Abstract:
The objective of the present invention is to provide a biodegradable material having improved flexibility, an increased percentage of shape recovery after the material has been deformed, and improved biodegradability. The present invention provides a biodegradable material resulting from chemically crosslinking: a polyvalent compound (A) having at least three functional groups (X) such as hydroxyl groups; a polyvalent compound (B) having at least three functional groups such as carboxyl groups; and a compound (C) having a structure derived from a hydroxycarboxylic acid and having a glass transition point of the homopolymerized homopolymer thereof of no greater than -40°C.
Abstract:
The purpose of the invention is to provide biodegradable particles for medical treatment and a vascular embolization material, the inadequate softness of which has been improved, the particles do not aggregate with each other easily, and the particle shape-restoring force after passing through a catheter, etc. has been improved. The invention provides biodegradable particles for medical treatment obtained from a tri-block copolymer of an A1-B-A2 form, wherein A1 and A2 are blocks of biodegradable copolymers configured from monomers comprising glycolic acid, lactic acid and 6-hydroxycaproic acid, and B is a block of a water-soluble polymer.
Abstract:
The objective of the present invention is to provide: spherical biodegradable particles having an ameliorated insufficiency in flexibility, having resistance to the occurrence of particle agglomeration, and having an increased particle shape restoring force after passing through a catheter or the like; and a method for producing the biodegradable particles. The present invention provides biodegradable particles formed from the chemical crosslinking of a synthetic polymer and a polyvalent carboxylic acid, and having a moisture content in a water saturated state of 20-90%.
Abstract:
The present invention aims to provide spherical biodegradable particles which have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like, and a method for producing the particles. The present invention provides biodegradable particles comprising a synthetic polymer chemically cross-linked to a polyvalent carboxylic acid, which biodegradable particles have a water content of 20 to 90% in the water-saturated state.
Abstract:
The purpose of the invention of the present application is to provide a medical material and a blood purification apparatus each having high anti-thrombotic properties and high safety. The apparatus is produced by incorporating therein a medical material which has a hydrophilic copolymerization polymer present on a surface thereof which is to be in contact with blood, wherein particulate protuberances each having a particle diameter of 50 nm or more are present on the surface which is to be in contact with blood at a density of 3 particles/µm 2 or less and the relaxation time of adsorbed water in the hydrophilic copolymerization polymer is 2.5 × 10 -8 seconds or shorter and 5.0 × 10 -10 seconds or longer at -40°C.
Abstract:
The present invention addresses the problem of providing an artificial blood vessel which is able to retain mechanical properties required for an artificial blood vessel, rarely undergoes the formation of thrombi when grafted into a blood vessel having a small or medium diameter, and has such an excellent cell colonization property that endothelial cells can be colonized rapidly to form an endothelial tissue. Thus, the present invention provides an artificial blood vessel comprising a tubular woven fabric which is composed of at least two types of polyester fibers, i.e., a multifilament yarn A and a multifilament yarn B, and has an inner diameter of 8 mm or less and a layer thickness of 50 µm or more and 250 µm or less, wherein the multifilament yarn A has a single fiber fineness of 1.0 dtex or more and a total fineness of 33 dtex or less, the multifilament yarn B has a single fiber fineness of 0.08 dtex or less and a total fineness of 66 dtex or less, and the multifilament yarn B forms loops on the inner wall surface of the composite tubular woven fabric.
Abstract:
An endovascular treatment aiding device whose filter is not caught by a treatment device during retrieval of the endovascular treatment aiding device is disclosed. The treatment aiding device comprises: a flexible shaft; a filter fixed to the shaft, which can be opened and closed in an umbrella-like manner; linear supporting members each of which connects the end portion in the opening-section side of the filter to a part of the shaft such that the filter can be closed by applying an external force to the proximal side; an elastomer member composed of an elastomer in which a penetrating hole (A) is formed, which elastomer member is arranged in the proximal side relative to the opening section of the filter such that the shaft penetrates the penetrating hole (A), wherein the outer diameter of the end face in which the penetrating hole (A) is formed is larger than the outer diameter of the opening-section side of the filter when the filter is closed; and an outer tube in which a penetrating hole (B) is formed, which outer tube is arranged in the proximal side relative to the opening section of the filter such that the shaft penetrates the penetrating hole (B) in a state which allows movement of the shaft in the longitudinal direction; wherein the elastomer member is fixed in the distal side of the outer tube.
Abstract:
The present invention aims to provide a biodegradable material having an improved biodegradability, an enhanced shape recovery rate after deformation of the material and an improved flexibility. The present invention provides a biodegradable material which is a chemically cross-linked product of: a multivalent compound A having 3 or more functional groups X such as hydroxyl group; a multivalent compound B having 3 or more functional groups Y such as carboxyl group; and a compound C having a structure originated from a hydroxycarboxylic acid whose homopolymer formed by homopolymerization has a glass transition point of -40°C or lower.