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    COMPOUNDS AND METHODS FOR SEPARATION AND MOLECULAR ENCAPSULATION OF METAL IONS
    61.
    发明申请
    COMPOUNDS AND METHODS FOR SEPARATION AND MOLECULAR ENCAPSULATION OF METAL IONS 审中-公开
    金属离子分离和分子包封的化合物和方法

    公开(公告)号：WO1994001527A1

    公开(公告)日：1994-01-20

    申请号：PCT/US1993006387

    申请日：1993-07-07

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  POPE, Michael, T. ,  CREASER, Inge, I. ,  HECKEL, Mark, C.

    IPC: C12B11/00

    CPC classification number: C22B60/00 ,  C01F17/0006 ,  C03C1/006 ,  G21F9/16

    Abstract: Anions of the formula (I): [DA5M30-xO110-x(M'L)x] in which D is Na , Ca ; A is P, As, Sb, Si, Ge, or combinations thereof, M is W , W , or mixtures thereof; M' is a metallic element from groups 2 to 15 of the periodic table; other than W; L is O , OH , H2O; x is 0-10; and m is 10-20; selectively react with cations Z to afford anions of the formula (II): [ZA5M30-xO110-x(M'L)x] , wherein n is 3 or 4; Z = Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, or Bi, when n = 3, and Z = Ce, U, Np, Pu, or Am, when n = 4. This reaction may be used for the selective encapsulation of lanthanide or actinide cations, and salts containing anions of formula (II) may be vitrified to form glasses or reduced to form tungsten "bronze" materials suitable for the long-term storage of radioactive lanthanides or actinides.

    Abstract translation: 式（I）的阴离子：[DA5M30-xO110-x（M'L）x] m->其中D是Na +，Ca 2+; A是P，As，Sb，Si，Ge或它们的组合，M是W 5+，W 6+或它们的混合物; M'是周期表第2〜15族的金属元素; 除了W; L是O 2，OH - ，H 2 O; x为0-10; m为10-20; 选择性地与阳离子Z n +反应得到式（II）的阴离子：[ZA5M30-xO110-x（M'L）x] <（m + 1-n） - >，其中n为3或4; 当n = 3时，Z = Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb，Lu，Y或Bi，当n = 4时，Z = Ce，U，Np，Pu或Am 该反应可用于选择性包封镧系元素或锕系阳离子，并且含有式（II）的阴离子的盐可以被玻璃化以形成玻璃或还原形成适于长期储存放射性镧系元​​素的钨“青铜”材料 或锕系元素。

    PAPILLOMAVIRUS VACCINES
    62.
    发明申请
    PAPILLOMAVIRUS VACCINES 审中-公开
    斑马鱼疫苗

    公开(公告)号：WO1994000152A1

    公开(公告)日：1994-01-06

    申请号：PCT/US1993006109

    申请日：1993-06-24

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  SCHLEGEL, C., Richard ,  JENSON, A., Bennett

    IPC: A61K39/12

    CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N2710/20022 ,  C12N2710/20034

    Abstract: A recombinantly produced L1 major capsid protein which mimics conformational neutralizing epitopes on human and animal papilloma virions is provided. The recombinant proteins are useful as vaccines protective against papillomavirus infection. Antibodies to the recombinant protein are also provided. Such antibodies are useful in the diagnosis and treatment of viral infection.

    Abstract translation: 提供了一种重组产生的模拟人和动物乳头瘤病毒体构象中和表位的L1主要衣壳蛋白。 重组蛋白可用作保护乳头瘤病毒感染的疫苗。 还提供了重组蛋白的抗体。 这些抗体可用于病毒感染的诊断和治疗。

    HUMAN PAPILLOMA VIRUS GENES AND THEIR USE IN GENE THERAPY
    64.
    发明申请
    HUMAN PAPILLOMA VIRUS GENES AND THEIR USE IN GENE THERAPY 审中-公开
    人类斑马鱼病毒基因及其在基因治疗中的应用

    公开(公告)号：WO1993021958A1

    公开(公告)日：1993-11-11

    申请号：PCT/US1993003712

    申请日：1993-04-27

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  SCHLEGEL, Richard

    IPC: A61K48/00

    CPC classification number: C07K14/005 ,  A61K48/00 ,  C12N2710/20022

    Abstract: A process of immortalizing cells with isolated HPV-16, 18, 31, 33 or 35 E6 and E7 genes or the E7 gene alone to produce non-tumorigenic immortalized cell lines which retain the differentiated phenotypic characteristics of the parent cells.

    Abstract translation: 用分离的HPV-16,18,33,33或35E6和E7基因或单独的E7基因使细胞永生化以产生保留母细胞的分化表型特征的非致瘤性永生化细胞系的过程。

    RECEPTOR BLOCKING PEPTIDES OF FIBROBLAST GROWTH FACTOR RECEPTOR
    65.
    发明申请
    RECEPTOR BLOCKING PEPTIDES OF FIBROBLAST GROWTH FACTOR RECEPTOR 审中-公开
    纤维母细胞生长因子受体的受体阻断肽

