公开(公告)号：US11324831B2

公开(公告)日：2022-05-10

申请号：US15585228

申请日：2017-05-03

Applicant: TOAGOSEI CO., LTD ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Ikuhiko Nakase ,  Tetsuhiko Yoshida ,  Nahoko Baileykobayashi

IPC: A61K47/46 ,  A61K38/18 ,  A61P35/00 ,  A61P43/00 ,  A61K9/50

Abstract: Provided is a novel material used to introduce an exogenous substance into cells. Also provided is a method for introducing an exogenous substance into target cells using this material. The present invention provides an exosome that is used to introduce an exogenous substance into target cells, wherein the exosome contains one type or two or more types of an exogenous substance and a substance that induces macropinocytosis in the target cells. The present invention also provides a composition containing the exosome and a method for introducing an exogenous substance into cells using this exosome.

公开(公告)号：US20190239793A1

公开(公告)日：2019-08-08

申请号：US16333285

申请日：2017-01-26

Applicant: Sharp Kabushiki Kaisha ,  Osaka Prefecture University Public Corporation

Inventor： Tetsuya HAYASHI ,  Hiroshi SAKAYA ,  Azusa NAKANO ,  Syunsuke SHIMAMURA ,  Terumasa SHIMADA

IPC: A61B5/16 ,  A61B5/044 ,  A61B5/0468 ,  A61B5/00

CPC classification number: A61B5/165 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/7235 ,  A61B2503/40

Abstract: A state acquisition computer is provided that includes an interface configured to acquire data for indicating an inter-beat interval of an animal, and a processor configured to convert a Poincare plot of inter-beat intervals into a prescribed coordinate system, and based on a standard deviation of the Poincare plot after conversion, acquire information indicating a psychological state or a physical state of the animal.

公开(公告)号：US20190209073A1

公开(公告)日：2019-07-11

申请号：US16299405

申请日：2019-03-12

Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION ,  EuSense Medical Co., Ltd. ,  HYOGO COLLEGE OF MEDICINE ,  J craft Co., Ltd.

Inventor： Michifumi Yoshioka ,  Katsufumi Inoue ,  Yoshitaka Oku

IPC: A61B5/00 ,  A61B5/08 ,  G06N20/10

CPC classification number: A61B5/4205 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/7257 ,  A61B5/7275 ,  A61B10/00 ,  G06N20/10

Abstract: A swallowing diagnosis apparatus includes a controller which enables a first swallowing determination process of determining whether or not there is an aspiration risk in the swallowing on the basis of respiratory phases before and after a period in which swallowing has been estimated as having occurred; and a second swallowing determination process of extracting reference information including at least one of the sound information and the respiration information in a predetermined period including the period in which swallowing has been estimated as having occurred, obtaining a feature quantity from the extracted reference information, and performing a machine learning process on the obtained feature quantity to determine whether or not there is a possibility of dysphagia in the swallowing; and a display control process of causing a determination result obtained by the first swallowing determination process and a determination result obtained by the second swallowing determination process to be displayed.

公开(公告)号：US10344042B2

公开(公告)日：2019-07-09

申请号：US15625909

申请日：2017-06-16

Applicant: Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

Inventor： Hiroshi Takenaka ,  Yoichiro Ohta ,  Yusuke Taguchi ,  Sayuri Ueda ,  Yuko Ishino ,  Tomohiro Yoshikawa ,  Hideki Nakashima ,  Kohki Uehara ,  Mitsunori Kirihata

IPC: C07F5/02 ,  C07C271/22 ,  C07C229/36 ,  C07C251/24

Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N═N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C═N, in which NR40R50 are together.

