中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

113 records (took 0.076 seconds)

    MICROORGANISMS FOR PRODUCING 4C-5C COMPOUNDS WITH UNSATURATION AND METHODS RELATED THERETO
    65.
    发明公开
    MICROORGANISMS FOR PRODUCING 4C-5C COMPOUNDS WITH UNSATURATION AND METHODS RELATED THERETO 审中-公开
    微生物用于生产4C-5C CONNECTIONS不饱和度和相关程序

    公开(公告)号：EP3164495A1

    公开(公告)日：2017-05-10

    申请号：EP15815561.4

    申请日：2015-07-02

    Applicant: Genomatica, Inc.

    Inventor： CULLER, Stephanie J. ,  BURK, Mark J. ,  OSTERHOUT, Robin E. ,  PHARKYA, Priti

    IPC: C12N15/70 ,  C12P1/04 ,  C12P5/02 ,  C12P7/16

    CPC classification number: C12P7/04 ,  C12N15/52 ,  C12P5/026 ,  C12P7/40 ,  Y02E50/343

    Abstract: The invention provides a non-naturally occurring microbial organism having a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol, pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a pathway. The invention additionally provides a method for producing butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol. The method can include culturing a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a pathway enzyme in a sufficient amount, and under conditions and for a sufficient period of time to produce butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol.

    Abstract translation: 本发明提供了具有丁二烯，巴豆醇，2,4-戊二烯酸，3-丁烯-2-醇，3-丁烯-1-醇，途径的非天然存在的微生物有机体。 微生物生物体含有至少一种外源核酸编码在一个途径中的酶。 本发明另外提供了用于产生丁二烯，巴豆醇，2,4-戊二烯酸，3-丁烯-2-醇，或3-丁烯-1-醇的方法。 该方法可以包括培养丁二烯，巴豆醇，2,4-戊二烯酸，3-丁烯-2-醇，3-丁烯-1-醇产生的微生物生物体，其中所述微生物生物体快车至少一种外源性核酸编码 一个途径酶以足够的量和条件下和足够的时间周期以产生丁二烯，巴豆醇，2,4-戊二烯酸，3-丁烯-2-醇，3-丁烯-1-醇。

    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    66.
    发明公开
    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 审中-公开
    ORGANISMEN ZUR HERSTELLUNG VON 1,3-BUTANDIOL

    公开(公告)号：EP3135760A1

    公开(公告)日：2017-03-01

    申请号：EP16168278.6

    申请日：2010-04-30

    Applicant: Genomatica, Inc.

    Inventor： BURGARD, Anthony P. ,  BURK, Mark J. ,  OSTERHOUT, Robin E. ,  PHARKYA, Priti

    IPC: C12N1/21 ,  C12P7/18 ,  C12N9/04

    CPC classification number: C12P7/18 ,  C07C29/80 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01 ,  C12Y101/01157 ,  C12Y102/01 ,  C12Y203/01 ,  C12Y206/01 ,  C12Y401/01 ,  C12Y402/01 ,  C12Y403/01

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    Abstract translation: 非天然存在的微生物体包括具有1,3-丁二醇（1,3-BDO）途径的微生物生物，其具有至少一种编码1,3-BDO途径酶的外源核酸，其表达量足以产生1 ，3-BDO。 途径包括选自2-氨基-4-酮戊酸酯（AKP）硫解酶，AKP脱氢酶，2-氨基-4-羟基戊酸转氨酶，2-氨基-4-羟基戊酸酯氧化还原酶（脱氨基），2- 4-羟基戊酸脱羧酶，3-羟基丁醛还原酶，AKP氨基转移酶，AKP氧化还原酶（脱氨基），2,4-二氧代戊酸脱羧酶，3-氧代丁醛还原酶（还原酮），3-氧代丁醛还原酶 ），4-羟基-2-丁酮还原酶，AKP脱羧酶，4-氨基丁-2-酮氨基转移酶，4-氨基丁-2-酮氧化还原酶（脱氨基），4-氨基丁-2-酮氨裂解酶 乙酰乙酰辅酶A还原酶（CoA依赖性醛形成），乙酰乙酰辅酶A还原酶（CoA依赖性醇成型），乙酰乙酰辅酶A还原酶（酮 还原），3-羟基丁酰辅酶A还原酶（醛形成），3-羟基丁酸 yyl-CoA还原酶（醇形成），4-羟基丁酰辅酶A脱水酶和巴豆酸酶。 一种生产1,3-BDO的方法包括在条件和足够的时间内培养这些微生物生产1,3-BDO。

    NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY
    68.
    发明公开
    NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY 审中-公开

    公开(公告)号：EP4421181A2

    公开(公告)日：2024-08-28

    申请号：EP24162808.0

    申请日：2015-09-18

    Applicant: Genomatica, Inc.

    Inventor： PHARKYA, Priti ,  BURGARD, Anthony P. ,  NUNEZ VAN NAME, Eric Roland

    IPC: C12P7/16

    CPC classification number: C12Y401/02022 ,  C12N9/88 ,  C12P7/18 ,  C12P7/42 ,  C12N15/52 ,  C12N9/1205 ,  C12Y207/0104 ,  C12Y401/02009 ,  Y02E50/10 ,  Y02E50/30

    Abstract: The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA, or oxaloacetate and acetyl-CoA. Embodiments of the invention include microbial organisms having a pathway to acetyl-CoA and oxaloacetate that includes phosphoketolase (a PK pathway). The organisms also have either (i) a genetic modification that enhances the activity of the non-phosphotransferase system (non-PTS) for sugar uptake, and/or (ii) a genetic modification(s) to the organism's electron transport chain (ETC) that enhances efficiency of ATP production, that enhances availability of reducing equivalents or both. The microbial organisms can optionally include (iii) a genetic modification that maintains, attenuates, or eliminates the activity of a phosphotransferase system (PTS) for sugar uptake. The enhanced carbon flux through acetyl-CoA and oxaloacetate can be used for production of a bioderived compound, and the microbial organisms can further include a pathway capable of producing the bioderived compound.

    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE
    69.
    发明公开
    MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE 审中-公开

    公开(公告)号：EP4273255A3

    公开(公告)日：2024-01-03

    申请号：EP23182826.0

    申请日：2010-05-07

    Applicant: Genomatica, Inc.

    Inventor： BURK, Mark J. ,  BURGARD, Anthony P. ,  OSTERHOUT, Robin E. ,  PHARKYA, Priti

    IPC: C12N1/38 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/02 ,  C12P17/10 ,  C12P13/00 ,  C12N9/10

    Abstract: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

Patent Agency Ranking