中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

159 records (took 0.024 seconds)

    Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or in diagnostic agents and drugs containing them
    61.
    发明专利
    Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or in diagnostic agents and drugs containing them 未知

    公开(公告)号：GR3036123T3

    公开(公告)日：2001-09-28

    申请号：GR20010400976

    申请日：2001-06-27

    Applicant: HOECHST AG

    Inventor： SCHWARK JAN-ROBERT DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER ,  LANG HANS JOCHEN DR ,  WEICHERT ANDREAS DR ,  JANSEN HANS-WILLI DR ,  SCHOLZ WOLFGANG DR

    IPC: C07D213/65 ,  A01N1/00 ,  A61K31/155 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P43/00 ,  C07C277/08 ,  C07C279/20 ,  C07C279/22

    Abstract: Phenyl-substituted alkenyl-carboxylic acid guanidide compounds of formula (I) are new. T = a group (i); Ra = H, F, Cl, Br, I , CN, OH, OR6, 1-4C alkyl, Or-(CH2)aCbF2b+1, 3-8C cycloalkyl or NR7R8; r = 0 or 1; a = 0 - 4; b = 1 - 4; R6 = 1-4C alkyl, 1-4C perfluoroalkyl, 3-6C alkenyl, 3-8C cycloalkyl, phenyl or benzyl; where the phenyl nucleus is optionally substituted by 1 - 3 F, Cl, CF3, CH3, OCH3 or NR9R10 groups; R9, R10 = H, 1-4C alkyl or 1-4C perfluoroalkyl; R7, R8 = as for R6; or R7+R8 = (CH2)4 or (CH2)5, where one of the CH2 groups may be replaced by O, S, NH, N-CH3 or N-benzyl; Rb, Rc, Rd = as for Ra; x, y = 0 - 2; Rf = H, F, Cl, Br, I, CN, OR12, 1-8C alkyl, Op-(CH2)f-CgF2g+1, 3-8C cycloalkyl or 1-9C heteroaryl; p = 0 or 1; f = 0 - 4; g = 1 - 8; R12 = 1-8C alkyl, 1-4C perfluoroalkyl, 3-8C alkenyl, 3-8C cycloalkyl, phenyl or benzyl; where the phenyl nucleus may be substituted by 1 - 3 F, Cl, CF3, CH3, OCH3 or NR13R14 groups; R13, R14 = H, 1-4C alkyl or 1-4C perfluoroalkyl; Re = as for Rf; R1 = as for T, or is H, Ok-CmH2m+1, On-(CH2)p-CqF2q+1, F, Cl, Br, I, CN, CO-N=C(NH2)2, SOr1R17, SOr2-NR31R32, Ou-(CH2)v-C6H5, Ou2-(1-9C heteroaryl) (sic) or Su2-(1-9C heteroaryl) (sic); k, n = 0 or 1; m = 0-8; q = 1 - 8; p = 0-4; r1, r2 = 0 - 2; R31, R32 = H, 1-8C alkyl or 1-8C perfluoroalkyl, or R31+R32 = (CH2)4 or (CH2)5, where one of the CH2 groups may be replaced by O, S, NH, N-CH3 or N-benzyl; R17 = 1-8C alkyl; u, u2 = 0 or 1; v = 0- 4. The phenyl nucleus may be substituted by 1-3 F, Cl, CF3, CH3, OCH3, (CH2)w-NR21R22, NR18R19 or 1-9C heteroaryl groups ÄsicÜ. R18, R19, R21, R22 = 1-4C alkyl or 1-4C perfluoroalkyl; w = 1 - 4; The heterocycle of the 1-9C heteroaryl may be substituted by 1 - 3 F, Cl, CF3, CH3 or OCH3 groups. R2, R3, R4 and R5 = as for R1; or R1+R2 or R2+R3 = CH-CH=CH-CH, which is optionally substituted by 1 - 3 F, Cl, CF3, CH3, OCH3, (CH2)w2-NR24R25 or NR26R27; R24, R25, R26, R27 = H, 1-4C alkyl or 1-4C perfluoroalkyl; w2 = 1 - 4; provided that T is present 2-3 times in the molecule.

