公开(公告)号：WO2010112820A1

公开(公告)日：2010-10-07

申请号：PCT/GB2010/000580

申请日：2010-03-26

Applicant: THE SCIENCE AND TECHNOLOGY FACILITES COUNCIL ,  STEVENS, Robert

Inventor： STEVENS, Robert

IPC: D01D5/00 ,  D01D5/30 ,  B05B5/025 ,  B81B1/00

CPC classification number: D01D5/0092 ,  B05B5/0255 ,  B05B5/16 ,  D01D5/0069 ,  D01D5/30 ,  Y10T428/2933 ,  Y10T428/2991

Abstract: Apparatus and methods for electrospinning, electrojetting and/or electrospraying are disclosed. The apparatus includes a nozzle for the formation of a fluid jet from a fluid cone, the nozzle having a plurality of ducts arranged for supplying a plurality of fluids for use in the formation of the fluid jet. The ducts may issue onto one or more openings, for example, concentric openings for the production of core-shell nanofibres and particles, or core- multishell nanofibres and particles. The apparatus may also include a manifold for supplying the fluids to the nozzle from one or more fluid reservoirs.

Abstract translation: 公开了用于静电纺丝，电喷射和/或电喷雾的装置和方法。 该装置包括用于从流体锥体形成流体射流的喷嘴，该喷嘴具有多个管道，其布置用于供应用于形成流体射流的多个流体。 管道可以发射到一个或多个开口，例如用于生产核 - 壳纳米纤维和颗粒的同心开口，或核 - 多壳纳米纤维和颗粒。 该装置还可以包括用于从一个或多个流体储存器将流体供应到喷嘴的歧管。

公开(公告)号：WO2004088712A3

公开(公告)日：2004-10-14

申请号：PCT/GB2004/001434

申请日：2004-04-01

Applicant: COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS ,  STEVENS, Robert ,  GRAYER, Geoffrey, Howard

Inventor： STEVENS, Robert ,  GRAYER, Geoffrey, Howard

IPC: H01J43/24

Abstract: The electron multiplier array consists of a plurality of multiplier channels (1) with each channel generally comprising a substrate (2), an anode (5) and a series of stacked insulation layers (7) and dynode layers (11) describing the walls of the channel neighbouring insulator and metallic layers being separated by planarising layers (10). The electron multiplier array is robust and reduces the extent of the correction required for variations in performance between channels.

公开(公告)号：WO0194941A3

公开(公告)日：2003-08-21

申请号：PCT/US0118288

申请日：2001-06-06

Applicant: UNIV DUKE ,  MILLINGTON DAVID S ,  AN YAN ,  CHEN YUAN TSONG ,  STEVENS ROBERT D ,  YOUNG SARAH P ,  VAN HOVE JOHAN L K

Inventor： MILLINGTON DAVID S ,  AN YAN ,  CHEN YUAN TSONG ,  STEVENS ROBERT D ,  YOUNG SARAH P ,  VAN HOVE JOHAN L K

IPC: G01N27/62 ,  G01N33/483 ,  G01N33/66 ,  G01N33/72 ,  G01N33/50

CPC classification number: G01N33/66 ,  Y10T436/143333 ,  Y10T436/24

Abstract: Provided are methods of screening subjects for lysosomal storage diseases, preferably glycogen storage diseases, using a tetrasaccharide as a biomarker. In a more preferred embodiment, subjects are screened for Pompe disease (i.e., glycogen storage disease type II). Also provided are neonatal screening assays. The present invention further provides methods of monitoring the clinical condition and efficacy of therapeutic treatment in affected subjects. Further provided are methods of measuring a tetrasaccharide biomarker by tandem mass spectrometry, preferably, as part of a neonatal screening assay for Pompe disease.

