公开(公告)号：WO1995030007A1

公开(公告)日：1995-11-09

申请号：PCT/US1995005561

申请日：1995-05-02

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  LOEB, Lawrence, A. ,  BLACK, Margaret, E.

IPC: C12N15/54

CPC classification number: C12N9/12 ,  A61K38/00 ,  A61K48/00

Abstract: The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution upstream from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as compared to unmutated thymidine kinase. Within another aspect, one of the mutations is an amino acid substitution within a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as compared to unmutated thymidine kinase. Also provided are vectors suitable for expressing such DNA molecules, as well as methods for utilizing such vectors.

Abstract translation: 本发明提供编码疱疹病毒科胸苷激酶的分离的核酸分子，其包含一个或多个突变，至少一个编码上游氨基酸取代的突变，其增加了胸苷激酶的生物学活性，所述突变增加了胸苷激酶的生物活性 未突变的胸苷激酶。 在另一方面，与未突变的胸苷激酶相比，突变之一是在DRH核苷结合位点内的氨基酸取代，其增加胸苷激酶的生物学活性。 还提供了适于表达这种DNA分子的载体，以及利用这些载体的方法。

公开(公告)号：WO1995008130A1

公开(公告)日：1995-03-23

申请号：PCT/US1994010417

申请日：1994-09-14

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  GOLDEN, Robert, N. ,  SILVERSTEIN, Fred, E.

IPC: G01V03/08

CPC classification number: A61B5/06 ,  A61M25/0127 ,  G01V3/081 ,  G01V3/15 ,  G01V15/00

Abstract: There is disclosed an apparatus and method for locating a medical tube within the body of a patient. The medical tube is located by a detection apparatus which senses the static magnetic field strength gradient generated by a magnet associated with the medical tube and indicates the value of the gradient to the user. The detection apparatus is moved about the body of the patient until the greatest gradient magnitude is indicated. The detection apparatus distinguishes the field strength of the magnet associated with the medical tube from the earth's field strength by sensing the magnet's field strength at two different distances from the magnet.

Abstract translation: 公开了一种用于在患者体内定位医用管的装置和方法。 医疗管由检测装置定位，该检测装置检测由与医用管相关联的磁体产生的静态磁场强度梯度，并向使用者指示梯度的值。 检测装置围绕患者的身体移动，直到指示最大的梯度大小。 检测装置通过在与磁体两个不同的距离处感测磁体的场强来区分与医疗管相关联的磁体的场强与地球场强。

公开(公告)号：WO1995007464A1

公开(公告)日：1995-03-16

申请号：PCT/US1994009937

申请日：1994-09-02

Applicant: UNIVERSITY OF WASHINGTON ,  KARLSEN, Allan, E. ,  LANDIN-OLSSON, Mona

Inventor： UNIVERSITY OF WASHINGTON ,  HAGOPIAN, William ,  LERNMARK, Ake

IPC: G01N33/564

CPC classification number: G01N33/564 ,  C07K14/4713 ,  G01N2800/042 ,  Y10S436/811

Abstract: Methods for predicting the clinical course of diabetes in patients diagnosed as having NIDDM are provided. Patients having NIDDM are tested for the presence of autoantibodies to human islet cell glutamic acid decarboxylase. Based on the presence or absence of autoantibodies, the patients are classified as to the predicted course of the disease. These methods can be used to predict the development of IDDM and to guide therapeutic intervention.

Abstract translation: 提供了诊断患有NIDDM的患者糖尿病临床病程的方法。 测试患有NIDDM的患者对人胰岛细胞谷氨酸脱羧酶的自身抗体的存在。 根据自身抗体的存在或不存在，将患者归类为疾病的预测过程。 这些方法可用于预测IDDM的发展并指导治疗干预。

公开(公告)号：WO1994029741A1

公开(公告)日：1994-12-22

申请号：PCT/US1994006337

申请日：1994-06-06

Applicant: UNIVERSITY OF WASHINGTON ,  ST. GEORGE'S HOSPITAL MEDICAL SCHOOL ,  THE WELLCOME TRUST ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED ,  FILLER, Aaron, G. ,  HOWE, Franklyn, A.

Inventor： UNIVERSITY OF WASHINGTON ,  ST. GEORGE'S HOSPITAL MEDICAL SCHOOL ,  THE WELLCOME TRUST ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

IPC: G01R33/38

CPC classification number: G01R33/34084 ,  G01R33/34 ,  G01R33/3806 ,  G01R33/385 ,  G01R33/56341

Abstract: A focal magnetic resonance imaging system (20) for generating images of neural structures such as nerves. The system (20) includes a control and analysis system (22), a polarizing system (24), and splint-coil assembly (26). The splint-coil assembly (26) includes a splint (28) and various magnetic and electromagnetic coils (32, 40, 42) incorporated within the splint (28). The splint (28) conforms snugly to a patient's body part, e.g., limb, so that the coils (32, 40, 42) are fixed with respect to the patient's body part. The splint-coil assembly (26) can be positioned independently of a main field generated by the polarizing system (24), and a stabilization apparatus (156) is included for adjustably securing the position of the splint-coil assembly (26) during imaging. A focal magnet assembly (60) that can serve as the polarizing system (24) is also provided. Further provided is a method of operating the control and analysis system (22) to consistently generate images depicting the fascicular structure of nerves (100) by ensuring that image gradients (108) are oriented orthogonal to the nerves (100).

