公开(公告)号：US20140180399A1

公开(公告)日：2014-06-26

申请号：US14162617

申请日：2014-01-23

Applicant: The Regents of the University of California

Inventor： Seyedhamed Alavi ,  Arash Kheradvar

IPC: A61F2/24

CPC classification number: A61L27/047 ,  A61F2/2415 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3826 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2430/20 ,  C12N5/0068 ,  C12N5/0691 ,  C12N2501/15 ,  C12N2513/00 ,  C12N2533/10 ,  C12N2533/54 ,  C12N2535/00 ,  C08L89/06

Abstract: Described is a heart valve leaflet manufactured from a mesh material. The mesh material may have an ability to capture circulatory/stationary/migratory cells of the body to become biologically active. In some cases, the mesh material is coated with a bioactive material, such as a molecule that binds to a cell adhesion molecule (CAM), a growth factor, an extracellular matrix molecule, a subendothelial extracellular matrix molecule or a peptide. The mesh has a stiffness that is comparable to a native heart valve leaflet, such that it functionally mimics a native heart valve.

Abstract translation: 描述了由网状材料制成的心脏瓣膜小叶。 网状材料可以具有捕获身体的循环/静止/迁移细胞以变得具有生物活性的能力。 在一些情况下，网状材料涂覆有生物活性材料，例如结合细胞粘附分子（CAM），生长因子，细胞外基质分子，内皮下细胞外基质分子或肽的分子。 网格具有与天然心脏瓣膜小叶相当的刚度，使得其功能性地模拟天然心脏瓣膜。

公开(公告)号：US20140154662A1

公开(公告)日：2014-06-05

申请号：US14094760

申请日：2013-12-02

Applicant: The Regents of the University of California

Inventor： Seyedhamed Alavi ,  Arash Kheradvar

IPC: A61K35/34

CPC classification number: A61K35/34 ,  A61F2/2415 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3826 ,  A61L27/3886 ,  A61L2430/20 ,  C12M23/02 ,  C12M23/20 ,  C12M25/14

Abstract: The present invention relates to a heart valve and, more particularly, to a mold and process shaping and securing cells and tissue layers as they are grown in three-dimensions into a heart valve.

Abstract translation: 本发明涉及一种心脏瓣膜，更具体地说，涉及在三维生长成心脏瓣膜时将细胞和组织层整形并固定的模具和工艺。