SYSTEMS AND METHODS FOR SYNTHESIZING MOLECULES ON SUBSTRATES
    61.
    发明申请
    SYSTEMS AND METHODS FOR SYNTHESIZING MOLECULES ON SUBSTRATES 审中-公开
    用于合成基底上分子的系统和方法

    公开(公告)号:WO2012057771A1

    公开(公告)日:2012-05-03

    申请号:PCT/US2010/054551

    申请日:2010-10-28

    Abstract: Systems and methods for synthesizing molecules on a substrate surface are disclosed. In one aspect, a molecule synthesizing system (100) includes a crossbar array (102) with a planar arrangement of crossbar junctions. Each crossbar junction is independently switchable between a high-resistance state and a low-resistance state. The system also includes a slab (104) with a first surface (114) and a second surface (116) parallel to the first surface. The second surface is disposed on the crossbar array. A current applied to a crossbar junction in a high-resistance state creates an adjacent heated site on the first surface for attaching thermally reactive molecules for molecular synthesis.

    Abstract translation: 公开了在衬底表面上合成分子的系统和方法。 一方面,分子合成系统(100)包括具有交叉点结的平面布置的交叉开关阵列(102)。 每个交叉连接点可以在高电阻状态和低电阻状态之间独立切换。 该系统还包括具有平行于第一表面的第一表面(114)和第二表面(116)的板坯(104)。 第二表面设置在横杆阵列上。 施加到高电阻状态的交叉连接处的电流在第一表面上产生相邻的加热部位,用于附加用于分子合成的热反应性分子。

    METALLIC-NANOFINGER DEVICE FOR CHEMICAL SENSING
    62.
    发明申请
    METALLIC-NANOFINGER DEVICE FOR CHEMICAL SENSING 审中-公开
    用于化学传感的金属 - 纳米芬设备

    公开(公告)号:WO2012054024A1

    公开(公告)日:2012-04-26

    申请号:PCT/US2010/053304

    申请日:2010-10-20

    CPC classification number: G01N21/658 G01N21/648

    Abstract: A metallic-nanofinger device (101) for chemical sensing. The device (101) includes a substrate (110), and a plurality (120) of nanofingers. A nanofinger (120-1) includes a flexible column (120-1A), and a metallic cap (120-1B) coupled to an apex (120-1C) of the flexible column (120-1A). At least the nanofinger (120-1) and a second nanofinger (120-2) are to self-arrange into a close-packed configuration with at least one analyte molecule (220-1) disposed between at least the metallic cap (120-1B) and a second metallic cap (120-2B) of respective nanofinger (120-1) and second nanofinger (120-2). A morphology of the metallic cap (120-1B) is to generate a shifted plasmonic-resonance peak (622) associated with amplified luminescence from the analyte molecule (220-1). A coating (120-1D) encapsulating the metallic cap (120-1B) to respond upon exposure to a liquid (212), and a chemical-sensing chip (701) including the metallic-nanofinger device (101) are also provided.

    Abstract translation: 一种用于化学感测的金属纳米装置(101)。 装置(101)包括基板(110)和多个(120)的纳米装置。 纳米针(120-1)包括柔性柱(120-1A)和耦合到柔性柱(120-1A)的顶点(120-1C)的金属盖(120-1B)。 至少纳米针(120-1)和第二纳米针(120-2)将自动排列成紧密构型,其中至少一个分析物分子(220-1)设置在至少金属盖(120- 1B)和相应的纳米针(120-1)和第二纳米片(120-2)的第二金属盖(120-2B)。 金属帽(120-1B)的形态是产生与来自分析物分子(220-1)的放大的发光相关的移位的等离子体共振峰(622)。 还提供了封装金属盖(120-1B)以在暴露于液体(212)时响应的涂层(120-1D),以及包括金属纳米酮装置(101)的化学感测芯片(701)。

    IONIC DEVICES WITH INTERACTING SPECIES
    63.
    发明申请
    IONIC DEVICES WITH INTERACTING SPECIES 审中-公开
    具有相互作用的物种的离子装置

    公开(公告)号:WO2011136806A1

    公开(公告)日:2011-11-03

    申请号:PCT/US2010/033257

    申请日:2010-04-30

    Abstract: An ionic device includes a layer (220) of an ionic conductor containing first and second species (222, 224) of impurities. The first species (222) of impurity in the layer (220) is mobile in the ionic conductor, and a concentration profile of the first species (222) determines a functional characteristic of the device (200). The second species (224) of impurity in the layer (220) interacts with the first species (222) within the layer (220) to create a structure (226) that limits mobility of the first species (222) in the layer (220).