公开(公告)号：US20180245191A1

公开(公告)日：2018-08-30

申请号：US15901941

申请日：2018-02-22

Applicant: HONDA MOTOR CO., LTD. ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Kazuki Nagao ,  Yusuke Kikuchi ,  Masahiro Hayashi ,  Takayuki Takasugi ,  Yasuyuki Kaneno

IPC: C22F1/10 ,  C22C19/03 ,  C22C1/02

Abstract: There is provided a Ni-based intermetallic alloy having a dual multi-phase microstructure containing a primary precipitate L12 phase and an (L12+D022) eutectoid microstructure. Thus, the Ni-based intermetallic alloy contains Ni, Al, and V as basic elements, and the contents of Ni, Al, and V are controlled to form the dual multi-phase microstructure. The Ni-based intermetallic alloy further contains at least one of Zr and Hf in addition to the basic elements.

公开(公告)号：US10005794B2

公开(公告)日：2018-06-26

申请号：US15105401

申请日：2014-12-16

Applicant: Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

Inventor： Hiroshi Takenaka ,  Yoichiro Ohta ,  Yusuke Taguchi ,  Sayuri Ueda ,  Yuko Ishino ,  Tomohiro Yoshikawa ,  Hideki Nakashima ,  Kohki Uehara ,  Mitsunori Kirihata

IPC: C07F5/02 ,  C07C271/22 ,  C07C229/36 ,  C07C251/24

CPC classification number: C07F5/027 ,  C07C229/36 ,  C07C251/24 ,  C07C271/22 ,  Y02P20/55

Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N═N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C═N, wherein NR40R50 are together.)

公开(公告)号：US09793499B2

公开(公告)日：2017-10-17

申请号：US15314648

申请日：2015-06-09

Applicant: Tanaka Kikinzoku Kogyo K.K. ,  Osaka Prefecture University Public Corporation

Inventor： Yasushi Masahiro ,  Shigeyuki Yagi ,  Junichi Taniuchi

IPC: C07F15/00 ,  H01L51/50 ,  H01L51/00 ,  C09K11/02 ,  C09K11/06

CPC classification number: H01L51/0085 ,  C07F15/0033 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1088 ,  C09K2211/1092 ,  C09K2211/185 ,  H01L51/5016

Abstract: The present invention provides an organic metal complex having high heat resistance while making it possible to realize electroluminescence with high quantum efficiency as a light-emitting material for organic electroluminescent (EL) element. The present invention relates to an organic iridium complex for an organic EL element, wherein a C—N ligand including a substituent of a tricyclic-based structure obtained by condensing a heterocyclic ring and two benzene rings, and a β-diketone ligand composed of a propane-1,3-dione having two tert-butyl-substituted phenyl groups are coordinated with an iridium atom. The complex of the present invention has high heat resistance and contributes to lifetime prolongation of the organic EL element.

公开(公告)号：US20170063185A1

公开(公告)日：2017-03-02

申请号：US15122476

申请日：2015-03-04

Applicant: DAIKIN INDUSTRIES, LTD. ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Toshinari KONDOU ,  Masayuki SANADA ,  Shigeo MORIMOTO ,  Yukinori INOUE

IPC: H02K1/27 ,  H02K1/02

CPC classification number: H02K1/276 ,  H02K1/02 ,  H02K2213/03

Abstract: Satisfactory magnet torque is achieved while avoiding a reduction in the reluctance torque generated. The rotor core is provided with a plurality of magnet slots arranged in the circumferential direction of the rotor core and a gap formed of base holes and a projecting hole. The base holes extend from both ends in the circumferential direction of each magnet slot to the outer side of the rotor core. The projecting hole projects in the circumferential direction of the rotor core from at least one of peripheral portions, opposed to each other, of the base holes provided at both of the ends of the magnet slot, when viewed in an axial direction. The projecting hole is located closer to the magnet slot than to an outer peripheral side end of the base hole.

