公开(公告)号：US3869729A

公开(公告)日：1975-03-11

申请号：US31948072

申请日：1972-12-29

Applicant: NAT RES DEV

Inventor： ATTENBOROUGH CHRISTOPHER GEORG

IPC: A61F2/00 ,  A61F2/38 ,  A61F2/42 ,  A61F1/24

CPC classification number: A61F2/4241 ,  A61F2/3854 ,  A61F2002/30354 ,  A61F2220/0033

Abstract: An endoprosthetic bone joint device, suitable for the knee or other joints, is provided by way of two components of which one is slotted to receive in captive rotatable engagement therein a linkage member projecting from the other. In the direction of the slot, the slotted component has a generally convex bearing surface which engages a similarly directed concave bearing surface on the other component, but in an orthogonal direction the former surface can present two raised portions to engage respective depressions in the latter surface and resulting in a rib and groove along each side of the slot. This double rib groove formation is appropriate to a knee joint device, but can be simplified to singular curvature for another joint such as a finger. Also, the lateral dimension of the slot can progressively vary to allow a progressively varying lateral rocking capability with rotation of the components.

Abstract translation: 适于膝盖或其他关节的假体内骨关节装置通过两个部件提供，其中一个部件被开槽以在其中可自由转动地接合在另一个中的连接部件。 在狭槽的方向上，开槽部件具有大致凸起的支承表面，该表面接合另一部件上的相似方向的凹形支承表面，但是在正交方向上，前者表面可以呈现两个凸起部分以与后面的相应的凹陷 并且沿着槽的每一侧产生肋和凹槽。 这种双肋槽形成适合于膝关节装置，但是可以简化为另一关节（例如手指）的单一曲率。 此外，槽的横向尺寸可以逐渐变化，以允许随着部件旋转而逐渐变化的横向摆动能力。

公开(公告)号：US3869437A

公开(公告)日：1975-03-04

申请号：US39021673

申请日：1973-08-21

Applicant: NAT RES DEV

Inventor： LINDSAY DAVID GORDON ,  SHALL SYDNEY

IPC: A61K38/00 ,  C07K14/62 ,  C07C103/52 ,  A61K17/02 ,  C07G7/00

CPC classification number: C07K14/62 ,  A61K38/00

Abstract: A physiologically acceptable insulin derivative has the terminal amino group of the B chain (B1, phenylalanine) protected by an acyl group or other blocking group containing up to seven carbon atoms and the amino group of the A chain (A1, glycine) is either free or protected by means of an acyl or other blocking group containing no more than four carbon atoms and preferably no more than three atoms other than hydrogen. Pharmaceutical preparations may be prepared containing an effective amount of such an insulin derivative together with a physiologically acceptable diluent. An insulin derivative of reduced antigenicity is obtainable from porcine or bovine insulin by reacting the insulin with an acylating agent or other blocking reagent to acylate or otherwise block the amino group of the B1 amino acid and optionally block the A1 and/or B29 amino acid, followed by purification of the derivative by various methods.

Abstract translation: 生理上可接受的胰岛素衍生物具有由酰基或其它含有至多7个碳原子的封闭基保护的B链（B1，苯丙氨酸）的末端氨基，A链（A1，甘氨酸）的氨基是游离的 或通过含有不超过四个碳原子，优选不超过三个除了氢原子的酰基或其它封闭基团来保护。 可以制备含有有效量的这种胰岛素衍生物和生理上可接受的稀释剂的药物制剂。 降低抗原性的胰岛素衍生物可通过使胰岛素与酰化剂或其它阻断试剂反应来从猪或牛胰岛素获得，以酰化或以其它方式阻断B1氨基酸的氨基并任选地阻断A1和/或B29氨基酸， 然后用各种方法纯化衍生物。

公开(公告)号：US3868357A

公开(公告)日：1975-02-25

申请号：US22106072

申请日：1972-01-26

Applicant: NAT RES DEV

Inventor： SMYTH DEREK GEORGE ,  KO ARTHUR SAI CHUN

IPC: A61K38/00 ,  C07K14/62 ,  C07K14/625 ,  C07C103/52 ,  A61K17/02 ,  C07G7/00

CPC classification number: C07K14/62 ,  A61K38/00 ,  C07K14/625

Abstract: Insulin derivatives which are water soluble, readily isolated, immunologically acceptable and which retain hypoglycaemic activity are those in which at least one of the A1, B1 and B29 aminoacid amino groups is converted into a blocked amino group having a substituent capable of forming an anion, e.g., by substitution with dicarboxylic acid radicals.