Abstract translation: 提供了使用四糖作为生物标志物来筛选受试者的溶酶体储存疾病，优选糖原储存疾病的方法。 在更优选的实施方案中，筛选受试者的庞培病（即II型糖原贮积病）。 还提供了新生儿筛查测定。 本发明还提供了监测受试者中治疗性治疗的临床状况和疗效的方法。 进一步提供的是通过串联质谱法测量四糖生物标志物的方法，优选作为Pompe病的新生儿筛选测定的一部分。

公开(公告)号：WO0066358A2

公开(公告)日：2000-11-09

申请号：PCT/US0011007

申请日：2000-04-24

Applicant: STEVENS ROBERT L

Inventor： STEVENS ROBERT L

IPC: B29C41/06 ,  B29C41/20 ,  B29C70/08 ,  B29C70/32 ,  B32B5/18 ,  B32B27/04 ,  B32B27/12 ,  B32B27/00

CPC classification number: B32B5/18 ,  B29C41/06 ,  B29C41/20 ,  B29C70/086 ,  B29C70/323 ,  B29C70/326 ,  B29K2105/043 ,  B32B27/04 ,  B32B27/065 ,  B32B27/12 ,  B32B27/32 ,  B32B2305/08 ,  B32B2323/04

Abstract: A reinforced structural foam article includes one or more skin layers (12, 14) bounding a structural foam layer (18) to form a composite structure. One or more reinforcing layers or members (20) are embedded within the composite structure. The reinforcing layer may include flexible, sheet-like materials, such as woven fabrics, or rigid support members, which may be provided separately or in assemblies or subassemblies. The article may be formed by rotational molding, wherein the reinforcing member or layer is supported within a mold cavity, the skin layers are formed by a first moldable plastic charge, and the intermediate foam layer is formed by a subsequent charge including an appropriate blowing agent. The reinforcing member is then embedded within the article during the molding process. Fittings may be provided for further reinforcement and for attachment of the article into further assemblies or subassemblies.

Abstract translation: 增强结构泡沫制品包括一个或多个界定结构泡沫层（18）以形成复合结构的表层（12,14）。 一个或多个增强层或构件（20）嵌入复合结构内。 加强层可以包括柔性的片状材料，例如机织织物或刚性支撑构件，其可以单独设置或者组件或子组件中提供。 制品可以通过旋转模制形成，其中加强构件或层被支撑在模具腔内，表皮层由第一可模塑塑料填充物形成，并且中间泡沫层通过后续装料形成，包括合适的发泡剂 。 然后在模制过程中将加强构件嵌入制品内。 可以提供配件以进一步加强并将物品附接到另外的组件或子组件中。

公开(公告)号：WO2011060508A1

公开(公告)日：2011-05-26

申请号：PCT/AU2010/001568

申请日：2010-11-22

Applicant: BUCHANAN BRANDS PTY LTD ,  STEVENS, Robert George ,  LEA, Garry Richard ,  BUCHANAN, Scott Charles William

Inventor： STEVENS, Robert George ,  LEA, Garry Richard ,  BUCHANAN, Scott Charles William

IPC: G06F17/40 ,  G07C1/00 ,  G07C3/00

CPC classification number: G07C1/10 ,  G07C5/085

Abstract: An activity recordal method comprising electronically monitoring for occurrence of events pertaining to one or more activities, electronically associating information relating to said events with respective activities, recording said information relating to said events with data indicative of said respective activities in a database, electronically generating reporting data from said information relating to said events recorded in said database, and electronically outputting said reporting data.

