公开(公告)号：WO0020018A9

公开(公告)日：2000-08-24

申请号：PCT/US9923218

申请日：1999-10-06

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND ,  SALK INST

Inventor： LAYER RICHARD T ,  PEMBERTON-GOODMAN KAREN E ,  JONES ROBERT M ,  GARRETT JAMES L ,  OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  HILLYARD DAVID R ,  GRILLEY MICHELLE ,  WATKINS MAREN ,  SANTOS AMEURFINA D ,  ZAFARALLA GLENN ,  CRAIG A GREY

IPC: A61K38/00 ,  C07K14/435 ,  C12N15/12 ,  A61K38/12 ,  A61K38/14 ,  A61K38/17

CPC classification number: A61K38/17 ,  C07K14/43504

Abstract: The present invention is directed to kappaA ( kappa A) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The kappa A conopeptides include unglycosylated and O-glycosylated peptides.

公开(公告)号：CA2743116C

公开(公告)日：2016-06-21

申请号：CA2743116

申请日：2000-01-28

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： WATKINS MAREN ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  JONES ROBERT M ,  OLIVERA BALDOMERO M

IPC: C07K14/435 ,  C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K7/08

Abstract: The invention relates to relatively short peptides (termed .alpha.-conotoxins herein), about 10-30 residues in length having the general formula III and containing 4/7 motif, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

公开(公告)号：CA2361534C

公开(公告)日：2011-08-30

申请号：CA2361534

申请日：2000-01-28

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： WATKINS MAREN ,  OLIVERA BALDOMERO M ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  JONES ROBERT M

IPC: C07K14/435 ,  C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K7/08

Abstract: The invention relates to relatively short peptides (termed .alpha. -conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

公开(公告)号：AU2005246980A1

公开(公告)日：2006-02-02

申请号：AU2005246980

申请日：2005-12-21

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： WATKINS MAREN ,  GARRETT JAMES E ,  WALKER CRAIG S ,  MCINTOSH J MICHAEL ,  OLIVERA BALDOMERA M ,  JONES ROBERT M

IPC: C07K5/00 ,  C07H21/02 ,  G01N33/53

公开(公告)号：AU770076B2

公开(公告)日：2004-02-12

申请号：AU2973500

申请日：2000-01-28

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： WATKINS MAREN ,  OLIVERA BALDOMERO M ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  JONES ROBERT M

IPC: C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K14/435 ,  C07K14/00 ,  A61K38/10 ,  A61K38/17 ,  C07K7/08

公开(公告)号：DE69911632D1

公开(公告)日：2003-10-30

申请号：DE69911632

申请日：1999-10-20

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND ,  SALK INST FOR BIOLOG STUDIES L

Inventor： CRAIG GREY ,  GRIFFIN DAVID ,  OLIVERA M ,  WATKINS MAREN ,  HILLYARD R ,  IMPERIAL JULITA ,  CRUZ J ,  WAGSTAFF D ,  LAYER T ,  JONES M ,  MCCABE TYLER

IPC: C12N15/09 ,  A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/435 ,  C07K14/575 ,  C12N15/12 ,  A61K38/10 ,  A61K38/16

Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr 10 -contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

公开(公告)号：AU9638901A

公开(公告)日：2002-04-08

申请号：AU9638901

申请日：2001-09-28

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： MARRA MICHELLE T ,  ANDERSON BRADLEY D ,  MCCABE R TYLER

IPC: A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  C07K7/06 ,  C07K7/08

公开(公告)号：CA2416287A1

公开(公告)日：2002-01-31

申请号：CA2416287

申请日：2001-07-23

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： JACOBSEN RICHARD B ,  SHON KI-JOON ,  GARRETT JAMES E ,  WATKINS MAREN ,  MCINTOSH J MICHAEL ,  CARTIER G EDWARD ,  OLIVERA BALDOMERO M ,  JONES ROBERT M

IPC: C12N15/09 ,  A61K38/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  C07K14/435 ,  C12N15/12 ,  C07K14/47

Abstract: The invention relates to .omega.-conopeptides, derivatives or pharmaceutical ly acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents, as cardiovascular agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

公开(公告)号：CA2386555A1

公开(公告)日：2001-03-15

申请号：CA2386555

申请日：2000-09-08

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： JONES ROBERT M ,  MCINTOSH J MICHAEL ,  OLIVERA BALDOMERO M ,  WATKINS MAREN ,  GARRETT JAMES E ,  WALKER CRAIG S

IPC: C12N15/09 ,  A61K38/00 ,  A61P3/08 ,  A61P9/00 ,  A61P9/10 ,  A61P13/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/36 ,  A61P27/02 ,  A61P31/18 ,  A61P33/00 ,  A61P39/00 ,  C07K7/02 ,  C07K7/08 ,  C07K14/435 ,  C07K5/00 ,  C07H21/02 ,  G01N33/53

Abstract: The invention relates to .gamma.-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

公开(公告)号：AU2973500A

公开(公告)日：2000-08-18

申请号：AU2973500

申请日：2000-01-28

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： WATKINS MAREN ,  OLIVERA BALDOMERO M ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  JONES ROBERT M

IPC: C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K14/435 ,  C07K14/00 ,  C07K7/08 ,  A61K38/10 ,  A61K38/17

Abstract: The invention relates to relatively short peptides (termed alpha -conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.