公开(公告)号：WO2017210134A1

公开(公告)日：2017-12-07

申请号：PCT/US2017/034806

申请日：2017-05-26

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： JONES, Philip ,  CZAKO, Barbara ,  CROSS, Jason ,  LEONARD, Paul ,  MSEEH, Faika ,  PARKER, Connon, Austin

IPC: A61K31/4162 ,  A61K31/4985 ,  C07D487/04

Abstract: The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.

Abstract translation: 本发明涉及可用作PTPN11抑制剂用于治疗或预防癌症和其他PTP介导的疾病的化合物。 本文公开了基于吡唑并吡嗪的新化合物和化合物及其作为用于治疗疾病的药物的应用。

公开(公告)号：WO2017152118A1

公开(公告)日：2017-09-08

申请号：PCT/US2017/020774

申请日：2017-03-03

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  TECNOLÓGICO DE MONTERREY

Inventor： LOZANO, Karen ,  GILKERSON, Robert ,  QUINONES, Karen Lorena Baylon ,  ZUNIGA, Alex Elias

IPC: D01F6/06 ,  C08L23/12

CPC classification number: D01F6/06 ,  C08K5/1345 ,  C08L7/02 ,  C08L2207/066 ,  D01D5/18 ,  D01F1/10 ,  D01F1/103 ,  D06M16/00 ,  D06M23/06 ,  D06M2101/20 ,  C08L23/10

Abstract: Described herein is the application of centrifugal spinning to provide a polypropylene (PP) nanofiber environment for cell growth. PP nanofiber mats, formed by centrifugal spinning are treated with one or more antimicrobial agents. The treated PP material was shown to have a 10 reduced rate of rejection and promote cell growth and proliferation.

Abstract translation: 这里描述的是应用离心纺丝来提供用于细胞生长的聚丙烯（PP）纳米纤维环境。 通过离心纺丝形成的PP纳米纤维垫用一种或多种抗微生物剂处理。 经处理的PP材料显示具有降低的排斥率并促进细胞生长和增殖。

公开(公告)号：WO2017070392A1

公开(公告)日：2017-04-27

申请号：PCT/US2016/057977

申请日：2016-10-20

Applicant: THE METHODIST HOSPITAL ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： SAKAMOTO, Jason Haruo ,  BEGARANI, Filippo ,  NICHOLS, Joan Elizabeth ,  CORTIELLA, Joaquin

IPC: A61K9/00 ,  A61K35/42 ,  A61L27/38 ,  A61P11/00 ,  C12N5/071

CPC classification number: A61K9/00 ,  A61K35/42 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/54 ,  A61L2300/41 ,  A61L2400/12 ,  A61L2430/40

Abstract: Disclosed are methods for decellularizing an isolated organ, or a portion thereof, by mechanically agitating the isolated organ with a detergent-containing fluid that removes the cellular membrane surrounding the isolated organ, in the presence of a regulatable source of air to control the removal of detergent from the decellularized organ, while maintaining the extracellular matrix and scaffold. Also disclosed are methods for producing mesoparticle-infused acellular tissues for generation of mammalian organs and tissues suitable, inter alia , for human transplantation

Abstract translation: 公开了通过在可调节的存在下用含去污剂的流体机械搅拌分离的器官来去细胞化分离的器官或其一部分的方法，所述含去污剂的流体移除分离的器官周围的细胞膜 空气来源以控制从去细胞器官去除去污剂，同时维持细胞外基质和支架。 还公开了用于产生用于人类移植的哺乳动物器官和组织的产生中颗粒细胞的无细胞组织的方法

公开(公告)号：WO2016004418A1

公开(公告)日：2016-01-07

申请号：PCT/US2015/039153

申请日：2015-07-03

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： HEFFERNAN, Timothy ,  TONIATTI, Carlo ,  KOVACS, Jeffrey ,  GIULIANI, Virginia ,  SPENCE, Nakia ,  DI FRANCESCO, Maria, Emilia ,  BRISTOW, Christopher, A.

IPC: A61P39/06

CPC classification number: A61K31/501 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed herein are methods of treating a subject having an altered NRF2/KEAP1 pathway, and compounds and compositions useful in such treatment. Also disclosed herein are methods of evaluating whether to administer a compound that inhibits glutathione production or a glutaminase inhibitor to a subject.