Abstract translation: 一种活动记录方法，包括电子监测与一个或多个活动有关的事件的发生，将与所述事件有关的信息与相应活动电子地相关联，将与所述事件有关的所述信息与表示所述相应活动的数据一起记录在数据库中， 来自与所述数据库中记录的所述事件相关的信息的数据，以及电子地输出所述报告数据。

公开(公告)号：WO2008140799A1

公开(公告)日：2008-11-20

申请号：PCT/US2008/006028

申请日：2008-05-12

Applicant: ONI MEDICAL SYSTEMS, INC. ,  MCNULTY, Christopher ,  ROEMER, Peter, B. ,  CHENG, Yuan ,  STEVENS, Robert

Inventor： MCNULTY, Christopher ,  ROEMER, Peter, B. ,  CHENG, Yuan ,  STEVENS, Robert

IPC: A61B5/055

CPC classification number: A61B5/055 ,  A61B5/0555 ,  A61B5/4528 ,  G01R33/30 ,  G01R33/307 ,  G01R33/3806

Abstract: A system and method are presented that facilitate imaging of the joints of the upper and lower extremities including, for example, the hip and shoulder as well as sections of the spine, among others. One embodiment of the invention includes a short bore cylindrical magnet with an imaging volume smaller than that of a comparable whole body system, an articulated table that allows placement of the joint to be imaged in the center of the magnet homogeneous volume while maintaining a high degree of patient comfort and openness. The gradient and RF coils may be positioned above and below the patient instead of 360 degrees surrounding the patient. A smaller RF and gradient coil is made feasible because of the reduced imaging volume.

Abstract translation: 提出了一种系统和方法，其促进上肢和下肢的关节的成像，包括例如臀部和肩部以及脊柱的部分等。 本发明的一个实施例包括具有小于可比较的全身系统的成像体积的短孔圆柱形磁体，铰接台允许将要成像的关节放置在磁体均匀体积的中心，同时保持高度 患者舒适和开放。 梯度和RF线圈可以位于患者的上方和下方，而不是围绕患者的360度。 由于成像体积的减小，较小的RF和梯度线圈是可行的。

公开(公告)号：WO2004088712A2

公开(公告)日：2004-10-14

申请号：PCT/GB2004001434

申请日：2004-04-01

Applicant: COUNCIL CENT LAB RES COUNCILS ,  STEVENS ROBERT ,  GRAYER GEOFFREY HOWARD

Inventor： STEVENS ROBERT ,  GRAYER GEOFFREY HOWARD

IPC: A61B6/00 ,  H01J43/24 ,  H01J43/00

CPC classification number: H01J43/243 ,  A61B6/4429

Abstract: The electron multiplier array consists of a plurality of multiplier channels (1) with each channel generally comprising a substrate (2), an anode (5) and a series of stacked insulation layers (7) and dynode layers (11) describing the walls of the channel. The electron multiplier array is robust and reduces the extent of the correction required for variations in performance between channels.

Abstract translation: 电子倍增器阵列由多个乘法器通道（1）组成，每个通道通常包括衬底（2），阳极（5）和一系列堆叠绝缘层（7）和倍增极层（11），其描述了 这个频道。 电子倍增器阵列是鲁棒的，并且减少了通道之间的性能变化所需的校正的程度。

公开(公告)号：WO2004034007A9

公开(公告)日：2004-09-02

申请号：PCT/GB0304362

申请日：2003-10-08

Applicant: COUNCIL CENT LAB RES COUNCILS ,  STEVENS ROBERT ,  HARPIN ARNOLD

Inventor： STEVENS ROBERT ,  HARPIN ARNOLD

IPC: B81B3/00 ,  G01L9/00 ,  G01N21/17 ,  G02B6/36 ,  H01L21/02

CPC classification number: G01L9/0079 ,  G01L9/0042

Abstract: An optical micro sensor (1) for measuring one or more environmental parameters, such as pressure and temperature, through the modification of incident radiation. The sensor (1) is fabricated using MEMS technology and is adapted to receive an optical fibre (40) which communicates radiation to and from the micro sensor (1). The sensor (1) has an environmentally-sensitive element (4) which modifies the incident radiation communicated by the optical fibre (40). The modified radiation is communicated back along the optical fibre (40) and provides information regarding the environmental conditions surrounding the sensor (1). The pressure sensor is provided with a Fabry Perot cavity (3) in a first surface of a silicon wafer (2). The cavity is covered by a reflector at the environmentally-sensitive element (4). The diameter of the channel (7) holding the optical fibre (40) is greater than the diameter of the cavity (3). The temperature sensor is provided with luminescent material at the element (4). Also, a method of securing an optical fibre to a silicon block is claimed.

