公开(公告)号：WO02055702A3

公开(公告)日：2004-02-12

申请号：PCT/US0150925

申请日：2001-10-26

Applicant: CURAGEN CORP ,  GANGOLLI ESHA A ,  SPYTEK KIMBERLY A ,  GILBERT JENNIFER ,  CASMAN STACIE ,  BLALOCK ANGELA ,  LI LI ,  VERNET CORINE A M ,  SHENOY SURESH ,  MISHRA VISHNU ,  FURTAK KATARZYNA ,  GERLACH VALERIE ,  EDINGER SHLOMIT ,  MALYANKAR URIEL ,  STONE DAVID ,  MILLET ISABELLE ,  SMITHSON GLENNDA ,  GUNTHER ERIK ,  PADIGARU MURALIDHARA ,  TAUPIER RAYMOND J JR ,  ANDERSON DAVID

Inventor： GANGOLLI ESHA A ,  SPYTEK KIMBERLY A ,  GILBERT JENNIFER ,  CASMAN STACIE ,  BLALOCK ANGELA ,  LI LI ,  VERNET CORINE A M ,  SHENOY SURESH ,  MISHRA VISHNU ,  FURTAK KATARZYNA ,  GERLACH VALERIE ,  EDINGER SHLOMIT ,  MALYANKAR URIEL ,  STONE DAVID ,  MILLET ISABELLE ,  SMITHSON GLENNDA ,  GUNTHER ERIK ,  PADIGARU MURALIDHARA ,  TAUPIER RAYMOND J JR ,  ANDERSON DAVID

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  A61K31/7088 ,  A61K38/17 ,  A61K39/395 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003076642A3

公开(公告)日：2003-09-18

申请号：PCT/US2002/024459

申请日：2002-08-02

Applicant: CURAGEN CORPORATION ,  ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  PENA, Carol, E., A. ,  SHIMKETS, Richard, A. ,  LI, Li ,  BERGHS, Constance ,  ZHONG, Mei ,  CASMAN, Stacie, J. ,  VOSS, Edward, Z. ,  BOLDOG, Ferenc, L. ,  PADIGARU, Muralidhara ,  SMITHSON, Glennda ,  SHENOY, Suresh, G. ,  JI, Weizhen ,  GORMAN, Linda ,  VERNET, Corine, A., M. ,  LEITE, Mario, W. ,  GUO, Xiaojia ,  ANDERSON, David, W. ,  SPYTEK, Kimberly, A. ,  GERLACH, Valerie, L. ,  BURGESS, Catherine, E. ,  KHRAMTSOV, Nikolai, V. ,  ORT, Tatiana ,  ELLERMAN, Karen ,  RASTELLI, Luca ,  AGEE, Michele, L. ,  CHAUDHURI, Amitabha ,  CHANT, John, S. ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  GANGOLLI, Esha, A. ,  GIOT, Loic ,  OOI, Chean, Eng ,  ROTHENBERG, Mark, E. ,  SPADERNA, Steven, K. ,  HJALT, Tord ,  LIU, Xiaohong ,  TAUPIER, Raymond, J., Jr. ,  CATTERTON, Elina

Inventor： ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  PENA, Carol, E., A. ,  SHIMKETS, Richard, A. ,  LI, Li ,  BERGHS, Constance ,  ZHONG, Mei ,  CASMAN, Stacie, J. ,  VOSS, Edward, Z. ,  BOLDOG, Ferenc, L. ,  PADIGARU, Muralidhara ,  SMITHSON, Glennda ,  SHENOY, Suresh, G. ,  JI, Weizhen ,  GORMAN, Linda ,  VERNET, Corine, A., M. ,  LEITE, Mario, W. ,  GUO, Xiaojia ,  ANDERSON, David, W. ,  SPYTEK, Kimberly, A. ,  GERLACH, Valerie, L. ,  BURGESS, Catherine, E. ,  KHRAMTSOV, Nikolai, V. ,  ORT, Tatiana ,  ELLERMAN, Karen ,  RASTELLI, Luca ,  AGEE, Michele, L. ,  CHAUDHURI, Amitabha ,  CHANT, John, S. ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  GANGOLLI, Esha, A. ,  GIOT, Loic ,  OOI, Chean, Eng ,  ROTHENBERG, Mark, E. ,  SPADERNA, Steven, K. ,  HJALT, Tord ,  LIU, Xiaohong ,  TAUPIER, Raymond, J., Jr. ,  CATTERTON, Elina