    Abstract translation: 离子装置包括含有杂质的第一和第二物质(222,224)的离子导体层(220)。 层(220)中的第一杂质物质(222)在离子导体中是可移动的,并且第一物质(222)的浓度分布决定了装置(200)的功能特征。 层(220)中的杂质的第二物质(224)与层(220)内的第一物质(222)相互作用以产生限制层(220)中第一物质(222)的迁移率的结构(226) )。

    MULTI-PILLAR STRUCTURE FOR MOLECULAR ANALYSIS
    64.
    发明申请
    MULTI-PILLAR STRUCTURE FOR MOLECULAR ANALYSIS 审中-公开
    用于分子分析的多支架结构

    公开(公告)号:WO2011133143A1

    公开(公告)日:2011-10-27

    申请号:PCT/US2010/031790

    申请日:2010-04-20

    CPC classification number: G01N21/658

    Abstract: A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.

    Abstract translation: 提供了一种用于分子分析的多支柱结构。 该结构包括至少两个纳米微粒,每个纳米孔一端连接到基底上,并可沿其长度自由移动。 至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。 每个纳米孔涂有金属涂层。 还提供了这种多支柱结构的阵列。 还提供了一种制备多支柱结构的方法。

    SELF-COLLECTING SERS SUBSTRATE
    65.
    发明申请
    SELF-COLLECTING SERS SUBSTRATE 审中-公开
    自拍收藏

    公开(公告)号:WO2011093879A1

    公开(公告)日:2011-08-04

    申请号:PCT/US2010/022579

    申请日:2010-01-29

    CPC classification number: G01N21/658 B82Y20/00 G01N21/554 G01N21/7743

    Abstract: A self-collecting substrate (10) for surface enhanced Raman spectroscopy having a first surface (10a) and a second surface (10b) opposed thereto, comprising: a waveguiding layer (10') supported on a support layer (10"), with the waveguiding layer associated with the first surface and the support layer associated with the second surface; and a plurality of metal nano-antennae (14) established on the first surface and operatively associated with the plurality of openings such that exposure of analyte (18) to the light causes preferential aggregation of the analytes in the vicinity of the nano-antennae. A system (50) for at least one of attracting the analytes 18) to the metal nano-antennae (14) and performing surface enhanced Raman spectroscopy using the substrate (10) and a method for increasing a signal for surface enhanced Raman spectroscopy are provided.

    Abstract translation: 一种用于表面增强拉曼光谱的自动采集衬底(10),具有与其相对的第一表面(10a)和第二表面(10b),包括:支撑在支撑层(10“)上的波导层(10'), 与第一表面相关联的波导层和与第二表面相关联的支撑层;以及多个金属纳米天线(14),其建立在第一表面上并与多个开口可操作地相关联,使得分析物(18) 对于光引起分析物在纳米天线附近的优先聚集,用于将金属纳米天线(14)吸引到分析物18)中的至少一种的系统(50),并使用 提供了基板(10)和增加表面增强拉曼光谱信号的方法。

    RAMAN SPECTROSCOPY LIGHT AMPLIFYING STRUCTURE
    66.
    发明申请
    RAMAN SPECTROSCOPY LIGHT AMPLIFYING STRUCTURE 审中-公开
    拉曼光谱放大结构

    公开(公告)号:WO2011049582A1

    公开(公告)日:2011-04-28

    申请号:PCT/US2009/061904

    申请日:2009-10-23

    CPC classification number: G01N21/658

    Abstract: A light amplifying structure (100) for Raman spectroscopy includes a resonant cavity (108). A distance between a first portion (102B) and a second portion (102A) of the structure (100) forming the resonant (cavity (108) is used to amplify excitation light emitted from a light source (420) into the resonant cavity (108) at a first resonant frequency of the resonant cavity (108). Also, the resonant cavity (108) amplifies radiated light radiated from a predetermined molecule excited by the excitation light in the resonant cavity at a second resonant frequency of the resonant cavity (108).

