公开(公告)号：KR1020070013482A

公开(公告)日：2007-01-31

申请号：KR1020050067815

申请日：2005-07-26

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  노호식 ,  김덕희 ,  장이섭

IPC: C07D317/64

Abstract: Sesamol derivatives and a process for preparing the same compounds are provided to improve anti-oxidizing activity and stability of sesamol, recover the skin damaged by reactive oxygen species, prevent aging of biological membranes, and inhibit production of peroxides of unsaturated fatty acid and its derivatives. The sesamol derivatives represented by the formula(1) are provided, wherein the sesamol derivatives are prepared by reacting sesamol with adamantanol in an equivalence ratio of 1:1.0~1.3 under acid condition, and recrystallizing the resulting product in polar solvent; the acid is hydrochloric acid, nitric acid, sulfuric acid, p-toluenesulfonic acid, benzene sulfonic acid, acetic acid, trichloroacetic acid or trifluoroacetic acid; the solvent used in the reaction is dichloromethane, tetrahydrofuran, ethyl acetate, acetonitrile, chloroform, ethyl ether, trichloro ethylene, benzene or toluene; and the polar solvent is methanol, ethanol, isopropanol, acetone, acetonitrile or water.

Abstract translation: 提供了芝麻酚衍生物和制备相同化合物的方法，以提高芝麻素的抗氧化活性和稳定性，回收活性氧损伤的皮肤，防止生物膜老化，抑制不饱和脂肪酸及其衍生物过氧化物的产生 。 提供由式（1）表示的芝麻酚衍生物，其中芝麻酚衍生物通过在酸性条件下使芝麻酚与当量比为1：1.0〜1.3的金刚烷醇反应制备，并将所得产物在极性溶剂中重结晶; 酸是盐酸，硝酸，硫酸，对甲苯磺酸，苯磺酸，乙酸，三氯乙酸或三氟乙酸; 反应中使用的溶剂是二氯甲烷，四氢呋喃，乙酸乙酯，乙腈，氯仿，乙醚，三氯乙烯，苯或甲苯; 极性溶剂为甲醇，乙醇，异丙醇，丙酮，乙腈或水。

公开(公告)号：KR101799050B1

公开(公告)日：2017-11-17

申请号：KR1020100088934

申请日：2010-09-10

Applicant: (주)아모레퍼시픽

Inventor： 이현석 ,  임형준 ,  심종원 ,  김도훈 ,  유재원 ,  김진웅

IPC: A61K8/90 ,  A61K9/24 ,  A61K47/30

Abstract: 본발명은자기회합성을갖는양친성고분자를사용하여난용성물질을포집시켜제조한나노입자및 이를함유하는화장료조성물에관한것으로, 보다상세하게는소수성고분자로이루어진복수의가지를갖는코어부; 및상기코어부의소수성고분자와결합하여이중블록공중합체를형성하는친수성고분자로이루어진암(arm)부로구성된자기회합성을갖는입체구조의양친성고분자에생리활성성분을함입시켜제조한나노입자및 이를유효성분으로함유하는화장료조성물에관한것이다.

Abstract translation: 具有两亲我纳米通过收集与聚合物可溶性物质粒子制备，并且涉及含有相同的，并且用于化妆品组合物本发明核心单元更具体地，多个具有磁性转子合成的疏水性聚合物组成的分支; 并结合由生物活性组分的掺入具有磁性转子合成部臂（臂）的三维结构的两亲聚合物中制备的由亲水性聚合物的疏水性聚合物纳米的芯部分，以形成二嵌段共聚物颗粒，并且该 本发明涉及含有作为活性成分的化妆品组合物。

公开(公告)号：KR1020170064473A

公开(公告)日：2017-06-09

申请号：KR1020160159460

申请日：2016-11-28

Applicant: (주)아모레퍼시픽

Inventor： 노호식 ,  유재원 ,  김용진

IPC: C07D309/34 ,  A61K8/49 ,  A61Q19/00

Abstract: 본발명은신규한히드록시피라논화합물, 이의제조방법및 이를포함하는화장료조성물에관한것이다. 본발명에따른신규한히드록시피라논화합물은기존의지방세포분화촉진물질대비현저히개선된효과를나타내므로, 피부볼륨또는탄력증진을위한화장료조성물의유효성분으로바람직하게포함된다.