    公开(公告)号：WO1992013958A1

    公开(公告)日：1992-08-20

    申请号：PCT/US1992000196

    申请日：1992-01-21

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  WELLSTEIN, Anton

    IPC: C12P01/00

    CPC classification number: C07K16/22 ,  A61K38/00 ,  C07K14/503 ,  Y02A50/389

    Abstract: A peptide of the formula: NH2- alpha - beta gamma delta epsilon eta THETA kappa lambda mu pi - rho -CO2H, wherein alpha is an amino acid having an R value of 4.5 +/- 1 unit; beta is an amino acid having an R value of 3.9 +/- 1 unit; gamma is an amino acid having an R value of -3.8 plus 1 unit; delta is an amino acid having an R value of -1.8 +/- 1 unit; epsilon is an amino acid having an R value of -4.2 +/- 1 unit; eta is an amino acid having an R value of -1.3 +/- 1 unit; THETA is an amino acid having an R value of 0.9 +/- 1 unit; kappa is an amino acid having an R value of 0.8 +/- 1 unit; lambda is an amino acid having an R value of 0.8 +/-1 unit, mu is an amino acid having an R value of -1.3 +/- 1 unit; pi is an amino acid having an R value of 3.9 +/- 1 unit; and rho is from 1 to about 18 amino acid residues having an average R value of at least about 0 +/- 1 unit; and wherein both alpha and the last residue of rho comprise hydrophilic end groups; or alpha is from 1 to about 18 amino acid residues having an average R value of at least about 0 +/- 1 unit; beta , gamma , delta , epsilon , eta , THETA , kappa , lambda , mu and pi are as defined above and rho is an amino acid having an R value of -1.3 +/- 1 unit; and wherein both the first residue of alpha and rho comprise hydrophilic end groups.

    Abstract translation: 下式的肽：NH 2-β-βγδεεTHETAκα-p-CH 2 -CO 2 H，其中α是R值为4.5 +/- 1单位的氨基酸; β是R值为3.9 +/- 1单位的氨基酸; γ是R值为-3.8加1单位的氨基酸; δ是R值为-1.8 +/- 1单位的氨基酸; ε是R值为-4.2 +/- 1单位的氨基酸; eta是R值为-1.3 +/- 1单位的氨基酸; THETA是R值为0.9 +/- 1单位的氨基酸; κ是R值为0.8 +/- 1单位的氨基酸; λ是R值为0.8 +/- 1单位的氨基酸，μ是R值为-1.3 +/- 1单位的氨基酸; pi是R值为3.9 +/- 1单位的氨基酸; Rho为平均R值为至少约0 +/- 1单位的1至约18个氨基酸残基; 并且其中rho的α和最后残基都包含亲水端基; 或α是具有至少约0 +/- 1单位的平均R值的1至约18个氨基酸残基; β，γ，δ，ε，eta，THETA，κ，λ，mu和pi如上所定义，rho是R值为-1.3 +/- 1单位的氨基酸; 并且其中α和rho的第一残基都包含亲水端基。

    LIGAND GROWTH FACTORS THAT BIND TO THE erbB-2 RECEPTOR PROTEIN AND INDUCE CELLULAR RESPONSES
    66.
    发明申请
    LIGAND GROWTH FACTORS THAT BIND TO THE erbB-2 RECEPTOR PROTEIN AND INDUCE CELLULAR RESPONSES 审中-公开
    绑定到erbB-2受体蛋白质和诱导细胞响应的配体生长因子

    公开(公告)号：WO1992012174A1

    公开(公告)日：1992-07-23

    申请号：PCT/US1992000329

    申请日：1992-01-13

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  LIPPMAN, Marc, E. ,  LUPU, Ruth

    IPC: C07K15/00

    CPC classification number: C07K14/4756 ,  A61K38/00 ,  C07K14/705 ,  C07K16/22

    Abstract: The present invention relates to erbB-2 ligands and function derivatives thereof which are capable of binding to the erbB-2 transmembrane protein but fail to bind to epidermal growth factor receptor. The present invention further pertains to anti-ligand molecules capable of recognizing and binding to the erbB-2 ligand molecule and to screening assays for such ligands. The present invention additionally relates to uses for the erbB-2 ligand, the anti-ligand molecules and the screening assays.

    Abstract translation: 本发明涉及能够结合erbB-2跨膜蛋白但不能结合表皮生长因子受体的erbB-2配体及其功能衍生物。 本发明还涉及能够识别和结合erbB-2配体分子并筛选这些配体的测定的抗配体分子。 本发明还涉及erbB-2配体，抗配体分子和筛选测定的用途。

    THERMALLY REVERSIBLE ORGANIC SOLVENT GELS
    70.
    发明申请
    THERMALLY REVERSIBLE ORGANIC SOLVENT GELS 审中-公开
    热可逆有机溶剂凝胶

    公开(公告)号：WO1988000938A1

    公开(公告)日：1988-02-11

    申请号：PCT/US1987001813

    申请日：1987-07-30

    Applicant: GEORGETOWN UNIVERSITY

    Inventor： GEORGETOWN UNIVERSITY ,  WEISS, Richard, G. ,  LIN, Yih-chyuan

    IPC: C07C50/18

    CPC classification number: C07J9/00 ,  B01J13/0065

    Abstract: Stable, thermally reversible gels of organic solvents and a gelling agent having the formula: R1-(CH2)n-CO2-R2, wherein R1 is an anthracene analogue or substituted anthracene analogue, n is zero or a whole number from 2 to 20, and R2 is cholesteryl or cholestanyl or a derivative of cholesteryl or cholestanyl, processes for producing same, and novel anthrance analogue cholesteryl and cholestanyl esters and derivatives.

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