公开(公告)号：EP0567230A2

公开(公告)日：1993-10-27

申请号：EP93302291.5

申请日：1993-03-25

Applicant: Becton Dickinson and Company

Inventor： Berndt, Klaus W.

IPC: C12M1/34 ,  G01N21/35

CPC classification number: G01N21/274 ,  C12M41/46 ,  G01N21/3504 ,  G01N2021/5969 ,  G01N2201/06106 ,  G01N2201/066 ,  G01N2201/0662 ,  Y10S435/808

Abstract: Methods and apparatus for detecting biological activity within a sample are disclosed. The present invention provides a combination of a first and a second infrared light source arranged on the side of a sample vial, and a first and a second narrow-band infrared detector similarly arranged on the side of the vial approximately opposite the sources. The disclosed arrangement cancels the sources of error while measuring the carbon dioxide content of the headspace gas above the sample. In operation, the present invention sequentially measures the photocurrents generated at each detector with no source turned on, with the first source turned on, and with the second source turned on and the first source turned off. The C0 2 absorption coefficient of the vial headspace gas is then calculated based on the photocurrents measured. This present invention allows compensation for source aging, detector aging, and vial wall thickness changes. Moreover, the present invention permits a determination of the absolute absorption coefficient at a selected wavelength, most preferably about 4.26 µm, which is the C0 2 absorption characteristic wavelength. The determination of the absolute C0 2 concentration within the headspace permits the detection of bacterial growth processes. Additionally, the disclosed source/detector combination can be produced at low cost. Thus, in preferred embodiments, the apparatus of the present invention comprises a plurality of vials that are simultaneously monitored by providing each of the plurality of vials with its own source/detector combination and activating and deactivating the sources and detectors using a multiplexer/demultiplexer arrangement.

Abstract translation: 公开了用于检测样品内生物活性的方法和装置。 本发明提供了布置在样品瓶侧面的第一和第二红外光源的组合，以及类似地布置在大致与源相对的小瓶侧面上的第一和第二窄带红外探测器。 所公开的布置在测量样品上方的顶空气体的二氧化碳含量时消除误差源。 在操作中，本发明顺序地测量在没有信号源被接通的情况下在每个检测器处产生的光电流，其中第一信号源被接通，并且第二信号源被接通并且第一信号源被关断。 然后基于测量的光电流计算出瓶顶空间气体的CO 2吸收系数。 本发明允许补偿源老化，检测器老化和小瓶壁厚变化。 此外，本发明允许确定选定波长的绝对吸收系数，最优选约4.26μm，这是CO 2吸收特性波长。 顶部空间中绝对二氧化碳浓度的测定允许细菌生长过程的检测。 此外，所公开的源/检测器组合可以以低成本生产。 因此，在优选实施例中，本发明的装置包括多个小瓶，其通过向多个小瓶中的每一个提供其自身的源/检测器组合并且使用多路复用器/解复用器布置来激活和去激活源和检测器来同时监视 。

公开(公告)号：EP2282204B1

公开(公告)日：2017-11-15

申请号：EP10183291.3

申请日：2004-05-25

Applicant: Alere Switzerland GmbH

Inventor： Sharrock, Stephen Paul ,  Phelan, Andrew

IPC: G01N33/487 ,  G01N21/86 ,  G01N33/543 ,  G01N33/76 ,  G01N21/78 ,  G01N21/27 ,  G01N21/47 ,  G01N21/84 ,  G01N31/22

CPC classification number: G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N21/8483 ,  G01N31/22 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

公开(公告)号：EP2385363A2

公开(公告)日：2011-11-09

申请号：EP10184102.1

申请日：2004-05-25

Applicant: Alere Switzerland GmbH

Inventor： Phelan, Andrew

IPC: G01N21/86 ,  G01N33/487 ,  G01N21/27 ,  G01N21/78

CPC classification number: G01N21/78 ,  G01N21/274 ,  G01N21/8483 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: An assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source(s) emitting light incident upon at least two, spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones; in a further aspect is disclosed an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: at least one light source incident upon a zone of the test strip; and at least two photodetectors both of which are able to detect some of the light emanating from the zone of the test strip illuminated by the light source.

