公开(公告)号：WO0043409A3

公开(公告)日：2003-12-31

申请号：PCT/US0001372

申请日：2000-01-21

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： OLIVERA BALDOMERO M ,  LAYER RICHARD T ,  WATKINS MAREN ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  JONES ROBERT M ,  SCHOENFELD ROBERT

IPC: C12N15/09 ,  A61K38/00 ,  A61P21/02 ,  A61P27/02 ,  C07K7/08 ,  C07K14/435 ,  C07K14/46 ,  C12N15/12 ,  A61K38/03 ,  A61K38/04 ,  A61K38/17 ,  C07K4/12

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The invention relates to relatively short peptides (termed alpha -conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The alpha -conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.

Abstract translation: 本发明涉及相对较短的肽（本文中称为α-肾上腺素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。 如本文所述，α-酮毒素可用作神经肌肉阻滞剂，例如肌肉松弛剂。

公开(公告)号：WO2003063782A3

公开(公告)日：2003-08-07

申请号：PCT/US2003/002384

申请日：2003-01-28

Applicant: COGNETIX, INC. ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： PEMBERTON-GOODMAN, Karen, E. ,  JONES, Robert, M. ,  TEMPLE, JR., Davis, L. ,  MCINTOSH, J., Michael ,  OLIVERA, Baldomero, M.

IPC: C07K14/00

Abstract: The invention relates to k-PVIIA-related conotoxins and their use as organ protecting agents, i.e., organ protectants. These conotoxins can be used for arresting, protecting or preserving an organ, such as a circulatory organ, a respiratory organ, a urinary organ, a digestive organ, a reproductive organ, an endocrine organ or a neurological organ. These conotoxins can also be used for arresting, protecting or preserving somatic cells.

公开(公告)号：WO2002064740A2

公开(公告)日：2002-08-22

申请号：PCT/US2002/003887

申请日：2002-02-11

Applicant: COGNETIX, INC. ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： OLIVERA, Baldomero, M. ,  MCINTOSH, J., Michael ,  WATKINS, Maren ,  GARRETT, James, E. ,  CRUZ, Lourdes, J. ,  GRILLEY, Michelle ,  WALKER, Craig, S. ,  SHETTY, Reshma ,  JONES, Robert, M. ,  SCHOENFELD, Robert, M.

IPC: C12N

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及芋螺毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。

公开(公告)号：WO0020018A8

公开(公告)日：2000-07-20

申请号：PCT/US9923218

申请日：1999-10-06

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND ,  SALK INST

Inventor： LAYER RICHARD T ,  PEMBERTON-GOODMAN KAREN E ,  JONES ROBERT M ,  GARRETT JAMES L ,  OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  HILLYARD DAVID R ,  GRILLEY MICHELLE ,  WATKINS MAREN ,  SANTOS AMEURFINA D ,  ZAFARALLA GLENN ,  CRAIG A GREY

IPC: A61K38/00 ,  C07K14/435 ,  C12N15/12 ,  A61K38/12 ,  A61K38/14 ,  A61K38/17

CPC classification number: A61K38/17 ,  C07K14/43504

Abstract: The present invention is directed to kappaA ( kappa A) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The kappa A conopeptides include unglycosylated and O-glycosylated peptides.

Abstract translation: 本发明涉及κA（κA）同肽以及这些肽用于阻断钾离子流过电压门控钾通道的用途。 κA同肽包括非糖基化和O-糖基化肽。

公开(公告)号：WO2000023092A1

公开(公告)日：2000-04-27

申请号：PCT/US1999/024380

申请日：1999-10-20

Applicant: COGNETIX, INC. ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  SALK INSTITUTE

Inventor： CRAIG, A., Grey ,  GRIFFIN, David ,  OLIVERA, Baldomero, M. ,  WATKINS, Maren ,  HILLYARD, David, R. ,  IMPERIAL, Julita ,  CRUZ, Lourdes, J. ,  WAGSTAFF, John, D. ,  LAYER, Richard, T. ,  JONES, Robert, M. ,  McINTOSH, J., Michael ,  McCABE, R., Tyler

IPC: A61K38/10

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K9/001 ,  C07K14/575

Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr 10 -contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

Abstract translation: 本发明涉及到编码该成熟肽的前体的cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的连翘蛋白-G（称为Thr10-contulakin-G）及其衍生物，以及 到前体肽。 本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍 焦虑症，迟发性运动障碍，药物依赖性，惊恐发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍以及神经系统，神经功能和 神经精神药理学障碍。