IPC: C07H21/04

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0250276A3

公开(公告)日：2003-07-24

申请号：PCT/US0149347

申请日：2001-12-18

Applicant: CURAGEN CORP ,  LI LI ,  PADIGARU MURALIDHARA ,  BALLINGER ROBERT A ,  KEKUDA RAMESH ,  COLMAN STEVEN D ,  SCIORE PAUL ,  SMITHSON GLENNDA ,  PEYMAN JOHN A ,  MACDOUGALL JOHN R ,  STONE DAVID ,  VERNET CORINE A M ,  SHENOY SURESH ,  GUNTHER ERIK ,  MILLET ISABELLE ,  TCHERNEV VELIZAR T ,  ANDERSON DAVID ,  GUSEV VLADIMIR ,  MALYANKAR URIEL M ,  ZHONG HAIHONG ,  ELLERMAN KAREN E ,  WOLENC ADAM

Inventor： LI LI ,  PADIGARU MURALIDHARA ,  BALLINGER ROBERT A ,  KEKUDA RAMESH ,  COLMAN STEVEN D ,  SCIORE PAUL ,  SMITHSON GLENNDA ,  PEYMAN JOHN A ,  MACDOUGALL JOHN R ,  STONE DAVID ,  VERNET CORINE A M ,  SHENOY SURESH ,  GUNTHER ERIK ,  MILLET ISABELLE ,  TCHERNEV VELIZAR T ,  ANDERSON DAVID ,  GUSEV VLADIMIR ,  MALYANKAR URIEL M ,  ZHONG HAIHONG ,  ELLERMAN KAREN E ,  WOLENC ADAM

IPC: A61K38/00 ,  C07K14/705 ,  C12N1/21 ,  C12N15/12 ,  A61K31/7088 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/11 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/68

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K2039/505

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclosed therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及这些新型人核酸和蛋白质中的任何一种的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003040330A2

公开(公告)日：2003-05-15

申请号：PCT/US2002/035536

申请日：2002-11-05

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BARON, Melanie ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHAPOVAL, Andrei ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HACKETT, Craig ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MAZUR, Ann ,  MCQUEENEY, Kelly ,  MEZES, Peter, S. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  MISHRA, Vishnu, S. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  STARLING, Gary ,  SPYTEK, Kimberley, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  TWOMLOW, Nancy ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BARON, Melanie ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHAPOVAL, Andrei ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HACKETT, Craig ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MAZUR, Ann ,  MCQUEENEY, Kelly ,  MEZES, Peter, S. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  MISHRA, Vishnu, S. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  STARLING, Gary ,  SPYTEK, Kimberley, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  TWOMLOW, Nancy ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: C12Q1/00

CPC classification number: C12N9/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47

公开(公告)号：WO2003029423A2

公开(公告)日：2003-04-10

申请号：PCT/US2002/031358

申请日：2002-10-02

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CATTERTON, Elina ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  JI, Weizhen ,  KEKUDA, Ramesh ,  LEACH, Martin, D. ,  LI, Li ,  MILLER, Charles, E. ,  PATTURAJAN, Meera ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CATTERTON, Elina ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  JI, Weizhen ,  KEKUDA, Ramesh ,  LEACH, Martin, D. ,  LI, Li ,  MILLER, Charles, E. ,  PATTURAJAN, Meera ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003023008A2

公开(公告)日：2003-03-20

申请号：PCT/US2002/028596

申请日：2002-09-09

Applicant: CURAGEN CORPORATION ,  ZHONG, Mei ,  LI, Li ,  GORMAN, Linda ,  SPYTEK, Kimberly, A. ,  KEKUDA, Ramesh ,  TAUPIER, Raymond, J., Jr. ,  ANDERSON, David, W. ,  VERNET, Corine, A., M. ,  CATTERTON, Elina ,  MILLER, Charles, E. ,  SHENOY, Suresh, G. ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  TCHERNEV, Velizar, T. ,  PADIGARU, Muralidhara ,  GUSEV, Vladimir, Y. ,  MALYANKAR, Uriel, M. ,  BURGESS, Catherine, E. ,  GERLACH, Valerie, L. ,  CASMAN, Stacie, J. ,  RIEGER, Daniel, K. ,  GROSSE, William, M. ,  SMITHSON, Glennda ,  PEYMAN, John, A. ,  STARLING, Gary ,  ROTHENBERG, Mark, E. ,  LAROCHELLE, William, J. ,  SHIMKETS, Richard, A. ,  CRABTREE, Julie ,  RASTELLI, Luca ,  VOSS, Edward, Z. ,  BOLDOG, Ferenc, L. ,  EDINGER, Shlomit, R. ,  MILLET, Isabelle ,  MACDOUGALL, John, R. ,  ELLERMAN, Karen ,  CHAPOVAL, Andrei