    SULFONAMIDE SUBSTITUTED ANNELLATED COMPOUNDS WITH SEVEN-MEMBERED RING, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF
    67.
    发明专利
    SULFONAMIDE SUBSTITUTED ANNELLATED COMPOUNDS WITH SEVEN-MEMBERED RING, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF 未知

    公开(公告)号：CZ53998A3

    公开(公告)日：1998-09-16

    申请号：CZ53998

    申请日：1998-02-24

    Applicant: HOECHST AG

    Inventor： BRENDEL JOACHIM DR ,  LANG HANS JOCHEN DR ,  GERLACH UWE DR

    IPC: C07D239/24 ,  A61K31/18 ,  A61K31/335 ,  A61K31/38 ,  A61K31/39 ,  A61K31/495 ,  A61P1/00 ,  A61P9/00 ,  C07C311/07 ,  C07D239/70 ,  C07D313/08 ,  C07D321/02 ,  C07D321/06

    Abstract: Benzoxepine and benzocycloheptane derivatives of formula (I), their stereoisomers and salts are new. X1 = O, S, SO, SO2, CR1R2, NR6, CO or CR1R7; R1, R2 = H, CF3, C2F5, C3F7, 1-6C alkyl or phenyl (optionally substituted by 1 or 2 of halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me; or R1+R2 = 2-10C alkylene; R6 = H or CnH2nR8 (with one CH2 group optionally replaced by O, CH=CH, C IDENTICAL C, CO, COO, OCO, S, SO, SO2, NR9 or CONR9; R9 = H or 1-4C alkyl; n = 0-8; R8 = H, CF3, C2F5, C3F7, 3-8C cycloalkyl, NMe2, NEt2, piperidino, pyrrolidino, morpholino, 4-methyl-1-piperazinyl or pyridyl, thienyl, imidazolyl or phenyl (all optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); X2 = CR1R2 or CR2R10; or X2 = O, S, SO, SO2 or NR6 if X3 and X1 are CR1R2; R10+R7 = bond; X3 = CR1R2; or X3 = O, S, SO, SO2 or NR6 if X2 and X4 are CR1R2; X4 = CR1R2, NR6, NR11, CH(OR30) or CR2R11; R30 = H, 1-3C alkyl or 1-4C acyl; R11+R5 = bond; Y1-Y4 = CR12 or N with no more than two being N; R12 = H, halo, 1-5C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, ZCmH2mR13 or phenyl (optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); Z = O, CO, COO, OCO, S, SO, SO2, SO2NR14, NR14 or CONR14; R14 = H or 1-3C alkyl; m = 0-6; R13 = H, CF3, C2F5, C3F7, 3-8C cycloalkyl, NR15R16, CONR15R16, OR30a or phenyl, thienyl or 1-9C N-containing heterocyclyl (all optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); R15, R16 = H or 1-3C alkyl; or R15+R16 = 4-5C methylene (with one carbon optionally replaced by O, S, NH, NMe or N(benzyl)); R30a = H, 1-3C alkyl or 1-4C acyl; or Y1+Y2 = S and Y3, Y4 = CR12; R3 = NR18CxH2xR17 or CxH2xR17 (with one CH2 group optionally replaced by O, CO, S, SO, SO2 or NR19); R19 = H, Me or Et; R17 = H, Me, 3-8C cycloalkyl, CF3, C2F5 or C3F7; x = 0-10; R18 = H or 1-8C alkyl; or R18+R17 = bond if x = 3-10; or R3 = phenyl (optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); or R3+R4 = 3-8C alkylene (with one CH2 optionally replaced by O, CO, S, SO or SO2); R4 = CrH2rR20 (with one CH2 group optionally replaced by O, CH=CH, C IDENTICAL C, CO, COO, OCO, S, SO, SO2, NR21 or CONR21); R21 = H or 1-3C alkyl; r = 0-20; R20 = H, CF3, C2F5, C3F7, 3-8C cycloalkyl, NR22R23 or phenyl, thienyl or 1-9C N-containing heterocyclyl (all optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); R22, R23 = H or 1-3C alkyl; or R22+R23 = 4-5C methylene (with one carbon optionally replaced by O, S, NH, NMe or N(benzyl)); and R5 = H; or R5+R11 = bond.