公开(公告)号：WO0207678A3

公开(公告)日：2003-12-18

申请号：PCT/US0123125

申请日：2001-07-23

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  GARRETT JAMES E ,  WATKINS MAREN ,  CRUZ LOURDES J ,  SHON KI-JOON ,  JACOBSEN RICHARD B ,  JONES ROBERT M ,  CARTIER G EDWARD ,  SHEN GREGORY S ,  WAGSTAFF JOHN D

IPC: G01N33/50 ,  A61K35/56 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  A61P3/12 ,  A61P9/10 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P21/00 ,  A61P21/02 ,  A61P23/00 ,  A61P23/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P39/00 ,  A61P43/00 ,  C07K14/435 ,  C12N15/09 ,  C12N15/12 ,  G01N33/15 ,  G01N33/58 ,  G01N33/68 ,  A61K38/04 ,  A61K38/17 ,  C07K7/08 ,  G01N33/53 ,  G01N33/566

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The present invention is to mu-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the mu-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The mu-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the mu -conopeptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及多肽，其衍生物或药学上可接受的盐。 本发明还涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控钠通道相关的疾病中的用途。 因此，μ-肽或衍生物可用作神经肌肉阻滞剂，局部麻醉剂，止痛剂和神经保护剂。 多肽也可用于治疗神经肌肉疾病。 本发明还涉及编码μ-多肽和编码前肽以及前肽的核酸序列。

公开(公告)号：WO2003014374A2

公开(公告)日：2003-02-20

申请号：PCT/US2002/025202

申请日：2002-08-07

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  COGNETIX, INC.

Inventor： GARRETT, James, E. ,  BANDYOPADHYAY, Pradip, K.

IPC: C12Q

CPC classification number: C12N9/93

Abstract: The present invention is relates to a γ-carboxylase from Conus snails, a nucleic acid sequence encoding the Conus γ-carboxylase and to a method for using the nucleic acid or protein sequences for preparing γ-carboxylated proteins.

Abstract translation: 本发明涉及来自锥螺旋体的γ-羧化酶，编码锥虫γ-羧化酶的核酸序列以及使用该核酸或蛋白质序列制备γ-羧化蛋白质的方法。

公开(公告)号：WO2002072005A2

公开(公告)日：2002-09-19

申请号：PCT/US2002/006863

申请日：2002-03-07

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  COGNETIX, INC

Inventor： OLIVERA, Baldomero, M. ,  MCINTOSH, J., Michael ,  GARRETT, James, E. ,  WALKER, Craig, S. ,  WATKINS, Maren ,  JONES, Robert, M.

IPC: A61K

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The invention relates to linear γ-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及含有γ-羧酸谷氨酸盐的线粒体，其衍生物或药学上可接受的盐及其用途，包括治疗神经和精神疾病，如抗惊厥剂，神经保护剂，神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。

公开(公告)号：WO2002064740A3

公开(公告)日：2002-08-22

申请号：PCT/US2002/003887

申请日：2002-02-11

Applicant: COGNETIX, INC. ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： OLIVERA, Baldomero, M. ,  MCINTOSH, J., Michael ,  WATKINS, Maren ,  GARRETT, James, E. ,  CRUZ, Lourdes, J. ,  GRILLEY, Michelle ,  WALKER, Craig, S. ,  SHETTY, Reshma ,  JONES, Robert, M. ,  SCHOENFELD, Robert, M.

IPC: G01N33/53

Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.

公开(公告)号：WO0202590A3

公开(公告)日：2002-05-30

申请号：PCT/US0120796

申请日：2001-06-29

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： WALKER CRAIG S ,  SHETTY RESHMA ,  JIMINEZ ELSIE C ,  MCINTOSH J MICHAEL ,  OLIVERA BALDOMERO M ,  WATKINS MAREN ,  JONES ROBERT M ,  SHEN GREG S

IPC: C07K14/435 ,  A61K38/17 ,  C12N15/12 ,  G01N33/53

CPC classification number: C07K14/43504

Abstract: The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.

Abstract translation: 本发明涉及长度约30-50个残基的相对较短的肽（称为I-芋螺毒素），其在锥形蜗牛的毒液中天然可获得或类似于天然可获得的肽，并且优选包括四个 二硫键。