Mutant Rev transdominant repressors of HIV replication
    51.
    发明授权
    Mutant Rev transdominant repressors of HIV replication 失效
    突变型转录反义寡核苷酸HIV复制

    公开(公告)号:US6162898A

    公开(公告)日:2000-12-19

    申请号:US138069

    申请日:1998-08-21

    Inventor: Bryan R. Cullen

    Abstract: Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II. And in some cases both the Rev and the Rex function and are, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example of these transdominant inhibitors may be used in such therapeutic approaches as intracellular immunization in order to protect cells against the deleterious effects of viral, e.g. HIV-1, infection.

    Abstract translation: 衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II。 在某些情况下,Rev和Rex的功能都是活跃在一种以上的病毒物种中。 这样的显性病毒突变体可用作抗病毒剂,例如这些跨主导抑制剂可用于诸如细胞内免疫的治疗方法中,以保护细胞免受病毒的有害影响,例如, HIV-1,感染。

    Papua New Guinea human T-lymphotropic virus
    57.
    发明授权
    Papua New Guinea human T-lymphotropic virus 失效
    巴布亚新几内亚人类T淋巴细胞病毒

    公开(公告)号:US5397696A

    公开(公告)日:1995-03-14

    申请号:US743518

    申请日:1991-08-12

    Abstract: The present invention relates to a human T-cell line (PNG-1) persistently infected with a Papua New Guinea (PNG) HTLV-I variant and to the infecting virus (PNG-1 variant). Cells of the present invention express viral antigens, type C particles and have a low level of reverse transcriptase activity. The establishment of this cell line, the first of its kind from an individual from Papua New Guinea, makes possible the screening of Melanesian populations using a local virus strain. The present invention also relates to vaccines for use in humans against infection with and diseases caused by HTLV-I and related viruses. The invention further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-I and related viruses.

    Abstract translation: 本发明涉及持续感染巴布亚新几内亚(PNG)HTLV-1变体和感染病毒(PNG-1变体)的人T细胞系(PNG-1)。 本发明的细胞表达病毒抗原,C型粒子并具有低水平的逆转录酶活性。 这种细胞系的建立是来自巴布亚新几内亚的第一种细胞系,使得可以使用当地病毒株筛选美拉尼西亚人群。 本发明还涉及用于人类针对感染的疫苗和由HTLV-1和相关病毒引起的疾病。 本发明还涉及用于检测和诊断由HTLV-1和相关病毒引起的感染和疾病的各种生物测定和试剂盒。

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