公开(公告)号：KR100600249B1

公开(公告)日：2007-04-12

申请号：KR1020030085837

申请日：2003-11-28

Applicant: 주식회사한국신약 ,  주식회사 한생화장품

Inventor： 나민균 ,  유재국 ,  이찬복 ,  김진표 ,  임곤혁 ,  민동일 ,  전영민

IPC: A61K8/97 ,  A61Q19/08

Abstract: 본 발명은 항산화, 피부 노화 억제, 피부 탄력 유지 또는 주름 억제용 박태기나무(
Cercis chinensis ) 추출물 및 이를 유효성분으로 함유하는 피부 노화 억제 및 주름 개선용 화장료 조성물에 관한 것으로서, 보다 상세하게는 자원확보가 용이하고 기존에 항산화 활성 및 피부세포 노화 억제활성에 관한 보고가 없었던 박태기나무의 알코올 조추출물을 용매 분획한 후, 항산화 활성을 보이는 에틸아세테이트 분획과 부탄올 분획으로부터 분리한 항산화 활성, 노화 억제 활성을 갖는 화학식 1 내지 화학식 20으로 표시되는 화합물을 포함하는 박태기나무 추출물 및 이를 포함하는 피부 노화 억제용 화장료 조성물에 관한 것이다. 본 발명의 박태기나무 추출물은 피부의 노화를 유발하는 산화적 스트레스를 억제하는 기능이 우수할 뿐 만 아니라 노화와 관련된 텔로미어 길이의 단축 속도를 늦춤으로써 피부세포의 수명을 연장시킬 수 있으므로, 박태기나무 추출물을 포함하는 화장료 조성물은 피부 노화 방지, 피부 탄력 유지 또는 주름 완화를 위한 피부외용제형의 화장료로서 유용하게 이용될 수 있다.

公开(公告)号：KR1020060133299A

公开(公告)日：2006-12-26

申请号：KR1020050053081

申请日：2005-06-20

Applicant: 주식회사한국신약

Inventor： 홍남두 ,  김동희 ,  김진표 ,  이찬복 ,  김환철 ,  서승보 ,  최창하 ,  조수묵

IPC: A61K36/07

Abstract: A large intestine cancer inhibiting and anti-metastasis composition comprising an extract of Fuscoporia obliqua is provided to die only cancer cell, inhibit the metastasis of the cancer cell with small side effects and not show cell toxicity on normal cells. The agent for treating large intestine cancer and inhibiting metastasis comprises an extract of Fuscoporia obliqua, which is prepared by using a solvent selected from the group consisting of water, C1-4 alcohol and a mixture thereof.

Abstract translation: 本发明提供一种包含Fuscoporia obliqua提取物的大肠癌抑制和抗转移组合物，仅死于癌细胞，抑制癌细胞的转移，副作用小，对正常细胞无细胞毒性。 用于治疗大肠癌和抑制转移的药剂包括通过使用选自水，C 1-4醇及其混合物的溶剂制备的Fuscoporia obliqua的提取物。

公开(公告)号：KR100455905B1

公开(公告)日：2004-11-06

申请号：KR1020020009081

申请日：2002-02-20

Applicant: 이기성 ,  주식회사한국신약

Inventor： 이기성 ,  홍남두 ,  장화형 ,  한갑진 ,  김영호 ,  유재국 ,  이찬복 ,  김환철 ,  김진표

IPC: C12N1/14

Abstract: PURPOSE: Provided is a microorganism Monascus purpureus KLHS4 having high pigment productivity, which produces a large amount of hong gook pigment and antibiotics. CONSTITUTION: A microorganism Monascus purpureus KLHS4(KCTC 18097P) having high pigment productivity is provided, wherein the microorganism is isolated by analysis of the color precipitation level in a Monascus sp. cultured solid medium and selecting a Monascus sp. strain showing the excellent hong gook pigment productivity. A process for producing the hong gook pigment comprises the steps of: (1) culturing Monascus purpureus KLHS4(KCTC 18097P) in a potato-sugar solid or liquid medium at 25 to 30 deg. C, preferably 28 deg. C for 10 to 20 days; and (2) extracting the cultured solid or liquid medium with methanol, wherein the solid medium is pulverized prior to the extraction; and the liquid medium is filtered and the supernatant thereof is extracted with methanol.