Inventor： ZHONG, Mei ,  LI, Li ,  GORMAN, Linda ,  SPYTEK, Kimberly, A. ,  KEKUDA, Ramesh ,  TAUPIER, Raymond, J., Jr. ,  ANDERSON, David, W. ,  VERNET, Corine, A., M. ,  CATTERTON, Elina ,  MILLER, Charles, E. ,  SHENOY, Suresh, G. ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  TCHERNEV, Velizar, T. ,  PADIGARU, Muralidhara ,  GUSEV, Vladimir, Y. ,  MALYANKAR, Uriel, M. ,  BURGESS, Catherine, E. ,  GERLACH, Valerie, L. ,  CASMAN, Stacie, J. ,  RIEGER, Daniel, K. ,  GROSSE, William, M. ,  SMITHSON, Glennda ,  PEYMAN, John, A. ,  STARLING, Gary ,  ROTHENBERG, Mark, E. ,  LAROCHELLE, William, J. ,  SHIMKETS, Richard, A. ,  CRABTREE, Julie ,  RASTELLI, Luca ,  VOSS, Edward, Z. ,  BOLDOG, Ferenc, L. ,  EDINGER, Shlomit, R. ,  MILLET, Isabelle ,  MACDOUGALL, John, R. ,  ELLERMAN, Karen ,  CHAPOVAL, Andrei

IPC: C07K1/00

CPC classification number: C07K14/47

公开(公告)号：WO2003023002A9

公开(公告)日：2003-03-20

申请号：PCT/US2002/028539

申请日：2002-09-09

Applicant: CURAGEN CORPORATION ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GORMAN, Linda ,  LI, Li ,  ANDERSON, David, W. ,  ZHONG, Mei ,  GERLACH, Valerie, L. ,  VERNET, Corine, A., M. ,  ELLERMAN, Karen ,  BERGHS, Constance ,  ROTHENBERG, Mark, E. ,  GUO, Xiaojia ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  CATTERTON, Elina ,  KEKUDA, Ramesh ,  JI, Weizhen ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  TAUPIER, Raymond, J., Jr. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  EDINGER, Shlomit, R. ,  BURGESS, Catherine, E.

Inventor： SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GORMAN, Linda ,  LI, Li ,  ANDERSON, David, W. ,  ZHONG, Mei ,  GERLACH, Valerie, L. ,  VERNET, Corine, A., M. ,  ELLERMAN, Karen ,  BERGHS, Constance ,  ROTHENBERG, Mark, E. ,  GUO, Xiaojia ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  CATTERTON, Elina ,  KEKUDA, Ramesh ,  JI, Weizhen ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  TAUPIER, Raymond, J., Jr. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  EDINGER, Shlomit, R. ,  BURGESS, Catherine, E.

IPC: C07K1/00 ,  C07K4/00 ,  C07K17/00 ,  C12N15/00 ,  C12N15/09 ,  C12N5/63 ,  C12N15/70 ,  C12N15/74

公开(公告)号：WO2003003984A8

公开(公告)日：2003-01-16

申请号：PCT/US2002/021268

申请日：2002-07-03

Applicant: CURAGEN CORPORATION ,  FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

Inventor： FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

IPC: G01N33/53 ,  C12N5/00 ,  C07K14/00 ,  A61K38/00

公开(公告)号：WO0158946A9

公开(公告)日：2003-01-16

申请号：PCT/US0104402

申请日：2001-02-08

Applicant: CURAGEN CORP ,  TAUPIER RAYMOND J JR ,  MAJUMDER KUMUD ,  VERNET CORINE A M ,  PRAYAGA SUDHIRDAS K

Inventor： TAUPIER RAYMOND J JR ,  MAJUMDER KUMUD ,  VERNET CORINE A M ,  PRAYAGA SUDHIRDAS K

IPC: A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N15/12 ,  C12N15/16 ,  A61K38/16 ,  A61K38/22 ,  A61K39/395 ,  C07K14/575 ,  C07K16/18 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00

Abstract: The present invention provides novel polypeptides, termed PROTX polypeptides, as well as polynucleotides encoding PROTX polypeptides and antibodies that immunospecifically bind to a PROTX or a derivative, variant, mutant, or fragment of a PROTX polypeptides, polynucleotide or antibody. The invention additionally provides methods in which the PROTX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.

Abstract translation: 本发明提供称为PROTX多肽的新型多肽，以及编码PROTX多肽的多核苷酸和免疫特异性结合PROTX或PROTX多肽，多核苷酸或抗体的衍生物，变体，突变体或片段的抗体。 本发明另外提供了PROTX多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其它用途的方法。

公开(公告)号：WO2002099116A3

公开(公告)日：2002-12-12

申请号：PCT/US2002/017428

申请日：2002-06-04

Applicant: CURAGEN CORPORATION ,  ANDERSON, David, W. ,  BAUMGARTNER, Jason, C. ,  BOLDOG, Ferenc, L. ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit, R. ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  HJALT, Tord ,  KEKUDA, Ramesh ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RASTELLI, Luca ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  SPYTEK, Kimberly, A. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D.

Inventor： ANDERSON, David, W. ,  BAUMGARTNER, Jason, C. ,  BOLDOG, Ferenc, L. ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit, R. ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  HJALT, Tord ,  KEKUDA, Ramesh ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RASTELLI, Luca ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  SPYTEK, Kimberly, A. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D.

IPC: C07K1/00

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.