Abstract:
PURPOSE: A microemulsion particle containing 20-0-£α-L-arabinopyranosyl(1->6)-β-D-glucopyranosyl|-20(S)-protopanaxadiol separated from bioconversion of ginseng saponin is provided. The external preparation composition of skin using the same has an excellent effect of preventing skin aging, such as wrinkle improvement. CONSTITUTION: The microemulsion particle contains 10¬-8 to 99.9999% by weight of 20-0-£α-L-arabinopyranosyl(1->6)-β-D-glucopyranosyl|-20(S)-protopanaxadiol of the formula 1 as an effective ingredient and liposome containing lecithin, lecithin derivatives and a co-emulsifier, based on the total weight of the particle. In formula, R2 is OH and R3 is H. The microemulsion particle is prepared from acid hydrolysis, base hydrolysis or enzymolysis of ginseng extract and ginseng saponin. The cosmetic and pharmaceutical composition having excellent effects of proliferating skin cells and promoting collagen biosynthesis is obtained by formulation of the microemulsion particle.
Abstract:
본 명세서에는 화학적 이방성 분체를 함유하는 효능원료가 안정화된 화장료 조성물이 개시된다. 본 명세서에 개시된 기술은 효능원료를 제형화함에 있어 pH, 염 등의 외부 조건 변화에 따른 효능원료의 변색, 변취 등의 문제를 극복하고 이들의 역치가 보존되며 점증 시스템의 붕괴를 막아 그에 따른 유화 입자들의 합일, 상분리가 일어나지 않는 안정화된 제형을 갖는 화장료 조성물을 제공하는 효과가 있다.