Abstract translation: 目的：提供一种具有高色素生产率的微生物红色曲霉KLHS4，其产生大量红勾色素和抗生素。 构成：提供了具有高色素生产力的微生物红色曲霉KLHS4（KCTC 18097P），其中通过分析红曲霉中的颜色沉淀水平分离微生物。 培养的固体培养基并选择红曲霉。 表现出优异的红勾色素生产力。 一种生产红勾色素的方法，包括以下步骤：（1）在25至30℃的马铃薯糖固体或液体培养基中培养红色红曲霉KLHS4（KCTC 18097P） C，优选28度。 C 10至20天; （2）用甲醇提取培养的固体或液体培养基，其中在提取之前粉碎固体培养基; 过滤液体培养基并用甲醇提取上清液。

公开(公告)号：KR1020040086142A

公开(公告)日：2004-10-08

申请号：KR1020030100577

申请日：2003-12-30

Applicant: 주식회사한국신약

Inventor： 홍남두 ,  조수묵 ,  유재국

IPC: A23L1/30

Abstract: PURPOSE: Provided is a functional food containing astaxanthin, red ginseng and polysaccharide extracted from mycelium of Phellinus sp. strain. The functional food increases immunity, and anticancer and antistress activities, and reduces serum cholesterol level. Therefore, it is used for prevention and treatment of diseases. CONSTITUTION: The functional food is characterized by containing 0.01-0.1 wt.% of astaxanthin, 40-60 wt.% of red ginseng and 40-60 wt.% of polysaccharide extracted from mycelium of Phellinus sp. strain. The polysaccharide is galactomannoglucan.

Abstract translation: 目的：提供从沙门氏菌菌丝体中提取的虾青素，红参和多糖的功能性食品。 应变。 功能性食品增加免疫力，抗癌和抗抑郁活性，降低血清胆固醇水平。 因此，它用于预防和治疗疾病。 构成：功能性食品的特征在于含有0.01-0.1重量％的虾青素，40-60重量％的红参和40-60重量％的从桑黄菌丝体中提取的多糖。 应变。 多糖是半乳糖葡聚糖。

公开(公告)号：KR1020040086141A

公开(公告)日：2004-10-08

申请号：KR1020030100575

申请日：2003-12-30

Applicant: 주식회사한국신약

Inventor： 홍남두 ,  조수묵 ,  유재국

IPC: A23L1/30

Abstract: PURPOSE: Provided is a functional food containing astaxanthin and polysaccharide extracted from mycelium of Phellinus sp. strain. The functional food increases immunity, and anticancer and antistress activities, and reduces serum cholesterol level. Therefore, it is used for prevention and treatment of diseases. CONSTITUTION: The functional food contains 40-60 wt.% of astaxanthin and 40-60 wt.% of polysaccharide extracted from mycelium of Phellinus sp. strain, as an active ingredient. The polysaccharide is galactomannoglucan.

Abstract translation: 目的：提供从沙门氏菌菌丝体中提取的虾青素和多糖的功能性食品。 应变。 功能性食品增加免疫力，抗癌和抗抑郁活性，降低血清胆固醇水平。 因此，它用于预防和治疗疾病。 构成：功能性食品含有40-60重量％的虾青素和40-60重量％的从桑黄菌丝体中提取的多糖。 应变，作为活性成分。 多糖是半乳糖葡聚糖。

公开(公告)号：KR1020040068455A

公开(公告)日：2004-07-31

申请号：KR1020030085836

申请日：2003-11-28

Applicant: 주식회사한국신약

Inventor： 나민균 ,  유재국

IPC: A23F3/16

Abstract: PURPOSE: Cercis chinensis tea using leaves, stems and roots of Cercis chinensis having excellent antioxidant activity and aging-inhibiting activity is provided. It can be effectively used as a useful adjunct for the treatment of disease associated with peroxidation and a food for inhibiting skin aging. CONSTITUTION: Cercis chinensis tea is prepared by the following process consisting of: drying leaves, stems and roots of Cercis chinensis; roasting the dried Cercis chinensis for 30min at 160deg.C; rolling the roasted Cercis chinensis, drying the rolled Cercis chinensis; and then packaging the dried Cercis chinensis. The product is in the form of paper-bagged tea or granulated tea. In the manufacture of paper-bagged tea, Cercis chinensis is ground, extracted in a solvent such as water at 75 to 85deg.C and concentrated. In the case of granulated tea, granules are dried at 50 to 70deg.C to a moisture content of 5% or less.

