公开(公告)号：WO2011163610A2

公开(公告)日：2011-12-29

申请号：PCT/US2011/041862

申请日：2011-06-24

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  LAVOIE, Edmond J. ,  PARHI, Ajit ,  PILCH, Daniel S.

Inventor： LAVOIE, Edmond J. ,  PARHI, Ajit ,  PILCH, Daniel S.

IPC: C07D213/30 ,  C07D215/10 ,  C07D215/20 ,  C07D217/10 ,  C07D221/18 ,  C07D239/26 ,  C07D307/52 ,  C07D405/10 ,  C07D407/10 ,  C07D471/04 ,  A61K31/47 ,  A61K31/495 ,  A61P31/04

CPC classification number: C07D215/14 ,  A61K9/0019 ,  A61K9/12 ,  A61K9/1623 ,  A61K9/2054 ,  A61K9/4858 ,  C07C211/27 ,  C07C211/29 ,  C07C211/45 ,  C07C211/52 ,  C07C211/63 ,  C07C211/64 ,  C07C217/70 ,  C07C217/78 ,  C07C217/80 ,  C07C217/94 ,  C07C229/38 ,  C07C257/14 ,  C07C279/04 ,  C07C279/06 ,  C07C279/08 ,  C07C279/14 ,  C07C2601/02 ,  C07D213/20 ,  C07D213/30 ,  C07D215/10 ,  C07D215/20 ,  C07D217/10 ,  C07D221/18 ,  C07D239/26 ,  C07D307/52 ,  C07D405/10 ,  C07D407/10 ,  C07D471/04 ,  C07D491/056 ,  Y02A50/401 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481

Abstract: The invention provides a compound of formula I:or a salt thereof, wherein R 3 -R 8 and X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.

Abstract translation: 本发明提供式I化合物或其盐，其中R3-R8和X和Y具有说明书中所述的任何值，以及包含式I化合物的组合物。该化合物可用作抗菌剂 。

公开(公告)号：WO2011156626A1

公开(公告)日：2011-12-15

申请号：PCT/US2011/039839

申请日：2011-06-09

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  LAVOIE, Edmond, J. ,  PARHI, Ajit ,  PILCH, Daniel, S.

Inventor： LAVOIE, Edmond, J. ,  PARHI, Ajit ,  PILCH, Daniel, S.

IPC: C07D217/14 ,  C07D217/22 ,  C07D405/10 ,  A61K31/472 ,  A61K31/4725 ,  A61P31/04

CPC classification number: C07D405/10 ,  C07D217/14 ,  C07D217/22

Abstract: The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein R 1 , R 4 -R 8 , R 10 , R 2' -R 6' , W, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.

Abstract translation: 本发明提供式（I）化合物或其盐或前药，其中R1，R4-R8，R10，R2'-R6'，W和A具有说明书中描述的任何值，以及 组合物，其包含式（I）化合物。 这些化合物可用作抗菌剂。

公开(公告)号：WO2011088318A1

公开(公告)日：2011-07-21

申请号：PCT/US2011/021296

申请日：2011-01-14

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  LIN, Sheldon, Suton ,  PAGLIA, David, Naisby ,  O'CONNOR, John, Patrick ,  BREITBART, Eric ,  BENEVENIA, Joseph

Inventor： LIN, Sheldon, Suton ,  PAGLIA, David, Naisby ,  O'CONNOR, John, Patrick ,  BREITBART, Eric ,  BENEVENIA, Joseph

IPC: A61K35/32 ,  A61K33/06 ,  A61K33/26

CPC classification number: A61K31/555 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/661 ,  A61K33/24 ,  A61K38/00 ,  A61K45/06 ,  A61L27/54 ,  A61L2300/102 ,  A61L2300/45 ,  A61L2430/02 ,  A61K2300/00

Abstract: This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.

Abstract translation: 本发明提供了一种通过局部给予有需要的患者的钒基胰岛素模拟物来促进骨愈合的方法。 本发明还提供了胰岛素模拟钒化合物的新用途，用于制造用于加速骨愈合过程的药物。 此外，本发明还包括适用于局部给予需要这种治疗的患者的胰岛素模拟钒化合物或其组合物的骨损伤治疗试剂盒。

公开(公告)号：WO2011047011A2

公开(公告)日：2011-04-21

申请号：PCT/US2010/052453

申请日：2010-10-13

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  KACHLANY, Scott, C. ,  BELINKA, Benjamin, A.

Inventor： KACHLANY, Scott, C. ,  BELINKA, Benjamin, A.

IPC: A61K38/16

CPC classification number: G01N33/564 ,  A61K38/164 ,  G01N33/5047 ,  G01N33/5695 ,  G01N33/6893 ,  G01N2333/195 ,  G01N2333/35 ,  G01N2333/70553 ,  G01N2800/205 ,  G01N2800/52

Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders.

Abstract translation: 本发明涉及治疗或诊断炎性疾病和其他疾病的组合物和方法。

公开(公告)号：WO2011046570A1

公开(公告)日：2011-04-21

申请号：PCT/US2009/061093

申请日：2009-10-16

Applicant: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  SABAAWY, Hatem

Inventor： SABAAWY, Hatem

IPC: A61K48/00 ,  C12N5/071

CPC classification number: C12N5/0663 ,  A61K2035/124

Abstract: A method for treating a degenerative or traumatic injury to a nerve tissue or the brain by administering at or near the injury site a composition containing adherent bone marrow stem cells suspended in a pharmaceutically acceptable liquid in an amount effective to elicit axonal regeneration or re-myelination at the site of injury.

