公开(公告)号：US4213002A

公开(公告)日：1980-07-15

申请号：US964555

申请日：1978-11-29

Applicant: Helmut Pieper

Inventor： Helmut Pieper

IPC: C03B5/027 ,  C03B5/26 ,  C03B7/098 ,  C03B5/02

CPC classification number: C03B7/098 ,  C03B5/0275 ,  C03B5/26

Abstract: An electrically heated melting furnace for the Melting of mineral materials, such as frits, (Vitreous) enamels and the like, wherein a bath of molten material (contained in a tank) is heated by means of electrodes contacting the molten material and having a current flowing therethrough which heats the molten material by Joule's heat, wherein a batch is fed onto the melt or molten bath, and the molten product is withdrawn from the bottom of the tank, wherein the furnace space or tank has the cross-section of a regular polygon; and wherein a plurality of heating elements are arranged above the batch material and said heating electrodes are positioned in the lower portion of the molten bath above the tank bottom, and comprising a bottom outlet including a cylindrical portion or element and a further underlying, concentrically disposed, circular disc-shaped or annular portion or element of a refractory material being conductive at high temperature and acting as an electrical conductor, and at least one counter or opposite electrode disposed above the outlet and being immersed into the molten bath, said electrode likewise being connected to the power source.

Abstract translation: 一种用于熔融矿物材料如玻璃料（玻璃质）搪瓷等的电加热熔化炉，其中通过接触熔融材料并具有电流的电极来加热熔融材料（容纳在罐中）的熔池 流过其中，其通过焦耳热量加热熔融材料，其中批料被供给到熔体或熔融浴上，并且熔融产物从罐的底部排出，其中炉空间或罐具有规则的横截面 多边形 并且其中多个加热元件布置在所述批料材料上方，并且所述加热电极位于所述罐底部上方的所述熔池的下部，并且包括底部出口，所述底部出口包括圆柱形部分或元件，以及进一步下面的同心设置 ，在高温下作为电导体的耐火材料的圆盘形或环形部分或元件，以及设置在出口上方并被浸入熔池中的至少一个反向或相对的电极，所述电极同样是 连接到电源。

公开(公告)号：US4184863A

公开(公告)日：1980-01-22

申请号：US872408

申请日：1978-01-26

Applicant: Helmut Pieper

Inventor： Helmut Pieper

IPC: C03B5/027 ,  C03B5/03 ,  C03B5/04 ,  C03B5/185 ,  C03B5/225 ,  C03B5/02

CPC classification number: C03B5/04 ,  C03B5/03 ,  C03B5/185 ,  C03B5/225

Abstract: A method for the melting of glass, wherein a layer or blanket of batch material is fed onto a bath of molten glass, the liquid glass is withdrawn from the bath in a lower position through an opening, and the batch material is subjected to thermal energy from above to melt said batch material providing passing the glass after the melting thereof in a vertically downwardly directed, non-turbulent stream, and additionally heating the glass in said stream by passing electric current therethrough until the final gas removal (refining) is obtained, whereupon the glass is further conducted in vertically downward direction, homogenized in the next lower zone without the supply of energy, and withdrawn from a lower point of said zone and a glass melting furnace for carrying out said method providing a depth of said refining section exceeding the depth of said melting section by about three times.

Abstract translation: 一种用于熔化玻璃的方法，其中将批次材料的层或毯子进料到熔融玻璃浴上，液体玻璃通过开口从较低位置从浴中取出，并将批料材料经受热能 从上方熔化所述批料，其在熔融之后在垂直向下的非湍流中提供通过玻璃，并且另外通过使电流通过其中来加热所述流中的玻璃，直到获得最终的气体去除（精炼） 于是玻璃进一步沿垂直向下的方向进入，在下一个下部区域中均匀化，而不会产生能量供应，并且从所述区域的较低点被取出，并且玻璃熔化炉用于执行提供所述精炼部分的深度超过 所述熔化部分的深度约为三次。

公开(公告)号：US4119710A

公开(公告)日：1978-10-10

申请号：US754981

申请日：1976-12-28

Applicant: Gunther Engelhardt ,  Johannes Keck ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Helmut Pieper

Inventor： Gunther Engelhardt ,  Johannes Keck ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Helmut Pieper

IPC: C07D263/04 ,  C07D317/58 ,  A61K31/04 ,  A61K31/135 ,  A61K31/275 ,  A61K31/36

CPC classification number: C07D263/04 ,  C07D317/58

Abstract: Racemic and optically active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, trifluoromethyl, nitro or cyano, andR.sub.3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as .beta..sub.2 -receptor mimetics and .beta..sub.1 -receptor blockers.

