公开(公告)号：AU2009294850B2

公开(公告)日：2015-07-02

申请号：AU2009294850

申请日：2009-09-22

Applicant: UNIV OREGON HEALTH & SCIENCE ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA D B A THE DEPARTMENT OF VETERANS AFFAIRS

Inventor： LEWINSOHN DEBORAH A ,  LEWINSOHN DAVID M

IPC: G01N33/569

Abstract: Methods for detecting an infection with

公开(公告)号：AU2013201187B2

公开(公告)日：2015-06-11

申请号：AU2013201187

申请日：2013-02-28

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： PLENZ DIETMAR

IPC: A61K38/20 ,  A61B5/0476

Abstract: Method and system for determining a cognitive enhancement and/or anti-epileptic effect comprising: detecting synchronized neuronal activity in neuronal tissue (601), monitoring spreading of the synchronized neuronal activity (602), determining a parameter (604, 605) indicative of the 5 closeness of the synchronized neuronal activity to the critical state and comparing (613) the parameter to a predetennined value.

公开(公告)号：AU2013256418A1

公开(公告)日：2014-11-20

申请号：AU2013256418

申请日：2013-04-30

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ,  UNIV JOHNS HOPKINS

Inventor： GARZA LUIS ANDRES ,  KANG SEWON ,  MEYERLE JON H

IPC: A61F2/10 ,  A61K35/12 ,  A61K35/36 ,  A61L27/38

Abstract: The present invention relates to the field of autologous fibroblasts. More specifically, the present invention provides methods and compositions comprising autologous fibroblasts and uses thereof to alter skin identity. In certain embodiments, volar fibroblasts can be expanded for the ability to induce volar skin at the stump site in amputees. In other embodiments, fibroblasts from haired scalp can be expanded to ameliorate alopecias.

公开(公告)号：AU2012202081B2

公开(公告)日：2014-09-25

申请号：AU2012202081

申请日：2012-04-11

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH

Inventor： GREIG NIGEL H ,  EGAN JOSEPHINE ,  DOYLE MAIRE ,  HOLLOWAY HAROLD ,  PERRY TRACY ANN

IPC: C07K14/47 ,  A61K38/00 ,  A61K38/26 ,  A61K38/28 ,  A61P3/10 ,  A61P9/10 ,  A61P19/08 ,  A61P25/00 ,  A61P25/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07K14/575 ,  C07K14/605

Abstract: The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the s polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP 1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects. 3285444_1 (GHMatters) P52050.AU.2 11-Apr-12

公开(公告)号：AU2012216642B2

公开(公告)日：2014-06-12

申请号：AU2012216642

申请日：2012-08-28

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN S

Inventor： PASTAN IRA H ,  ONDA MASANORI ,  NAGATA SATOSHI ,  FITZGERALD DAVID ,  KREITMAN ROBERT ,  LEE BYUNGKOOK

IPC: C07K14/195 ,  A61K38/16 ,  A61K47/48 ,  C07K14/21 ,  C07K19/00

Abstract: Abstract The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided. e) x C" 0) ED oD 0 ? Cor o) C'* C~l C (Uw

公开(公告)号：AU2008307308C1

公开(公告)日：2014-06-05

申请号：AU2008307308

申请日：2008-08-18

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY ,  THE HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INC

Inventor： MATROSOVA VERA K ,  DALY MICHAEL J ,  WEHR NANCY B ,  LEVINE RODNEY L ,  GAIDAMAKOVA ELENA K

IPC: A61K31/7076 ,  A61K33/32 ,  A61K35/74 ,  A61P39/00

Abstract: This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

公开(公告)号：AU2011232787B2

公开(公告)日：2013-05-02

申请号：AU2011232787

申请日：2011-10-06

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： BEALL BERNARD W ,  CARLONE GEORGE M ,  SAMPSON JACQUELYN S ,  ADES EDWIN W

IPC: C07K14/315 ,  A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  C12N1/21

Abstract: This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of the most prevalent United States (U.S.) Group A Streptococcus (GAS) serotypes. At least some of the synthetic peptides can be recognized by M type-specific antibodies and are capable of eliciting functional opsonic antibodies and/or anti-attachment antibodies without eliciting tissue cross- reactive antibodies. In another aspect, it relates to compositions or vaccines comprising these synthetic serotype-specific peptides, including polypeptides and proteins. The invention may also be isolated antibodies which are raised in response to the peptides, compositions or vaccines. The invention further relates to kits for using the peptides, compositions, or antibodies. In still further aspects, the invention also relates to methods for using the peptides, compositions, vaccines, or antibodies and methods for tailoring vaccines.

公开(公告)号：AU2007286161B2

公开(公告)日：2013-05-02

申请号：AU2007286161

申请日：2007-08-09

Applicant: MEDIMMUNE LLC ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA NAT INSTITUTES OF HEALTH

Inventor： YANG CHIN-FEN ,  MURPHY BRIAN ,  KEMBLE GEORGE ,  SUBBARAO KANTA

IPC: A61K39/00 ,  A61P43/00 ,  C12N7/00 ,  C12N15/87

Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.

公开(公告)号：AU2009238379B2

公开(公告)日：2013-01-10

申请号：AU2009238379

申请日：2009-11-23

Applicant: ORTHO MCNEIL PHARM INC ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： KAFRISSEN MICHAEL E

IPC: A61K31/00 ,  A61K45/00 ,  A61K31/505 ,  A61K31/519 ,  A61K31/565 ,  A61K31/57 ,  A61P5/24 ,  A61P9/00 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00

Abstract: This invention provides folic acid-containing pharmaceutical compositions comprising either an oral contraceptive or a hormone replacement composition. This 5 invention also provides methods of administering folic acid to a subject using the instant pharmaceutical compositions. Finally, this invention provides a drug delivery system useful for administering the instant pharmaceutical compositions.

公开(公告)号：AU2006236910B2

公开(公告)日：2012-06-07

申请号：AU2006236910

申请日：2006-04-10

Applicant: PURDUE RESEARCH FOUNDATION ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT HEA

Inventor： HOELSCHER MARY ,  SAMBHARA SURYAPRAKASH ,  MITTAL SURESH K ,  BANGARI DINESH S ,  KATZ JACQUELINE

IPC: C12N7/00 ,  A61K39/145 ,  C07K14/11 ,  C12N5/10 ,  C12N15/861

Abstract: The present disclosure provides compositions and methods for eliciting an immune response against avian or pandemic influenza. The compositions include adenovirus vectors comprising avian influenza antigens, recombinant adenovirus and immunogenic compositions comprising such recombinant vectors and adenovirus. Methods for eliciting an immune response against avian or pandemic influenza involving administering such adenovirus vectors or recombinant adenovirus are also provided.