公开(公告)号：EP2917253A1

公开(公告)日：2015-09-16

申请号：EP13793047.5

申请日：2013-11-08

Applicant: Howard University ,  Colgate-Palmolive Company

Inventor： WANG, Tongxin ,  LEI, Yanda ,  MITCHELL, James E. ,  ZAIDEL, Lynette ,  QIU, Jianhong ,  HASSAN, Mahmoud

IPC: C08F293/00 ,  A61Q11/02 ,  A61K8/90 ,  A61K6/00

Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same are also described.

公开(公告)号：EP2847163A1

公开(公告)日：2015-03-18

申请号：EP13787229.7

申请日：2013-03-14

Applicant: Howard University

Inventor： NEKHAI, Sergei ,  KOVALSKYY, Dmytro Borisovych

IPC: C07C337/00 ,  C07C337/08 ,  A61P35/00

CPC classification number: C07D213/59 ,  C07C337/08 ,  C07D213/53

Abstract: The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/ or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.

公开(公告)号：EP2844268A1

公开(公告)日：2015-03-11

申请号：EP13777952.6

申请日：2013-03-15

Applicant: Howard University ,  Karla, Pradeep K. ,  Mangat, Harpal S.

Inventor： KARLA, Pradeep K. ,  MANGAT, Harpal S.

IPC: A61K38/13

CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K31/496 ,  A61K31/53 ,  A61K31/546 ,  A61K31/573 ,  A61K38/14 ,  A61K2300/00

Abstract: Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subjects eye. By one approach, the ocular disease is endophthalmitis. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for treating the ocular disease. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of Pglycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 19 (MRP19). In one aspect, cyclosporine A is the efflux transporter inhibitor.

公开(公告)号：EP2836546A1

公开(公告)日：2015-02-18

申请号：EP13775678.9

申请日：2013-03-08

Applicant: Howard University

Inventor： WANG, Tongxin ,  MITCHELL, James W.

IPC: C08K9/02 ,  C08K9/06

Abstract: A method is provided for synthesizing PLA/apatite composites with improved mechanical strength. In one aspect, a calcium-phosphate/phosphonate hybrid shell is developed to incorporate more reactive hydroxyl groups onto hydroxyapatite (HA) particles. PLA is covalently bonded to HA calcium phosphate hybrid shell, creating a strong interphase between HA and PLA, thus significantly improve the mechanical strength in comparison to that of non-modified HA.

Abstract translation: 提供了合成聚丙交酯/磷酸钙复合材料的方法。 在一种形式中，磷酸钙材料用酸质子化，质子化后与硅烷材料结合形成中间体硅烷化磷酸钙材料。 然后将中间体硅烷化磷酸钙材料与丙交酯材料混合以形成聚乳酸/磷酸钙基体材料，该材料的拉伸强度至少为未将硅烷与磷酸钙材料结合制备的聚丙交酯/磷酸钙材料的拉伸强度的1.3倍。

公开(公告)号：EP2647262A2

公开(公告)日：2013-10-09

申请号：EP11844199.7

申请日：2011-11-29

Applicant: Howard University

Inventor： KIM, Charles J.

IPC: H05B37/02 ,  F21S2/00 ,  F21V23/00

CPC classification number: F21V23/0457 ,  F21S2/005 ,  F21W2131/406 ,  F21Y2105/10 ,  F21Y2113/13 ,  F21Y2115/10 ,  H05B33/0851 ,  H05B33/0869 ,  H05B37/029

Abstract: A lighting element is disposed in an array of lighting elements. At the lighting element, a lighting status of at least one neighboring lighting element is sensed. Independent of any other lighting element, a lighting adjustment for the lighting element by applying the sensed lighting status to a predetermined rule is determined. The lighting adjustment is applied to the lighting element to adjust an illumination of the lighting element.

Abstract translation: 照明元件设置在照明元件的阵列中。 在照明元件处，感测至少一个相邻照明元件的照明状态。 独立于任何其他照明元件，确定通过将感测到的照明状态应用于预定规则的照明元件的照明调整。 照明调节被施加到照明元件以调节照明元件的照明。

公开(公告)号：EP2643382A2

公开(公告)日：2013-10-02

申请号：EP11842970.3

申请日：2011-11-22

Applicant: Howard University

Inventor： AKALA, Emmanuel Oyekanmi ,  ADESINA, Simeon Kolawole

IPC: C08G63/08 ,  C08F283/01 ,  C08J3/12 ,  C08F20/10 ,  A61K47/30

CPC classification number: C08G63/78 ,  A61K9/1635 ,  A61K9/5153 ,  A61K31/337 ,  A61K31/7034 ,  A61K31/704 ,  B01J13/06 ,  B01J13/16 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C08F299/024 ,  C08G63/06 ,  C08G63/82 ,  C08G63/85 ,  C08G63/912 ,  Y10S977/773 ,  Y10T428/2982

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monmer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.