Abstract translation: 其中R 1为氢，氟，氯，溴，碘或氰基的外消旋和旋光活性化合物，R 2为氟，三氟甲基，硝基或氰基，R 3为3至5个碳原子的烷基，羟基（烷基 3至5个碳原子的环烷基，3至5个碳原子的环烷基，1-（3,4-亚甲二氧基 - 苯基）-2-丙基或1-（对羟基 - 苯基）-2-丙基，和非毒性 其药理学可接受的酸添加剂; 这些化合物作为其作为骨质疏松症，骨质疏松症，骨质疏松症和骨质疏松症的抗生素有用的化合物，特别适用于β2受体的MIME和β受体阻断剂。

公开(公告)号：US4099951A

公开(公告)日：1978-07-11

申请号：US804404

申请日：1977-06-07

Applicant: Helmut Pieper

Inventor： Helmut Pieper

IPC: C03B5/027 ,  C03B5/187 ,  C03B5/26

CPC classification number: C03B5/26 ,  C03B5/0275 ,  C03B5/1875 ,  Y02P40/57

Abstract: Glass is melted in a furnace having a melting zone and one or more processing tanks adjacent to the melting zone. Molten glass flows from the melting zone to the processing tank through a passage. A portion of the molten glass is withdrawn from the top of the processing tank and is recirculated to the processing tank or to a separate refining zone. The furnace includes a melting section and at least one adjacent processing tank communicating with the melting section through a passage. A recirculating passage connects the top of the processing tank and the passage connecting the melting section and the processing tank. Additional means are provided to establish a recirculating flow of molten glass via the recirculating passage.

公开(公告)号：US07498325B2

公开(公告)日：2009-03-03

申请号：US10835495

申请日：2004-04-29

Applicant: Klaus Rudolf ,  Wolfgang Eberlein ,  Wolfhard Engel ,  Helmut Pieper ,  Henri Doods ,  Gerhard Hallermayer ,  Michael Entzeroth ,  Wolfgang Wienen

Inventor： Klaus Rudolf ,  Wolfgang Eberlein ,  Wolfhard Engel ,  Helmut Pieper ,  Henri Doods ,  Gerhard Hallermayer ,  Michael Entzeroth ,  Wolfgang Wienen

IPC: C07D498/02 ,  C07D285/22 ,  A61K31/50

CPC classification number: G01N33/58 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/549 ,  G01N33/9406

Abstract: The present invention relates to modified amino acids of general formula wherein A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.

公开(公告)号：US5958952A

公开(公告)日：1999-09-28

申请号：US945611

申请日：1997-12-17

Applicant: Frank Himmelsbach ,  Volkhard Austel ,  Gunther Linz ,  Helmut Pieper ,  Brian Guth ,  Johannes Weisenberger

Inventor： Frank Himmelsbach ,  Volkhard Austel ,  Gunther Linz ,  Helmut Pieper ,  Brian Guth ,  Johannes Weisenberger

IPC: C07D295/14 ,  A61K31/155 ,  A61K31/215 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/495 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07C257/18 ,  C07D211/06 ,  C07D211/34 ,  C07D211/74 ,  C07D211/76 ,  C07D241/08 ,  C07D295/15 ,  C07D401/12

CPC classification number: C07D295/15 ,  C07C257/18 ,  C07D211/34 ,  C07C2101/14

Abstract: The present invention relates to phenyl amidines of general formula (I), ##STR1## in which R.sup.1 to R.sup.5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their salts, especially their physiologically acceptable salts with inorganic or organic acids or bases also having valuable pharmacological properties, preferably aggregation-limiting effects, producing them.