Abstract translation: 一种用于产生诸如神经的神经结构图像的聚焦磁共振成像系统（20）。 系统（20）包括控制和分析系统（22），偏振系统（24）和夹板 - 线圈组件（26）。 夹板线圈组件（26）包括夹板（28）和并入夹板（28）内的各种磁力和电磁线圈（32,40,42）。 夹板（28）紧贴地与患者的身体部分（例如肢体）相适应，使得线圈（32,40,42）相对于患者的身体部分固定。 夹板线圈组件（26）可以独立于由偏振系统（24）产生的主场定位，并且包括稳定装置（156），用于在成像期间可调节地固定夹板线圈组件（26）的位置 。 还提供了可以用作偏振系统（24）的聚焦磁体组件（60）。 还提供了一种操作控制和分析系统（22）的方法，以通过确保图像梯度（108）定向为与神经（100）正交的方式来一致地产生描绘神经（100）的束状结构的图像。

公开(公告)号：WO1994019016A1

公开(公告)日：1994-09-01

申请号：PCT/US1994001611

申请日：1994-02-17

Applicant: ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON

Inventor： ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON ,  HART, Charles, E. ,  KENAGY, Richard, D. ,  CLOWES, Alexander, W.

IPC: A61K39/395

CPC classification number: C07K16/2863 ,  A61K38/00 ,  A61K39/395 ,  C07K2317/24 ,  C07K2319/30 ,  C07K2319/32 ,  A61K2300/00

Abstract: Methods of inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an anti-PDGF receptor antibody, such as an anti-PDGF-alpha receptor antibody or an anti-PDGF-beta receptor antibody. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft.

Abstract translation: 公开了抑制哺乳动物（包括灵长类动物）脉管系统内膜增生的方法。 所述方法包括向哺乳动物施用抗PDGF受体抗体，例如抗PDGF-α受体抗体或抗PDGF-β受体抗体。 该方法可用于减少由于例如血管成形术，血管移植物的血管成形术，内膜切除术，粥样斑块切除术或吻合术引起的血管损伤引起的内膜增生。

公开(公告)号：WO1994013273A1

公开(公告)日：1994-06-23

申请号：PCT/US1993011595

申请日：1993-12-03

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  UNIVERSITY OF WASHINGTON

Inventor： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  UNIVERSITY OF WASHINGTON ,  PALMITER, Richard, D. ,  SANDGREN, Eric, P. ,  BRINSTER, Ralph, L.

IPC: A61K31/00

CPC classification number: A01K67/0278 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/20 ,  A01K2227/105 ,  C07K14/825 ,  C12N15/85 ,  C12N15/8509 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/85

Abstract: Vertebrate gene locus control regions or a component thereof containing at least one DNaseI hypersensitivity site, when operably linked to a cistron, confer to the cistron essentially tissue-independent, copy number-dependent, position-independent expression. The genes are those expressed in most vertebrate cells, as illustrated by the metallothionein genes.

Abstract translation: 当与顺顺子可操作地连接时，脊椎动物基因座控制区或其含有至少一个DNaseI超敏反应位点的组分基本上与组织依赖性无关，拷贝数依赖性，位置无关表达。 这些基因是在大多数脊椎动物细胞中表达的基因，如金属硫蛋白基因所示。

公开(公告)号：WO1993018415A1

公开(公告)日：1993-09-16

申请号：PCT/US1993002036

申请日：1993-03-08

Applicant: UNIVERSITY OF WASHINGTON ,  ST. GEORGE'S HOSPITAL MEDICAL SCHOOL

Inventor： UNIVERSITY OF WASHINGTON ,  ST. GEORGE'S HOSPITAL MEDICAL SCHOOL ,  FILLER, Aaron, G. ,  HOWE, Franklyn, A. ,  TSURUDA, Jay, S. ,  RICHARDS, Todd, L.

IPC: G01R33/56

CPC classification number: G01R33/56341

Abstract: A neurography system (10) is disclosed for generating diagnostically useful images of neural tissue (i.e. neurograms) employing a modified magnetic resonance imaging system (14). In one embodiment, the neurography system selectively images neural tissue by employing one or more gradients to discriminate diffusion anisotropy in the tissue and further enhances the image by suppressing the contribution of fat to the image. The neurography system is part of a broader medical system (12), which may include an auxiliary data collection system (22), diagnostic system (24), therapeutic system (26), surgical system (28), and training system (30). These various systems are all constructed to take advantage of the information provided by the neurography system regarding neural networks, which information was heretofore unavailable.

