-
51.发明申请公开(公告)号：US20220273434A1
公开(公告)日：2022-09-01
申请号：US17680636
申请日：2022-02-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar , Daryl C. Nguyen
IPC: A61F2/24
Abstract: The present invention is directed to a device for first grabbing, and then securing the native atrioventricular valve's leaflet to a prosthesis via transcatheter means. The present invention features a grasping device for securing a leaflet component of a native mitral valve. The leaflet component comprises a leaflet and chordae tendineae associated with the. In some embodiments, the device may comprise a first grasping component configured to grab chordae tendineae of said native mitral leaflet component, and a second grasping component configured to anchor the native mitral leaflet component to a prosthetic component. In some embodiments, the first grasping component may comprise at least one grasping arm configured to transition from a non-extended state to an extended state to a grasping state. In some embodiments, the second grasping component may comprise a hook disposed at a distal end of the device capable of anchoring to the prosthetic component.
-
公开(公告)号：US20220023020A1
公开(公告)日：2022-01-27
申请号：US17381831
申请日：2021-07-21
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar , Hamid R. Djalilian
Abstract: An oral irrigator system having an ergonomic casing with a pliable nozzle assembly, and coupled to a detachable and refillable fluid reservoir. The ergonomic casing contains a power source and a pump mechanism. The detachable nozzle head delivers a pulsating jet of fluid with adjustable speed into the oropharyngeal cavity. When the system is turned on, the rechargeable battery activates the diaphragm pump to draw fluid from the reservoir using a fluid pipe and delivers the fluid to the tip of the nozzle head.
-
53.发明申请公开(公告)号：US20210312242A1
公开(公告)日：2021-10-07
申请号：US17214442
申请日：2021-03-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Hamid Jafarkhani , Saeed Karimi-Bidhendi , Arash Kheradvar
Abstract: Methods, devices, and systems that are related to facilitating an automated, fast and accurate model for cardiac image segmentation, particularly for image data of children with complex congenital heart disease are disclosed. In one example aspect, a generative adversarial network is disclosed. The generative adversarial network includes a generator configured to generate synthetic imaging samples associated with a cardiovascular system, and a discriminator configured to receive the synthetic imaging samples from the generator and determine probabilities indicating likelihood of the synthetic imaging samples corresponding to real cardiovascular imaging sample. The discriminator is further configured to provide the probabilities determined by the discriminator to the generator and the discriminator to allow the parameters of the generator and the parameters of the discriminator to be adjusted iteratively until an equilibrium between the generator and the discriminator is established.
-
公开(公告)号：US20210137676A1
公开(公告)日：2021-05-13
申请号：US17088989
申请日：2020-11-04
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar , Daryl C. Nguyen
IPC: A61F2/24
Abstract: Disclosed herein is a valve system with an original deployed diameter that is suitable for a child and/or young adult and that can accommodate the patient's growth by a one-time balloon expansion to attain an expanded diameter in that patient. This novel valve addresses an unmet need for children with valve dysfunction and to stop valve-related progressive ventricular dysfunction, and ultimately avoid heart failure in children and young adults.
-
公开(公告)号：US10792396B2
公开(公告)日：2020-10-06
申请号：US16198116
申请日：2018-11-21
Applicant: The Regents of the University of California
Inventor： Arash Kheradvar , Ramin Zareian
Abstract: A hybrid tissue engineered heart valve leaflet including a polyurethane core, such as a polycarbonate-based thermoplastic polyurethane like carbothane. The polyurethane core is enclosed within one or more layer of a patient's cells and collagen. Also disclosed are hybrid tissue engineered heart valves, including a frame; and at least two leaflets attached thereto in a configuration of a heart valve, wherein the leaflets are hybrid tissue engineered heart valve leaflets, and methods of making a hybrid tissue engineered heart valve for deployment in a patient.
-
Patent Agency Ranking
56.发明授权公开(公告)号：US10521902B2
公开(公告)日：2019-12-31
申请号：US15294207
申请日：2016-10-14
Applicant: The Regents of the University of California
Inventor： Michael Rashidi Avendi , Hamid Jafarkhani , Arash Kheradvar
Abstract: Systems and methods are disclosed for automatically segmenting a heart chamber from medical images of a patient. The system may include one or more hardware processors configured to: obtain image data including at least a representation of the patient's heart; obtain a region of interest from the image data; organize the region of interest into an input vector; apply the input vector through a trained graph; obtain an output vector representing a refined region of interest corresponding to the heart based on the application of the input vector through the trained graph; apply a deformable model on the obtained output vector representing the refined region of interest; and identify a segment of a heart chamber from the application of the deformable model on the obtained output vector.
