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    CLEANING AND FINISHING A CERAMIC MOLD
    51.
    发明申请
    CLEANING AND FINISHING A CERAMIC MOLD 审中-公开
    清洁和完成陶瓷模具

    公开(公告)号：WO1994012284A1

    公开(公告)日：1994-06-09

    申请号：PCT/US1993011318

    申请日：1993-11-22

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SACHS, Emanuel, M. ,  CIMA, Michael, J. ,  BREDT, James, F. ,  KHANUJA, Satbir

    IPC: B05B03/02

    CPC classification number: B22F3/008 ,  B08B3/10 ,  B08B3/12 ,  B08B5/04 ,  B08B7/00 ,  B08B9/00 ,  B22C9/18 ,  B24B1/04 ,  B29C33/56 ,  B33Y40/00 ,  B33Y70/00 ,  B33Y80/00

    Abstract: A technique for removing loose powder (31) from the interior surfaces of a ceramic mold (17) made using layer manufacturing processes, such as three-dimensional printing processes. The interior of a mold (17) can be filled with water (21) which is boiled and the particles are entrained in the flow caused by the boiling liquid. Alternatively, fine particles (51) are introduced into the mold (47) and agitated in the mold (47) to dislodge the particles (51) and the powder so that they can be poured out of the mold (47). Such technique tends also to remove the surface finish of the mold (47). Any of the particles (51) which remain can be dissolved in a liquid and removed in the liquid from the mold (47). Further, the surface finish of the mold (47) can be improved by casting a slip of fine particles on to the surface to form a generally level, and preferably non-conformal, coating on the surfaces.

    Abstract translation: 一种从使用诸如三维印刷工艺的层制造工艺制成的陶瓷模具（17）的内表面去除松散粉末（31）的技术。 模具（17）的内部可以填充沸水的水（21），并且颗粒被夹带在由沸腾液体引起的流中。 或者，将细颗粒（51）引入模具（47）中并在模具（47）中搅动以移除颗粒（51）和粉末，使得它们可以从模具（47）中注出。 这种技术也倾向于去除模具（47）的表面光洁度。 残留的任何颗粒（51）可以溶解在液体中并从模具（47）中移出液体。 此外，可以通过在表面上浇铸细小颗粒的滑动来形成模具（47）的表面光洁度，以在表面上形成大致水平的，优选非保形的涂层。

    RELEASE OF ALZHEIMER AMYLOID PRECURSOR STIMULATED BY ACTIVATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS
    53.
    发明申请
    RELEASE OF ALZHEIMER AMYLOID PRECURSOR STIMULATED BY ACTIVATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS 审中-公开
    通过激活乙酰胆碱受体刺激的阿尔茨海默乳胶前体的释放

    公开(公告)号：WO1994009370A1

    公开(公告)日：1994-04-28

    申请号：PCT/US1993009466

    申请日：1993-10-05

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NITSCH, Roger, M. ,  SLACK, Barbara, E. ,  WURTMAN, Richard, J. ,  GROWDON, John, H.

    IPC: G01N33/68

    CPC classification number: G01N33/6896 ,  G01N2800/2821 ,  Y10S436/815

    Abstract: Amyloid precursor protein (APP) processing which is activated by cell-surface neurotransmitter receptors, is described. An assay for testing an agent for the capacity to stimulate secretion of amyloid precursor protein (APP), a description of the characteristics of agents identified by the assay, and a method of altering APP processing in an individual are also disclosed. The assay, agents, and method of altering APP processing are particularly useful for the treatment and prevention of diseases involving APP processing, such as Alzheimer's disease.