Abstract translation: PCT No.PCT / EP96 / 01615 Sec。 371 1997年12月17日第 102（e）1997年12月17日PCT PCT 1996年4月18日PCT公布。 公开号WO96 / 33970 日期：1996年10月31日本发明涉及通式（I）的苯基脒，其中R 1至R 5如权利要求1所定义，其互变异构体，其立体异构体及其混合物及其盐，特别是其与无机的生理学上可接受的盐 或具有有价值的药理学性质的有机酸或碱，优选聚集限制作用，产生它们。

公开(公告)号：US5922763A

公开(公告)日：1999-07-13

申请号：US978739

申请日：1997-11-26

Applicant: Frank Himmelsbach ,  Helmut Pieper ,  Volkhard Austel ,  Gunter Linz ,  Thomas Muller ,  Wolfgang Eisert ,  Johannes Weisenberger

Inventor： Frank Himmelsbach ,  Helmut Pieper ,  Volkhard Austel ,  Gunter Linz ,  Thomas Muller ,  Wolfgang Eisert ,  Johannes Weisenberger

IPC: C07C211/44 ,  A61K38/00 ,  C07C211/48 ,  C07C211/50 ,  C07C211/53 ,  C07C233/65 ,  C07C237/36 ,  C07C237/38 ,  C07C243/22 ,  C07C255/54 ,  C07C255/56 ,  C07C255/57 ,  C07C255/58 ,  C07C255/59 ,  C07C255/60 ,  C07C257/18 ,  C07C271/64 ,  C07C275/28 ,  C07C275/32 ,  C07C275/38 ,  C07C275/42 ,  C07C279/18 ,  C07C307/10 ,  C07C309/11 ,  C07C311/04 ,  C07C311/06 ,  C07C311/08 ,  C07C311/11 ,  C07C311/16 ,  C07C311/19 ,  C07C311/21 ,  C07C311/29 ,  C07C317/14 ,  C07C317/44 ,  C07C317/46 ,  C07C321/24 ,  C07C323/60 ,  C07C323/62 ,  C07D207/08 ,  C07D207/26 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D211/70 ,  C07D257/04 ,  C07D295/192 ,  C07F9/40 ,  C07K5/06 ,  A61K31/24 ,  A61K31/19 ,  C07C229/34 ,  C07C251/16

CPC classification number: C07D295/192 ,  C07C237/36 ,  C07C237/38 ,  C07C243/22 ,  C07C255/56 ,  C07C255/57 ,  C07C255/59 ,  C07C255/60 ,  C07C257/18 ,  C07C271/64 ,  C07C275/42 ,  C07C307/10 ,  C07C309/11 ,  C07C311/04 ,  C07C311/06 ,  C07C311/08 ,  C07C311/19 ,  C07C311/21 ,  C07C311/29 ,  C07C317/44 ,  C07C317/46 ,  C07C323/60 ,  C07C323/62 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D211/70 ,  C07K5/06026 ,  A61K38/00 ,  C07C2101/14

Abstract: The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.

Abstract translation: 本发明涉及通式的联苯衍生物，其中A至E和X如权利要求1所定义，其立体异构体包括它们的混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，其具有 有价值的性质，优选聚集抑制作用，含有这些化合物的药物组合物及其制备方法。

公开(公告)号：US5852192A

公开(公告)日：1998-12-22

申请号：US847048

申请日：1997-05-01

Applicant: Frank Himmelsbach ,  Helmut Pieper ,  Volkhard Austel ,  Guenter Linz ,  Johannes Weisenberger ,  Wolfgang Eisert ,  Thomas Mueller

Inventor： Frank Himmelsbach ,  Helmut Pieper ,  Volkhard Austel ,  Guenter Linz ,  Johannes Weisenberger ,  Wolfgang Eisert ,  Thomas Mueller

IPC: C07D211/58 ,  C07D233/36 ,  C07D235/26 ,  C07D239/10 ,  C07D239/36 ,  C07D249/12 ,  C07D285/10 ,  C07D309/12 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04 ,  C07F9/6506 ,  C07D233/32

CPC classification number: C07D239/10 ,  C07D211/58 ,  C07D233/36 ,  C07D235/26 ,  C07D239/36 ,  C07D249/12 ,  C07D285/10 ,  C07D309/12 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04 ,  C07F9/65061

Abstract: The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.

