Abstract:
The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.
Abstract translation:本发明涉及式I的新型苯基恶唑烷酮化合物,其药学上可接受的类似物,互变异构形式,立体异构体,多晶型物,前药,代谢物,盐或溶剂化物。 本发明还涉及合成式I的新化合物或其药学上可接受的类似物,互变异构形式,立体异构体,多晶型物,前药,代谢物,盐或溶剂合物的方法。 本发明还提供了包含新型式I化合物和使用它们的方法的药物组合物。 本发明化合物可用作抗微生物剂,有效对抗许多需氧和/或厌氧革兰氏阳性和/或革兰氏阴性病原体,例如葡萄球菌,链球菌,肠球菌,细菌,梭菌,流感嗜血菌 ,莫拉菌属(Moraxella),耐酸生物体如结核分枝杆菌(Mycobacterium tuberculosis)以及耐利奈唑胺菌(Staphylococcus and Enterococcus)。
Abstract:
A drive system for a grid blower of a vehicle is provided. The system includes: an electrical bus, a grid of resistive elements connected to the electrical bus, the grid of resistive elements configured to thermally dissipate electrical power generated from braking of the vehicle, the electrical power being transmitted on the electrical bus to the grid of resistive elements, an electrical power modulation device configured to modify electrical power received from at least one of the electrical bus and the grid of resistive elements, and a grid blower motor coupled to an output of the electrical power modulation device, wherein a speed of the grid blower motor varies based on the electrical power that has been modified by the electrical power modulation device.
Abstract:
The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more conditions that may be regulated or normalized via inhibition of dipeptidyl peptidase IV (DPP-IV). Formula I
Abstract:
The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more conditions that may be regulated or normalized via inhibition of dipeptidyl peptidase IV (DPP-IV). Formula I
Abstract:
A plasma pyrolysis device is provided for dispensing-off a variety of waste materials. The device has two metallic chambers, a plasma torch, a number of electrodes, means to provide air and means for transfer of pyrolysed gases, a feeder, scrubber and control circuits. The process for carrying out pyrolysis, under oxygen starved environment, is also provided. The process is optimized to operate at extremely low power levels. The device is energy efficient, simple in construction and cost- effective.
Abstract:
A silica insulating refractory brick comprising: 70 to 95% agricultural waste ash such as rice husk ash; 1 to 20% binder; remainder water; and optionally additives.
Abstract:
Certain aspects of the present disclosure provide techniques for receiver side protection in sidelink communications. In certain aspects, a method performed by an apparatus generally includes obtaining, from a first user equipment (UE), first control information, which includes a first resource allocation information of one or more resources allocated for transmission by the first UE to the apparatus and an indication of a first cell associated with the first UE. The method generally includes obtaining, from a second UE, second control information, which generally includes a second resource allocation information of resources allocated for transmission by the second UE to the apparatus and an indication of a second cell associated with the second UE. The method generally includes determining, based on the first and second control information, potential interference from transmissions by the first UE and the second UE and taking one or more actions to mitigate the potential interference.
Abstract:
Certain aspects provide a method for wireless communication by a user-equipment (UE). The method generally includes determining a configuration of resources for discovery of a relay UE of a plurality of relay UEs, wherein the resources are used by each of the plurality of relay UEs for communication of one or more discovery messages, performing discovery operations to connect with the relay UE in accordance with the configuration, and communicating with a base station through the relay UE after connecting with the relay UE.
Abstract:
Some aspects described herein relate to determining, by a transmitter user equipment (UE) in sidelink communications with a receiver UE, a feedback forwarding timing capability based at least in part on a first timing for receiving and processing feedback from the receiver UE, and receiving, from an access point and based on the feedback forwarding timing capability, at least an uplink resource grant for transmitting feedback for at least one of sidelink communications or downlink communications. Other aspects relate to determining, by a transmitter UE in sidelink communications with a receiver UE, a timing capability for the receiver UE to at least one of receive sidelink communications from the transmitter UE or report feedback for the sidelink communications to the transmitter UE.
Abstract:
The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula (I) and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).