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公开(公告)号：US20210238647A1
公开(公告)日：2021-08-05
申请号：US17234066
申请日：2021-04-19
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , Moshe Ben-David , Mushki Fridman , Yael Gluckman , Dina Gohman , Orly Hammer Munz , Anita Shinderman , Eran Zahavy
Abstract: Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.
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公开(公告)号：US10801962B2
公开(公告)日：2020-10-13
申请号：US16057948
申请日：2018-08-08
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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公开(公告)号：US20180348135A1
公开(公告)日：2018-12-06
申请号：US16057948
申请日：2018-08-08
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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公开(公告)号：US10082452B2
公开(公告)日：2018-09-25
申请号：US14172491
申请日：2014-02-04
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.
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公开(公告)号：US09606105B2
公开(公告)日：2017-03-28
申请号：US14330450
申请日：2014-07-14
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico , John S. Laudo
CPC classification number: G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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Patent Agency Ranking
公开(公告)号：US20140170740A1
公开(公告)日：2014-06-19
申请号：US14102742
申请日：2013-12-11
Applicant: Pocared Diagnostics Ltd.
Inventor： Gal Ingber , Martha J. Rogers
IPC: C12Q1/04
CPC classification number: C12M41/36 , B01L3/508 , B01L2300/0809 , B01L2300/0851 , G01N21/0303 , G01N2021/0382 , G01N2021/6469 , G01N2021/6482 , G01N2035/0436 , G01N2201/0655
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.
Abstract translation: 本发明涉及用于在生物样品中进行微生物（例如细菌）的鉴定和定量的系统。 更具体地说，本发明涉及一种包括一次性药筒和具有锥形表面的光学杯或试管的系统; 其中壁是成角度的，以允许更好的涂层和更好的光线条纹。 系统可以利用样品处理器中的一次性盒，以及光学分析器中的光学杯或试管，其中光学杯还具有倒拱形状的底板。
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公开(公告)号：WO2018127853A1
公开(公告)日：2018-07-12
申请号：PCT/IB2018/050134
申请日：2018-01-09
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal , BEN-DAVID, Moshe , FRIDMAN, Mushki , GLUCKMAN, Yael , GOHMAN, Dina , MUNZ, Orly, Hammer , SHINDERMAN, Anita , ZAHAVY, Eran
Abstract: Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.
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公开(公告)号：WO2014123896A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/014658
申请日：2014-02-04
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal
CPC classification number: G01N1/34 , B01L3/502753 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2400/049 , G01N1/4077 , G01N2001/4088
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.
Abstract translation: 具有顶部元件和底部元件以及过滤元件的过滤器装置在过滤器元件的上表面上捕获过大的颗粒，并使用洗脱流体切向冲洗这些颗粒，以提供相对低体积的流体中的颗粒浓度 进一步分析。 在中间步骤中，由过滤器捕获的颗粒可以用诸如水的冲洗液冲洗以通过另外的过小的颗粒通过过滤器，从而提供更纯的样品。 为了提高效率，止回阀可用于单向流动的通道。 另外，也可以使用三通旋塞的构造。 最后，三明治布置是可能的，其中单个底部元件夹在两个相对的顶部元件之间。
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公开(公告)号：WO2014093463A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/074342
申请日：2013-12-11
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal , ROGERS, Martha, J.
CPC classification number: C12M41/36 , B01L3/508 , B01L2300/0809 , B01L2300/0851 , G01N21/0303 , G01N2021/0382 , G01N2021/6469 , G01N2021/6482 , G01N2035/0436 , G01N2201/0655
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.
Abstract translation: 本发明涉及用于在生物样品中进行微生物（例如细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或杯的系统， 其中壁是成角度的，以允许更好的涂层和更好的光线条纹。 系统可以利用样品处理器中的一次性盒，以及光学分析器中的光学杯或试管，其中光学杯还具有倒拱形状的底板。
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公开(公告)号：WO2010089749A1
公开(公告)日：2010-08-12
申请号：PCT/IL2010/000108
申请日：2010-02-07
Applicant: Pocared Diagnostics Ltd. , INGBER, Gal
Inventor： INGBER, Gal
IPC: G01J3/42
CPC classification number: G01J1/32 , G01J3/42 , G01J2003/2866 , G01N21/031 , G01N21/253 , G01N2201/0415 , G01N2201/0469 , G01N2201/0692
Abstract: A method and device for enhancing the power correction of optical measurements in an optical measurement arrangement, the steps including: providing a light source for producing a light beam; splitting the light beam into two beams; directing a first split light beam through an interrogation area and into an optics separation device; directing the light beams from the optics separation device and a second split light beam representing the intensity of the illumination of the main light beam of the light source into cells of a detector array; measuring and assessing the information obtained in the cells; and using this information to calculate the corrected value for the cells receiving the light beams from the optics separation device in order to adjust the power for the intensity of the light beam of the light source and/or to correct the intensity of the light beams from the interrogation area.
Abstract translation: 一种用于增强光学测量装置中的光学测量的功率校正的方法和装置，所述步骤包括：提供用于产生光束的光源; 将光束分成两束; 将第一分裂光束引导通过询问区并进入光学分离装置; 引导来自光学分离装置的光束和将光源的主光束的照明强度表示为检测器阵列的单元的第二分裂光束; 测量和评估细胞中获得的信息; 并且使用该信息来计算接收来自光学分离装置的光束的单元的校正值，以便调整光源的光束强度的功率和/或校正来自光源的光束的强度 询问区。
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