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公开(公告)号:KR101219295B1
公开(公告)日:2013-01-14
申请号:KR1020050102895
申请日:2005-10-31
Applicant: (주)아모레퍼시픽
IPC: A61K31/335 , A61P19/02 , A61K8/49
Abstract: 본 발명은 Musk T를 유효성분으로 함유하는 히알루론산 생성촉진용 조성물에 관한 것이다. 보다 구체적으로, 본 발명에 의한 히알루론산 생성촉진용 조성물은 유효성분으로 Musk T를 함유함으로써 인간 피부 진피 섬유아세포(Human Dermal Fibroblast)에 존재하는 히알루론산 합성효소(hyaluronic acid synthase; HAS) 유전자의 발현을 증가시켜 인체세포에서 히알루론산(hyaluronic acid) 생성을 촉진하는 효과를 나타낸다.
Musk T, 히알루론산, 섬유아세포, HAS, 피부 노화방지제, 퇴행성 관절염치료제-
62.
公开(公告)号:KR101155194B1
公开(公告)日:2012-06-13
申请号:KR1020060029257
申请日:2006-03-31
Applicant: (주)아모레퍼시픽
IPC: G01N33/48 , G01N33/483
Abstract: 본 발명은 피부표면의 멜라닌 분포를 가시적으로 표현할 수 있는 각질세포의 멜라닌을 정량하는 방법에 관한 것이다. 보다 상세하게는, 본 발명에 의한 각질세포의 멜라닌을 정량하는 방법은 피부표면에서 각질세포를 채취한 후 멜라닌 염색을 수행한 다음 이를 이미지화하고 화상분석 기술을 이용하여 각질세포 당 멜라닌 스팟(spot)의 면적을 정량함으로써, 기존의 수치로만 제시한 멜라닌의 양을 가시적, 정량적으로 표현할 수 있다.
멜라닌 정량 * 각질세포 * 멜라닌 염색 * 이미지 * 멜라닌 스팟-
公开(公告)号:KR101096409B1
公开(公告)日:2011-12-21
申请号:KR1020050086765
申请日:2005-09-16
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 모아레 이미지(moire image)를 이용한 피부탄력 측정방법에 관한 것으로서, 피험자 피부의 모아레 이미지를 촬영하는 단계, 상기 촬영된 모아레 이미지에서 나타난 등고선의 간격을 계산하거나 등고선의 각도를 측정하는 단계; 상기 간격 또는 각도로부터 피부탄력지수를 산출하는 단계를 포함하는 피부 탄력 측정방법을 제공한다.
모아레, 피부, 탄력, 등고선-
公开(公告)号:KR1020090020834A
公开(公告)日:2009-02-27
申请号:KR1020070085431
申请日:2007-08-24
Applicant: (주)아모레퍼시픽
Abstract: An in vitro skin sensitization test method is provided to rapidly analyze the skin sensitization-inducing possibility of material through the cell derived from the human body without use of animal, and classify and grade the skin sensitization-inducing possibility, thereby easily finding out the procedure required for the following process. The in vitro skin sensitization test method comprises the steps of: determining the treatment concentration of the estimation target material for the skin sensitization-inducing test; contacting the determined concentration of the estimation target material with the human origin cell, and culturing the cell; detecting CD86, CD54 and CD83 as costimulatory molecule, expressed from the cultured human origin cell; indexing the detected costimulatory molecules; grading and classifying the indexed detection amount; and determining the estimation target material as the skin sensitization-inducing material when the classified detection amount is the risk grade.
Abstract translation: 提供体外皮肤致敏试验方法,以快速分析通过源自人体的细胞的材料的皮肤敏化诱导可能性,而不使用动物,并分类和分级皮肤致敏诱导的可能性,从而容易地找出程序 需要以下过程。 体外皮肤致敏试验方法包括以下步骤:确定用于皮肤致敏诱导试验的估计目标材料的处理浓度; 将所测定的所述目标物质浓度与所述人源细胞接触,培养所述细胞; 从培养的人源细胞中检测CD86,CD54和CD83作为共刺激分子; 索引检测到的共刺激分子; 索引检测量分级和分类; 以及当所述分类检测量为风险等级时,将所述估计目标材料确定为所述皮肤致敏诱导材料。
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65.