Abstract translation: 在避免产生的磁阻转矩降低的同时实现令人满意的磁力矩。 所述转子铁芯具有沿所述转子铁心的圆周方向配置的多个磁铁槽和由基座孔和突出孔形成的间隙。 基孔从每个磁体槽的圆周方向的两端延伸到转子芯的外侧。 所述突出孔从所述转子铁芯的圆周方向上从设置在所述磁体槽的两端的所述基座的相对的周向部分中的至少一个沿轴向观察而突出。 突出孔比基座孔的外周侧更靠近磁体槽。

公开(公告)号：US09422341B2

公开(公告)日：2016-08-23

申请号：US14377748

申请日：2013-02-07

Applicant: Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

Inventor： Mitsunori Kirihata ,  Kohki Uehara

IPC: C07K11/02 ,  C07C229/08 ,  C07C235/12 ,  C07K14/32 ,  C07C229/24 ,  C07D273/00 ,  C07C237/12 ,  C07K11/00

CPC classification number: C07K11/02 ,  C07C229/08 ,  C07C229/24 ,  C07C235/12 ,  C07C237/12 ,  C07D273/00 ,  C07K11/00 ,  C07K14/32

Abstract: The purpose of the present invention is to provide a novel method for producing cereulide and a derivative thereof; an intermediate for cereulide; and a novel cereulide derivative. A novel didepsipeptide, a novel tetradepsipeptide, a novel octadepsipeptide and a novel dodecadepsipeptide are prepared. A linear precursor of cereulide or a derivative thereof, which is composed of any one of the novel depsipeptides, is cyclized by forming an intramolecular amide bond.

Abstract translation: 本发明的目的是提供一种制备大戟素及其衍生物的新方法; 大众中间物 和一种新型的cereulide衍生物。 制备了一种新型的七叶皂苷肽，一种新型的四肽类，一种新的十八肽和一种新的十二十一生物肽。 通过形成分子内酰胺键将由任何一种新的缩肽组成的大脑或其衍生物的线性前体环化。

公开(公告)号：US09409926B2

公开(公告)日：2016-08-09

申请号：US14435678

申请日：2013-10-08

Applicant: Osaka Prefecture University Public Corporation ,  Stella Pharma Corporation

Inventor： Hiroshi Takenaka ,  Yoichiro Ohta ,  Yusuke Taguchi ,  Sayuri Ueda ,  Yuko Ishino ,  Hideki Nakashima ,  Kohki Uehara ,  Mitsunori Kirihata

IPC: C07F5/02 ,  C07C229/08 ,  C07F5/04 ,  C07C229/36 ,  C07B59/00 ,  C07C271/22 ,  C07C251/24

CPC classification number: C07F5/025 ,  C07B59/001 ,  C07C229/08 ,  C07C229/36 ,  C07C251/24 ,  C07C271/22 ,  C07F5/027 ,  C07F5/04 ,  Y02P20/55

Abstract: Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18F-2-fluoro-4-borono-L-phenylalanine (18F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR3R4, BX3− or BX3−M+ (wherein X represents a halogen atom, and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R1 represents a hydrogen atom or a protecting group PG1; R2 represents a hydrogen atom or a protecting group PG2; R3 and R4 independently represent OH, or R3, R4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO2, NH2, Sn(R6)3, N═N—NR7R8, OSO2R9, NR10R11, a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18F-labeled BPA.

Abstract translation: 提供：新型手性4-硼苯丙氨酸（BPA）衍生物; 一种制备衍生物的方法; 以及使用该衍生物制备18F-2-氟-4-硼羟-L-苯丙氨酸（18F标记的BPA; 18F-BPA）的方法。 制备由式（1）表示的化合物。 在该式中，R表示BR 3 R 4，BX 3 - 或BX 3 -M +（其中X表示卤原子，M +表示一价单原子阳离子，多原子阳离子或络合阳离子）。 R1表示氢原子或保护基PG1; R2表示氢原子或保护基PG2; R3和R4独立地表示OH，或R3，R4和B一起形成用作保护基的环; Y表示卤素原子，NO 2，NH 2，Sn（R 6）3，N = N-NR 7 R 8，OSO 2 R 9，NR 10 R 11，取代或未取代的苯基碘基或取代或未取代的杂环碘基。 使化合物与氟化试剂反应以制备18F标记的BPA。