Abstract translation: 本发明涉及一种新颖的羟基蒽酮酮化合物，其制备方法和含有该化合物的化妆品组合物。 根据本发明的新颖的羟基吡唑化合物的非显示出常规的脂肪细胞分化促进材料相比显著改善效果，并且优选地包括，如化妆品组合物用于改善皮肤弹性或体积的活性成分。

公开(公告)号：KR1020160064420A

公开(公告)日：2016-06-08

申请号：KR1020140168005

申请日：2014-11-28

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  빈성아 ,  정인근 ,  김세현 ,  신송석 ,  이존환

IPC: A61K8/362 ,  A61K8/36 ,  A61Q5/00 ,  A61Q19/00

CPC classification number: A61K8/362 ,  A61K8/36 ,  A61Q5/00 ,  A61Q19/00 ,  Y10S514/859

Abstract: 발명은말레산(maleic acid)을유효성분으로포함하는모발용화장료조성물에관한것으로, 보다상세하게는모발내부에들어가모발직경을증가시켜모발을두껍게함으로써모발볼륨을증진시키는화장료조성물에관한것이다. 본발명의말레산(maleic acid)을유효성분으로포함하는화장료조성물을통해빠른시간내에모발의직경의증가를유도하고이를통해모발의볼륨을증진시킬수 있는효과를얻을수 있었다.

Abstract translation: 本发明涉及一种用于头发的化妆品组合物，其包含马来酸作为活性成分，更具体地，涉及通过在进入毛发之后增加毛发直径来增加头发来增强头发体积的化妆品组合物。 包含本发明的马来酸作为活性成分的化妆品组合物在快速时间引起毛发直径的增加，并且可以获得能够增加头发体积的效果。

公开(公告)号：KR101056879B1

公开(公告)日：2011-08-12

申请号：KR1020050048717

申请日：2005-06-08

Applicant: (주)아모레퍼시픽

Inventor： 노호식 ,  유재원 ,  김덕희 ,  장이섭

IPC: C07F9/54

CPC classification number: A61K8/55 ,  A61K2800/522 ,  A61Q19/08 ,  C07F9/65517

Abstract: 본 발명은 하기 화학식(I)로 표시되는 세사몰 유도체 또는 그의 염, 그 제조방법, 및 이를 함유하는 피부외용제 조성물에 관한 것이다. 더욱 상세하게는 인산 디에스테르 결합에 의해 연결된 세사몰과 3-아미노프로판 인산이 피부에 존재하는 효소에 의해 분해되어 세사몰과 3-아미노프로판 인산의 생리활성을 동시에 나타낼 수 있는 세사몰 유도체 또는 그의 염, 그 제조방법, 및 이를 함유하는 피부외용제 조성물에 관한 것이다.
[화학식 I]

세사몰유도체*옥시염화인*3-아미노프로판 인산*유기용매

Abstract translation: 本发明涉及一种芝麻酚衍生物或由结构式（I）表示它的盐，其制造方法，以及含有其的皮肤外用组合物。 更具体地，通过磷酸二酯键和3-氨基丙烷磷酸连接在芝麻酚是通过皮肤上存在的芝麻酚和3-氨基酸可同时表现出生理活性的酶分解，所述芝麻酚衍生物或它的丙烷 盐及其制造方法，以及含有其的皮肤外用组合物。

公开(公告)号：KR101013365B1

公开(公告)日：2011-02-14

申请号：KR1020080052505

申请日：2008-06-04

Applicant: (주)아모레퍼시픽

Inventor： 박우람 ,  박창만 ,  유재원 ,  박성희 ,  김진웅 ,  김한곤

IPC: D04H1/4266 ,  D04H1/64

Abstract: 본 발명은 해조류 섬유를 원료로 하여 만들어진 부직포에 관한 것이다. 보다 자세하게는 일반적으로 사용되는 부직포에서 나일론이나 면사 등의 기존 섬유 대신 해조류 섬유를 사용하여 부직포를 제조하고 이를 마스크팩이나 시트, 패치 제형에 활용시킴으로써 친환경적인 공법을 이용하여 제조된 해조류 섬유의 우수한 함수율과 유해성분 흡착 능력을 활용하여 화장료 유효성분의 전달 능력과 그 효능을 극대화시킨 제품에 관한 것이다.
해조류 섬유, 해조류 펄프, 마스크팩, 부직포, 패치

公开(公告)号：KR1020080029342A

公开(公告)日：2008-04-03

申请号：KR1020060095279

申请日：2006-09-29

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  노호식 ,  이진영 ,  심종원 ,  최동원 ,  김덕희

IPC: C07C233/11 ,  C07C233/21

Abstract: A retinoic acid derivative is provided to exhibit a collagen production effect and a collagenase expression inhibition effect and cause less skin irritation. A method for preparing a retinoic acid derivative includes the steps of: (i) reacting retinoic acid with alkylchloroformate to prepare an anhydride compound represented by the following formula 2; and (ii) reacting the prepared anhydride compound with an amine hydrochloride represented by the following formula 3 to prepare the retinoic acid derivative represented by the following formula 1. In the formulae, R1 is hydrogen, linear or branched C1-7 alkyl or C3-7 cycloalkyl, R2 is hydroxyl, linear or branched C1-7 alkyl substituted by 1-4 hydroxyl groups, or linear branched C1-5 alkyl substituted by hydroxy pyranone, and R3 is C1-7 alkyl.