Abstract translation: 公开了神经系统（10），用于产生使用修改的磁共振成像系统（14）的神经组织（即神经图）的诊断有用的图像。 在一个实施例中，神经系统通过采用一个或多个梯度来选择性地图像神经组织，以区分组织中的扩散各向异性，并通过抑制脂肪对图像的贡献来进一步增强图像。 神经系统是更广泛的医疗系统（12）的一部分，其可以包括辅助数据收集系统（22），诊断系统（24），治疗系统（26），外科系统（28）和训练系统（30） 。 这些各种系统都被构造为利用神经系统提供的关于神经网络的信息，该信息迄今为止不可用。

公开(公告)号：WO1991019247A1

公开(公告)日：1991-12-12

申请号：PCT/US1991001437

申请日：1991-03-07

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  KIM, Yongmin ,  MILLS, Karl, Scott ,  WONG, Gilman, Kuey

IPC: G06F03/14

CPC classification number: G09G5/06

Abstract: An image computing system (10) providing at least two display modes and including a set of image coprocessors (16a-d) is disclosed. The system (10) converts image data into signals representing pixel characteristics. The signals can be displayed via a video display device (18). In a first display mode, pixel characteristic signals are generated for related image planes of a single image by a series of display generating devices (16a-d) and each signal is selected from a separate display generating device. The selected signals are output to a video display device (18). In a second display mode, pixel characteristic signals for an independant image plane are selected from a single display generating device. The signals are output to a video display device (18). In this mode, each display generating device converts image data for an independant image plane. In this manner, the system (10) provides single or multiple image display modes. The image coprocessors (16a-d) provide efficient image processing of the image data.

Abstract translation: 公开了一种提供至少两种显示模式并包括一组图像协处理器（16a-d）的图像计算系统（10）。 系统（10）将图像数据转换成表示像素特性的信号。 可以通过视频显示装置（18）显示信号。 在第一显示模式中，通过一系列显示产生装置（16a-d）为单个图像的相关图像平面生成像素特征信号，并且从单独的显示生成装置中选择每个信号。 选择的信号被输出到视频显示装置（18）。 在第二显示模式中，从单个显示生成装置中选择独立图像平面的像素特征信号。 信号被输出到视频显示装置（18）。 在该模式中，每个显示生成装置转换独立图像平面的图像数据。 以这种方式，系统（10）提供单个或多个图像显示模式。 图像协处理器（16a-d）提供图像数据的有效图像处理。

公开(公告)号：WO1990004950A1

公开(公告)日：1990-05-17

申请号：PCT/US1988004041

申请日：1988-11-10

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  ENGEL, David ,  MARTIN, Roy, W. ,  MILLER, Josef, M.

IPC: A61C03/03

CPC classification number: A61C17/20

Abstract: A method and apparatus for demobilizing the motile subgingival bacteria and for removing soft plaque from the teeth on a substantially daily basis as a means to prevent, treat and/or limit periodontal diseases. A piezoelectric multimorph transducer (24) is used to generate low-energy vibrations, these vibrations are applied to the teeth and gingival fluids to cause mild cavitation within the fluid to remove subgingival plaque and to demobilize motile bacteria. Means (28) for driving the transducer at its resonant frequency or multiples thereof and for electrically isolating the user are included.

公开(公告)号：WO1999005512A1

公开(公告)日：1999-02-04

申请号：PCT/US1997021258

申请日：1997-11-21

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  WEIGL, Bernhard, H. ,  HOLL, Mark, R. ,  ZEBERT, Diane ,  KENNY, Margaret ,  WU, Caicai

IPC: G01N21/64

CPC classification number: B01F13/0093 ,  B01F5/0403 ,  B01F13/0059 ,  B01J19/0093 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/148 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0457 ,  B01L2400/0487 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1404 ,  G01N15/1484 ,  G01N30/0005 ,  G01N30/38 ,  G01N30/6095 ,  G01N30/74 ,  G01N35/085 ,  G01N2035/00237 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: A reference T-sensor system is provided for detecting the presence and/or measuring the concentration of analyte particles in a sample stream comprising a laminar flow channel (100), three or more inlet means (40, 50, 55) in fluid connection with the laminar flow channel (100) for respectively conducting into the laminar flow channel an indicator stream (70) which may comprise an indicator substance which indicates the presence of the analyte particles by a detectable change in property when contacted with analyte particles, the sample stream (80), and a reference stream (75), which can be either a control stream or an internal standard stream or both.

Abstract translation: 提供了一种参考T传感器系统，用于检测样品流中存在和/或测量分析物颗粒的浓度，所述样品流包括层流通道（100），三个或更多个入口装置（40,50,55），其与 用于分别导入层流通道的层流通道（100）是指示物流（70），其可以包括指示剂物质，其指示当与分析物颗粒接触时通过可检测的性质变化来指示分析物颗粒的存在，样品流 （80）和参考流（75），其可以是控制流或内部标准流或两者。