Abstract translation: 一种用于通过改变入射辐射来测量一个或多个环境参数（例如压力和温度）的光学微传感器（1）。 传感器（1）使用MEMS技术制造并且适于接收将光辐射与微传感器（1）进行通信的光纤（40）。 传感器（1）具有对由光纤（40）传播的入射辐射进行改变的环境敏感元件（4）。 改变的辐射沿着光纤（40）传回，并提供关于传感器（1）周围的环境条件的信息。 压力传感器在硅晶片（2）的第一表面中设置有法布里珀罗腔（3）。 空腔由环境敏感元件（4）上的反射器覆盖。 保持光纤（40）的通道（7）的直径大于空腔（3）的直径。 温度传感器在元件（4）处设置有发光材料。 另外，要求保护光纤到硅块的方法。

公开(公告)号：WO2004034007A3

公开(公告)日：2004-04-22

申请号：PCT/GB2003/004362

申请日：2003-10-08

Applicant: COUNCIL FOR THE CENTRAL LABORATORY OF THE RESEARCH COUNCILS ,  STEVENS, Robert ,  HARPIN, Arnold

Inventor： STEVENS, Robert ,  HARPIN, Arnold

IPC: G01L9/00

Abstract: An optical micro sensor (1) for measuring one or more environmental parameters, such as pressure and temperature, through the modification of incident radiation. The sensor (1) is fabricated using MEMS technology and is adapted to receive an optical fibre (40) which communicates radiation to and from the micro sensor (1). The sensor (1) has an environmentally-sensitive element (4) which modifies the incident radiation communicated by the optical fibre (40). The modified radiation is communicated back along the optical fibre (40) and provides information regarding the environmental conditions surrounding the sensor (1). The pressure sensor is provided with a Fabry Perot cavity (3) in a first surface of a silicon wafer (2). The cavity is covered by a reflector at the environmentally-sensitive element (4). The diameter of the channel (7) holding the optical fibre (40) is greater than the diameter of the cavity (3). The temperature sensor is provided with luminescent material at the element (4). Also, a method of securing an optical fibre to a silicon block is claimed.

公开(公告)号：WO2004034007A2

公开(公告)日：2004-04-22

申请号：PCT/GB0304362

申请日：2003-10-08

Applicant: COUNCIL CENT LAB RES COUNCILS ,  STEVENS ROBERT ,  HARPIN ARNOLD

Inventor： STEVENS ROBERT ,  HARPIN ARNOLD

IPC: B81B3/00 ,  G01L9/00 ,  G01N21/17 ,  G02B6/36 ,  H01L21/02

CPC classification number: G01L9/0079 ,  G01L9/0042

Abstract: An optical micro sensor (1) for measuring one or more environmental parameters, such as pressure and temperature, through the modification of incident radiation. The sensor (1) is fabricated using MEMS technology and is adapted to receive an optical fibre (40) which communicates radiation to and from the micro sensor (1). The sensor (1) has an environmentally-sensitive element (4) which modifies the incident radiation communicated by the optical fibre (40). The modified radiation is communicated back along the optical fibre (40) and provides information regarding the environmental conditions surrounding the sensor 1.

Abstract translation: 一种用于通过改变入射辐射来测量一个或多个环境参数（如压力和温度）的光学微传感器（1）。 传感器（1）使用MEMS技术制造并且适于接收将光辐射与微传感器（1）进行通信的光纤（40）。 传感器（1）具有对由光纤（40）传播的入射辐射进行改变的环境敏感元件（4）。 修改的辐射沿着光纤（40）传回，并提供关于传感器1周围的环境条件的信息。