公开(公告)号：EP0443908B1

公开(公告)日：1994-11-30

申请号：EP91400341.3

申请日：1991-02-12

Applicant: SEXTANT AVIONIQUE S.A.

Inventor： Fima, Henri

IPC: G01L11/00 ,  G01N21/33 ,  G01K11/00

CPC classification number: G01N21/47 ,  G01L11/02 ,  G01N2021/4709 ,  G01N2201/0662

公开(公告)号：EP0567230A2

公开(公告)日：1993-10-27

申请号：EP93302291.5

申请日：1993-03-25

Applicant: Becton Dickinson and Company

Inventor： Berndt, Klaus W.

IPC: C12M1/34 ,  G01N21/35

CPC classification number: G01N21/274 ,  C12M41/46 ,  G01N21/3504 ,  G01N2021/5969 ,  G01N2201/06106 ,  G01N2201/066 ,  G01N2201/0662 ,  Y10S435/808

Abstract: Methods and apparatus for detecting biological activity within a sample are disclosed. The present invention provides a combination of a first and a second infrared light source arranged on the side of a sample vial, and a first and a second narrow-band infrared detector similarly arranged on the side of the vial approximately opposite the sources. The disclosed arrangement cancels the sources of error while measuring the carbon dioxide content of the headspace gas above the sample. In operation, the present invention sequentially measures the photocurrents generated at each detector with no source turned on, with the first source turned on, and with the second source turned on and the first source turned off. The C0 2 absorption coefficient of the vial headspace gas is then calculated based on the photocurrents measured. This present invention allows compensation for source aging, detector aging, and vial wall thickness changes. Moreover, the present invention permits a determination of the absolute absorption coefficient at a selected wavelength, most preferably about 4.26 µm, which is the C0 2 absorption characteristic wavelength. The determination of the absolute C0 2 concentration within the headspace permits the detection of bacterial growth processes. Additionally, the disclosed source/detector combination can be produced at low cost. Thus, in preferred embodiments, the apparatus of the present invention comprises a plurality of vials that are simultaneously monitored by providing each of the plurality of vials with its own source/detector combination and activating and deactivating the sources and detectors using a multiplexer/demultiplexer arrangement.

Abstract translation: 公开了用于检测样品内生物活性的方法和装置。 本发明提供了布置在样品瓶侧面的第一和第二红外光源的组合，以及类似地布置在大致与源相对的小瓶侧面上的第一和第二窄带红外探测器。 所公开的布置在测量样品上方的顶空气体的二氧化碳含量时消除误差源。 在操作中，本发明顺序地测量在没有信号源被接通的情况下在每个检测器处产生的光电流，其中第一信号源被接通，并且第二信号源被接通并且第一信号源被关断。 然后基于测量的光电流计算出瓶顶空间气体的CO 2吸收系数。 本发明允许补偿源老化，检测器老化和小瓶壁厚变化。 此外，本发明允许确定选定波长的绝对吸收系数，最优选约4.26μm，这是CO 2吸收特性波长。 顶部空间中绝对二氧化碳浓度的测定允许细菌生长过程的检测。 此外，所公开的源/检测器组合可以以低成本生产。 因此，在优选实施例中，本发明的装置包括多个小瓶，其通过向多个小瓶中的每一个提供其自身的源/检测器组合并且使用多路复用器/解复用器布置来激活和去激活源和检测器来同时监视 。

公开(公告)号：EP0443908A1

公开(公告)日：1991-08-28

申请号：EP91400341.3

申请日：1991-02-12

Applicant: SEXTANT AVIONIQUE S.A.

Inventor： Fima, Henri

IPC: G01L11/00 ,  G01N21/33 ,  G01K11/00

CPC classification number: G01N21/47 ,  G01L11/02 ,  G01N2021/4709 ,  G01N2201/0662

Abstract: A l'aide d'un générateur laser de raie très fine P o et par excitation d'une raie d'absorption R de l'oxygène moléculaire, on provoque un rayonnement rétrodiffusé, on mesure les énergies rétrodiffusées à deux distances différentes, on détermine le rapport de ces énergies, on en déduit un coefficient d'absorption, fonction de la température et de la densité moléculaire d'oxygène et, ayant déterminé la température de l'air, on calcule la densité et donc la pression. On excite une raie d'absorption R appartenant à une bande de Schumann-Runge de l'oxygène moléculaire et la raie d'absorption R est très large par rapport au spectre de diffusion Rayleigh.

Abstract translation: 使用激光发生器，其产生一个很细的线宝和通过吸收线的分子氧（R）的激发，背散射辐射引起的，在两个不同的距离处的后向散射的能量被测量，合成能量的比值是确定的矿洞 和吸收系数，所有这一切都为温度和氧的分子密度的函数，即源于此和中，具有确定性开采的空气，密度和压力。因此，被计算的温度。 属于分子氧的舒曼 - 龙格带的吸收线R被激发和吸收线R是非常宽相对于瑞利扩散谱。 ... ...