    GUANIDINES OF PHENYL SUBSTITUTED ALKENYLCARBOXYLIC ACID, PROCESS OF THEIR PREPARATION, THEIR USE AS A MEDICAMENT OR A DIAGNOSTIC AGENT AND A MEDICAMENT CONTAINING THEREOF
    70.
    发明专利
    GUANIDINES OF PHENYL SUBSTITUTED ALKENYLCARBOXYLIC ACID, PROCESS OF THEIR PREPARATION, THEIR USE AS A MEDICAMENT OR A DIAGNOSTIC AGENT AND A MEDICAMENT CONTAINING THEREOF 未知

    公开(公告)号：CZ265997A3

    公开(公告)日：1998-03-18

    申请号：CZ265997

    申请日：1997-08-20

    Applicant: HOECHST AG

    Inventor： SCHWARK JAN-ROBERT DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  WEICHERT ANDREAS DR ,  JANSEN HANS-WILLI DR ,  SCHOLZ WOLFGANG DR

    IPC: C07D213/65 ,  A01N1/00 ,  A61K31/155 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P43/00 ,  C07C277/08 ,  C07C279/20 ,  C07C279/22

    Abstract: Phenyl-substituted alkenyl-carboxylic acid guanidide compounds of formula (I) are new. T = a group (i); Ra = H, F, Cl, Br, I , CN, OH, OR6, 1-4C alkyl, Or-(CH2)aCbF2b+1, 3-8C cycloalkyl or NR7R8; r = 0 or 1; a = 0 - 4; b = 1 - 4; R6 = 1-4C alkyl, 1-4C perfluoroalkyl, 3-6C alkenyl, 3-8C cycloalkyl, phenyl or benzyl; where the phenyl nucleus is optionally substituted by 1 - 3 F, Cl, CF3, CH3, OCH3 or NR9R10 groups; R9, R10 = H, 1-4C alkyl or 1-4C perfluoroalkyl; R7, R8 = as for R6; or R7+R8 = (CH2)4 or (CH2)5, where one of the CH2 groups may be replaced by O, S, NH, N-CH3 or N-benzyl; Rb, Rc, Rd = as for Ra; x, y = 0 - 2; Rf = H, F, Cl, Br, I, CN, OR12, 1-8C alkyl, Op-(CH2)f-CgF2g+1, 3-8C cycloalkyl or 1-9C heteroaryl; p = 0 or 1; f = 0 - 4; g = 1 - 8; R12 = 1-8C alkyl, 1-4C perfluoroalkyl, 3-8C alkenyl, 3-8C cycloalkyl, phenyl or benzyl; where the phenyl nucleus may be substituted by 1 - 3 F, Cl, CF3, CH3, OCH3 or NR13R14 groups; R13, R14 = H, 1-4C alkyl or 1-4C perfluoroalkyl; Re = as for Rf; R1 = as for T, or is H, Ok-CmH2m+1, On-(CH2)p-CqF2q+1, F, Cl, Br, I, CN, CO-N=C(NH2)2, SOr1R17, SOr2-NR31R32, Ou-(CH2)v-C6H5, Ou2-(1-9C heteroaryl) (sic) or Su2-(1-9C heteroaryl) (sic); k, n = 0 or 1; m = 0-8; q = 1 - 8; p = 0-4; r1, r2 = 0 - 2; R31, R32 = H, 1-8C alkyl or 1-8C perfluoroalkyl, or R31+R32 = (CH2)4 or (CH2)5, where one of the CH2 groups may be replaced by O, S, NH, N-CH3 or N-benzyl; R17 = 1-8C alkyl; u, u2 = 0 or 1; v = 0- 4. The phenyl nucleus may be substituted by 1-3 F, Cl, CF3, CH3, OCH3, (CH2)w-NR21R22, NR18R19 or 1-9C heteroaryl groups ÄsicÜ. R18, R19, R21, R22 = 1-4C alkyl or 1-4C perfluoroalkyl; w = 1 - 4; The heterocycle of the 1-9C heteroaryl may be substituted by 1 - 3 F, Cl, CF3, CH3 or OCH3 groups. R2, R3, R4 and R5 = as for R1; or R1+R2 or R2+R3 = CH-CH=CH-CH, which is optionally substituted by 1 - 3 F, Cl, CF3, CH3, OCH3, (CH2)w2-NR24R25 or NR26R27; R24, R25, R26, R27 = H, 1-4C alkyl or 1-4C perfluoroalkyl; w2 = 1 - 4; provided that T is present 2-3 times in the molecule.

Patent Agency Ranking