    Abstract translation: 用于拉曼光谱的光放大结构(100)包括谐振腔(108)。 形成谐振腔(108)的结构(100)的第一部分(102B)和第二部分(102A)之间的距离用于将从光源(420)发射的激发光放大到谐振腔(108) 谐振腔(108)在谐振腔(108)的第二谐振频率处放大从由谐振腔中的激发光激发的预定分子辐射的辐射光 )。

    BROAD BAND STRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY
    67.
    发明申请
    BROAD BAND STRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
    表面增强拉曼光谱的宽带结构

    公开(公告)号:WO2010104520A1

    公开(公告)日:2010-09-16

    申请号:PCT/US2009/037167

    申请日:2009-03-13

    Inventor: LI, Zhiyong HU, Min

    CPC classification number: G01N21/554 B82Y30/00 G01N21/553 G01N21/658

    Abstract: Broad band structures (10, 10', 10") for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure (10, 10', 10") is made up of a metal layer, and a dielectric layer (16A, 16S, 16P) established on at least a portion of the metal layer. The dielectric layer (16A, 16S, 16P) has a controlled thickness that varies from at least one portion of the dielectric layer (16A, 16s, 16p) to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer (16A, 16S, 16P) at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.

    Abstract translation: 本文公开了用于表面增强拉曼光谱的宽带结构(10,10',10“)。结构(10,10',10”)的每个实施例由金属层和电介质层(16A, 16S,16P)建立在金属层的至少一部分上。 电介质层(16A,16S,16P)具有从电介质层(16A,16s,16p)的至少一部分至电介质层的至少另一部分变化的受控厚度。 至少在部分和另一部分,在介电层(16A,16S,16P)上建立纳米结构,因此纳米结构被配置为展现可变的等离子体共振。

    MONOLITHIC SYSTEM AND METHOD FOR ENHANCED RAMAN SPECTROSCOPY
    68.
    发明申请
    MONOLITHIC SYSTEM AND METHOD FOR ENHANCED RAMAN SPECTROSCOPY 审中-公开
    用于增强拉曼光谱的单体系统和方法

    公开(公告)号:WO2006081565A1

    公开(公告)日:2006-08-03

    申请号:PCT/US2006/003264

    申请日:2006-01-26

    CPC classification number: G01N21/658 G01N2201/0873

    Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device (100', 100") for performing Raman spectroscopy comprises a substrate (110) and a laser source (120) disposed on the substrate (110). The laser source (120) may be configured for generating a laser radiation (125), which may irradiate an analyte (31 ) disposed on a Raman enhancement structure (300). The Raman enhancement structure (300) may be disposed in a waveguide (130). The molecular analysis device (100', 100") also includes a wavelength demultiplexer (240) and radiation sensors (290) disposed on the substrate (110) and configured for receiving a Raman scattered radiation (160), which may be generated by the irradiation of the analyte (310) and Raman enhancement structure (300).

    Abstract translation: 公开了用于增强拉曼光谱和超拉曼的装置,系统和方法。 用于进行拉曼光谱分析的分子分析装置(100',100“)包括基板(110)和设置在基板(110)上的激光源(120),激光源(120)可以被配置为产生激光辐射 (125),其可以照射设置在拉曼增强结构(300)上的分析物(31),拉曼增强结构(300)可以设置在波导管(130)中,分子分析装置(100',100“) 还包括布置在衬底(110)上并被配置用于接收拉曼散射辐射(160)的波长解复用器(240)和辐射传感器(290),其可以通过分析物(310)的照射和拉曼增强结构 (300)。

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