-
公开(公告)号：DE353252T1
公开(公告)日：1990-08-16
申请号：DE88904745
申请日：1988-03-23
Inventor： WELDON, F., WILLIAM, AUSTIN, TX 78746, US , DRIGA, D., MIRCEA, AUSTIN, TX 78731, US , PRATAP, B., SIDDHARTH, AUSTIN, TX 78758, US
IPC: H02K39/00
-
公开(公告)号：DE267026T1
公开(公告)日：1988-10-13
申请号：DE87309774
申请日：1987-11-04
Inventor： LINNER, JOHN G., HOUSTON TEXAS 77027, US
Abstract: This invention relates to apparatus for the cryopreparation of biological tissue samples for ultrastructural analysis. The use of the apparatus comprises vitrifying a biological tissue sample under cryogenic temperature conditions and ultra low vacuum conditions. The depressurized, vitrified tissue sample is brought to equilibrium in a sample holder at a temperature of less than -140 DEG C. The tissue sample is then dehydrated while maintained in a state of thermal equilibrium. After reaching equilibrium the tissue sample is optionally infiltrated with a degassed resin followed by a polymerization of the resin to form an embedded tissue sample.
-
公开(公告)号：US12290454B2
公开(公告)日：2025-05-06
申请号：US16755711
申请日：2018-10-13
Inventor： Corinne Nawn , Carlyn Abbott , Caroline Campbell , Sarah Robinson , Robert Hood , Christian Wahrmund , Andrea Afanador
Abstract: Certain embodiments are directed to mechanical devices for augmenting dexterous reach and sensing of a user. The devices can include a proximal portion configured to receive an appendage of a user; a distal portion configured to detect sensory information; an articulation positioned between the proximal and distal portion to provide for motion of the distal portion via manipulation of the proximal portion; wherein the distal portion comprising a sensing element and the proximal portion comprises a feedback element, the feedback element being connected to the sensing element providing for physical extension of sensory capabilities of the appendage.
-
公开(公告)号：US20250134917A1
公开(公告)日：2025-05-01
申请号：US18730565
申请日：2023-01-20
Inventor： Hesham A. Sadek , Ngoc Uyen Nhi Nguyen , Mahmoud Salama Ahmed , Diana Tomchick , Jianyi Zhang
IPC: A61K31/7036 , A61P9/00
Abstract: Disclosures herein are directed to methods of regenerating cardiomyocytes in heart tissue damaged as a result heart failure in a subject by administering one or more aminoglycosides to a subject in need thereof. Accordingly, disclosures herein are also toward methods of administering one or more aminoglycosides to treat heart failure in a subject in need thereof.
-
公开(公告)号：US20250115579A1
公开(公告)日：2025-04-10
申请号：US18829953
申请日：2024-09-10
Inventor： Jian Qiu , Qi Wei , Matt Tschantz , Heping Shi , Youtong Wu , Huiling Tan , Lijun Sun , Chuo Chen , Zhijian Chen
IPC: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/6503 , C07F9/6506
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
-
Patent Agency Ranking
公开(公告)号：US20250115546A1
公开(公告)日：2025-04-10
申请号：US18809438
申请日：2024-08-20
Inventor： Kyoji TSUCHIKAMA , Yasuaki ANAMI , Chisato TSUCHIKAMA , Ningyang ZHANG , Zhiqiang AN
IPC: C07C247/04 , A61K31/40 , A61K45/06 , A61K47/68 , A61P35/00 , C07D209/20 , C07D403/12
Abstract: In one aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein.
In another aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.-
67.发明申请公开(公告)号：US20250111960A1
公开(公告)日：2025-04-03
申请号：US18827374
申请日：2024-09-06
Applicant: Rutgers, The State University of New Jersey , The Board of Regents of The University of Texas System
Inventor： Jennifer K. Lynch-Branzoi , Ali Ashraf , Ashiqur Rahman , Nazmul Islam
IPC: H01B1/20 , B01F23/50 , B01F23/53 , B01F23/70 , B01F27/232 , B01F101/00 , C08J3/22 , C08K9/00 , G01L1/14 , G01L1/22 , G01N27/30 , G06F3/0354
Abstract: Sensors employing elastomers enhanced with electrically conductive 2D nanoparticles are provided. The nanoparticles are formed by applying shear to layered materials present in elastomer precursors (e.g., elastomeric monomer(s) and/or curing agent(s)). Subsequent exfoliation of the layers occurs directly within the precursor and/or curing agent. The cured elastomer nanocomposites can be employed for electrochemical sensing, flexible touchpads, pressure sensors, and wireless sensors, amongst other applications.
-
公开(公告)号：US20250099720A1
公开(公告)日：2025-03-27
申请号：US18972487
申请日：2024-12-06
Inventor： Daniel H. KIM , Dong Suk SHIN , Viljar PALMER , Younghee SHIM , Bhavik PATEL
Abstract: A catheter comprises a hollow sheath, a guidewire extendable through the hollow sheath, where the guidewire comprises a controllably bendable tip portion, a hollow tubular intermediate portion connected to the tip portion, an electrical connection portion connected to the hollow tubular portion, at least a first wire extending through the hollow tubular portion and connected at a first end thereof to a first circumferential conductor and at a second end thereof to a surface of the tip end, and a power supply connector, therein the electrical connection portion is received in the power supply connector and a first terminal in the power supply connector contacts the first circumferential conductor.
-
公开(公告)号：US20250099095A1
公开(公告)日：2025-03-27
申请号：US18728046
申请日：2023-02-02
Inventor： Philippe E. Zimmern
Abstract: Suture tensioning systems, methods, and devices include a suture device for extracting a suture thread from a patient and then determining a location to secure the suture knot based on a balanced tension measurement. The suture device has a needle pass mount with needle passes, and a slidable eyelet assembly positioned opposite the needle passes. The eyelet assembly includes gripping portions for moving the eyelet assembly relative to other components of the suture device. Accordingly, eyelets extending from the eyelet assembly move through the needle pass mounts and extend out the needle passes. With the suture thread secured in the extended eyelet, the eyelet assembly is retracted. The suture thread is attached to a tensioning bar and tension meter. The tension meter indicates if the suture tension is within a threshold range and comparable to the opposite side, and a precise tying location for the suture knot is determined.
-
70.发明申请公开(公告)号：US20250092468A1
公开(公告)日：2025-03-20
申请号：US18965965
申请日：2024-12-02
Inventor： Min Soo KIM , James BRUGAROLAS , Tae Hyun HWANG , Yang XIE
IPC: C12Q1/6886 , A61P35/00 , C12N15/52 , C40B40/08 , G01N33/50 , G16B25/00 , G16B25/10 , G16B25/20 , G16B30/00 , G16H50/20 , G16H50/30
Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2α.
-
-
-
-
-
-
-
-
-
Search Results
3224
records
(took 0.083 seconds)
