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61.发明申请COMPOSITIONS FOR TARGETING CONDUCTING AIRWAY CELLS COMPRISING ADENO-ASSOCIATED VIRUS CONSTRUCTS 审中-公开用于引导包含腺相关病毒构建物的导引气道细胞的组合物公开(公告)号：US20120046349A1
公开(公告)日：2012-02-23
申请号：US13266599
申请日：2010-04-29
Applicant: Christie L. Bell , James M. Wilson
Inventor： Christie L. Bell , James M. Wilson
Abstract: An artificial AAV capsid comprising a heterologous conducting airway targeting sequence is provided. The artificial AAV is useful as a targeting moiety, for delivery of heterologous molecules which are associated therewith. The artificial AAV is also useful in the generation of AAV vectors having the artificial capsid. Also described are methods of modifying the native tropism and transduction efficiency of vectors by improving and/or ablating their ability to transduce conducting airway cells. Methods of targeting conducting airway cells and delivering therapeutic and other molecules thereto are also provided.
Abstract translation: 提供了包含异源导管气道靶向序列的人造AAV衣壳。 人造AAV可用作靶向部分，用于递送与其相关的异源分子。 人造AAV也可用于产生具有人造衣壳的AAV载体。 还描述了通过改善和/或消除其转导导管气道细胞的能力来改变载体的天然向性和转导效率的方法。 还提供了靶向导管气道并递送治疗剂和其它分子的方法。
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62.发明申请SIMIAN ADENOVIRUSES SAdV-43, -45, -46, -47, -48, -49, AND -50 AND USES THEREOF 有权SIMIAN ADENOVIRUSES SAdV-43，-45，-46，-47，-48，-49，AND-50及其用途公开(公告)号：US20110223135A1
公开(公告)日：2011-09-15
申请号：US13126557
申请日：2009-10-29
Applicant: Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
Inventor： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
CPC classification number: C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10341 , C12N2710/10342 , C12N2710/10343 , C12N2710/10345 , C12N2710/10352 , C12N2810/6018
Abstract: A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Abstract translation: 重组载体包含猿猴腺病毒43,45,46,47,48,49或50个序列，以及在调控序列控制下的异源基因。 还公开了表达猿腺病毒43,45,46,47,48,49或50个基因的细胞系。 提供了使用载体和细胞系的方法。
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63.发明申请System and Method for Converting Graphical Call Flows Into Finite State Machines 有权将图形调用流转换为有限状态机的系统和方法公开(公告)号：US20110208510A1
公开(公告)日：2011-08-25
申请号：US13099805
申请日：2011-05-03
Applicant: Cecilia Castillo , Theodore J. Roycraft , James M. Wilson
Inventor： Cecilia Castillo , Theodore J. Roycraft , James M. Wilson
IPC: G06F17/27
CPC classification number: G06F17/28 , G06F8/35 , G06F9/4498
Abstract: A method, system and module for automatically converting a call flow into a state-based representation are disclosed. The method comprises walking a call flow and converting each page of the call flow into a rule of a higher level representation of the call flow, augmenting the higher level representation with terminal symbols representing state variable assignments and comparisons associated with decision and computation shapes in the call flow and converting the higher level representation into a state-based representation.
Abstract translation: 公开了一种用于将呼叫流自动转换为基于状态的表示的方法，系统和模块。 该方法包括步行呼叫流并将呼叫流的每一页转换成呼叫流程的较高级别表示的规则，用表示状态变量分配的终端符号和与决策和计算形状相关联的比较来增加更高级别表示 调用流程并将较高级别的表示转换为基于状态的表示。
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64.发明申请SIMIAN SUBFAMILY B ADENOVIRUSES SAdV-28, -27, -29, -32, -33, AND -35 AND USES THEREOF 有权SIMIAN SUBFAMILY B腺病毒SAdV-28，-27，-29，-32，-33，AND -35及其用途公开(公告)号：US20100254947A1
公开(公告)日：2010-10-07
申请号：US12744375
申请日：2008-11-24
Applicant: Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
Inventor： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
CPC classification number: A61K35/761 , A61K38/162 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10351 , C12N2810/6018 , Y02A50/463
Abstract: A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided.
Abstract translation: 重组载体包含猿猴腺病毒28，猿猴腺病毒27，猿猴腺病毒32，猿腺病毒33和/或猿腺病毒35序列和在调节序列控制下的异源基因。 还公开了表达一种或多种猿猴腺病毒-28,27，-32，-33或-35基因的细胞系。 提供了使用载体和细胞系的方法。
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65.发明授权Adeno-associated virus (AAV) serotype 8 sequences, vectors containing the same, and uses therefor 有权腺相关病毒（AAV）血清型8序列，含有它们的载体及其用途公开(公告)号：US07790449B2
公开(公告)日：2010-09-07
申请号：US11899500
申请日：2007-09-06
Applicant: Guangping Gao , James M. Wilson , Mauricio R. Alvira
Inventor： Guangping Gao , James M. Wilson , Mauricio R. Alvira
CPC classification number: C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
Abstract: Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes, including Factor VIII, is also provided.