Abstract translation: 本文公开了治疗具有改变的NRF2 / KEAP1途径的受试者的方法，以及可用于这种治疗的化合物和组合物。 本文还公开了评估是否向受试者施用抑制谷胱甘肽产生的化合物或谷氨酰胺酶抑制剂的方法。

公开(公告)号：WO2013049153A2

公开(公告)日：2013-04-04

申请号：PCT/US2012/057264

申请日：2012-09-26

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  AGAIAN, Sos, S. ,  LOPEZ, Clara M. Mosquera ,  ALMUNTASHRI, Ali ,  METZLER, Richard

Inventor： AGAIAN, Sos, S. ,  LOPEZ, Clara M. Mosquera ,  ALMUNTASHRI, Ali ,  METZLER, Richard

CPC classification number: G06K9/0014 ,  A61B5/4381 ,  A61B5/7203 ,  A61B5/725 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7267 ,  A61B10/0241 ,  G01N15/1475 ,  G06F19/00 ,  G06F19/321 ,  G06K9/00127 ,  G06K9/00147 ,  G06K9/46 ,  G06K9/6228 ,  G06T5/002 ,  G06T5/20 ,  G06T7/0012 ,  G06T7/13 ,  G06T7/181 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/20036 ,  G06T2207/20081 ,  G06T2207/30024 ,  G06T2207/30081 ,  G06T2207/30096 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70

Abstract: The invention provides systems and methods for detection, grading, scoring and tele-screening of cancerous lesions. A complete scheme for automated quantitative analysis and assessment of human and animal tissue images of several types of cancers is presented. Various aspects of the invention are directed to the detection, grading, prediction and staging of prostate cancer on serial sections/slides of prostate core images, or biopsy images. Accordingly, the invention includes a variety of sub-systems, which could be used separately or in conjunction to automatically grade cancerous regions. Each system utilizes a different approach with a different feature set. For instance, in the quantitative analysis, textural-based and morphology-based features may be extracted at image- and (or) object-levels from regions of interest. Additionally, the invention provides sub-systems and methods for accurate detection and mapping of disease in whole slide digitized images by extracting new features through integration of one or more of the above-mentioned classification systems. The invention also addresses the modeling, qualitative analysis and assessment of 3-D histopathology images which assist pathologists in visualization, evaluation and diagnosis of diseased tissue. Moreover, the invention includes systems and methods for the development of a tele-screening system in which the proposed computer-aided diagnosis (CAD) systems. In some embodiments, novel methods for image analysis (including edge detection, color mapping characterization and others) are provided for use prior to feature extraction in the proposed CAD systems.

Abstract translation: 本发明提供用于癌性病变的检测，分级，评分和远程筛查的系统和方法。 提出了一种用于自动定量分析和评估几种类型癌症的人和动物组织图像的完整方案。 本发明的各个方面涉及前列腺核心图像或活检图像的连续切片/载玻片上的前列腺癌的检测，分级，预测和分期。 因此，本发明包括各种子系统，其可以单独使用或结合使用以自动分级癌症区域。 每个系统使用不同的方法与不同的功能集。 例如，在定量分析中，可以从感兴趣的区域的图像和（或）对象层面提取基于纹理和基于形态的特征。 此外，本发明提供了通过一个或多个上述分类系统的集成来提取新特征来准确地检测和映射整个幻灯片数字化图像中的疾病的子系统和方法。 本发明还涉及三维组织病理学图像的建模，定性分析和评估，其帮助病理学家在患病组织的可视化，评估和诊断中。 此外，本发明包括用于开发远程筛选系统的系统和方法，其中所提出的计算机辅助诊断（CAD）系统。 在一些实施例中，提供用于图像分析（包括边缘检测，颜色映射表征等）的新方法，用于在所提出的CAD系统中的特征提取之前使用。

公开(公告)号：WO2013003533A1

公开(公告)日：2013-01-03

申请号：PCT/US2012/044536

申请日：2012-06-28

Applicant: BOARD OF REGENTS-UNIVERSITY OF TEXAS SYSTEM ,  MAH, Peter ,  MCDAVID, W. Doss

Inventor： MAH, Peter ,  MCDAVID, W. Doss

IPC: A61B6/14 ,  A61B6/03

CPC classification number: A61B6/583 ,  A61B6/032 ,  A61B6/14 ,  A61B6/4423 ,  A61B6/5205

Abstract: Described herein is a device and method to derive density measurements for features depicted in computed tomography systems. A radiographic device is used in some embodiments to derive a correlation between measured grey levels in an image produced using a CT system and the attenuation coefficients and/or the CT numbers of the depicted features.

