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    65.
    发明专利
    未知

    公开(公告)号：NO822876L

    公开(公告)日：1982-04-07

    申请号：NO822876

    申请日：1982-08-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： REINER ROLAND

    IPC: C07D253/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D253/075 ,  C07D501/00 ,  C07D501/18 ,  C07D501/36 ,  C07D

    Abstract: There is presented compounds of the formula I wherein X represents the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl group or its corresponding tautomeric form, the 2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl group, and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of the compounds and hydrates of the compounds of formula I or of their esters, ethers and salts. Also provided is a method of their manufacture and intermediates therefor as well as corresponding pharmaceutical preparations.

    CEPHALOSPORIN ESTERS AND ETHERS
    67.
    发明专利
    CEPHALOSPORIN ESTERS AND ETHERS 未知

    公开(公告)号：AU4888079A

    公开(公告)日：1980-01-24

    申请号：AU4888079

    申请日：1979-07-12

    Applicant: HOFFMANN LA ROCHE

    Inventor： MONTAVON MARC ,  REINER ROLAND

    IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56

    Abstract: There is presented cephalosporin derivatives which are the readily hydrolysable esters and ethers of compounds of the general formula (I) wherein R represents furyl, thienyl or phenyl optionally substituted by halogen, hydroxy, lower alkoxy or lower alkyl, R1 represents lower alkyl or aminocarbonylmethyl and X represents a group of the formula in which one of the two symbols R2 and R3 represents hydrogen and the other represents lower alkyl and R4 represents lower alkyl, as well as salts of said esters and ethers and hydrates of said esters, ethers and salts.

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