公开(公告)号：NO930719A

公开(公告)日：1993-08-30

申请号：NO930719

申请日：1993-02-26

Applicant: CIBA GEIGY AG

Inventor： CAPRARO HANS GEORG ,  BAUMANN MARCUS

IPC: A61K31/555 ,  A61P35/00 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  C07F7/00 ,  C07F7/08 ,  C07F7/30 ,  C07F15/00 ,  C07H23/00 ,  C07J43/00 ,  C07J51/00 ,  C08G65/32 ,  C07F7/18 ,  A61K31/695

CPC classification number: C07F5/069 ,  C07F5/003 ,  C07F7/003 ,  C07F7/0836 ,  C07F15/0053 ,  C07H23/00 ,  C07J43/003 ,  C07J51/00

公开(公告)号：AU7828687A

公开(公告)日：1988-03-17

申请号：AU7828687

申请日：1987-09-11

Applicant: CIBA GEIGY AG

Inventor： MOSER HANS ,  PISSIOTAS GEORG ,  BRUNNER HANS-GEORG ,  BOHNER BEAT ,  BAUMANN MARCUS

IPC: C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D207/448 ,  C07D405/10 ,  C07D207/452 ,  A01N43/36 ,  C07D207/408

公开(公告)号：CA1199635A

公开(公告)日：1986-01-21

申请号：CA414197

申请日：1982-10-26

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07D295/10 ,  A61K8/00 ,  A61K8/49 ,  A61P25/04 ,  A61P29/00 ,  A61Q17/04 ,  C07C45/46 ,  C07C49/84 ,  C07C59/76 ,  C07C59/80 ,  C07D207/32 ,  C07D207/325 ,  C07D209/08 ,  C07D295/112 ,  C07D295/155 ,  C07D295/185 ,  C07D295/194 ,  C07D307/83 ,  C07D307/92 ,  C07D405/04 ,  C07D405/12 ,  C07D471/04 ,  C08K5/1535 ,  C07D413/04

Abstract: Furans The invention relates to novel furans, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：GB2110210B

公开(公告)日：1985-07-03

申请号：GB8230351

申请日：1982-10-25

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: A61K8/00 ,  A61K8/49 ,  A61P25/04 ,  A61P29/00 ,  A61Q17/04 ,  C07C45/46 ,  C07D295/10 ,  C07C49/84 ,  C07C59/76 ,  C07C59/80 ,  C07D207/32 ,  C07D207/325 ,  C07D209/08 ,  C07D295/112 ,  C07D295/155 ,  C07D295/185 ,  C07D295/194 ,  C07D307/83 ,  C07D307/92 ,  C07D405/04 ,  C07D405/12 ,  C07D471/04 ,  C08K5/1535 ,  A61K31/40 ,  A61K31/55 ,  A61K31/445 ,  A61K31/535 ,  C07D413/04

Abstract: The invention relates to novel furans, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of anti-inflammatory agents or analgesics and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：DD223450A5

公开(公告)日：1985-06-12

申请号：DD26208384

申请日：1984-04-18

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BAUMANN MARCUS ,  BREITENSTEIN WERNER

IPC: C07D307/83 ,  C07D405/04

Abstract: Prodn. of benzofuranones of formula (I) (and their salts, tautomers and/or isomers) comprises converting X in cpds. (II) (or their salts) to OH, opt. followed by conversion of salts to free bases (or vice versa) and/or sepn.of isomers. - R1 = H or aliphatic gp. R2 = amino substd. by a divalent hydrocarbyl gp. ring A may contain other substitis.

公开(公告)号：AU1995783A

公开(公告)日：1984-04-12

申请号：AU1995783

申请日：1983-10-07

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07C45/46 ,  C07C205/37 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D295/194 ,  C07D307/79 ,  C07D307/83 ,  C07D405/04 ,  A61K31/34 ,  C07D405/10

Abstract: Benzofurans or 2,3-dihydrobenzofurans of the formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group disubstituted by a bivalent aliphatic radical which is optionally interrupted by at least one hetero atom, and the aromatic ring may be additionally substituted, and the salts thereof, have anti-inflammatory and/or analgesic activities.

公开(公告)号：DD208798A5

公开(公告)日：1984-04-11

申请号：DD24434782

申请日：1982-10-28

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07D295/14 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  A61Q17/04 ,  C07C67/00 ,  C07C227/00 ,  C07C227/18 ,  C07C229/42 ,  C07C233/00 ,  C07C235/34 ,  C07C313/00 ,  C07C317/46 ,  C07C323/20 ,  C07C323/56 ,  C07C323/60 ,  C07D207/08 ,  C07D207/32 ,  C07D207/333 ,  C07D209/08 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D295/185 ,  C07D307/83 ,  C07D405/04 ,  C07D471/04 ,  C07C87/62 ,  C07C91/42 ,  C07C93/26 ,  C07C101/44 ,  C07D309/04

Abstract: The invention relates to novel phenol derivatives, especially those of the general formula in which R0 represents hydrogen or an acyl radical, R1 represents carboxy, esterified carboxy or amidated carboxy, R2 represents hydrogen or an aliphatic radical, R3 represents an amino group di-substituted by two monovalent radicals or by one divalent radical, and the aromatic ring A may be additionally substituted, and their salts and isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：FI833676A0

公开(公告)日：1983-10-10

申请号：FI833676

申请日：1983-10-10

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07C69/157 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61P25/04 ,  A61P29/00 ,  C07C27/00 ,  C07C39/02 ,  C07C41/00 ,  C07C43/178 ,  C07C45/00 ,  C07C45/46 ,  C07C47/27 ,  C07C59/76 ,  C07C67/00 ,  C07C213/00 ,  C07C215/76 ,  C07C219/34 ,  C07D207/32 ,  C07D207/325 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D307/83 ,  C07D405/04 ,  C07D471/04 ,  C07D

Abstract: Novel phenol derivatives, in particular those of the general formula in which R0 represents hydrogen or an acyl radical, R1 denotes hydroxymethyl, esterified or etherified hydroxymethyl, formyl or acetalised formyl, R2 represents hydrogen or an aliphatic radical, R3 represents an amino group which is disubstituted by two monovalent hydrocarbon radicals or by a divalent hydrocarbon radical which may be interrupted by at least one hetero atom and the aromatic ring A can additionally be substituted, and their salts and isomers, a process for their preparation and pharmaceutical preparations containing them and their use as active pharmaceutical compounds and/or in preparing pharmaceutical preparations.

公开(公告)号：FI833610A0

公开(公告)日：1983-10-05

申请号：FI833610

申请日：1983-10-05

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07C45/46 ,  C07C205/37 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D295/194 ,  C07D307/79 ,  C07D307/83 ,  C07D405/04 ,  C07D

Abstract: Benzofurans or 2,3-dihydrobenzofurans of the formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group disubstituted by a bivalent aliphatic radical which is optionally interrupted by at least one hetero atom, and the aromatic ring may be additionally substituted, and the salts thereof, have anti-inflammatory and/or analgesic activities.

公开(公告)号：ZA8207846B

公开(公告)日：1983-08-31

申请号：ZA8207846

申请日：1982-10-27

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: A61K31/34 ,  A61K31/343 ,  A61P25/04 ,  A61P29/00 ,  C07C59/76 ,  C07D307/83 ,  C07D471/04 ,  C07D ,  A61K

CPC classification number: C07D471/04 ,  C07C59/76 ,  C07D307/83