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    PRRSV VACCINES
    61.
    发明专利
    PRRSV VACCINES 未知

    公开(公告)号：CA2366072C

    公开(公告)日：2007-07-10

    申请号：CA2366072

    申请日：2000-03-08

    Applicant: ID LELYSTAD INST DIERHOUDERIJ

    Inventor： MEULENBERG JANNEKE ,  VERHEIJE HELENE

    IPC: C12N15/86 ,  A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07K14/08 ,  C12N7/01 ,  C12N7/04 ,  C12N15/40

    Abstract: The invention relates to the field of PRRS viruses and infectious clones obtained from PRRS viruses. Furthermore, the invention relates to vaccines a nd diagnostic assays obtainable by using and modifying such infectious clones o f PRRS viruses. The invention provides a porcine reproductive and respiratory syndrome virus (PRRSV) replicon having at least some of its original PRRSV nucleic acid deleted, said replicon capable of in vivo RNA replication, said replicon further having been deprived of at least some of its original PRRSV nucleic acid and/or having been supplemented with nucleic acid derived from a heterologous micro-organism.

    Differences in intestinal gene expression profiles
    63.
    发明专利
    Differences in intestinal gene expression profiles 未知

    公开(公告)号：AU2005263015A1

    公开(公告)日：2006-01-19

    申请号：AU2005263015

    申请日：2005-07-08

    Applicant: ID LELYSTAD INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID B V

    Inventor： SMITS MARINUS ADRIANUS ,  NIEWOLD THEODOOR ABRAM ,  REBEL JOHANNA MARINA JACOBA

    IPC: C12Q1/68

    Abstract: The invention provides a set of genes or gene sequences comprising at least two genes and the use of the set of genes or gene sequences for the determination of intestinal health and/or disease of an animal or a human. The invention further provides methods to detect the presence or absence of an intestinal disease in an animal or a human comprising measuring, in a sample of the animal or human, expression levels of a set of genes or gene sequences according to the invention, or a gene-specific fragment of the genes and comparing the expression levels with a reference value, such as the expression levels of the set of genes in a sample of intestinal tissue of a healthy animal or human.

    DETECTION OF POLYMORPHISMS
    66.
    发明专利
    DETECTION OF POLYMORPHISMS 未知

    公开(公告)号：CA2481417A1

    公开(公告)日：2003-10-23

    申请号：CA2481417

    申请日：2003-04-04

    Applicant: ID LELYSTAD INST DIERHOUDERIJ

    Inventor： TE PAS MARINUS FREDERICK WILLE ,  AGBO EDWIN CHUKWURA ,  SMITS MARINUS ADRIANUS

    IPC: C12P19/34 ,  C12Q1/68

    Abstract: The present invention provides methods for producing a nucleic acid fingerprint as well as methods for detecting sequence polymorphisms between one or more genomes. The methods involve: (a) fragmenting a nucleic acid int o nucleic acid fragments with ends that are compatible to ligation with at lea st one adapter, (b) performing a ligation reaction between the compatible ends of the nucleic acid fragments and at least one adapter, (c) amplifying the nucleic acid fragments by using at least one amplification primer, and (d) generating a nucleic acid fingerprint from the amplified fragments. A method according to the present invention permits high-resolution fingerprinting while maintaining stringency in a PCR reaction. In another aspect, the invention also provides a kit for preparing nucleic acid fingerprints according to methods of the invention.

    PRRSV VACCINES
    69.
    发明专利
    PRRSV VACCINES 未知

    公开(公告)号：CA2366072A1

    公开(公告)日：2000-09-14

    申请号：CA2366072

    申请日：2000-03-08

    Applicant: ID LELYSTAD INST DIERHOUDERIJ

    Inventor： MEULENBERG JANNEKE ,  VERHEIJE HELENE

    IPC: A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07K14/08 ,  C12N7/01 ,  C12N7/04 ,  C12N15/40 ,  C12N15/86

    Abstract: The invention relates to the field of PRRS viruses and infectious clones obtained from PRRS viruses. Furthermore, the invention relates to vaccines a nd diagnostic assays obtainable by using and modifying such infectious clones o f PRRS viruses. The invention provides a porcine reproductive and respiratory syndrome virus (PRRSV) replicon having at least some of its original PRRSV nucleic acid deleted, said replicon capable of in vivo RNA replication, said replicon further having been deprived of at least some of its original PRRSV nucleic acid and/or having been supplemented with nucleic acid derived from a heterologous micro-organism.

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