Abstract translation: 提供视黄酸衍生物以表现出胶原产生效果和胶原酶表达抑制作用，并且引起较少的皮肤刺激。 视黄酸衍生物的制备方法包括以下步骤：（i）使视黄酸与氯甲酸烷基酯反应，制备下式2表示的酸酐化合物; 和（ii）使所制备的酸酐化合物与由下式3表示的胺盐酸盐反应以制备由下式1表示的视黄酸衍生物。在式中，R 1是氢，直链或支链C 1-7烷基或C 3- 7环烷基，R2是羟基，被1-4个羟基取代的直链或支链C 1-7烷基，或被羟基吡喃酮取代的直链支链C 1-5烷基，R 3是C 1-7烷基。

公开(公告)号：KR1020080014279A

公开(公告)日：2008-02-14

申请号：KR1020060075755

申请日：2006-08-10

Applicant: (주)아모레퍼시픽

Inventor： 백흥수 ,  유재원 ,  노호식 ,  김덕희

IPC: C07C233/10 ,  C07C233/11 ,  C07C235/36

CPC classification number: C07C235/36 ,  C07C231/02

Abstract: A hydroxycinnamic acid derivative compound is provided to realize improved anti-oxidation property and skin permeability, effects of inhibiting active oxygen and melanin generation and stimulating procollagen generation, thereby providing a cosmetic composition for improving wrinkles and whitening. A hydroxycinnamic acid derivative compound has an adamantyl amide linking group and is represented by the following formula I. In formula I, R1 is H or a C1-C7 alkyl group; and A is -CH=CH- or -CH2-CH2-. The hydroxycinnamic acid derivative compound is obtained by the method comprising the steps of: (1) substituting the hydroxyl group of hydroxycinnamic acid with an acetyl group to provide an acetylated compound; (2) reacting the acetylated compound with ethyl chloroformate and oleophilic group-containing adamantanamine to provide an amide compound; and (3) hydrolyzing the acetyl group of the amide compound.

Abstract translation: 提供羟基肉桂酸衍生物以提高抗氧化性和皮肤渗透性，抑制活性氧和黑色素产生的作用，刺激前胶原生成，从而提供改善皱纹和美白的化妆品组合物。 羟基肉桂酸衍生物具有金刚烷基酰胺连接基团，由下式I表示。在式I中，R 1为H或C 1 -C 7烷基; A是-CH = CH-或-CH 2 -CH 2 - 。 通过包括以下步骤的方法获得羟基肉桂酸衍生物化合物：（1）用乙酰基取代羟基肉桂酸的羟基以提供乙酰化合物; （2）使乙酰化化合物与氯甲酸乙酯和含亲油基团的金刚烷胺反应，得到酰胺化合物; 和（3）水解酰胺化合物的乙酰基。

公开(公告)号：KR100786300B1

公开(公告)日：2007-12-18

申请号：KR1020060090560

申请日：2006-09-19

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  노호식 ,  김수정 ,  윤준원 ,  안성연 ,  김덕희

IPC: A61K8/49 ,  A61Q19/08

CPC classification number: A61Q19/08 ,  A61K8/498

Abstract: A 4-substituted benzoic acid derivative compound having 3,4-methylenedioxybenzene or 3,4-ethylenedioxybenzene moiety is provided to promote the biosynthesis of main constituents of skin dermis such as collagen, elastin, fibrillin, glycosaminoglycan(GAG) closely related to skin wrinkles, thereby being usefully used as medicines and skin external applying agents for preventing aging and improving the wrinkles. An anti-aging cosmetic composition comprises 0.01-20.0 wt.% of a 4-substituted benzoic acid derivative compound having 3,4-methylenedioxybenzene or 3,4-ethylenedioxybenzene moiety and represented by the formula(I), wherein R1 is -CH2- or -CH2=CH2-, R2 is the structural formula(Ia), and R3 is H, methyl or ethyl. A method for preparing the 4-substituted benzoic acid derivative compound comprises the steps of: (a) preparing a compound(1) represented by the formula(1) from 3,4-methylenedioxybenzoic acid or 3,4-ethylenedioxybenzoic acid; and (b) hydrolyzing the compound of the formula(1) with a base to prepare a compound(2) represented by the formula(2).