Abstract translation: 一种通过在损伤部位或其附近施用含有悬浮在药学上可接受的液体中的粘附骨髓干细胞的组合物，其量以有效引发轴突再生或再髓鞘形成的方式来治疗对神经组织或脑的退行性或创伤性损伤的方法 在受伤现场。

公开(公告)号：WO2010030818A2

公开(公告)日：2010-03-18

申请号：PCT/US2009/056564

申请日：2009-09-10

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  RAJ, Arjun ,  TYAGI, Sanjay

Inventor： RAJ, Arjun ,  TYAGI, Sanjay

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6841 ,  C12Q2537/143 ,  C12Q2565/102

Abstract: A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non- overlapping probe binding regions of 15-100 nucleotides, comprising immersing said cell in an excess of at least 30 nucleic acid hybridization probes, each singly labeled with the same fluorescent label and each containing a nucleic acid sequence that is complementary to a different probe binding region of said target sequence; washing said fixed cell to remove unbound probes; and detecting fluorescence from said probes.

Abstract translation: 一种用于在固定的透化细胞中探测信使核糖核酸分子（mRNA）的靶序列的方法，所述靶序列包括至少30个具有15-100个核苷酸的非重叠探针结合区域，包括将所述细胞浸入过量的 至少30个核酸杂交探针，每个单独标记有相同的荧光标记，每个含有与所述靶序列的不同探针结合区互补的核酸序列; 洗涤所述固定电池以除去未结合的探针; 并检测来自所述探针的荧光。

公开(公告)号：WO2009109855A3

公开(公告)日：2009-09-11

申请号：PCT/IB2009/000466

申请日：2009-03-09

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  LATTIME, Edmund, C.

Inventor： LATTIME, Edmund, C.

IPC: A61K39/275 ,  A61K39/285 ,  A61P35/00

Abstract: The present invention provides a novel cancer immunotherapy comprising a vaccination schedule of both intratumoral and systemic injections followed by peripheral boost injection. The immunotherapy can then be followed by other standard treatment as is known in the art for locoregional or metastatic pancreatic cancer. The present invention further provides a kit for administering the cancer immunotherapy described herein. The present invention further provides a method of decreasing the dose of cancer immunotherapy vaccines.

公开(公告)号：WO2009035460A1

公开(公告)日：2009-03-19

申请号：PCT/US2007/078550

申请日：2007-09-14

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  GOYDOS, James, S. ,  CHEN, Suzie

Inventor： GOYDOS, James, S. ,  CHEN, Suzie

IPC: A61K38/00 ,  C07K7/00

CPC classification number: A61K31/00 ,  A61K31/337 ,  A61K31/365 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/4188 ,  A61K31/428 ,  A61K31/44 ,  A61K31/495 ,  A61K31/555 ,  A61K31/655 ,  A61K45/06 ,  A61K2300/00

Abstract: A method for inhibiting melanoma cell growth in a patient by administering to the patient a therapeutically effective amount of a glutamate release inhibitor, a GRMl antagonist, or a combination thereof.

Abstract translation: 一种通过向患者施用治疗有效量的谷氨酸释放抑制剂，GRM1拮抗剂或其组合来抑制患者黑素瘤细胞生长的方法。

公开(公告)号：WO2008115809A2

公开(公告)日：2008-09-25

申请号：PCT/US2008/057052

申请日：2008-03-14

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  WALLIS, Robert

Inventor： WALLIS, Robert

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  C12Q1/28 ,  G01N33/5695 ,  G01N33/6863 ,  G01N33/6866 ,  G01N2800/50

Abstract: The present invention is directed to cytokines and genes that are differential iy affected by TNF blockers and the use of these genes and cytokines to help asses the TB risks of new immunosuppressive therapies, to help evaluate the effects of new TB vaccines, and to help assess TB susceptibility in persons exposed to Mycobacterium tuberculosis.

Abstract translation: 本发明涉及由TNF阻断剂影响的细胞因子和基因，以及这些基因和细胞因子的使用以帮助评估新的免疫抑制疗法的结核病风险，以帮助评估新的结核病疫苗的效果，并帮助评估 暴露于结核分枝杆菌患者的结核病易感性。

公开(公告)号：WO2008112144A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/003027

申请日：2008-03-07

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  BANERJEE, Debabrata ,  BERTINO, Joseph R. ,  HUMENIUK, Rita ,  MISHRA, Prasun J.

Inventor： BANERJEE, Debabrata ,  BERTINO, Joseph R. ,  HUMENIUK, Rita ,  MISHRA, Prasun J.

IPC: A61K31/70

CPC classification number: A61K45/06 ,  A61K31/70 ,  A61K2300/00

Abstract: Methods for the treatment of disorders, including cancer, are described which include administering to a subject a DNA methylation inhibitor and an antineoplastic agent. Compositions containing a DNA methylation inhibitor and an antineoplastic agent, which are useful in treating disorders including cancer, are also described. Additionally, methods useful for developing a prognosis for or diagnosing a subject's development of resistance to treatment with a chemotherapeutic agent are described.

Abstract translation: 描述了治疗包括癌症的病症的方法，其包括向受试者施用DNA甲基化抑制剂和抗肿瘤剂。 还描述了含有DNA甲基化抑制剂和抗肿瘤剂的组合物，其可用于治疗包括癌症的病症。 另外，描述了用于开发用化学治疗剂治疗受试者耐药性发展的预后或诊断方法的方法。