-
57.发明申请公开(公告)号：US20170360557A1
公开(公告)日：2017-12-21
申请号：US15627360
申请日：2017-06-19
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar , Gregory S, Kelley
Abstract: Described is a delivery system for percutaneous delivery and implantation of a heart valve. The delivery system includes a handle with a sheath extending therefrom. A splay shaft extends from the handle through the sheath. At least two arms extend from the handle through the splay shaft. The at least two arms are operable for holding a heart valve. A sheath controller is housed within the handle and is operable for selectively advancing or retracting the sheath to constrain or expose a heart valve as attached with the at least two arms. A splay shaft controller is housed within the handle for allowing the user to selectively advance or retract the splay shaft to constrain or expose the at least two arms. Finally, a valve release is attached with the handle to allow a user to selectively release a heart valve as attached with the at least two arms.
-
58.发明申请METHOD FOR POST-PROCESSING FLOW-SENSITIVE PHASE CONTRAST MAGNETIC RESONANCE IMAGES 审中-公开用于后处理流敏相位对比磁共振图像的方法公开(公告)号：US20160358328A1
公开(公告)日：2016-12-08
申请号：US15102853
申请日：2014-12-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmad Falahatpisheh , Arash Kheradvar
IPC: G06T7/00 , G01R33/56 , G01R33/563 , G06T15/08
CPC classification number: G06T7/0012 , G01R33/5608 , G01R33/56316 , G06F19/321 , G06T7/11 , G06T15/08 , G06T19/00 , G06T2210/24 , G06T2210/41
Abstract: A method for generating fluid flow images of a region of interest is disclosed. The method includes: scanning the region of interest to acquire a set of 4D-Flow magnetic resonance images, wherein the set comprises an anatomical magnitude image, a first velocity component image, a second velocity component image, and a third velocity component image; isolating the anatomical magnitude image, the first velocity component image, the second velocity component image, and the third velocity component image from the set of 4D-Flow magnetic resonance images; converting the first, second, and third velocity component images into a velocity vector field; modeling a location of an anatomical wall within the region of interest; calculating at least one flow dynamics parameter for the region of interest; and generating a visual representation of the anatomical wall and the at least one flow dynamics parameter.
Abstract translation: 公开了一种用于产生感兴趣区域的流体流动图像的方法。 该方法包括：扫描感兴趣区域以获取一组4D-Flow磁共振图像，其中该组包括解剖幅度图像，第一速度分量图像，第二速度分量图像和第三速度分量图像; 从4D-Flow磁共振图像的组中分离解剖幅度图像，第一速度分量图像，第二速度分量图像和第三速度分量图像; 将第一，第二和第三速度分量图像转换成速度矢量场; 在感兴趣区域内建模解剖墙的位置; 计算感兴趣区域的至少一个流动动力学参数; 以及产生所述解剖壁和所述至少一个流动动力学参数的视觉表示。
-
公开(公告)号：US20140336755A1
公开(公告)日：2014-11-13
申请号：US14205820
申请日：2014-03-12
Applicant: The Regents of the University of California
Inventor： Arash Kheradvar , Seyedhamed Alavi
IPC: A61F2/24
CPC classification number: A61F2/2415 , A61L27/56 , A61L2430/20 , C12M23/02 , C12M23/20 , C12M25/14
Abstract: A tubular braided mesh scaffold for fabrication of heart valves is described. The tubular braided scaffold can be formed of a shape memory metal, such as Nitinol, and pinched or pressed to form a leaflet shape. When heat treated, the braided mesh scaffold holds and retains its valve-like shape.
Abstract translation: 描述了用于制造心脏瓣膜的管状编织网格支架。 管状编织支架可以由诸如镍钛诺的形状记忆金属形成，并且被挤压或压制以形成小叶形状。 当经过热处理时，编织网格支架保持并保持其阀状。
-
公开(公告)号：US20140277414A1
公开(公告)日：2014-09-18
申请号：US14221194
申请日：2014-03-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar
CPC classification number: A61F2/2439 , A61B8/0841 , A61B8/0891 , A61B8/12 , A61B90/37 , A61B2090/3782 , A61F2/2427
Abstract: Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self-expandable stent frame to control its state of deployment. With additional features, lateral positioning of the stent frame may also be controlled. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Still another embodiment integrates a visualization system in the subject delivery system. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.
Abstract translation: 本文描述的实施例解决了对用于经皮植入的心脏瓣膜的输送，重新定位和/或经皮取出的改进的导管装置的需要。 一个实施例采用可释放地与支架框架接合的多个弹簧加载臂，用于控制阀部署的膨胀。 另一个实施例采用多个细丝穿过推进套筒的远端和自扩张支架框架中的孔，以控制其展开状态。 通过附加特征，还可以控制支架框架的横向定位。 又一个实施例包括多个向外偏置的臂，通过覆盖护套段保持到互补的支架框架特征。 另一个实施例将可视化系统集成在主体传送系统中。 除了显示和描述的之外，还考虑了与使用这些实施例相关联的硬件和方法的变化。
-
-
-
-
-
-
-
-
-
Search Results
62
records
(took 0.041 seconds)
