公开(公告)号：CA903033A

公开(公告)日：1972-06-20

申请号：CA903033D

Applicant: MICROMEDIC SYSTEMS INC

Inventor： SANZ MANUEL ,  REVILLET GEORGES

IPC: A61B10/00

公开(公告)号：CA892147A

公开(公告)日：1972-02-01

申请号：CA892147D

Applicant: MICROMEDIC SYSTEMS INC

Inventor： SANZ MANUEL ,  REVILLET GEORGES

公开(公告)号：CH505380A

公开(公告)日：1971-03-31

申请号：CH385469

申请日：1969-03-14

Applicant: MICROMEDIC SYSTEMS INC

Inventor： MANUEL SANZ

IPC: G01J1/30 ,  G01N21/24

公开(公告)号：CH495555A

公开(公告)日：1970-08-31

申请号：CH1239968

申请日：1968-08-16

Applicant: MICROMEDIC SYSTEMS INC

Inventor： BIO-ING SANZ MANUEL DR ,  RENE WEBER

IPC: A61B5/155 ,  B01L3/00 ,  B01L3/02 ,  F04B7/00 ,  F04B53/00 ,  G01N1/00 ,  G01N1/18 ,  G01N1/14

公开(公告)号：IL34113D0

公开(公告)日：1970-05-21

申请号：IL3411370

申请日：1970-03-19

Applicant: MICROMEDIC SYSTEMS INC

IPC: G01N33/49 ,  G04F8/00

Abstract: 1310246 Determination of coagulation time of blood samples MICROMEDIC SYSTEMS Inc 19 March 1972 [19 March 1969] 13252/70 Heading B1X [Also in Divisions G1 and G3] Apparatus for measuring the coagulation time of a blood sample in a container 1, 2 equipped with a stirrer and supported on heatable turntable 52 comprises (Fig. 1) electric motor M, a rotatable drive assembly comprising two coaxial drive shafts 38, 31, shaft 38 being connectable to the stirrer and shaft 31 being drivable by the motor through bevel gears 29, 30 shaft 38 (Fig. 4) being capable of limited rotational movement relative to shaft 31 between first and second angular positions, friction means which may comprise spring 36 with its lower end engaging gear 30 when shaft 38 has been manually lowered to lower the stirrer into the container, the friction means holding the shaft 38 in its first position until the sample coagulates, the circuit to the motor M including a switch the movable part of which may be spring 36, the disengagement of the end of the spring from gear 30 when coagulation of the sample increases the drag on shaft 38 and moves it to its second angular position operating automatically to break the circuit and stop motor M, and means for example counter 19 for measuring the time of operation of the motor. In the apparatus shown, shaft 38 is lowered to engage the stirrer in the sample container by manual operation of rod 23. Shaft 38 carries key 37 to move in a slot (35) in the outer shaft 31 until it bears against the lower end of spring 36 forcing it into contact with gear 30 and so starting the motor. Containers 1, 2 may be prepacked with reagents for use in the test as in Specification 1310245.

公开(公告)号：NL178486B

公开(公告)日：1985-11-01

申请号：NL7612395

申请日：1976-11-08

Applicant: MICROMEDIC SYSTEMS INC

IPC: B65G35/06 ,  B01L9/06 ,  B25B7/00 ,  C01G9/06 ,  G01N1/00 ,  G01N35/04

Abstract: A guide rail or track system for guiding test tube holders or racks from one station to another, e.g., in a mono-channel analyzer, for presenting test tubes in such holders in sequence to one or more servicing operations at a plurality of stations. The rail system may comprise a main linear guide rail along which a holder having a row of test tubes supported therein is adapted to be moved longitudinally stepwise to present each test tube in the holder in sequence to a given station, or a given position therein, where an operation is to be carried out with respect to each test tube as it is presented in the station. Arranged at right angles to the main rail, one or more branch rails leading to or from other service stations are provided at spaced intervals and the main rail at each juncture or intersection of these rails is constructed to allow a lateral shift of the holder (also specially constructed to allow such shift) to or from the main rail respectively from or to the branch rail along which the holder moves laterally, i.e., the lengthwise dimension of the holder extends across the branch rail at right angles to it as the test tube holder moves along the branch rail, which may terminate at a junction or intersection with another or subsidiary rail or guideway along which the holder moves longitudinally in a direction parallel to the main rail. Means is provided for moving the holder along the main rail and means is provided at the junction of a branch rail with an intersecting rail such as the main rail, for laterally shifting the holder from the junction.

