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    PROCESS FOR PREPARING NOVEL ACYL DERIVATIVES
    53.
    发明专利
    PROCESS FOR PREPARING NOVEL ACYL DERIVATIVES 未知

    公开(公告)号：PT73764B

    公开(公告)日：1983-10-14

    申请号：PT7376481

    申请日：1981-10-02

    Applicant: HOFFMANN LA ROCHE

    Inventor： REINER ROLAND

    IPC: C07D253/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D253/075 ,  C07D501/00 ,  C07D501/18 ,  C07D501/36

    Abstract: There is presented compounds of the formula I wherein X represents the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl group or its corresponding tautomeric form, the 2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl group, and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of the compounds and hydrates of the compounds of formula I or of their esters, ethers and salts. Also provided is a method of their manufacture and intermediates therefor as well as corresponding pharmaceutical preparations.

    ACYL DERIVATIVES
    59.
    发明专利
    ACYL DERIVATIVES 未知

    公开(公告)号：CA1141373A

    公开(公告)日：1983-02-15

    申请号：CA328630

    申请日：1979-05-29

    Applicant: HOFFMANN LA ROCHE

    Inventor： MONTAVON MARC ,  REINER ROLAND

    IPC: C07D501/04 ,  A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/00 ,  C07D501/16 ,  C07D501/22 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

    Abstract: This invention is concerned with the manufacture of an acyl derivative of the general formula , wherein X represents the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl group, or the corresponding tautomeric form thereof, the 2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl group as well as readily hydrolysable ester/ethers and pharmaceutically acceptable salts of this compound and hydrates of the compound of formula I and of its esters/ethers and salts. The invention is also concerned with pharmaceutical preparations having antibiotic activity containing the aforementioned acyl derivative for the treatment or prophylaxis of diseases, especially of infectious diseases. Again, the invention is concerned with novel starting materials useful in the aforementioned process.

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