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    Drug Delivery Medical Device
    71.
    发明申请
    Drug Delivery Medical Device 审中-公开

    公开(公告)号：US20190046695A1

    公开(公告)日：2019-02-14

    申请号：US16160157

    申请日：2018-10-15

    Applicant: Micell Technologies, Inc.

    Inventor： James B. McClain ,  Charles Douglas Taylor ,  Brett G. Zani ,  John Neet ,  Timothy Charles Kiorpes

    IPC: A61L31/08 ,  A61M25/10 ,  A61B17/12 ,  A61L29/08 ,  A61L31/16 ,  A61L29/16 ,  B05D7/24

    Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until implantable device is deployed a an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

    Drug delivery medical device
    72.
    发明授权
    Drug delivery medical device 有权

    公开(公告)号：US10188772B2

    公开(公告)日：2019-01-29

    申请号：US14437097

    申请日：2013-10-18

    Applicant: Micell Technologies, Inc.

    Inventor： James B. McClain ,  Charles Douglas Taylor ,  Meagan M. Fagan

    IPC: A61M25/00 ,  A61L29/08 ,  A61L29/16 ,  A61L29/14 ,  A61M25/10

    Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. The coating includes particles of a pharmaceutical agent. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer material. A method of releasing a pharmaceutical agent at a target site is also disclosed. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer material; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

    LOW BURST SUSTAINED RELEASE LIPOPHILIC AND BIOLOGIC AGENT COMPOSITIONS
    75.
    发明申请
    LOW BURST SUSTAINED RELEASE LIPOPHILIC AND BIOLOGIC AGENT COMPOSITIONS 审中-公开
    低爆发持续释放脂肪和生物代谢物组合物

    公开(公告)号：US20150087671A1

    公开(公告)日：2015-03-26

    申请号：US14401496

    申请日：2013-05-16

    Applicant: Micell Technologies, Inc.

    Inventor： James B. McClain ,  Charles Douglas Taylor ,  Wenda C. Carlyle

    IPC: A61K47/10 ,  A61L31/06 ,  A61L31/16 ,  A61K31/436 ,  A61K9/06

    CPC classification number: A61K47/10 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/436 ,  A61L31/06 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/602

    Abstract: A drug delivery composition including a lipophilic agent or a biologic agent and a polymer wherein the lipophilic agent exhibits sustained release and wherein there is less than 35% agent release within the first hour of elution. A drug delivery composition including a lipophilic agent or a biologic agent and a polymer wherein the elution profile is substantially linear, and wherein there is less than 35% agent release within the first hour of elution. The lipophilic agent may be crystalline and the biologic agent may be in active form.

    Abstract translation: 包含亲脂性试剂或生物制剂的药物递送组合物和其中所述亲脂性试剂显示持续释放的聚合物，其中在洗脱的第一小时内存在少于35％的药剂释放。 包含亲脂剂或生物制剂的药物递送组合物和其中洗脱曲线基本上是线性的聚合物，并且其中在洗脱的第一个小时内存在少于35％的药剂释放。 亲脂剂可以是结晶的，并且生物剂可以是活性形式。

    DRUG DELIVERY MEDICAL DEVICE
    78.
    发明申请
    DRUG DELIVERY MEDICAL DEVICE 审中-公开
    药物递送医疗设备

    公开(公告)号：US20140371717A1

    公开(公告)日：2014-12-18

    申请号：US14352664

    申请日：2012-10-18

    Applicant: Micell Technologies, Inc.

    Inventor： James B. McClain ,  Charles Douglas Taylor

    IPC: A61L29/08 ,  A61M25/10 ,  A61K31/436 ,  A61B17/12

    Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

    Abstract translation: 公开了将药剂释放到目标部位的医疗装置。 该医疗装置包括气囊和至少一部分气囊上的涂层。 药剂颗粒的每个颗粒至少部分地包封在聚合物层中。 该方法包括以下步骤：在球囊的至少一部分上提供包括球囊和涂层的装置，所述涂层包括药剂的颗粒，药剂的每个颗粒至少部分地包封在聚合物层 ; 定位设备以允许气球到达目标位置; 并使装置的气球膨胀。

    Bioabsorbable biomedical implants
    79.
    发明授权
    Bioabsorbable biomedical implants 有权

    公开(公告)号：US11039943B2

    公开(公告)日：2021-06-22

    申请号：US14207336

    申请日：2014-03-12

    Applicant: Micell Technologies, Inc.

    Inventor： James B. McClain ,  Charles Douglas Taylor

    IPC: A61F2/86 ,  A61L31/10 ,  A61L31/16 ,  A61L31/06 ,  A61L31/14

    Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 120 μm. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.

    Biopharma Application Of Micell Technology
    80.
    发明申请
    Biopharma Application Of Micell Technology 审中-公开

    公开(公告)号：US20190231691A1

    公开(公告)日：2019-08-01

    申请号：US16380186

    申请日：2019-04-10

    Applicant: Micell Technologies, Inc.

    Inventor： Wenda C. Carlyle

    IPC: A61K9/16

    CPC classification number: A61K9/1647 ,  A61K9/1676

    Abstract: Drug delivery systems are disclosed which include a drug in dry powder form and a biodegradable or metabolizable carrier having an average particle size of less than about 1 mm for delivery of the drug to a particular location in the body and for providing for the timed elution of the drug at that location, preferably by exhibiting a linear drug elution profile for a sustained drug release period of at least 30 days. Methods for manufacturing these drug delivery systems are also disclosed.

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