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    Bacterial host strain
    62.
    发明授权
    Bacterial host strain 有权
    细菌宿主菌株

    公开(公告)号：US09550973B2

    公开(公告)日：2017-01-24

    申请号：US15083446

    申请日：2016-03-29

    Applicant: UCB PHARMA, S.A.

    Inventor： Mark Ellis ,  David Paul Humphreys

    IPC: C12P21/02 ,  C12N1/20 ,  C12R1/19 ,  C07K16/24 ,  C12N9/52 ,  C12N15/70

    CPC classification number: C12N1/20 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/55 ,  C12N9/52 ,  C12N15/70 ,  C12P21/02 ,  C12R1/19 ,  Y02P20/52

    Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest.

    Abstract translation: 包含一个或多个以下突变蛋白酶基因的重组革兰氏阴性细菌细胞：a）突变的Tsp基因，其中突变的Tsp基因编码具有降低的蛋白酶活性的Tsp蛋白或是敲除突变的Tsp基因; b）突变的ptr基因，其中突变的ptr基因编码具有降低的蛋白酶活性的蛋白酶III蛋白质或是敲除突变的ptr基因; 和c）编码具有伴侣活性和降低的蛋白酶活性的DegP蛋白的突变DegP基因; 其中所述细胞与野生型细菌细胞是同基因的，除了突变的Tsp基因和/或突变的ptr基因和/或突变的DegP基因和任选的编码目的蛋白质的多核苷酸序列。

    Compounds for Enhancing the Cognitive Function
    65.
    发明申请
    Compounds for Enhancing the Cognitive Function 有权
    用于增强认知功能的化合物

    公开(公告)号：US20160185761A1

    公开(公告)日：2016-06-30

    申请号：US14909246

    申请日：2014-07-28

    Applicant: UCB PHARMA, S.A.

    Inventor： Florian Montel ,  Eric Jnoff

    IPC: C07D403/06

    CPC classification number: C07D403/06

    Abstract: The invention relates to 2-oxo-1-pyrrolidinyl triazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for enhancing the cognitive function or to counteract cognitive decline.

    Abstract translation: 本发明涉及2-氧代-1-吡咯烷基三唑衍生物，其制备方法，含有它们的药物组合物及其作为用于增强认知功能或抵抗认知衰退的药物的用途。

    BACTERIAL HOST STRAIN
    67.
    发明申请
    BACTERIAL HOST STRAIN 有权
    细菌宿主菌株

    公开(公告)号：US20150344840A1

    公开(公告)日：2015-12-03

    申请号：US14827408

    申请日：2015-08-17

    Applicant: UCB PHARMA, S.A.

    Inventor： MARK ELLIS ,  DAVID PAUL HUMPHREYS

    IPC: C12N1/20 ,  C12R1/19

    CPC classification number: C12N1/20 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/55 ,  C12N9/52 ,  C12N15/70 ,  C12P21/02 ,  C12R1/19 ,  Y02P20/52

    Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest.

    Abstract translation: 包含一个或多个以下突变蛋白酶基因的重组革兰氏阴性细菌细胞：a）突变的Tsp基因，其中突变的Tsp基因编码具有降低的蛋白酶活性的Tsp蛋白或是敲除突变的Tsp基因; b）突变的ptr基因，其中突变的ptr基因编码具有降低的蛋白酶活性的蛋白酶III蛋白质或是敲除突变的ptr基因; 和c）编码具有伴侣活性和降低的蛋白酶活性的DegP蛋白的突变DegP基因; 其中所述细胞与野生型细菌细胞是同基因的，除了突变的Tsp基因和/或突变的ptr基因和/或突变的DegP基因和任选的编码目的蛋白质的多核苷酸序列。

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