Abstract translation: 提供血清型8腺相关病毒和含有这些序列的载体和宿主细胞的序列。 还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。 还提供rAAV8介导的治疗和免疫原性基因的递送，包括因子VIII。
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Patent Agency Ranking
公开(公告)号：US20090275107A1
公开(公告)日：2009-11-05
申请号：US12226588
申请日：2007-04-27
Applicant: Martin Lock , Luc H. Vandenberghe , James M. Wilson
Inventor： Martin Lock , Luc H. Vandenberghe , James M. Wilson
CPC classification number: C12N7/00 , A61K48/0091 , C07K14/005 , C12N2750/14151
Abstract: A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and the cells, thereby allowing the AAV to pass into the supernatant, i.e., media. Thus, the method of the invention provides supernatant containing high yields of AAV which have a higher degree of purity from cell membranes and intracellular materials, as compared to AAV produced using methods using a cell lysis step.
Abstract translation: 描述了不需要细胞裂解的生产AAV的方法。 该方法包括从上清液中收获AAV。 对于具有肝素结合位点的衣壳的AAV，该方法包括修饰AAV衣壳和/或培养条件以消除AAV肝素结合位点与细胞之间的结合，从而允许AAV进入上清液，即培养基 。 因此，与使用细胞裂解步骤的方法产生的AAV相比，本发明的方法提供了含有高产率的AAV的上清液，其具有比细胞膜和细胞内物质更高的纯度。
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67.发明申请SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT RELATED INFORMATION 有权用于检测，收集，分析和传播相关信息的系统和方法公开(公告)号：US20090216860A1
公开(公告)日：2009-08-27
申请号：US12274243
申请日：2008-11-19
Applicant: Peter Chao-Yuan Li , Jeffrey R. Collmann , Jane W. Blake , Mark G. Polyak , James M. Wilson , Jae In Yoon
Inventor： Peter Chao-Yuan Li , Jeffrey R. Collmann , Jane W. Blake , Mark G. Polyak , James M. Wilson , Jae In Yoon
CPC classification number: G06F17/30867 , G06F17/30887 , G06F19/00 , G06Q10/067 , G16H50/80 , H04L29/08072 , Y02A90/24 , Y02A90/26
Abstract: A system and method involves detecting operational social disruptive events on a global scale, assigning disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling disease propagation for containment and forecasting purposes.
Abstract translation: 一种系统和方法涉及在全球范围内检测运营中的社会破坏性事件，分配疾病事件分期和警告以更简单的术语表达数据，结合语言学分析建立数据以建立响应动作，生成用于传达信息的可视化和建模能力， 并为遏制和预测目的建模疾病传播。
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68.发明申请System and method for detecting, collecting, analyzing, and communicating event-related information 有权用于检测，收集，分析和传送事件相关信息的系统和方法公开(公告)号：US20090216747A1
公开(公告)日：2009-08-27
申请号：US12230397
申请日：2008-08-28
Applicant: Peter Chao-Yuan Li , Jeffrey R. Collmann , Jane W. Blake , Mark G. Polyak , James M. Wilson , Jae in Yoon
Inventor： Peter Chao-Yuan Li , Jeffrey R. Collmann , Jane W. Blake , Mark G. Polyak , James M. Wilson , Jae in Yoon
IPC: G06F17/30
CPC classification number: G06F17/30867 , G06F17/30887 , G06F19/00 , G06Q10/067 , G16H50/80 , H04L29/08072 , Y02A90/24 , Y02A90/26
Abstract: A system and method involves detecting operational social disruptive events on a global scale, assigning disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling disease propagation for containment and forecasting purposes.
Abstract translation: 一种系统和方法涉及在全球范围内检测运营中的社会破坏性事件，分配疾病事件分期和警告以更简单的术语表达数据，结合语言学分析建立数据以建立响应动作，生成用于传达信息的可视化和建模能力， 并为遏制和预测目的建模疾病传播。
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公开(公告)号：US20090215871A1
公开(公告)日：2009-08-27
申请号：US11978477
申请日：2007-10-29
Applicant: James M. Wilson , Guangping Gao , Soumitra Roy
Inventor： James M. Wilson , Guangping Gao , Soumitra Roy
IPC: A61K31/711 , C07H21/04
CPC classification number: C12N15/86 , A61K39/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362 , C12N2740/16122 , C12N2740/16134 , C12N2750/14122 , C12N2760/20122 , C12N2760/20134 , C12N2830/001 , C12N2830/55
Abstract: A recombinant vector comprises a simian adenovirus capsid and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Abstract translation: 重组载体包含猿猴腺病毒衣壳和在调节序列控制下的异源基因。 还公开了表达猿腺病毒基因的细胞系。 提供了使用载体和细胞系的方法。
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公开(公告)号：US20090074810A1
公开(公告)日：2009-03-19
申请号：US12226593
申请日：2007-04-27
Applicant: Soumitra Roy , James M. Wilson
Inventor： Soumitra Roy , James M. Wilson
CPC classification number: C12N7/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , C07K14/005 , C07K2319/00 , C07K2319/01 , C12N15/86 , C12N2710/10022 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2740/16134 , C12N2810/60 , C12N2810/6018 , C12N2810/6054 , C12N2810/85
Abstract: The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The modified adenovirus has a capsid comprising a hexon protein with a deletion in hypervariable region 1 and/or hypervariable region 4 of the hexon and an insert of an exogenous molecule therein.
Abstract translation: 本发明提供了改变腺病毒载体的特异性的方法。 该方法涉及提供具有修饰的腺病毒六邻体蛋白的衣壳的腺病毒。 修饰的腺病毒具有包含在六倍体的高变区1和/或高变区4中的缺失的六邻体蛋白和其中的外源分子的插入物的衣壳。
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