    Abstract translation: 描述了由细胞表面神经递质受体激活的淀粉样蛋白前体蛋白（APP）处理。 还公开了用于测试刺激分泌淀粉样蛋白前体蛋白（APP）的能力的试剂的测定，通过测定鉴定的试剂的特征的描述以及改变个体中的APP处理的方法。 改变APP处理的测定，试剂和方法对于治疗和预防涉及APP加工的疾病如阿尔茨海默氏病是特别有用的。

    REDUCED AERODYNAMIC DRAG BASEBALL BAT
    55.
    发明申请
    REDUCED AERODYNAMIC DRAG BASEBALL BAT 审中-公开
    减少航空拖车基地台BAT

    公开(公告)号：WO1994006522A1

    公开(公告)日：1994-03-31

    申请号：PCT/US1993008995

    申请日：1993-09-22

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  DITULLIO, Jeffrey, C.

    IPC: A63B59/06

    CPC classification number: A63B59/58 ,  A63B59/50 ,  A63B60/48 ,  A63B2060/006 ,  A63B2102/18

    Abstract: The invention is a baseball bat having a handle portion and an end portion, the end portion having a generally cylindrical surface, and a striking portion, the surface of the striking portion impressed with a plurality of shallow depressions (2). The depressions (2) are sized and located so as to increase the turbulence of the boundary layer of air flowing over the bat, as compared to the turbulence that would arise under identical conditions due to flow of air over a substantially smooth surfaced control bat, so as to trip the boundary layer and reduce the drag coefficient experienced by the bat, as compared to the drag coefficient that would be experienced by the control bat. Suggested parameters for optimization of the dimple sizes are provided.

    Abstract translation: 本发明是一种具有手柄部分和端部的棒球棒，该端部具有大致圆柱形的表面，以及一击打部分，该打击部分的表面被多个浅凹陷部分（2）所压印。 与由于空气流过基本上光滑的表面控制蝙蝠而在相同条件下将产生的湍流相比，凹陷（2）的尺寸和位置以增加流过蝙蝠的空气边界层的湍流， 以便与控制棒所经历的阻力系数相比，跳过边界层并减小蝙蝠经历的阻力系数。 提供了用于优化凹坑尺寸的建议参数。

    RECOVERED ENERGY LOGIC CIRCUITS
    56.
    发明申请
    RECOVERED ENERGY LOGIC CIRCUITS 审中-公开
    恢复能源逻辑电路

    公开(公告)号：WO1994002993A1

    公开(公告)日：1994-02-03

    申请号：PCT/US1993006630

    申请日：1993-07-14

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SCHLECHT, Martin, F. ,  HINMAN, Roderick, T.

    IPC: H03K19/082

    CPC classification number: H03K19/0019

    Abstract: A logic circuit is driven by a single alternating voltage power supply so that the energy stored in parasitic capacitances can be mostly recovered, rather than dissipated, as in conventional logic designs. Successive stages of the logic circuit are of opposite conductivity types such that the successive stages are activated in alternate half cycles of the power supply without separate clock signals. Each stage of the logic circuit is precharged during a respective first half cyclo of the power supply and is active in logical processing during a second half cycle. The half cycles are defined by the rising and falling edges of the power sypply. The logic circuit resonates with an inductor coupled across the power supply but closely coupled to the logic circuit. This inductor and the method of charging and discharging the capacitors in the logic circuit serve to minimize the power dissipated during logical processing.

    Abstract translation: 逻辑电路由单个交流电压电源驱动，使得存储在寄生电容中的能量可以大部分被恢复，而不是耗散，如在常规逻辑设计中。 逻辑电路的连续级具有相反的导电类型，使得连续级在电源的交替半周期中被激活，而没有单独的时钟信号。 逻辑电路的每个级在电源的相应的第一半环期间被预充电，并且在第二个半周期期间在逻辑处理中有效。 半周期由电源的上升沿和下降沿限定。 逻辑电路与耦合在电源上但紧密耦合到逻辑电路的电感谐振。 该电感器和对逻辑电路中的电容器进行充电和放电的方法用于使逻辑处理期间的功耗最小化。

    A TREE-LIKE PERCEPTRON AND A METHOD FOR PARALLEL DISTRIBUTED TRAINING OF SUCH PERCEPTRONS
    58.
    发明申请
    A TREE-LIKE PERCEPTRON AND A METHOD FOR PARALLEL DISTRIBUTED TRAINING OF SUCH PERCEPTRONS 审中-公开
    一种类似的PERCEPTRONON和一种用于并行分布式培养这种PERCEPTRON的方法

