公开(公告)号：EP3504291A1

公开(公告)日：2019-07-03

申请号：EP17765293.0

申请日：2017-08-24

Applicant: Life Technologies Corporation

Inventor： YORK, Adam ,  WELCH, Eric ,  GEE, Kyle ,  WANG, Xin ,  AGGELER, Robert ,  HU, Yi-Zhen

IPC: C09K11/02 ,  C09K11/06 ,  C08G61/10 ,  C08G61/12 ,  G01N33/533

Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

公开(公告)号：EP3492921A1

公开(公告)日：2019-06-05

申请号：EP18198082.2

申请日：2013-01-25

Applicant: Life Technologies Corporation

Inventor： ERGY, Levente ,  GEE, Kyle

IPC: G01N33/68

Abstract: Systems and methods for protein melt analysis are provided that utilize a dye of formula (I). In some embodiments, a method comprises preparing a sample by mixing at least one protein with a dye, and applying a controlled heating while recording the fluorescence emission of the sample.

公开(公告)号：EP2807489B1

公开(公告)日：2018-10-03

申请号：EP13702569.8

申请日：2013-01-25

Applicant: Life Technologies Corporation

Inventor： ERGY, Levente ,  GEE, Kyle

IPC: G01N33/68

CPC classification number: G01N33/6803 ,  C07F5/022 ,  C09B23/04 ,  C09B57/00 ,  G01N33/52 ,  G01N33/582 ,  G01N33/68

Abstract: According to the present teachings, systems, compositions, kits and methods for protein melt analysis are provided that utilizing a dye that is a dipyrrometheneboron difluoride compound. In some embodiments, a method comprises preparing a sample by mixing at least one protein with a dye, and applying a controlled heating, while recording the fluorescence emission of the sample.

公开(公告)号：EP2928965B1

公开(公告)日：2018-07-04

申请号：EP13812349.2

申请日：2013-12-06

Applicant: Life Technologies Corporation

Inventor： DALLWIG, Jason ,  GEE, Kyle ,  AHNERT, Nancy ,  KANG, Hee Chol ,  YANG, Jongtae

IPC: C09B23/00 ,  C12Q1/68 ,  G01N33/52 ,  G01N33/58 ,  G01N33/68

CPC classification number: C12Q1/6825 ,  C09B23/00 ,  C09B23/04 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q2525/207 ,  C12Q2563/107 ,  C12Q2563/173

Abstract: Substituted unsymmetrical cyanine dyes are provided herein, including kits, assays systems and methods for their use in the detection of RNA compounds (e.g., miRNA).

公开(公告)号：EP3227264A2

公开(公告)日：2017-10-11

申请号：EP15828557.7

申请日：2015-12-03

Applicant: Life Technologies Corporation

Inventor： ZHOU, Wenjun ,  GEE, Kyle ,  TENNICO, Yolanda ,  SLADE, Peter ,  KANG, Hee Chol ,  KHAN, Shaheer ,  EVANS, Brian ,  STRAY, James

IPC: C07D261/00 ,  G01N33/58

Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

Abstract translation: 本公开内容涉及含有肼基取代基和任选地一个或多个带负电基团（例如磺酸根，磷酸根，膦酸根和/或羧酸根基团）和含有氨氧基取代基的染料化合物的染料化合物。 这些化合物可用于检测含有醛和酮基的分析物，包括例如聚糖。

公开(公告)号：EP1685117B1

公开(公告)日：2015-01-07

申请号：EP04810240.4

申请日：2004-11-01

Applicant: Life Technologies Corporation

Inventor： BATCHELOR, Robert ,  GE, Yue ,  GEE, Kyle ,  JOHNSON, Iain ,  LEUNG, Wai-Yee ,  LIU, Jixiang ,  PATCH, Brian ,  SMALLEY, Peter ,  STEINBERG, Thomas

IPC: C07D265/38 ,  C12Q1/28 ,  C07D495/04 ,  C07D413/12

CPC classification number: C09B19/00 ,  C07D265/38 ,  C07D413/12 ,  C07D495/04 ,  C12Q1/28

公开(公告)号：EP2379515B1

公开(公告)日：2014-02-12

申请号：EP09837113.1

申请日：2009-12-29

Applicant: Life Technologies Corporation

Inventor： GEE, Kyle ,  MARTIN, Vladimir

IPC: C07D263/56 ,  G01N33/58 ,  G01N33/84 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/06 ,  C07D491/16 ,  C07D263/57 ,  C07F3/04 ,  C09K11/06 ,  G01N33/52

CPC classification number: G01N21/75 ,  C07D263/56 ,  C07D263/57 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/06 ,  C07D491/16 ,  C09B57/00 ,  C09B57/02 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1048 ,  C09K2211/1088 ,  G01N33/582 ,  G01N33/84

公开(公告)号：EP2064290B1

公开(公告)日：2013-10-09

申请号：EP07871255.1

申请日：2007-10-26

Applicant: Life Technologies Corporation

Inventor： DZUBAY, Jeffrey ,  GEE, Kyle ,  MARTIN, Vladimir ,  RUKAVISHNIKOV, Aleksey ,  BEACHAM, Daniel

IPC: C09B7/00 ,  C09B11/12 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  G01N31/22 ,  C07K1/13

CPC classification number: G01N33/84 ,  C07D209/14 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/24 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  C09K11/06 ,  G01N31/22 ,  G01N33/5005 ,  G01N33/5058 ,  G01N33/5091 ,  G01N33/582 ,  G01N33/80 ,  G01N2333/245 ,  Y10T436/143333

Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula (I), wherein the variables are described throughout the application.

公开(公告)号：EP2201367B1

公开(公告)日：2013-03-20

申请号：EP08840647.5

申请日：2008-10-15

Applicant: Life Technologies Corporation

Inventor： BEACHAM, Daniel ,  GEE, Kyle

IPC: G01N33/50

CPC classification number: G01N33/84 ,  C12Q1/02 ,  G01N33/6872 ,  G01N2333/705

公开(公告)号：EP2379515A2

公开(公告)日：2011-10-26

申请号：EP09837113.1

申请日：2009-12-29

Applicant: Life Technologies Corporation

Inventor： GEE, Kyle ,  MARTIN, Vladimir

IPC: C07D263/58 ,  C07D263/56

CPC classification number: G01N21/75 ,  C07D263/56 ,  C07D263/57 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/06 ,  C07D491/16 ,  C09B57/00 ,  C09B57/02 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1048 ,  C09K2211/1088 ,  G01N33/582 ,  G01N33/84

Abstract: Disclosed are benzoxazole-based compounds, kits, and methods of producing and using the described compounds in fluorescence-based detection of analytes (e.g., metal ions). Also disclosed are uses of benzoxazole-based compounds as ratiometric metal ion indicators.

Abstract translation: 公开了基于苯并恶唑的化合物，试剂盒以及在分析物（例如金属离子）的基于荧光的检测中制备和使用所述化合物的方法。 还公开了苯并恶唑类化合物作为比例金属离子指示剂的用途。