Abstract translation: 本发明涉及一种交联或非交联的聚合物粒子，worin的交联聚合物颗粒包括聚的共聚物（alklyene乙二醇 - 接枝 - 乳酸盐）并通过至少一个可水解monmer交联。 本发明的另一个实施方案是包含交联的聚合物粒子的聚合物粒子确实是起始材料，包括：（a）亲水性单体的产物，（b）一种疏水性单体，和（c）的水解性交联剂。 本发明的另一个实施方案是包含聚合物颗粒，交联共聚物包含由式（I）表示的结构，（II）和（III），其中式（I），（II）和（III）在所限定 规范。 然而，本发明的其他实施方式包括制备甲基丙烯酸酯封端的大分子，制备交联剂的方法的方法，以及制备的治疗剂通过分散聚合装载的纳米球的方法。

公开(公告)号：EP2643372A2

公开(公告)日：2013-10-02

申请号：EP11842912.5

申请日：2011-11-22

Applicant: Howard University

Inventor： AKALA, Emmanuel Oyekanmi ,  OKUNOLA, Oluyomi Modupe

IPC: C08F265/06 ,  C08F220/10 ,  C08F220/18 ,  C08F283/06 ,  A61K47/30

CPC classification number: A61K9/1641 ,  A61K9/5146 ,  A61K31/135 ,  A61K31/337 ,  A61K31/704 ,  C08F8/00 ,  C08F8/30 ,  C08F220/68 ,  C08F290/062 ,  Y10T428/2982 ,  C08F120/14 ,  C08F220/18 ,  C08F222/00

Abstract: The present invention is directed to a crosslinked or non-croslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly (alklyene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monmer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

公开(公告)号：EP2628252A1

公开(公告)日：2013-08-21

申请号：EP11833197.4

申请日：2011-10-10

Applicant: Howard University ,  San Diego Gas & Electric Company

Inventor： KIM, Charles, J.

IPC: H04B3/46 ,  H04B3/54

CPC classification number: G01R31/086 ,  G01R29/18 ,  Y04S10/522

Abstract: An electrical waveform is received over an electrical power line. A plurality of nominal electrical parameters are determined for the electrical power network and the plurality of nominal electrical parameters are associated with a state of the electrical power network in the absence of at least one transitory electrical fault in the network. Subsequently, a plurality of electrical parameters of the electrical waveform are sampled when the at least one transitory electrical fault exists in the network. A plurality of inductances are determined based at least in part upon a comparison of the nominal electrical parameters and the plurality of sampled electrical parameters. The plurality of inductances are representative of inductances present in the network when the at least one transitory electrical fault exists in the network. The plurality of inductances are analyzed to determine a distance and/or direction to the at least one electrical fault.

Abstract translation: 在电力线上接收电波形。 为电力网络确定多个标称电参数，并且多个标称电参数在网络中没有至少一个暂时性电故障的情况下与电力网络的状态相关联。 随后，当网络中存在至少一个瞬时电气故障时，对电波形的多个电参数进行采样。 至少部分地基于标称电参数和多个采样电参数的比较来确定多个电感。 当网络中存在至少一个瞬时电气故障时，多个电感代表存在于网络中的电感。 分析多个电感以确定与至少一个电气故障的距离和/或方向。

公开(公告)号：WO2022251622A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/031327

申请日：2022-05-27

Applicant: HOWARD UNIVERSITY

Inventor： TANG, Qiyi ,  ZHU, Hua

IPC: C12N15/113 ,  A61K31/7105 ,  A61K31/7115 ,  A61P31/22

Abstract: The present disclosure provides small complementary RNAs (scRNAs), compositions containing the same, and methods for using such small complementary RNAs as antivirals. The present disclosure provides, in more specific embodiments, scRNAs that are single-stranded and which are about 20–30 nucleotides (nt) long, and which are complementary to the intron of an essential viral gene, such as the major immediate early (MIE) gene of human cytomegalovirus (HCMV). Also provided herein are pharmaceutical compositions additionally containing a pharmaceutically acceptable carrier system, wherein the carrier system includes a cationic polymer which releases the scRNA in response to endosomal pH.

公开(公告)号：WO2022132918A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/063544

申请日：2021-12-15

Applicant: HOWARD UNIVERSITY ,  NEKHAI, Sergei ,  STEININGER, Christoph

Inventor： NEKHAI, Sergei ,  STEININGER, Christoph

IPC: A61K31/165 ,  A61K31/216 ,  C07D219/04 ,  A61P31/20

Abstract: A method for treating or inhibiting cytomegalovirus infection, including administrating an effective amount of a class of small molecules targeting protein phosphatase 1 (PP1) to a subject in need thereof. A method for inhibiting replication of cytomegalovirus, including contacting cytomegalovirus or cells containing the cytomegalovirus with a class of small molecules targeting protein phosphatase 1 (PP1).