公开(公告)号：WO1992008196A1

公开(公告)日：1992-05-14

申请号：PCT/US1991007397

申请日：1991-10-07

Applicant: VANDERBILT UNIVERSITY

Inventor： VANDERBILT UNIVERSITY ,  SZTIPANOVITS, Janos ,  BIEGL, Csaba ,  KARSAI, Gabor

IPC: G06F13/14

CPC classification number: G06F8/451 ,  G06F15/17343

Abstract: In a model-based dynamically configured system (15, 25), various processing components (65, 75, 87) are created dynamically, interfaced to each other, and scheduled upon demand. A combination of data driven and demand-driven scheduling techniques (Fig. 5, 6) are used to enhance the effectiveness of the dynamically configured system.

公开(公告)号：WO1991004048A1

公开(公告)日：1991-04-04

申请号：PCT/US1990005177

申请日：1990-09-13

Applicant: VANDERBILT UNIVERSITY

Inventor： VANDERBILT UNIVERSITY ,  HELLERQUIST, Carl, G.

IPC: A61K39/085

CPC classification number: A61K31/715 ,  Y10S514/908

Abstract: A method and therapeutic agent for at least partially inhibiting vascularization of a developing solid tumor. The therapeutic agent comprises polysaccharide toxin, a GBS toxin, produced by group B β-hemolytic Streptococcus bacteria. The GBS agent is in a purified, toxin-active form which can be parenterally administered in an amount effective for vascularization inhibition.

公开(公告)号：WO1990006311A1

公开(公告)日：1990-06-14

申请号：PCT/US1988004253

申请日：1988-11-29

Applicant: VANDERBILT UNIVERSITY ,  CHA, Jin, Kun ,  BENNETT, Richard, Bernard, III

Inventor： VANDERBILT UNIVERSITY

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D207/04

Abstract: A method of synthesizing swainsonine and its analogues employing a unique intermediate imine and a unique intermediate enamide.

Abstract translation: 使用独特的中间体亚胺和独特的中间体酰胺合成磺胺辛胺及其类似物的方法。

公开(公告)号：WO1988001874A1

公开(公告)日：1988-03-24

申请号：PCT/US1986001917

申请日：1986-09-15

Applicant: VANDERBILT UNIVERSITY

Inventor： VANDERBILT UNIVERSITY ,  HARSHMAN, Sidney

IPC: A61K39/085

CPC classification number: A61K39/085

Abstract: Inactivated staphylococcal alpha toxin which is in a detoxified immunogenically active form prepared as a vaccine and administered parenterally to patients having multiple sclerosis or other disease involving demyelination of nerve sheath myelin. The amount of the inactivated alpha toxin administered is sufficient to effectively immunize the patient against active staphylococcal alpha toxin. The patient becomes subsequently infected with staphylococcus, the alpha toxin resulting from the infection is neutralized by the alpha toxin binding antibodies. This prevents exacerbation of the demyelination of the nerve sheaths, which otherwise can be promoted by the alpha toxin resulting from the staphylococcus infection.

Abstract translation: 灭活的葡萄球菌α毒素，其为制备为疫苗的解毒的免疫原性活性形式，并且肠胃外给予患有多发性硬化症或涉及神经鞘髓鞘脱髓鞘的其它疾病的患者。 所施用的灭活的α毒素的量足以有效地免疫患者抗活性葡萄球菌α毒素。 患者随后被葡萄球菌感染，由感染引起的α毒素被α毒素结合抗体中和。 这防止神经鞘的脱髓鞘恶化，否则可能由葡萄球菌感染引起的α毒素促进。