Abstract translation: 本发明涉及通式为（I）的环脲衍生物，其中Ra，Rb，X和Y如本文所定义，含有衍生物的药物组合物及其制备方法。

公开(公告)号：US5817677A

公开(公告)日：1998-10-06

申请号：US733898

申请日：1996-10-18

Applicant: Gunter Linz ,  Frank Himmelsbach ,  Helmut Pieper ,  Volkhard Austel ,  Brian Guth ,  Johannes Weisenberger

Inventor： Gunter Linz ,  Frank Himmelsbach ,  Helmut Pieper ,  Volkhard Austel ,  Brian Guth ,  Johannes Weisenberger

IPC: C07D277/20 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/497 ,  A61P3/00 ,  A61P3/10 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00 ,  A61P19/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D277/50 ,  C07D285/12 ,  C07D285/135 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/455 ,  A61K31/41

CPC classification number: C07D401/04 ,  C07D401/06 ,  C07D417/04

Abstract: 5-Membered heterocyclic compounds, of which the following compounds are exemplary: (a) 4-��trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piperidyl)imidazole, (b) 5-��trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (c) 5-��4-(carboxymethoxy)phenyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (d) 5-��trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (e) 5-��4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (f) 5-��trans-4-(carboxymethoxy)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (g) 5-��4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (h) 5-��trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, and (i) 4-��trans-4-carboxycyclohexyl!aminocarbonyl!-1-�2-(4-piperidyl)ethyl!imidazole. These are useful for the treatment or prevention of illnesses in which relatively small or relatively large cell aggregates occur or cell-matrix interactions play a part.

Abstract translation: 5-部分杂环化合物，其中以下化合物是示例性的：（a）4 - [[反-4-（2-羧乙基）环己基]氨基羰基] -1-（4-哌啶基）咪唑，（b）5- [ [反-4-（2-羧乙基）环己基]氨基羰基] -4-甲基-2-（4-哌啶基）-1,3-噻唑，（c）5 - [[4-（羧基甲氧基）苯基]氨基羰基] 4-甲基-2-（4-哌啶基）-1,3-噻唑，（d）5 - [[反式-4-（2-羧乙基）环己基]氨基羰基] -2-（4-哌啶基） （e）5 - [[4-（羧甲氧基）苯基]氨基羰基] -2-（4-哌啶基）-1,3,4-噻二唑，（f）5 - [[反式-4- 羧基甲氧基）环己基]氨基羰基] -2-（4-哌啶基）-1,3-噻唑，（g）5 - [[4-（羧基甲氧基）苯基]氨基羰基] -2-（4-哌啶基） 噻唑，（h）5 - [[反-4-（2-羧乙基）环己基]氨基羰基] -2-（4-哌啶基）-1,3-噻唑，和（i）4 - [[反-4-羧基环己基 ]氨基羰基] -1- [2-（4-哌啶基）乙基]咪唑。 这些可用于治疗或预防其中相对较小或相对较大的细胞聚集物发生或细胞 - 基质相互作用发挥作用的疾病。

公开(公告)号：US5591769A

公开(公告)日：1997-01-07

申请号：US458096

申请日：1995-06-01

Applicant: Frank Himmelsbach ,  Volkhard Austel ,  Helmut Pieper ,  Wolfgang Eisert ,  Thomas Mueller ,  Johannes Weisenberger ,  Guenter Linz ,  Gerd Krueger

Inventor： Frank Himmelsbach ,  Volkhard Austel ,  Helmut Pieper ,  Wolfgang Eisert ,  Thomas Mueller ,  Johannes Weisenberger ,  Guenter Linz ,  Gerd Krueger

IPC: A61K31/40 ,  A61K31/00 ,  A61K31/395 ,  A61K31/397 ,  A61K31/401 ,  A61K31/4015 ,  A61K31/402 ,  A61P7/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P35/00 ,  C07D205/08 ,  C07D207/00 ,  C07D207/04 ,  C07D207/08 ,  C07D207/12 ,  C07D207/26 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D211/76 ,  C07D223/10 ,  C07F9/572 ,  C07D207/02 ,  C07D207/48

CPC classification number: C07D207/26 ,  C07D207/273 ,  C07D207/277 ,  C07F9/5722

Abstract: The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.

Abstract translation: 本发明涉及具有有价值的药理学性质，特别是对细胞聚集的抑制作用的环状亚氨基化合物，其含有这些化合物的药物组合物及其制备方法。