Abstract translation: 一种用于读取使用测试条进行的分析结果的测定结果读取装置，所述装置包括：光源或所述光源，所述光源发射入射到所述测试条的至少两个空间上分离的区域的光; 以及光电检测器，其检测从所述两个所述区域中的每一个发出的光; 在另一方面公开了一种用于读取使用测试条执行的分析结果的测定结果读取装置，该装置包括：入射到测试条带的至少一个光源; 以及至少两个光电检测器，它们都能够检测从由光源照射的测试条带的区域发出的一些光。

公开(公告)号：EP2293068A1

公开(公告)日：2011-03-09

申请号：EP10183375.4

申请日：2004-05-25

Applicant: Alere Switzerland GmbH

Inventor： Sharrock, Stephen Paul

IPC: G01N33/543 ,  G01N33/76 ,  G01N33/558

CPC classification number: G01N21/8483 ,  G01N21/274 ,  G01N21/78 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: Disclosed is an assay result reading device for reading the result of an assay performed using a liquid transport carrier, the device comprising:
at least one light source capable of emitting light incident upon at least one of two or more spatially separated zones of the carrier;
a photodetector so positioned as to be capable of detecting light emanating from each of the two said zones and generating signals representing the presence or absence of a fluid sample in the respective zone; and
a computation circuit responsive to the signals to:
calculate a flow rate for a fluid flowing along the carrier;
compare the calculated flow rate to upper and lower limits; and
reject the assay result if the calculated flow rate is outside the upper and lower limits

Abstract translation: 公开了一种用于读取使用液体输送载体进行的分析结果的测定结果读取装置，该装置包括：能够发射入射在载体的两个或更多个空间分离区域中的至少一个上的光的至少一个光源; 光电检测器，其被定位成能够检测从两个所述区域中的每一个发出的光，并产生表示在相应区域中存在或不存在流体样品的信号; 以及响应于所述信号的计算电路：计算沿着所述载体流动的流体的流量; 将计算流量与上限和下限进行比较; 如果计算出的流量超出上限和下限，则拒绝测定结果

公开(公告)号：EP1484601B1

公开(公告)日：2009-02-04

申请号：EP04253078.2

申请日：2004-05-25

Applicant: Inverness Medical Switzerland GmbH

Inventor： Phelan, Andrew Peter

IPC: G01N21/78 ,  G01N31/22

CPC classification number: G01N21/78 ,  G01N21/274 ,  G01N21/8483 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

公开(公告)号：EP1484611A2

公开(公告)日：2004-12-08

申请号：EP04253077.4

申请日：2004-05-25

Applicant: Inverness Medical Switzerland GmbH

Inventor： Sharrock, Stephen Paul UNIPATH LTD

IPC: G01N33/00

CPC classification number: G01N21/8483 ,  G01N21/274 ,  G01N21/78 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: An assay result reading device for reading the result of an assay performed using a liquid transport carrier may include at least one light source capable of emitting light incident upon at least one of two or more spatially separated zones of the carrier, a photodetector so positioned as to be capable of detecting light emanating from each of the two said zones and generating signals representing the presence or absence of a fluid sample in the respective zone, and a computation circuit. The computation circuit may be responsive to the signals to calculate a flow rate for a fluid flowing along the carrier, compare the calculated flow rate to upper and lower limits, and reject the assay result if the calculated flow rate is outside the upper and lower limits.

Abstract translation: 用于读取使用液体输送载体进行的分析结果的测定结果读取装置可以包括能够发射入射到载体的两个或更多个空间分离区域中的至少一个的光的至少一个光源， 能够检测从两个所述区域中的每一个发出的光并产生表示各个区域中是否存在流体样品的信号，以及计算电路。 计算电路可以响应于信号来计算沿着载体流动的流体的流量，将计算的流速与上限和下限进行比较，并且如果计算出的流量超出上限和下限，则拒绝测定结果 。

公开(公告)号：EP0567230A3

公开(公告)日：1995-04-26

申请号：EP93302291.5

申请日：1993-03-25

Applicant: Becton Dickinson and Company

Inventor： Berndt, Klaus W.

