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    A PARTICULATE DETECTOR
    51.
    发明公开
    A PARTICULATE DETECTOR 有权
    TEILCHENDETEKTOR

    公开(公告)号：EP2350616A1

    公开(公告)日：2011-08-03

    申请号：EP09785183.6

    申请日：2009-10-01

    Applicant: Thorn Security Limited

    Inventor： PENNEY, Stephen, John ,  SHAW, John, E., A. ,  TAYLOR, Paul, J. ,  BENNETT, Steven, Ian

    IPC: G01N21/53 ,  G01N15/02 ,  G08B17/107

    CPC classification number: G01N21/53 ,  F21K9/64 ,  F21V7/06 ,  F21V9/30 ,  F21Y2115/10 ,  G01J1/0214 ,  G01J1/0422 ,  G01J1/08 ,  G01N15/0211 ,  G01N2021/3181 ,  G01N2021/4733 ,  G01N2201/06193 ,  G01N2201/0625 ,  G01N2201/0696 ,  G08B17/107 ,  G08B17/113 ,  G08B17/117

    Abstract: A particulate detector (10) comprises a radiation source (12) arranged to emit radiation in at least first and second predetermined wavebands towards a sampling region (18) suspected of containing particulates, and a detection element (14), shielded from the radiation source (12), and arranged to detect radiation from the sampling region (18) at least first and second instances. The radiation source (12) is such that the emissions in the wavebands temporarily overlap. The detector is such that, at the instances at which the radiation is detected, the relative contributions from the emissions in each predetermined waveband are distinguishable, thereby allowing characteristics of the particulates to be determined. The radiation source (12) may comprise a light emitting diode (24).

    Abstract translation: 微粒检测器（10）包括辐射源（12），其被布置成在至少第一和第二预定波段中向被怀疑含有微粒的采样区域（18）发射辐射;以及检测元件（14），其与辐射源 （12），并且被布置成在至少第一和第二实例中检测来自采样区域（18）的辐射。 辐射源（12）使得波段中的发射暂时重叠。 检测器使得在检测到辐射的情况下，来自每个预定波段中的发射的相对贡献是可区分的，从而允许确定颗粒的特性。 辐射源（12）可以包括发光二极管（24）。

    SERS NANOTAG ASSAYS
    54.
    发明申请
    SERS NANOTAG ASSAYS 审中-公开
    SERS纳米测试

    公开(公告)号：WO2009009198A3

    公开(公告)日：2009-02-19

    申请号：PCT/US2008060871

    申请日：2008-04-18

    Applicant: BECTON DICKINSON CO ,  NATAN MICHAEL J

    Inventor： NATAN MICHAEL J

    IPC: G01J3/00

    CPC classification number: C40B70/00 ,  B01J2219/00572 ,  B01J2219/00576 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/658 ,  G01N2201/06193 ,  Y10S977/773

    Abstract: A method of producing a surface enhanced Raman scattering spectrum which is useful for certain types of assays, in particular proximity assays. The method includes providing two SERS-active nanoparticles. The first SERS-active nanoparticle will absorb a photon at a first wavelength and emit a Raman-shifted photon at a second wavelength. The second SERS-active nanoparticle will absorb a photon at the second wavelength and emit a Raman-shifted photon at a third wavelength. Accordingly, when the first and second SERS-active nanoparticles are proximate to one another and the first SERS-active nanoparticle is illuminated at the first wavelength a Raman-shifted photon at the second wavelength may be emitted. This photon can be absorbed by the second SERS-active nanoparticle causing detectable emission of a second Raman-shifted photon at the third wavelength. Various assays may be designed based upon the above. Proximity assays using two SERS-active nanoparticles will have advantageous background signal characteristics.

    Abstract translation: 产生表面增强拉曼散射光谱的方法，其可用于某些类型的测定，特别是邻近测定。 该方法包括提供两种SERS活性纳米颗粒。 第一SERS活性纳米颗粒将吸收第一波长的光子并发射第二波长的拉曼偏移光子。 第二SERS活性纳米颗粒将吸收第二波长的光子并发射第三波长的拉曼偏移光子。 因此，当第一和第二SERS活性纳米粒子彼此接近并且第一SERS活性纳米粒子在第一波长处被照射时，可以发射第二波长的拉曼位移光子。 该光子可被第二SERS活性纳米颗粒吸收，引起第三波长处的第二拉曼位移光子的可检测发射。 基于上述可以设计各种分析。 使用两种SERS活性纳米粒子的接近测定法将具有有利的背景信号特征。

    METHOD AND DEVICES FOR LASER INDUCED FLUORESCENCE ATTENUATION SPECTROSCOPY (LIFAS)
    56.
    发明申请
    METHOD AND DEVICES FOR LASER INDUCED FLUORESCENCE ATTENUATION SPECTROSCOPY (LIFAS) 审中-公开
    用于激光诱导荧光衰减光谱（LIFAS）的方法和装置

    公开(公告)号：WO9902956A3

    公开(公告)日：1999-04-29

    申请号：PCT/US9811937

    申请日：1998-06-09

    Applicant: CEDARS SINAI MEDICAL CENTER

    Inventor： SHEHADA RAMEZ E ,  MARMARELIS VASILIS Z ,  GRUNDFEST WARREN S

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/27 ,  G01N21/49 ,  G01N21/64

    CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

    Abstract: The Laser Induced Fluorescence Attenuation Spectroscopy method and apparatus include a source (311) adapted to emit modulated radiation that is directed at a sample volume in a sample (314) to produce return light from the sample, a first sensor (321), displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor (322) displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor (323) adapted to process the first and second signals so as to determine the modulation of the sample. Methods and devices are well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence thereof, and can be used to determine the ischemic or hypoxic condition of biological tissue.

