公开(公告)号：US10449297B2

公开(公告)日：2019-10-22

申请号：US14617415

申请日：2015-02-09

Applicant: Palo Alto Research Center Incorporated

Inventor： David K. Biegelsen ,  Eugene M. Chow ,  Armin R. Volkel ,  Ashish Pattekar ,  Mandana Veiseh

IPC: A61M5/30 ,  A61M31/00 ,  A61M37/00 ,  A61M5/20

Abstract: A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.

公开(公告)号：US10388730B2

公开(公告)日：2019-08-20

申请号：US15476830

申请日：2017-03-31

Applicant: Palo Alto Research Center Incorporated

Inventor： Jeng Ping Lu ,  Eugene M. Chow ,  David K. Biegelsen ,  Sourobh Raychaudhuri

IPC: H01L23/48 ,  H01L21/44 ,  H01L29/06 ,  B82Y30/00 ,  B82Y40/00 ,  H01L21/06 ,  H01L31/0352 ,  H01L23/00 ,  B81C3/00

Abstract: An electrode array including a substrate. The electrode array includes a first plurality of electrodes disposed above a first zone of the substrate, wherein the first plurality of electrodes has a first range of spacing. The electrode array further includes a second plurality of electrodes disposed above a second zone of the substrate, wherein the second plurality of electrodes has a second range of spacing that is less than the first range of spacing.

公开(公告)号：US10308504B2

公开(公告)日：2019-06-04

申请号：US15476843

申请日：2017-03-31

Applicant: Palo Alto Research Center Incorporated

Inventor： Jeng Ping Lu ,  Eugene M. Chow ,  David K. Biegelsen ,  Sourobh Raychaudhuri

IPC: H01L21/06 ,  B81C1/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L21/027 ,  H01L29/06

Abstract: A method of manufacturing and using micro assembler systems are described. A method of manufacturing includes disposing a first plurality of electrodes above a first zone of the substrate, wherein the first plurality of electrodes has a first range of spacing. The method further includes disposing a second plurality of electrodes above a second zone of the substrate, wherein the second plurality of electrodes has a second range of spacing that is less than the first range of spacing. A method of using micro assembler systems includes disposing a mobile particle at least partially submersed in an assembly medium above a substrate, a first plurality of electrodes and a second plurality of electrodes. The method further includes conducting a field through individual electrodes of the first plurality of electrodes and the second plurality of electrodes to generate electrophoretic forces or dielectrophoretic forces on the mobile particle.

公开(公告)号：US20180294232A1

公开(公告)日：2018-10-11

申请号：US16008961

申请日：2018-06-14

Applicant: PALO ALTO RESEARCH CENTER INCORPORATED

Inventor： Eugene M. Chow ,  JenPing Lu ,  Armin R. Volkel ,  Bing R. Hsieh ,  Gregory L. Whiting ,  Sean E. Doris

IPC: H01L23/544 ,  H01L23/00

Abstract: A method of forming a charge pattern on a microchip includes depositing a material on the surface of the microchip, and immersing the microchip in a fluid to develop charge in or on the material through interaction with the surrounding fluid.

公开(公告)号：US10039885B2

公开(公告)日：2018-08-07

申请号：US14617430

申请日：2015-02-09

Applicant: Palo Alto Research Center Incorporated

Inventor： Eugene M. Chow ,  David K. Biegelsen ,  Michael I Recht ,  Fatemeh Primoradi ,  Felicia Linn ,  Ashish Pattekar ,  Mandana Veiseh

IPC: A61M31/00 ,  A61M5/30

Abstract: A device for delivery of particles into biological tissue includes at least one conduit and a propellant source configured to release a propellant into the conduit. A source of first particles is configured to release first particles into the conduit. A source of second particles is configured to release second particles into the conduit. The second particles comprise a functional material intended to interact with the biological tissue and having a density less than a density of the first particles. The propellant source and the conduit are configured to propel the particles in a collimated stream toward the biological tissue. The first particles are configured to penetrate the biological tissue to create micropores that increase porosity of the biological tissue and the second particles configured to enter the porous biological tissue.

公开(公告)号：US20160317747A1

公开(公告)日：2016-11-03

申请号：US15209450

申请日：2016-07-13

Applicant: Palo Alto Research Center Incorporated

Inventor： Peter Kiesel ,  Joerg Martini ,  Eugene M. Chow ,  Scott Uhland ,  Noble M. Johnson

IPC: A61M5/30 ,  G01N15/14 ,  G01B11/14

CPC classification number: A61M5/3015 ,  A61M5/2053 ,  A61M2205/3306 ,  A61M2210/04 ,  G01B11/14 ,  G01N15/00 ,  G01N15/1434 ,  G01N2015/0003 ,  G01N2015/0046 ,  G01N2015/1075 ,  G01N2015/1087 ,  G01N2015/1093

Abstract: Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

公开(公告)号：US20160228646A1

公开(公告)日：2016-08-11

申请号：US14617415

申请日：2015-02-09

Applicant: Palo Alto Research Center Incorporated

Inventor： David K. Biegelsen ,  Eugene M. Chow ,  Armin R. Volkel ,  Ashish Pattekar ,  Mandana Veiseh

IPC: A61M5/30 ,  A61M37/00 ,  A61N2/00 ,  A61N5/06

CPC classification number: A61M5/3015 ,  A61M5/2046 ,  A61M5/2053 ,  A61M2037/0007 ,  A61M2202/064

Abstract: A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.