公开(公告)号：CA1014530A

公开(公告)日：1977-07-26

申请号：CA207864

申请日：1974-08-27

Applicant: MICROMEDIC SYSTEMS INC

Inventor： DOWNING HARVEY T ,  STURGIS BYRON E

IPC: A61M5/20 ,  G01F11/04

Abstract: The invention is concerned with a novel container for receiving a liquid material having a fitting at one end adapted to provide a discharge port for the liquid within the container and having at its other end a plunger or piston adapted to be moved within the inside wall of the container to discharge one or more predetermined "aliquots" or "doses" of liquid from the container through the port. The invention also comprises a novel device adapted to receive a liquid-containing cartridge or package of the type just mentioned and having means for coacting with the package to move the plunger within the container during dose-dispensing or -discharge in such a manner as to gradually accelerate movement of the plunger from a position of rest within the container through a maximum rate of motion and then gradually decelerate the motion of the plunger to a final position at the end of the dose-discharge. The device also comprises means for accurately predetermining or "measuring" the amount of liquid discharged during each individual movement of the plunger. The device may comprise means for repeatedly actuating the piston with an accelerating-decelerating movement to discharge a plurality of measured samples repeatedly under non-spurt and non-splash conditions.

公开(公告)号：FR2247709B1

公开(公告)日：1976-10-22

申请号：FR7433870

申请日：1974-10-08

Applicant: MICROMEDIC SYSTEMS INC

IPC: A61M5/20 ,  G01F11/04 ,  G01F11/06 ,  B65D85/72

Abstract: The invention is concerned with a novel container for receiving a liquid material having a fitting at one end adapted to provide a discharge port for the liquid within the container and having at its other end a plunger or piston adapted to be moved within the inside wall of the container to discharge one or more predetermined "aliquots" or "doses" of liquid from the container through the port. The invention also comprises a novel device adapted to receive a liquid-containing cartridge or package of the type just mentioned and having means for coacting with the package to move the plunger within the container during dose-dispensing or -discharge in such a manner as to gradually accelerate movement of the plunger from a position of rest within the container through a maximum rate of motion and then gradually decelerate the motion of the plunger to a final position at the end of the dose-discharge. The device also comprises means for accurately predetermining or "measuring" the amount of liquid discharged during each individual movement of the plunger. The device may comprise means for repeatedly actuating the piston with an accelerating-decelerating movement to discharge a plurality of measured samples repeatedly under non-spurt and non-splash conditions.

公开(公告)号：GB1444807A

公开(公告)日：1976-08-04

申请号：GB3718773

申请日：1973-08-06

Applicant: MICROMEDIC SYSTEMS INC

IPC: G01T7/08 ,  G01N1/00

Abstract: A sample measuring device, for example for measuring the radio-activity of a number of samples, comprises a carriage movable along first guides, and a slide movable along second guides on the carriage, the second guides extending transversely to the first guides. A vertically movable grab is carried by the slide and can be positioned, by movement of the carriage and slide, over a sample holder, a plurality of sample holders being arranged in rows in a stationary rack. The grab is arranged to remove the sample holder from the rack, to carry the sample holder to a measuring position and then to return the sample holder to its former position in the rack. The grab is moved by a control program to transfer each sample holder between the rack and the measuring position.