公开(公告)号:KR100862274B1
公开(公告)日:2008-10-09
申请号:KR1020070039895
申请日:2007-04-24
Applicant: (주)아모레퍼시픽
Abstract: A method for evaluating human skin damage by detecting furrows of human skin is provided to evaluate damage to human skin caused by a body washer by visualizing and quantifying the furrows. A method for evaluating human skin damage by detecting furrows of human skin includes the steps of: taking an image of the furrows by the skin damage by photographing human skin using an in vivo laser confocal microscopy; setting analysis section of the image of the furrows; visualizing the furrows of the human skin by using an image analysis program; and quantifying the number of pixels by measuring an area of the furrows in the analysis section.
Abstract translation: 提供了一种通过检测人体皮肤的沟槽来评价人体皮肤损伤的方法,以通过可视化和量化沟槽来评估由人体垫圈引起的对人体皮肤的损伤。 通过检测人皮肤的沟槽来评估人体皮肤损伤的方法包括以下步骤:通过使用体内激光共焦显微镜拍摄人体皮肤,通过皮肤损伤拍摄犁沟的图像; 犁沟图像的设定分析部分; 通过使用图像分析程序可视化人体皮肤的沟槽; 以及通过测量分析部分中的沟槽的面积来量化像素的数量。
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66.
公开(公告)号:KR1020070098073A
公开(公告)日:2007-10-05
申请号:KR1020060029257
申请日:2006-03-31
Applicant: (주)아모레퍼시픽
IPC: G01N33/48 , G01N33/483
Abstract: A quantitatively analyzing method of melanin in a corneocyte for visually expressing distribution of melanin in the skin surface is provided to express melanin amount visually and quantitatively by quantification of melanin spot area per corneocyte, so that a user confirm the efficacy of skin whitening cosmetics easily. A quantitatively analyzing method of melanin in a corneocyte for visually expressing distribution of melanin in the skin surface comprises the steps of: (a) collecting a horny layer from the skin surface; (b) dyeing melanin in the collected horny layer; and (c) observing the dyed horny layer sample with a microscope, picturing the image of dyed horny layer sample, and quantifying the melanin spot area per corneocyte, wherein the melanin amount is classified into 5 grades; and a first grade corresponds to 0-5% melanin distribution per corneocyte, a second grade corresponds to 5-10% melanin distribution per corneocyte, a third grade corresponds to 10-20% melanin distribution per corneocyte, a fourth grade corresponds to 20-40% melanin distribution per corneocyte, and a fifth grade corresponds to more than 40% melanin distribution per corneocyte.
Abstract translation: 提供角质细胞中黑色素在视觉上表达黑色素在皮肤表面的分布的定量分析方法,以通过定量每个角质细胞的黑色素斑点面积来定量表达黑色素量,从而使用者容易地确认皮肤美白化妆品的功效。 用于视觉表达皮肤表面黑色素分布的角质细胞中黑色素的定量分析方法包括以下步骤:(a)从皮肤表面收集角质层; (b)在收集的角质层中染黑色素; 和(c)用显微镜观察染色的角质层样品,绘制染色角质层样品的图像,并定量每个角质细胞的黑色素斑点面积,其中黑色素量分为5个等级; 一级对应于每个角质细胞的0-5%黑色素分布,二级对应于每个角质细胞的5-10%黑色素分布,三级对应于每个角质细胞的10-20%黑色素分布,四级对应于20- 每个角质细胞的黑色素分布为40%,五年级对应于每个角质细胞超过40%的黑色素分布。
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