公开(公告)号：US20230375461A1

公开(公告)日：2023-11-23

申请号：US18230670

申请日：2023-08-07

Applicant: Beihang University

Inventor： Yanyu ZHAO ,  Yubo FAN

IPC: G01N21/17 ,  G01N21/31 ,  G01N33/49

CPC classification number: G01N21/1702 ,  G01N21/3151 ,  G01N33/492 ,  G01N2201/0662 ,  G01N2201/06146

Abstract: The embodiments of the present invention disclose a method, system, device and electronic apparatus for measuring concentration of water and lipids components. The method includes acquiring an optical absorption coefficient of a sample to be measured irradiated by a light source of at least two wavelengths, wherein a wavelength of the light source of at least two wavelengths is not greater than 1000 nm; and acquiring an extinction coefficient of water irradiated by the light source of at least two wavelengths and an extinction coefficient of lipids irradiated by the light source of at least two wavelengths; determining a concentration of water in the sample to be measured and a concentration of lipids in the sample to be measured, respectively, based on the optical absorption coefficient of the sample to be measured irradiated by the light source of at least two wavelengths, the extinction coefficient of water irradiated by the light source of at least two wavelengths, and the extinction coefficient of lipids irradiated by the light source of at least two wavelengths.

公开(公告)号：US20180120224A1

公开(公告)日：2018-05-03

申请号：US15795954

申请日：2017-10-27

Applicant: Drägerwerk AG & Co. KGaA

Inventor： Peter DREYER ,  Günter STEINERT ,  Bernd-Michael DICKS ,  Ralph-Peter JACOBI

IPC: G01N21/3504 ,  G01J5/00 ,  G01N33/497

CPC classification number: G01N21/3504 ,  A61B5/08 ,  G01J5/0014 ,  G01N33/497 ,  G01N2021/3166 ,  G01N2021/3177 ,  G01N2201/0662 ,  G01N2201/0686

Abstract: A device (1) for determining the concentration of a gas component is configured with a radiation source (30) for emitting (31) a light radiation or heat radiation in an infrared wavelength range. A detector array (40) has at least two detector elements (50, 60), configured to detect the radiation generated by the radiation source (30), in an angular arrangement (52, 62) and with filter elements (51, 61). At least one of the two detector elements (50, 60) is oriented in an angular arrangement (52, 62) in relation to a vertical axis (32), so that a range of overlap (65) is obtained due to the angular arrangements (52, 62). The range of overlap (65) causes attenuations in the propagation of light, which attenuations may be due, for example, to gas molecules or moisture (400), affect both detector elements (50, 60) and are thus compensated concerning the concentration determination.

公开(公告)号：US20170197207A1

公开(公告)日：2017-07-13

申请号：US15472327

申请日：2017-03-29

Applicant: Dale Lee Heintzelman

Inventor： Dale Lee Heintzelman

IPC: B01L3/02 ,  G01N21/59 ,  B01L9/00

CPC classification number: B01L3/0275 ,  B01L3/021 ,  B01L9/543 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0654 ,  B01L2300/0858 ,  B01L2300/123 ,  B01L2300/168 ,  G01N1/14 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/13 ,  G01N21/59 ,  G01N35/10 ,  G01N2021/0367 ,  G01N2035/1062 ,  G01N2201/0662

Abstract: This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A measuring system is provided having: a base unit with a means for locating a pipette tip; a pipette tip designed to interact with the base unit for purposes of accurate pipette tip positioning; at least one light supplying unit positioned to supply light to a liquid sample in the pipette tip and at least one light collecting unit positioned to collect light from a liquid sample in the pipette tip.

公开(公告)号：US20160377548A1

公开(公告)日：2016-12-29

申请号：US15167721

申请日：2016-05-27

Applicant: KLA-Tencor Corporation

Inventor： Romain Sappey

IPC: G01N21/64 ,  G01N21/95 ,  G01N21/88

CPC classification number: G01N21/6489 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/6495 ,  G01N2021/8845 ,  G01N2201/06113 ,  G01N2201/0662

Abstract: Defect detection and photoluminescence measurement of a sample directing a beam of oblique-illumination wavelength light onto a portion of the sample, directing a beam of normal-illumination wavelength light for causing one or more photoluminescing defects of the sample to emit photoluminescent light onto a portion of the sample, collecting defect scattered radiation or photoluminescence radiation from the sample, separating the radiation from the sample into a first portion of radiation in the visible spectrum, a second portion of radiation including the normal-illumination wavelength light, and at least a third portion of radiation including the oblique-illumination wavelength light, measuring one or more characteristics of the first portion, the second portion or the third portion of radiation; detecting one or more photoluminescence defects or one or more scattering defects based on the measured one or more characteristics of the first portion, the second portion or the third portion of radiation.

