ,  ARVANITIDOU, Evangelia S. ,  CUIULE, Christine

IPC: A61K8/34 ,  A61K8/44 ,  A61K8/49 ,  A61Q11/00

CPC classification number: A61K8/49 ,  A61K8/34 ,  A61K8/347 ,  A61K8/44 ,  A61Q11/00

Abstract: This invention relates to a mouthwash comprising an aqueous solution of an effective amount of a basic amino acid, in free or salt form together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, phenoxyethanol, and combinations thereof; as well as to methods of using and of making such compositions.

公开(公告)号：EP2637633A1

公开(公告)日：2013-09-18

申请号：EP10779424.0

申请日：2010-11-12

Applicant: Colgate-Palmolive Company

Inventor： LEWUS, Catherine ,  SZEWCZYK, Gregory ,  MELLO, Sarita ,  SMITH-WEBSTER, Kimdra ,  NESTA, Jason ,  DILLON, Rensl ,  ARVANITIDOU, Evangelia, S. ,  CUIULE, Christine

IPC: A61K8/27 ,  A61K8/34 ,  A61K8/37 ,  A61K8/49 ,  A61Q11/00

CPC classification number: A61K8/4913 ,  A61K8/27 ,  A61K8/34 ,  A61K8/365 ,  A61K8/375 ,  A61K8/49 ,  A61K2800/524 ,  A61Q11/00

Abstract: This invention relates to a mouthwash comprising an aqueous solution of an effective amount of an orally acceptable, soluble zinc salt together with an effective amount of a preservative selected from methylisothiazolinone (MIT), benzyl alcohol, glycerol monocaprylate, and combinations thereof; as well as to methods of using and of making such compositions.

公开(公告)号：EP3377026A1

公开(公告)日：2018-09-26

申请号：EP16823135.5

申请日：2016-12-20

Applicant: Colgate-Palmolive Company

Inventor： SZEWCZYK, Gregory ,  MANUS, Lisa ,  SCHAEFFER-KORBYLO, Lyndsay ,  POTANIN, Andrei ,  SUBRAMANYAM, Ravi

IPC: A61K8/24 ,  A61Q11/00 ,  A61Q11/02 ,  A61K8/81 ,  A61K8/27 ,  A61K8/44

CPC classification number: A61K8/27 ,  A61K8/21 ,  A61K8/24 ,  A61K8/44 ,  A61K8/8176 ,  A61K8/8182 ,  A61K2800/58 ,  A61Q11/00 ,  A61Q11/02

Abstract: Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.

公开(公告)号：EP3233206A1

公开(公告)日：2017-10-25

申请号：EP14821478.6

申请日：2014-12-26

Applicant: Colgate-Palmolive Company

Inventor： QIAO, Baohua ,  PAN, Long ,  SZEWCZYK, Gregory ,  SUBRAMANYAM, Ravi

IPC: A61Q11/00 ,  A61K8/27 ,  A61K8/24 ,  A61K6/00 ,  A61K33/42

CPC classification number: A61K8/27 ,  A61K6/0017 ,  A61K6/0082 ,  A61K8/24 ,  A61K33/42 ,  A61K2800/58 ,  A61Q11/00

Abstract: An oral care composition having a soluble zinc polyphosphate complex made by combining ingredients including an inorganic zinc salt, and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of treating a subject suffering from dentinal sensitivity applying the oral care composition to the teeth and gums of the subject.

Abstract translation: 1。一种口腔护理组合物，其具有通过组合包含无机锌盐和多个具有6个或更多个磷酸酯聚合物单元的长链多磷酸盐的成分而制成的可溶性聚磷酸锌复合物，提供磷的无机锌盐和长链多磷酸盐的相对量 锌的摩尔比至少为6：1。 还提供了一种治疗患有牙质敏感性的受试者的方法，将该口腔护理组合物施用于受试者的牙齿和牙龈。