Abstract translation: 本文描述了用于导出计算机断层摄影系统中描绘的特征的密度测量的装置和方法。 在一些实施例中使用射线照相装置来导出使用CT系统产生的图像中的测量灰度级与所描绘的特征的衰减系数和/或CT数之间的相关性。

公开(公告)号：WO2012155061A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037560

申请日：2012-05-11

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  YUAN, Zhi-Min

Inventor： YUAN, Zhi-Min

IPC: A61K33/36 ,  A61P39/00 ,  A61P43/00

CPC classification number: A61K45/06 ,  A61K33/36 ,  A61K2300/00

Abstract: A method of inhibiting, preventing, or reducing damage to non-cancerous cells in a human subject during chemotherapeutic treatment or radiation treatment of cancer cells in the human subject includes administering to the human subject arsenic and/or one or more compounds of arsenic in a therapeutically effective amount prior to treatment with radiation or one or more chemotherapeutic agents.

Abstract translation: 在人类受试者的癌症细胞的化学治疗或放射治疗期间抑制，预防或减少人类受试者对非癌细胞的损害的方法包括向人类受试者施用砷和/或一种或多种砷化合物 在用辐射或一种或多种化学治疗剂治疗之前的治疗有效量。

公开(公告)号：WO2009082691A1

公开(公告)日：2009-07-02

申请号：PCT/US2008/087680

申请日：2008-12-19

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  UNIVERSITY OF WASHINGTON ,  PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  GUJJAR, Ramesh ,  MARWAHA, Alka, S. ,  CHARMAN, Susan, A.

Inventor： PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  GUJJAR, Ramesh ,  MARWAHA, Alka, S. ,  CHARMAN, Susan, A.

IPC: A01N43/54 ,  A01N43/90 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D473/34

Abstract: Compounds according to Formula (I), Formula (II), Formula (III), Formula (V), Formula (VI), or to Formula (VII), and pharmaceutical compositions of compounds that conform to Formula (IV) or (Formula VIII): where R 1 through R 33 are prescribed, selectively inhibit P. falciparum dihydroorotate dehydrogenase. Accordingly, a method for preventing and treating malaria attaches to such compounds, as well as to pharmaceutically acceptable salts, solvates, stereoisomers, tautomers, and prodrugs thereof.

Abstract translation: 根据式（I），式（II），式（III），式（V），式（VI）或式（VII））的化合物和符合式（IV）或（式 VIII）：其中R1至R33被规定，选择性地抑制恶性疟原虫二氢乳清酸脱氢酶。 因此，用于预防和治疗疟疾的方法附着于这些化合物，以及其药学上可接受的盐，溶剂合物，立体异构体，互变异构体和前药。

公开(公告)号：WO2008134086A1

公开(公告)日：2008-11-06

申请号：PCT/US2008/005617

申请日：2008-05-01

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  ZHONG, Guangming

Inventor： ZHONG, Guangming

IPC: C12Q1/02 ,  G01N33/52

CPC classification number: C12Q1/02 ,  G01N2333/295

Abstract: The present invention provides a method of diagnosing a Chlamydia infection in a subject, comprising contacting a sample from the subject with a substrate of chlamydial protease/proteasome-like activity factor (CPAF) under conditions whereby cleavage of the substrate can occur; and b) detecting cleavage of the substrate, thereby diagnosing a Chlamydia infection in the subject.

Abstract translation: 本发明提供了一种诊断受试者中衣原体感染的方法，包括：在可以发生底物裂解的条件下，使来自受试者的样品与衣原体蛋白酶/蛋白酶体样活性因子（CPAF）的底物接触; 和b）检测底物的裂解，从而诊断受试者的衣原体感染。

公开(公告)号：WO2006062826A3

公开(公告)日：2006-06-15

申请号：PCT/US2005/043686

申请日：2005-12-05

Applicant: NANOTECHNOLOGIES, INC. ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  YACAMAN, Miguel, Jose ,  SCHRODER, Kurt, A. ,  MARTIN, Karl, Matthew ,  WILLAUER, Darrin, Lee

Inventor： YACAMAN, Miguel, Jose ,  SCHRODER, Kurt, A. ,  MARTIN, Karl, Matthew ,  WILLAUER, Darrin, Lee

IPC: A61K9/14

Abstract: This invention generally relates to use of novel nanomaterials comprised of metals in anti-viral applications. Such nanomaterials, for example, can be produced using a high power, pulsed plasma process, which plasma process, optionally, can be performed on the metal with a precursor (i.e., a gaseous precursor, such as acetylene or methane) when forming the unagglomerated nanomaterials. In embodiments of the invention, the metal is nanosilver. Optionally, the nanomaterials may also comprise carbon, including in the form of carbyne.