公开(公告)号：US20160341947A1

公开(公告)日：2016-11-24

申请号：US15224712

申请日：2016-08-01

Applicant: Panasonic Intellectual Property Management Co.,Ltd

Inventor： TAICHI SATO ,  YOSHIHIDE SAWADA ,  YASUHIKO ADACHI ,  HIDETO MOTOMURA

IPC: G02B21/36 ,  G02B21/06 ,  H04N5/225 ,  H04N5/232 ,  H04N5/235

CPC classification number: G02B21/365 ,  G01N21/49 ,  G01N21/59 ,  G01N2201/0662 ,  G02B21/0008 ,  G02B21/06 ,  G02B21/086 ,  G02B21/26 ,  H04N5/2256 ,  H04N5/23232 ,  H04N5/2354 ,  H04N5/2356

Abstract: An image acquisition device according to the present disclosure includes a lighting system and an irradiation direction decision section. In a module, a subject and an imaging element are integrally formed. The lighting system sequentially irradiates the subject with illumination light in a plurality of different irradiation directions based on the subject such that the illumination light transmitted through the subject is incident on the imaging element. The module acquires a plurality of images according to the plurality of different irradiation directions. Before the plurality of images are acquired according to the plurality of different irradiation directions, the irradiation direction decision section decides the plurality of different irradiation directions based on a difference between a first preliminary image and a second preliminary image. The first preliminary image is acquired when the subject is irradiated with first illumination light in a first irradiation direction, and the second preliminary image is acquired when the subject is irradiated with second illumination light in a second irradiation direction.

Abstract translation: 根据本公开的图像获取装置包括照明系统和照射方向判定部。 在模块中，主体和成像元件整体形成。 照明系统基于被摄体以多个不同的照射方向的照明光顺序照射被摄体，使得透过被摄体的照明光入射到摄像元件上。 模块根据多个不同的照射方向获取多个图像。 在根据多个不同的照射方向获取多个图像之前，照射方向判定部基于第一预备图像和第二预备图像之间的差异来决定多个不同的照射方向。 当在第一照射方向上照射第一照明光时拍摄第一预备图像，并且当在第二照射方向上照射第二照明光时获取第二预备图像。

公开(公告)号：US09470674B2

公开(公告)日：2016-10-18

申请号：US14174964

申请日：2014-02-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Darko Klinec

IPC: G01N33/49 ,  G01N21/25 ,  G01N21/31 ,  G01N21/51 ,  G01N35/10 ,  G01N15/06 ,  G01N35/02 ,  G01N21/13 ,  G01N15/04 ,  G01N35/04

CPC classification number: G01N33/491 ,  G01N15/06 ,  G01N21/13 ,  G01N21/253 ,  G01N21/3151 ,  G01N21/51 ,  G01N35/02 ,  G01N35/1016 ,  G01N2015/045 ,  G01N2015/0693 ,  G01N2035/0406 ,  G01N2035/1018 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/0668

Abstract: A method for detecting clots in a liquid is presented. The liquid is in a sample container. Light is irradiated having a first wavelength to the sample container by a first light source at a changeable vertical irradiating position (P_0 to P_n) such that the light irradiated by the first light source passes through the sample container along a first measurement path. An intensity of light having the first wavelength passing along the first measurement path and exiting the sample container is measured. Clots are detected in response to the measured intensity.

Abstract translation: 提出了一种用于检测液体中凝块的方法。 液体在样品容器中。 通过第一光源以可变的垂直照射位置（P_0至P_n）将第一波长的光照射到样品容器，使得由第一光源照射的光沿着第一测量路径通过样品容器。 测量具有沿着第一测量路径通过并离开样品容器的第一波长的光的强度。 根据测量的强度检测到凝块。

公开(公告)号：US20150148627A1

公开(公告)日：2015-05-28

申请号：US14091645

申请日：2013-11-27

Applicant: UNIVERSITEIT GENT

Inventor： Roeland BAETS ,  Eva RYCKEBOER

IPC: A61B5/145 ,  B01L3/00 ,  A61B5/1459

CPC classification number: A61B5/14532 ,  A61B5/14503 ,  A61B5/1459 ,  A61B5/150022 ,  A61B5/157 ,  A61B2562/04 ,  B01L3/5027 ,  G01N21/03 ,  G01N21/274 ,  G01N2201/0662

Abstract: A sensing system and method for sensing a component in a liquid is disclosed. The system comprises a microfluidic channel, the microfluidic channel comprising a first end and a second end, wherein the microfluidic channel is open at the first end and closed at the second end. The system also comprises at least one measurement sensor positioned adjacent the first end, the measurement sensor being arranged for detecting a measurement signal and a reference sensor positioned in the microfluidic channel adjacent the second end, the reference sensor being arranged for detecting a reference signal of the liquid. The system further is configured for combining the measurement signal and the reference signal so as to filter out background influences.

Abstract translation: 公开了用于感测液体中的组分的感测系统和方法。 所述系统包括微流体通道，所述微流体通道包括第一端和第二端，其中所述微流体通道在所述第一端开放并且在所述第二端封闭。 所述系统还包括邻近所述第一端定位的至少一个测量传感器，所述测量传感器被布置用于检测位于所述微流体通道中的测量信号和参考传感器，所述参考传感器邻近所述第二端，所述参考传感器被布置用于检测参考信号 液体。 该系统还被配置为组合测量信号和参考信号，以便滤除背景影响。