    Abstract translation: 激光诱导荧光衰减光谱方法和装置包括适于发射调制的辐射的源（311），其被引导到样品（314）中的样品体积以产生来自样品的返回光;第一传感器（321） 与用于监测返回光并且产生指示返回光强度的第一信号的第一距离;第二传感器（322）从样本体积移动了第二距离，用于监视返回光并产生第二信号 指示返回光的强度，以及适于处理第一和第二信号以便确定样本的调制的处理器（323）。 方法和装置非常适用于确定样品的波长相关衰减，并使用衰减来恢复其内在激光诱导的荧光，并可用于确定生物组织的缺血或缺氧状态。

    INSPECTION APPARATUS
    57.
    发明申请
    INSPECTION APPARATUS 审中-公开
    检查装置

    公开(公告)号：WO2015063300A1

    公开(公告)日：2015-05-07

    申请号：PCT/EP2014/073578

    申请日：2014-11-03

    Applicant: TOMRA SORTING NV

    Inventor： HARBECK, Hartmut ,  BALTHASAR, Dirk

    IPC: G01N21/85 ,  B07C5/342

    CPC classification number: G01N21/85 ,  B07C5/342 ,  G01N2201/06113 ,  G01N2201/06193 ,  G01N2201/062 ,  G01N2201/0636 ,  G01N2201/068

    Abstract: The present invention relates to an apparatus (100) for inspecting a stream of matter (10) comprising: a first and a second light source (101;102) for emitting a first and a second light beam (111;112); a first and a second detector (131;132); a first scanning element (151) adapted to redirect the detection area (137) of the second detector from side to side across said stream, and a beam splitting element (140) arranged to receive said first and second light beams (111), after they have been reflected against said matter, wherein said beam splitting element (140) is adapted to guide said reflected first light beam (111) towards said first detector (131) and to guide said reflected second light beam (112) towards said second detector (132).

    Abstract translation: 本发明涉及一种用于检查物质流（10）的装置（100），包括：用于发射第一和第二光束（111; 112）的第一和第二光源（101; 102） 第一和第二检测器（131; 132）; 第一扫描元件（151），其适于将所述第二检测器的检测区域（137）从一侧到另一侧重新定向穿过所述流;以及分束元件（140），被布置成接收所述第一和第二光束（111），所述分束元件 它们已经反对所述物质反射，其中所述分束元件（140）适于将所述反射的第一光束（111）引向所述第一检测器（131）并且将所述反射的第二光束（112）引向所述第二检测器 （132）。

    BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM
    59.
    发明申请
    BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM 审中-公开
    使用光源子系统的生物仪器

    公开(公告)号：WO2007137273A2

    公开(公告)日：2007-11-29

    申请号：PCT/US2007/069490

    申请日：2007-05-22

    Applicant: LUMENCOR, INC. ,  JAFFE, Claudia B. ,  JAFFE, Steven M. ,  JONES, Michieal L.

    Inventor： JAFFE, Claudia B. ,  JAFFE, Steven M. ,  JONES, Michieal L.

    IPC: G01N33/53 ,  G01J3/427

    CPC classification number: G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

    Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

    Abstract translation: 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。

    METHOD AND DEVICES FOR LASER INDUCED FLUORESCENCE ATTENUATION SPECTROSCOPY (LIFAS)
    60.
    发明申请
    METHOD AND DEVICES FOR LASER INDUCED FLUORESCENCE ATTENUATION SPECTROSCOPY (LIFAS) 审中-公开
    用于激光诱导荧光衰减光谱（LIFAS）的方法和装置

    公开(公告)号：WO99002956A2

    公开(公告)日：1999-01-21

    申请号：PCT/US1998/011937

    申请日：1998-06-09

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/27 ,  G01N21/49 ,  G01N21/64 ,  G01N

    CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

    Abstract: Methods and devices for Laser Induced Fluorescence Attenuation (LIFAS) Spectroscopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue. The LIFAS method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determine a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

    Abstract translation: 用于激光诱导荧光衰减（LIFAS）光谱的方法和装置，特别包括用于检测生物组织中缺血和缺氧的方法和装置。 LIFAS方法和装置优选地包括适于发射针对样品中的样品体积的辐射的源，以产生来自样品的返回光，这种返回光包括由样品的调制产生的调制的返回光，第一传感器，位移 距离样品体积的第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，与样品体积相距离第二距离，用于监测返回光，并产生指示的第二信号 的返回光的强度，以及与第一传感器和第二传感器相关联的处理器并且适于处理第一和第二信号以便确定样本的调制的处理器。 本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。 反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

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