    公开(公告)号：WO1994001823A1

    公开(公告)日：1994-01-20

    申请号：PCT/US1993006449

    申请日：1993-07-08

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  CHI-SANG, Poon

    IPC: G06F15/18

    CPC classification number: G06N3/08 ,  G06N3/04

    Abstract: A neural network (20) has an input layer (26) comprising a plurality of neurons (28), a hidden layer (24) comprising a plurality of neurons (22), each neuron being either inhibitory or excitatory, and an output layer (30) comprising at least one neuron (32). Each synapse (34) of a first set of synapses connects a neuron in the input layer to a neuron in the hidden layer. Each synapse (36) of a second set of synapses connects a neuron in the hidden layer to a neuron in the output layer. With a plurality of output neurons, a plurality of parallel output paths is thus created. Each neuron in the hidden layer receives a reinforcement signal from its corresponding neuron in the output layer.

    Abstract translation: 神经网络（20）具有包括多个神经元（28）的输入层（26），包括多个神经元（22）的隐藏层（24），每个神经元是抑制或兴奋性的，以及输出层 30）包括至少一个神经元（32）。 第一组突触的每个突触（34）将输入层中的神经元连接到隐藏层中的神经元。 第二组突触的每个突触（36）将隐层中的神经元连接到输出层中的神经元。 利用多个输出神经元，由此产生多个并行输出路径。 隐层中的每个神经元从输出层中相应的神经元接收加强信号。

    A GENE WHICH PREVENTS PROGRAMMED CELL DEATH
    59.
    发明申请
    A GENE WHICH PREVENTS PROGRAMMED CELL DEATH 审中-公开
    预防编程性细胞死亡的基因

    公开(公告)号：WO1993025683A1

    公开(公告)日：1993-12-23

    申请号：PCT/US1993005651

    申请日：1993-06-14

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  HORVITZ, H., Robert ,  HENGARTNER, Michael

    IPC: C12N15/12

    CPC classification number: C12Q1/6876 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/4747 ,  C12Q2600/156

    Abstract: The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell death. As described herein, a cell death-protective gene from the nematode Caenorhabditis elegans, called ced-9, has been identified, sequenced, and characterized. ced-9 is essential for C. elegans development and apparently functions by protecting cells which normally live during development from programmed cell death. Mutations which constitutively activate and inactivate the ced-9 gene are also described. ced-9 was shown to function by antagonizing the activities of the cell death genes, ced-3 and ced-4. As further described, the protein product of the human oncogene bcl-2 was found to have a similar sequence to the ced-9 protein. Methods and agents for both increasing and decreasing the occurrence of cell death are described that are potentially useful for diagnosis, prevention and therapy of diseases and conditions involving cell death; for the treatment of viral, parasitic, and other types of infection; and for killing organisms that are detrimental or potentially detrimental to the environment or to humans, pets, livestock, or agriculture.

    Abstract translation: 本发明涉及本文称为细胞死亡保护基因的基因，其通过拮抗引起细胞死亡的基因的活性来保护细胞免于程序性细胞死亡。 如本文所述，已鉴定，测序和表征来自线虫秀丽隐杆线虫的细胞死亡保护基因，称为ced-9。 ced-9对于秀丽隐杆线虫的发育至关重要，并且显然通过保护通常在程序性细胞死亡过程中生存的细胞起作用。 还描述了组成型激活和灭活ced-9基因的突变。 ced-9显示通过拮抗细胞死亡基因ced-3和ced-4的活性起作用。 如进一步所述，发现人癌基因bcl-2的蛋白质产物具有与ced-9蛋白相似的序列。 描述了增加和减少细胞死亡发生的方法和试剂，其潜在地用于诊断，预防和治疗涉及细胞死亡的疾病和病症; 用于治疗病毒，寄生虫等感染类型; 并且用于杀死有害或可能对环境或人类，宠物，家畜或农业有害的生物。

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