Abstract translation: 提供具有3,4-亚甲二氧基苯或3,4-亚乙二氧基苯部分的4-取代苯甲酸衍生物化合物，以促进皮肤真皮主要成分的生物合成，如与皮肤皱纹密切相关的胶原蛋白，弹性蛋白，纤维蛋白，糖胺聚糖（GAG） 从而有效地用作用于防止老化和改善皱纹的药物和皮肤外用施用剂。 抗衰老化妆品组合物包含0.01-20.0重量％的具有3,4-亚甲二氧基苯或3,4-亚乙二氧基苯部分并由式（I）表示的4-取代苯甲酸衍生物化合物，其中R 1是-CH 2 - 或-CH 2 = CH 2 - ，R 2是结构式（Ia），R 3是H，甲基或乙基。 制备4-取代苯甲酸衍生物化合物的方法包括以下步骤：（a）由3,4-亚甲二氧基苯甲酸或3,4-亚乙二氧基苯甲酸制备由式（1）表示的化合物（1） 和（b）用碱水解式（1）的化合物以制备由式（2）表示的化合物（2）。

公开(公告)号：KR100740575B1

公开(公告)日：2007-07-18

申请号：KR1020060029631

申请日：2006-03-31

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  백흥수 ,  노호식 ,  김덕희 ,  장이섭

IPC: C07D319/18 ,  C07D317/60

Abstract: 2,3-Dihydroxybenzoic acid derivatives, a preparation method thereof, and a skin-whitening cosmetic composition containing the same compounds are provided to inhibit activity of tyrosinase and melanin formation while cytotoxicity of the compounds is very low, so that the compounds are useful for improvement of pigmentation in the skin. The method for preparing the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1) comprises the steps of: (A) reacting 2,3-dihydroxybenzoic acid with acetic acid anhydride in the presence of base to prepare a 2,3-diacetyloxybenzoic acid compound represented by the formula(2); (B) preparing an amide compound represented by the formula(3) from the 2,3-diacetyloxybenzoic acid compound by using ethylchloroformate and amine having a lipophilic group; and (C) hydrolyzing an acetyl group of the amide compound represented by formula (3) to prepare 2,3-dihydroxybenzoic acid represented by the formula (1), wherein R is 4-ethoxyphenyl, 2-cyclohexenylethyl, cycloheptyl, cyclohexyl, tert-octyl, 4-isopropylphenyl, 2,3-dihydrobenzo[1,4]dioxin-7-yl, benzo[1,3]-dioxol-6-yl or adamantyl-1-yl; and the amine having the lipophilic group is an amine selected from 4-ethoxyphenylamine, 2-cyclohexenylethylamine, cycloheptylamine, cyclohexylamine, tert-octylamine, 4-isopropylphenylamine, 2,3-dihydrobenzo[1,4]dioxin-7-amine, benzo[1,3]-dioxol-6-amine or adamantyl-1-amine. The skin-whitening cosmetic composition contains 0.01-20 wt.% of the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1).

Abstract translation: 提供了2,3-二羟基苯甲酸衍生物，其制备方法和含有相同化合物的美白化妆品组合物，以抑制酪氨酸酶的活性和黑色素形成，同时化合物的细胞毒性非常低，使得该化合物可用于 改善皮肤色素沉着。 制备式（1）代表的2,3-二羟基苯甲酸衍生物的方法包括以下步骤：（A）使2,3-二羟基苯甲酸与乙酸酐在碱存在下反应，制得2,3-二羟基苯甲酸衍生物， 由式（2）表示的二乙酰氧基苯甲酸化合物; （B）使用氯甲酸乙酯和具有亲油性基团的胺，由2,3-二乙酰氧基苯甲酸化合物制备式（3）所示的酰胺化合物; （C）水解式（3）所示的酰胺化合物的乙酰基，制备式（1）所示的2,3-二羟基苯甲酸，其中R为4-乙氧基苯基，2-环己烯基乙基，环庚基，环己基，叔丁基 - 辛基，4-异丙基苯基，2,3-二氢苯并[1,4]二氧杂环己烯-7-基，苯并[1,3] - 二氧杂环戊烯-6-基或金刚烷基-1-基; 具有亲脂性基团的胺是选自4-乙氧基苯胺，2-环己烯基乙胺，环庚胺，环己胺，叔辛胺，4-异丙基苯胺，2,3-二氢苯并[1,4]二氧杂环己烯-7-胺，苯并[ 1,3] - 二氧六环-6-胺或金刚烷基-1-胺。 该美白化妆品组合物含有0.01-20重量％的由式（1）表示的2,3-二羟基苯甲酸衍生物。