Abstract translation: 水溶性，易分离，免疫学可接受且保持低血糖活性的胰岛素衍生物是其中A1，B1和B29氨基酸氨基中的至少一个转化为具有能够形成阴离子的取代基的封闭氨基的那些， 例如，用二羧酸基取代。

公开(公告)号：US3863276A

公开(公告)日：1975-02-04

申请号：US22752872

申请日：1972-02-17

Applicant: NAT RES DEV

Inventor： AGNEW KENNETH MALCOLM ,  COWARD TIMOTHY ,  TOMKIN DOUGLAS FRAZER

IPC: A47K13/00 ,  G03D9/00 ,  A47K11/02 ,  G03D11/00

CPC classification number: A47K13/00

Abstract: A seat for sanitary equipment such as water closets and commodes, has an elongated aperture extending between the front and rear, two non-planar profiled areas bordering the sides of the aperture towards its front, and a relieved area bordering the aperture behind the two areas. The profiled areas are trough formations to receive and support the thighs, and the relieved area is U-shaped and dished around the aperture to clear the buttocks. In a commode, such a seat conveniently forms part of a platform including at least one supplementary seating area extending laterally from the seat, there preferably being two such areas to form wings in an overall configuration which is curved or angled in plan view. Other features associated with such a commode comprise a user support arrangement upstanding from the platform rear and including a back rest and hand rail/arm rests, and also legs with rollers which can be rendered effective or not, the legs and support arrangement being adjustable in height and, in the latter case, angular disposition.

Abstract translation: 用于卫生设备（例如水厕和垃圾）的座椅具有在前后之间延伸的细长孔，两个非平面轮廓区域邻近孔的侧面朝向其前部，以及与两个区域后面的孔对接的缓解区域 。 形状区域是接收和支撑大腿的槽形结构，缓解区域是U形的，并围绕孔径抛出以清除臀部。 在通风口中，这样的座位可方便地形成平台的一部分，该平台包括至少一个从座椅横向延伸的辅助座位区域，优选地具有两个这样的区域以形成在俯视图中弯曲或成角度的整体构造的翼。 与这种接头相关联的其他特征包括从平台后部竖立的用户支撑装置，并且包括靠背和手扶轨/扶手，以及具有可以有效或无效的滚轮的腿，腿和支撑装置可调节 高度，在后一种情况下，角度配置。

公开(公告)号：US3862425A

公开(公告)日：1975-01-21

申请号：US33826273

申请日：1973-03-05

Applicant: NAT RES DEV

Inventor： MYERS MELVYN JOHN

IPC: G01T1/164 ,  G01T1/29 ,  G21K1/02 ,  G01T1/20

CPC classification number: G01T1/2985 ,  A61B6/4258 ,  G01T1/1642 ,  G21K1/025

Abstract: A radiation position detector is described particularly for detecting the source of gamma radiation over which a gamma camera is scanned. Electrical signals are generated representing the coordinates of the focal point of the gamma camera and of the received radiation. The received radiation signals are multiplied by a compensating factor to correct for a particular depth of radiation so that radiation starting at that depth is in focus. The corrected signals and the camera co-ordinate signals are combined so that a picture can be obtained in focus for the particular depth. Multiplexing may be used to provide correction for a plurality of depths.

Abstract translation: 特别地描述了一种辐射位置检测器，用于检测伽马照相机被扫描的伽马辐射源。 产生电信号，表示γ照相机的焦点和所接收的辐射的坐标。 所接收的辐射信号乘以补偿因子以校正特定的辐射深度，使得从该深度开始的辐射是焦点。 校正的信号和相机坐标信号被组合，使得可以获得针对特定深度的图像。 多路复用可用于为多个深度提供校正。

公开(公告)号：US3859106A

公开(公告)日：1975-01-07

申请号：US27542072

申请日：1972-07-26

Applicant: NAT RES DEV

Inventor： MAJUMDAR AMALENDU JYOTI

IPC: C03C13/00 ,  C04B14/42 ,  C04B7/34

CPC classification number: C04B14/42 ,  C03C13/002

Abstract: An autoclaved calcium silicate product comprises reinforcing fibres of an alkali-resistant glass containing zirconia.

Abstract translation: 高压灭菌的硅酸钙产品包括含氧化锆的耐碱玻璃的增强纤维。

公开(公告)号：US3840014A

公开(公告)日：1974-10-08

申请号：US29115972

申请日：1972-09-22

Applicant: NAT RES DEV

Inventor： LING R ,  LEE A

IPC: A61B17/02 ,  A61B17/28 ,  A61B17/88

CPC classification number: A61B17/8866 ,  A61B17/025 ,  A61B17/2833

Abstract: Surgical apparatus for separating the femur from the acetabulum, such as in total hip joint replacement by the Southern Approach, takes the form of an inverse pair of tongs which open when the handles are closed. More particularly, the free ends of the tongs respectively carry a pin and a hook which extend in a generally orthogonal direction relative to their respective tong arms and the plane of movement therebetween, while the bight of the hook extends away from its arm.