公开(公告)号：GB1435382A

公开(公告)日：1976-05-12

申请号：GB1956673

申请日：1973-04-25

Applicant: MICROMEDIC SYSTEMS INC

IPC: G01N21/27 ,  G01N33/483 ,  G06J1/00 ,  H03M1/00 ,  G01N21/22

Abstract: 1435382 Spectrophotometers MICROMEDIC SYSTEMS Inc 25 April 1973 [28 April 1972] 19566/73 Heading G1A [Also in Division G4] The output of a spectrophotometer is multiplied by a factor to correct for any changes in the test sample which may have occurred from the time the sample was taken, the factor being initially set by inserting a standard sample in the spectrophotometer, comparing the multiplied output signal with a pre-selected standard value and changing the multiplying factor in accordance therewith until the two signals are equal. Spectrophotometer, Fig. 1 A beam of white light 101 from lamp 104 is reflected by spherical mirror 108 on to a grating 201, the angle of which is adjustable about vertical axis 209 by micrometer screw 212 to select the required wavelength passing through aperture 202. The monochromatic beam 102 after passing through one of the pre-selected ultraviolet 203, infrared 204 or white light 206 filters is scanned to and fro across the ends of reference liquid (blank) cuvette 301 and sample liquid cuvette 302 by scanner 400. Scanner 400 comprises a pair of plates 401, 402 of rectangular cross-section arranged in overlapping cross-wise superposition, Fig. 2 (not shown) and held at one end in support 407 connected to lever 408 pivotable about horizontal axis 409 by the action of eccentric 410 driven by motor 411. Thus optical plates 401, 402 describe an up and down movement so that they are inserted alternately in path 102 and the light beam is shifted alternately between one position in alignment with cuvette 301 and another position in alignment with cuvette 302. After passing through the cuvettes the light beams are refracted by prism 502 on to the same spot of photo-multiplier 501, the output of which is connected to processing circuit 700. Processing circuit, Fig. 3 The photo-multiplier 501 output is amplified at 701, provided with a feedback circuit 702 for dark current compensation, and applied to one or other of capacitors 712, 713 dependent upon the position of switches 798, 799 which are controlled by synchronization pulses from pulse generator 706 which is under the control of pulses from coils 605, 606 of synchronization generating means 600, Fig. 1 indicating which of the two paths the light beam 102 lies. The output current from 501 charges capacitor 712 when the light passes through the reference cuvette and charges capacitor 713 when it passes through the sample cuvette. The capacitor voltages are compared in respective comparators 716, 717 with an exponential waveform from generator 722 to provide rectangular pulses having a time duration proportional to the log of the ratio between the voltages on lines 714, 715 and the peak voltage from generator 722. Gate 725 acts as a subtractor and provides a rectangular pulse the duration of which is proportional to the log of the ratio between the signals on 714, 715 i.e. the attenuation of the light beam in the sample compared with the reference. The pulse is digitized at 726 and applied via drift correcting circuit 729 to counter 801. Drift correcting circuit 729 Fig. 4 (not shown) The pulse train generated by the digitizer is applied to a multiplier which multiplies the pulses by a factor less than one to compensate for changes in the sample. The factor is set by first filling the sample cuvette with a standard test sample solution i.e. one which may have changed due to chemical action (urea, blood) and applying the digitized output to the multiplier, the output from which is then compared in a digital comparator with a pre-selected number e.g. the value of the attenuation or concentration of the standard used for initial calibration of the spectrophotometer. An up/down converter determining the multiplying factors counts up, does not count, or counts down according to whether the digital number inputed to the comparator is greater than, equal to, or lower than the predetermined value. The value of the multiplying factor is changed until equality exists between the multiplied factor and the pre-set value when the factor is fixed for subsequent measurements of samples in the sample cuvette. In order to decrease the time to bring about equality the up/down counter has its contents modified in greater steps at the beginning and then in steps of successively reduced magnitude as the correction proceeds. The output of the up/down counter is also connected to a threshold detector which monitors the amount of correction needed and sounds an alarm if it exceeds predetermined upper and lower limits Fig. 6 (not shown). The standard sample may be periodically placed in the sample cuvette to determine the amount of correction needed.