Abstract translation: 目的：提供具有优异抗氧化活性和老化抑制活性的中华using藜叶，茎，根的中华茶。 它可以有效地用作治疗与过氧化相关的疾病的有用的辅助剂和用于抑制皮肤老化的食物。 构成：通过以下方法制备枸杞茶，其中包括：干燥中华猕猴桃的叶，茎和根; 在160℃烘烤30分钟， 卷起中华烤鸡，烘干中华枸杞; 然后包装干燥的Cercis chinensis。 该产品采用纸袋茶或颗粒茶的形式。 在制造纸袋茶时，将中华is草研磨，在75至85℃的溶剂如水中提取并浓缩。 在造粒茶的情况下，将颗粒在50〜70℃下干燥至水分含量为5％以下。

公开(公告)号：KR1020040060730A

公开(公告)日：2004-07-06

申请号：KR1020030085838

申请日：2003-11-28

Applicant: 주식회사한국신약

Inventor： 나민균 ,  유재국 ,  이찬복 ,  김진표

IPC: A23L1/30

Abstract: PURPOSE: A functional food comprising as a main component a Cercis chinensis extract having antioxidant activity and aging-inhibiting activity is provided. It is harmless to the human body as compared to synthetic antioxidants and extends the life of skin cells by suppressing the telomere length associated with cell aging. CONSTITUTION: The functional food contains a Cercis chinensis extract obtained by extracting with an aqueous alcohol solution selected from the group consisting of an aqueous methanol solution, an aqueous ethanol solution, an aqueous propanol solution and an aqueous butanol solution. The food is effective in preventing and treating disease induced from aging or active oxygen. For an example, 0.48 to 1.28mg Cercis chinensis extract is mixed with 522mg honey, 5mg thioctic acid amide, 10mg nicotinic acid amide, 3mg sodium riboflavin HCl, 30mg pyridoxine HCl, 30mg inositol, 50mg ortho acid and 200ml water to give a beverage.

Abstract translation: 目的：提供具有抗氧化活性和老化抑制活性的作为主要成分的中华菊提取物的功能性食品。 与合成抗氧化剂相比，对人体无害，通过抑制与细胞衰老相关的端粒长度延长皮肤细胞的寿命。 构成：功能性食品含有通过用选自甲醇水溶液，乙醇水溶液，丙醇水溶液和丁醇水溶液的醇水溶液萃取而获得的中华柑橘提取物。 食物有效预防和治疗由老化或活性氧引起的疾病。 例如，将0.48〜1.28mg Cercis chinensis提取物与522mg蜂蜜，5mg硫辛酸酰胺，10mg烟酸酰胺，3mg钠核黄素HCl，30mg吡哆醇盐酸盐，30mg肌醇，50mg原酸和200ml水混合，得到饮料。

公开(公告)号：KR1020040060729A

公开(公告)日：2004-07-06

申请号：KR1020030085837

申请日：2003-11-28

Applicant: 주식회사한국신약 ,  주식회사 한생화장품

Inventor： 나민균 ,  유재국 ,  이찬복 ,  김진표 ,  임곤혁 ,  민동일 ,  전영민

IPC: A61K8/97 ,  A61Q19/08

CPC classification number: A61K8/97 ,  A61K8/347 ,  A61K8/35 ,  A61K8/368 ,  A61K8/375 ,  A61K8/498 ,  A61K8/60 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/08 ,  C07H17/07

Abstract: PURPOSE: Provided is Cercis chinensis Bunge extract which has anti-oxidation and anti-aging activities and a cosmetic composition for anti-oxidation, anti-aging and wrinkle improvement containing the same. The cosmetic composition is useful for the external application to the skin which prevents skin aging, maintains skin tightening or wrinkle improvement. CONSTITUTION: Cercis chinensis Bunge extract for anti-oxidation, anti-aging and skin tightening or anti-wrinkle is obtained by extracting Cercis chinensis Bunge with water or alcohol solution as an extraction solvent. The extract contains 0.01-1.00 wt.% of gallic acid of the formula(6), 0.01-1.00 wt.% of myricitrin of the formula(12) and 0.01-0.5 wt.% of piceatannol of the formula(5).