Abstract translation: 用于将股骨与髋臼分离的手术装置，例如通过Southern Approach进行的全髋关节置换时，采用逆向对的钳子的形式，当手柄关闭时打开。 更具体地，钳子的自由端分别具有销和钩，钩和钩相对于它们各自的钳臂和它们之间的运动平面在大致正交的方向上延伸，而钩的弯曲远离其臂。

公开(公告)号：US3817634A

公开(公告)日：1974-06-18

申请号：US23040672

申请日：1972-02-29

Applicant: NAT RES DEV

Inventor： BARRON L ,  BUCKINGHAM A

IPC: G01J4/04 ,  G01N21/21 ,  G01N21/65 ,  G01J3/44

CPC classification number: G01N21/21 ,  G01J4/04 ,  G01N21/65 ,  G01N2021/4792

Abstract: In testing a sample of an optically active substance, the sample is irradiated with polarized electromagnetic radiation and the intensity of radiation scattered from the sample in a given direction is detected. The state of polarization of the incident radiation from which the detected radiation is derived is modulated, preferably by alternating it between right and left circular polarization, to cause a periodic variation of the detected intensity, and a signal related to this variation is derived.

Abstract translation: 在测试光学活性物质的样品时，用极化电磁辐射照射样品，并且检测从给定方向上从样品散射的辐射强度。 检测出的辐射源的入射辐射的偏振状态优选地通过在右和左圆极化之间进行交替调制，以引起检测强度的周期性变化，导出与该变化有关的信号。

公开(公告)号：US3816855A

公开(公告)日：1974-06-18

申请号：US25791072

申请日：1972-05-30

Applicant: NAT RES DEV

Inventor： SALEH B

IPC: A61F2/38 ,  A61F1/24

CPC classification number: A61F2/38 ,  Y10S264/30

Abstract: A prosthetic knee joint device comprises a femoral component in the form of a shell member having two condylar portions with major convex bearing surfaces areas, which portions are bridged at one end by a portion defining a trough between the convex areas. An associated tibial component has similar portions in a platform bearing member defining major concave bearing surface areas and a ridge therebetween. The convex bearing areas are longer than the concave bearing areas and generally U-shaped longitudinally to simulate the corresponding shaping in the natural joint from which the shell member can in fact be derived. The concave bearing areas however simulate the menisci of the natural joint different phases of rotation to provide an optimized congruity between the bearing surfaces during rotation of the predetermined geometry of the prosthesis as compared to the variable geometry in the natural joint.

Abstract translation: 假体膝关节装置包括具有两个具有主凸起轴承表面区域的两个髁部分的外壳构件形式的股骨部件，该部分在一端由在凸区域之间限定槽的部分桥接。 相关联的胫骨部件在平台支承构件中具有相似的部分，其限定主凹入支承表面区域和其间的脊。 凸起的承载区域比凹入的承载区域长，并且大致为U形的纵向以模拟天然接头中相应的成形，壳体构件实际上可由该凹槽导出。 然而，凹形轴承区域模拟天然接头不同旋转相位的弯矩，从而在假体的预定几何形状的旋转期间在天然接头中的可变几何形状之间在轴承表面之间提供优化的一致性。

公开(公告)号：US3812743A

公开(公告)日：1974-05-28

申请号：US32615073

申请日：1973-01-23

Applicant: NAT RES DEV

Inventor： SHAW A ,  MC KIE J

IPC: A61B17/32 ,  B25B7/02

CPC classification number: A61B17/3217 ,  Y10T29/537 ,  Y10T29/539

Abstract: A tool for separating detachable blades from surgical scalpels takes the form of a pair of pliers having a respective channel formation in each jaw, the side walls of which formations approach engagement in mutually facing and aligned disposition during closure of the tool to define a passageway therethrough. This passageway receives the stem portion of a holder on which a conventional detachable scalpel blade is clipped, and the side walls of one of the channel formations are relieved towards one end thereof, and the side walls of the other formation elevated towards the corresponding end thereof, so that closure of the tool jaws grips the blade while lifting one end of the blade from the holder. The blade can then be slid off the holder while still held by the tool.

Abstract translation: 用于从手术手术刀分离可拆卸刀片的工具采取在每个钳口中具有相应通道形成的一对钳子的形式，其中，在工具闭合期间，它们的侧壁在工具关闭期间接合相互面对并且对准的配置，以限定穿过其中的通道 。 该通道容纳固定器的杆部，其上固定有常规的可拆卸手术刀刀片，并且其中一个通道结构的侧壁朝向其一端释放，并且另一组织的侧壁朝向其相应的端部 ，使得工具夹的闭合将刀片的一端从保持器提起，从而夹持刀片。 然后，刀片可以在仍然被工具握住的同时从支架滑出。