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    INDEPENDENT COMPONENT IMAGING
    62.
    发明申请
    INDEPENDENT COMPONENT IMAGING 审中-公开
    独立分量成像

    公开(公告)号：WO2003073064A2

    公开(公告)日：2003-09-04

    申请号：PCT/US2003/005265

    申请日：2003-02-25

    Applicant: THE CATHOLIC UNIVERSITY OF AMERICA ,  WANG, Yue, Joseph

    Inventor： WANG, Yue, Joseph

    IPC: G01N

    CPC classification number: G06K9/0014 ,  G06K9/6232 ,  G06K9/6242 ,  G06T7/0012 ,  G06T2207/30072 ,  Y10S128/922

    Abstract: The present invention describes a partial independent component analysis (PICA) technique for blindly separating partially independent and/or gaussian-like sources from mixed observations over an informative index subspace, which allows various applications in independent component imaging. The present invention estimates a demixing matrix using only the independent and/or nongaussian portion of the observations. Specifically, rather than using all the data points which give rise to a large separation error, a subset of the data points is identified such that the partial source profiles defined over such a subset are statistically independent and/or nongaussian. The present invention describes a complete implementation of such a technique, whose steps and parameters may be achieved and estimated using an information theoretic-based neural computational algorithm. The present invention also demonstrates the principle of the approach on both controlled cases and real-world problems, and describes many extended applications of such a technique.

    Abstract translation: 本发明描述了一种用于在信息索引子空间上将部分独立和/或高斯状源从混合观察中盲目分离的部分独立分量分析（PICA）技术，其允许独立分量成像中的各种应用。 本发明仅使用观察值的独立和/或非整数部分来估计分类矩阵。 特别地，不是使用引起大的分离误差的所有数据点，而是识别数据点的子集，使得在这样的子集上定义的部分源简档是统计独立的和/或非泛素的。 本发明描述了这样的技术的完整实现，其技术的步骤和参数可以使用基于信息理论的神经计算算法来实现和估计。 本发明还演示了对控制案例和现实世界问题的方法的原理，并且描述了这种技术的许多扩展应用。

    PROTECTION OF LIVING SYSTEMS FROM ADVERSE EFFECTS OF ELECTRIC, MAGNETIC AND ELECTROMAGNETIC FIELDS
    63.
    发明申请
    PROTECTION OF LIVING SYSTEMS FROM ADVERSE EFFECTS OF ELECTRIC, MAGNETIC AND ELECTROMAGNETIC FIELDS 审中-公开
    电气，电磁场的不良影响对生活系统的保护

    公开(公告)号：WO1996008207A1

    公开(公告)日：1996-03-21

    申请号：PCT/US1994009771

    申请日：1994-09-12

    Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

    Inventor： THE CATHOLIC UNIVERSITY OF AMERICA ,  LITOVITZ, Theodore, A. ,  PENAFIEL, Luis, Miguel

    IPC: A61B19/00

    CPC classification number: A61B90/04 ,  A61B2090/0418 ,  A61B2090/0481

    Abstract: The embodiments of the inventions disclosed in this application develop a "protection" electric, magnetic or electromagnetic field or fields which are either superimposed upon an ambient field which is detrimental to the health of living systems, or incorporated into the electrical circuit of the device which is generating the detrimental field. Either arrangement is successful in "confusing" living cells, and thereby reducing the harmful effects of the otherwise detrimental field.

    Abstract translation: 本申请中公开的本发明的实施例开发出一种“保护”的电，磁或电磁场或场，它们叠加在不利于生命系统的健康的环境场上，或并入到设备的电路中， 正在产生有害的领域。 任何一种安排都是成功的“混淆”活细胞，从而减少其他有害的领域的有害影响。

    BACTERIOPHAGE-BASED, NEEDLE AND ADJUVANT-FREE, MUCOSAL COVID-19 VACCINE
    64.
    发明公开
    BACTERIOPHAGE-BASED, NEEDLE AND ADJUVANT-FREE, MUCOSAL COVID-19 VACCINE 审中-公开

    公开(公告)号：US20230355738A1

    公开(公告)日：2023-11-09

    申请号：US18138183

    申请日：2023-04-24

    Applicant: The Catholic University of America

    Inventor： Venigalla B. RAO ,  Jingen ZHU

    IPC: A61P37/04 ,  A61K39/12

    CPC classification number: A61K39/12 ,  A61P37/04 ,  A61K2039/545

    Abstract: A bacteriophage T4-based, multivalent/multicomponent, needle and adjuvant-free, mucosal vaccine by engineering spike trimers on capsid exterior and nucleocapsid protein in the interior is disclosed herein. Intranasal administration of this T4-COVID vaccine induces higher virus neutralization antibody titers against multiple variants, balanced Th1/Th2 antibody and cytokine responses, stronger CD4+ and CD8+ T cell immunity, and higher secretory IgA titers in sera and bronchoalveolar lavage with no effect on the gut microbiota, compared to vaccination of mice intramuscularly. The vaccine is stable at ambient temperature, induce apparent sterilizing immunity, and provide complete protection against original SARS-CoV-2 strain and its Delta variant with minimal lung histopathology. This mucosal vaccine is an excellent candidate for boosting immunity of immunized and/or as a second-generation vaccine for the unimmunized population. This needle-free platform could be used to develop effective vaccines against many other respiratory infectious pathogens including Flu and any future emerging epidemic and pandemic pathogens.

    ENGINEERING OF BACTERIOPHAGES BY GENOME EDITING USING THE CRISPR-CAS9 SYSTEM
    70.
    发明申请
    ENGINEERING OF BACTERIOPHAGES BY GENOME EDITING USING THE CRISPR-CAS9 SYSTEM 审中-公开

    公开(公告)号：US20190330643A1

    公开(公告)日：2019-10-31

    申请号：US16355932

    申请日：2019-03-18

    Applicant: The Catholic University of America

    Inventor： Venigalla B. Rao ,  Pan Tao

    IPC: C12N15/70 ,  C12N15/11 ,  C12N9/22

    Abstract: Embodiments of the invention provide systems, methods, and kits for CRISPR-based editing of DNA targets by a CRISPR-associated (Cas) enzyme. The systems include a bacterial host cell adapted to produce an engineered bacteriophage comprising a Cas protein and guide RNA that do not naturally occur together, i.e. they are engineered to occur together, as well as a DNA repair template comprising a donor DNA having a desired mutation. The guide RNA comprises a trans-activating crRNA and a guide sequence complementary to a target protospacer in a bacteriophage genome. A wild-type bacteriophage or a glucosylhydroxymethyl cytosine (ghmC)-unmodified mutant bacteriophage may be delivered into a disclosed bacterial host cell to create recombinants of bacteriophage having the desired mutation provided by the donor DNA.

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