Abstract translation: 用于将颗粒递送到生物组织的装置包括至少一个导管和推进剂源，该导管和推进剂源流体地联接到导管并且被配置为将推进剂输送到导管中。 颗粒源构造成将细长颗粒释放到导管中，细长颗粒具有宽度w，长度l> w。 推进剂源和导管构造成将准直的颗粒物流中的细长颗粒推向生物组织。 对准机构构造成使细长颗粒的纵向轴线基本上平行于导管的对准区域中的颗粒物流的方向。 对准的细长颗粒从导管喷射并撞击生物组织。

公开(公告)号：US20150359522A1

公开(公告)日：2015-12-17

申请号：US14307193

申请日：2014-06-17

Applicant: Palo Alto Research Center Incorporated

Inventor： Michael I. Recht ,  Joerg Martini ,  Abhishek Ramkumar ,  Peter Kiesel ,  Ben Hsieh ,  Eugene M. Chow

IPC: A61B10/00 ,  G01N15/14 ,  G01N21/25 ,  G01N21/64 ,  E03D9/00 ,  G01N27/416

CPC classification number: A61B10/007 ,  E03D9/00 ,  G01N15/06 ,  G01N15/1434 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/255 ,  G01N21/645 ,  G01N21/6486 ,  G01N33/62 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

Abstract: A urine capturing arrangement is configured to receive urine from a user of a toilet, and a chamber is fluidically coupled to the capturing arrangement. A diverter is fluidically coupled between the capturing arrangement and the chamber. The diverter is configured to divert a volume of the received urine to the chamber. A detection unit is configured to sense for presence of a predetermined characteristic in the volume of the urine and to generate at least one electrical signal comprising information about the predetermined characteristic.

Abstract translation: 尿液捕获装置被配置为从马桶的使用者接收尿液，并且腔室流体地联接到捕获装置。 分流器流体耦合在捕获装置和室之间。 分流器构造成将一定体积的尿液转移到腔室。 检测单元被配置为感测尿液体积中的预定特征的存在并且产生包括关于预定特征的信息的至少一个电信号。

公开(公告)号：US20150158295A1

公开(公告)日：2015-06-11

申请号：US14099873

申请日：2013-12-06

Applicant: Palo Alto Research Center Incorporated

Inventor： Armin R. Volkel ,  Eugene M. Chow

IPC: B41J2/14

CPC classification number: B41J2/1433 ,  B41J2/04 ,  B41J2/14 ,  B41J2202/02

Abstract: Disclosed herein is a material ejector (e.g., print head) geometry having alignment of material inlet channels in-line with microchannels, symmetrically disposed in a propellant flow, to obtain smooth, well-controlled, trajectories in a ballistic aerosol ejection implementation. Propellant (e.g., pressurized air) is supplied from above and below (or side-by-side) a microchannel array plane. Obviating sharp (e.g., 90 degree) corners permits propellant to flow smoothly from macroscopic source into the microchannels.

Abstract translation: 本文公开了一种材料喷射器（例如，打印头）几何形状，其具有与对准地设置在推进剂流中的微通道成对准的材料入口通道，以在弹道气溶胶喷射实施中获得平滑的，良好控制的轨迹。 推进剂（例如，加压空气）从微通道阵列平面的上方和下方（或并排）提供。 避免锋利（例如，90度）的拐角允许推进剂从宏观光源平稳地流入微通道。

公开(公告)号：US09034563B2

公开(公告)日：2015-05-19

申请号：US14056909

申请日：2013-10-17

Applicant: Palo Alto Research Center Incorporated

Inventor： Philipp H. Schmaelzle ,  Eugene M. Chow ,  Kai Melde

IPC: G02B6/138 ,  G02B6/12 ,  G03F7/20 ,  G03F7/00

CPC classification number: G02B6/138 ,  G02B6/12002 ,  G02B2006/1219 ,  G03F7/0005

Abstract: An enhanced self-writing method for generating in-plane (horizontally-oriented) polymer lightguides that includes disposing one or more light deflecting structures in or on the upper surface of a uncured layer that deflect incident collimated light beams in a transverse direction (i.e., parallel to the uncured layer top layer surface), whereby the deflected collimated light beam polymerizes a corresponding elongated portion of the uncured material in a self-propagating manner to form in-plane polymer lightguides. When used in the fabrication of micro-truss structures, the in-plane polymer lightguides are linked to diagonal polymer lightguides to form superior truss configurations, such as that of the ideal octet-truss structure. Non-polymerized portions of the uncured layer are removed to expose the micro-truss structure for further processing.

Abstract translation: 一种用于产生平面（水平取向）聚合物光导的增强的自写入方法，其包括将一个或多个光偏转结构设置在未固化层的上表面中或其上，该未固化层在横向上偏转入射准直光束（即， 平行于未固化层顶层表面），由此偏转的准直光束以自传播方式聚合未固化材料的相应细长部分以形成平面内聚合物光导。 当用于制造微型桁架结构时，平面内聚合物光导与对角聚合物光导相连以形成优良的桁架结构，例如理想的八位字节桁架结构。 去除未固化层的未聚合部分以暴露微型桁架结构以进行进一步处理。