IPC: C12M1/34 ,  G01N21/35

CPC classification number: G01N21/274 ,  C12M41/46 ,  G01N21/3504 ,  G01N2021/5969 ,  G01N2201/06106 ,  G01N2201/066 ,  G01N2201/0662 ,  Y10S435/808

Abstract: Methods and apparatus for detecting biological activity within a sample are disclosed. The present invention provides a combination of a first and a second infrared light source arranged on the side of a sample vial, and a first and a second narrow-band infrared detector similarly arranged on the side of the vial approximately opposite the sources. The disclosed arrangement cancels the sources of error while measuring the carbon dioxide content of the headspace gas above the sample. In operation, the present invention sequentially measures the photocurrents generated at each detector with no source turned on, with the first source turned on, and with the second source turned on and the first source turned off. The C0 2 absorption coefficient of the vial headspace gas is then calculated based on the photocurrents measured. This present invention allows compensation for source aging, detector aging, and vial wall thickness changes. Moreover, the present invention permits a determination of the absolute absorption coefficient at a selected wavelength, most preferably about 4.26 µm, which is the C0 2 absorption characteristic wavelength. The determination of the absolute C0 2 concentration within the headspace permits the detection of bacterial growth processes. Additionally, the disclosed source/detector combination can be produced at low cost. Thus, in preferred embodiments, the apparatus of the present invention comprises a plurality of vials that are simultaneously monitored by providing each of the plurality of vials with its own source/detector combination and activating and deactivating the sources and detectors using a multiplexer/demultiplexer arrangement.

公开(公告)号：JP2011257414A

公开(公告)日：2011-12-22

申请号：JP2011156548

申请日：2011-07-15

Applicant: Alere Switzerland Gmbh ,  アレル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング

Inventor： SHERLOCK STEVEN PAUL

IPC: G01N21/78 ,  G01N33/53 ,  G01N21/27 ,  G01N21/47 ,  G01N21/77 ,  G01N21/86 ,  G01N33/48 ,  G01N33/52 ,  G01N35/00

CPC classification number: G01N21/8483 ,  G01N21/274 ,  G01N21/78 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: PROBLEM TO BE SOLVED: To provide a method for deciding optimal read time to address a situation where a flow rate of a liquid flowing along a porous carrier fluctuates for every inspection in a manner that a convection current surface moves along the carrier at a faster rate than usual in one inspection and at a slower rate than usual in the other inspection causing optimal read time to be fluctuated accordingly.SOLUTION: An analysis result reading device to read a result of an analysis performed with a liquid transfer carrier comprises: at least one light source to radiate light incident on at least one of two or more spatially isolated regions in the carrier; a light detector which is positioned to receive light emitted from each of the two or more regions and generates a signal to indicate whether or not a liquid sample is present in each of the region; and a calculation circuit. The calculation circuit calculates a flow rate of a fluid stream along the carrier in response to the signal, compares the calculated flow rate with an upper limit and a lower limit, and rejects an analysis result when the calculated flow rate is outside a range between the upper limit and the lower limit.

Abstract translation: 要解决的问题：提供一种用于确定最佳读取时间的方法，以解决沿着多孔载体流动的液体的流量对于每次检查而波动的情况，其中对流电流表面沿着载体移动 在一次检查中比通常更快，在另一次检查中以比通常更慢的速度导致最佳读取时间相应地波动。 解决方案：用于读取用液体转移载体进行的分析结果的分析结果读取装置包括：至少一个光源，用于辐射入射在载体中的两个或更多个空间隔离区域中的至少一个上的光; 光检测器，其被定位成接收从两个或更多个区域中的每个区域发射的光，并产生一个信号，以指示液体样品是否存在于每个区域中; 和计算电路。 计算电路响应于信号计算沿着载波的流体流的流量，将计算出的流量与上限和下限进行比较，并且当计算流量超出上限和下限之间的范围时，拒绝分析结果 上限和下限。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP4812264B2

公开(公告)日：2011-11-09

申请号：JP2004167288

申请日：2004-06-04

Applicant: アレル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング

Inventor： シャーロック、スティーブン・ポール

IPC: G01N21/77 ,  G01N33/53 ,  G01N21/27 ,  G01N21/47 ,  G01N21/78 ,  G01N21/86 ,  G01N33/48

CPC classification number: G01N21/8483 ,  G01N21/274 ,  G01N21/78 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

公开(公告)号：JP4630003B2

公开(公告)日：2011-02-09

申请号：JP2004166895

申请日：2004-06-04

Applicant: アレル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング

Inventor： ペラン、アンドリュー・ペーター

IPC: G01N21/47 ,  G01N33/53 ,  G01N21/27 ,  G01N21/59 ,  G01N21/77 ,  G01N21/78 ,  G01N21/86 ,  G01N33/48 ,  G01N33/487

CPC classification number: G01N21/78 ,  G01N21/274 ,  G01N21/8483 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062