Abstract translation: 目的：提供具有抗氧化和抗衰老活性的中华荆芥提取物，以及含有抗氧化和抗衰老活性的抗氧化，抗老化和皱纹改善的化妆品组合物。 化妆品组合物可用于外用于皮肤，防止皮肤老化，维持皮肤紧致或皱纹改善。 构成：用水或乙醇溶液提取Cercis chinensis Bunge作为提取溶剂，可以获得Cercis chinensis Bunge提取物，用于抗氧化，抗衰老和皮肤紧致或抗皱。 提取物含有0.01-1.00重量％的式（6）的没食子酸，0.01-1.00重量％的式（12）的丝氨酸和0.01-0.5重量％的式（5）的吡草胺。

公开(公告)号：KR1020040045794A

公开(公告)日：2004-06-02

申请号：KR1020020073652

申请日：2002-11-25

Applicant: 주식회사한국신약

Inventor： 홍남두 ,  유재국 ,  조수묵

IPC: A61K31/715

Abstract: PURPOSE: Provided is a composite anticancer agent containing polysaccharide and adriamycin extracted form Phellinus linteus, thereby reducing adverse side effects of cancer chemotherapy and consequently treating cancer without adverse side effects. CONSTITUTION: A composite anticancer agent is characterized by containing polysaccharide and adriamycin extracted form Phellinus linteus, wherein the polysaccharide is galactomannoglucan, and the weight ratio of galactomannoglucan to adriamycin is 400-500:1. Therefore, the composite anticancer agent is useful for the treatment of cancers without adverse side effects.

Abstract translation: 目的：提供含有多糖和阿霉素的复合抗癌剂，从而减少癌症化疗的不良副作用，从而减少癌症的不良副作用，无不良副作用。 构成：复合抗癌剂的特征在于含有多糖和阿霉素，其中多糖是半乳糖葡聚糖，半乳糖葡聚糖与阿霉素的重量比为400-500:1。 因此，复合抗癌剂可用于治疗癌症而没有副作用。

公开(公告)号：KR1020020018100A

公开(公告)日：2002-03-07

申请号：KR1020010052436

申请日：2001-08-29

Applicant: 주식회사한국신약

Inventor： 유익동 ,  홍남두 ,  조원제 ,  이찬복 ,  김진표 ,  김원곤

IPC: C07D209/24

Abstract: PURPOSE: Provided is a novel compound useful as an intermediate in manufacturing benzastatin derivatives having an excellent inhibition activity of lipid peroxidation. Also, its manufacturing method is provided. CONSTITUTION: The novel compound is a basic structure of benzastatin useful as an inhibitor of lipid peroxidation and represented by the formula(1), wherein R1 is H, CH3, OH, nitrile group, amide group, C1-C4 alkoxy group or hydroxymethyl group; R2 is a nitrogen protection group, such as H, CH3 or PMB(paramethoxy benzyl); and R3 is H, CH3, C1-C10 alkyl group or partially unsaturated linear or branched hydrocarbon. Aldehyde compound of the formula(1a) is manufactured by the steps of: reducing a compound of the formula(5) with a reductant to prepare a compound of the formula(6); and oxidizing the alcohol compound of the formula(6) to obtain a compound of the formula(1a).

Abstract translation: 目的：提供一种在制备具有优异的脂质过氧化抑制活性的苯达斯汀衍生物中作为中间体的新型化合物。 此外，还提供了其制造方法。 构成：新化合物是用作脂质过氧化抑制剂的苯达斯汀的基本结构，由式（1）表示，其中R1是H，CH3，OH，腈基，酰胺基，C1-C4烷氧基或羟甲基 ; R2是氮保护基团，例如H，CH 3或PMB（对甲氧基苄基）; 并且R 3是H，CH 3，C 1 -C 10烷基或部分不饱和直链或支链烃。 通过以下步骤制备式（1a）的醛化合物：用还原剂还原式（5）的化合物以制备式（6）的化合物; 氧化式（6）的醇化合物，得到式（1a）的化合物。