公开(公告)号：US20150141273A1

公开(公告)日：2015-05-21

申请号：US14396522

申请日：2013-04-26

Applicant: STICHTING VU-VUMC

Inventor： Linda Janna Willemien Bosch ,  Meike De Wit ,  Beatriz Pinto Morais de Carvalho ,  Remond Johnnes Adriaan Fijneman ,  Gerrit Albert Meijer ,  Comelia Ramona Jimenez ,  Sander Rogier Piersma ,  Viet Thang Pham ,  Gideon Oudgenoeg

IPC: G01N33/68 ,  G01N33/574

CPC classification number: G01N33/57419 ,  G01N33/6848 ,  G01N2500/10 ,  G01N2570/00 ,  G01N2800/7028

Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

Abstract translation: 本发明提供了筛选结肠直肠癌的方法，该方法包括：从个体中筛选一种或多种选自表1和/或表6中定义的组的生物标志物的生物样品，其中存在或增加表达 一个或多个相对于对照样品的生物标志物表明个体处于患有或正在患有结肠直肠癌的风险中。 本发明还提供适用于本发明方法的阵列和试剂盒，治疗结肠直肠癌的方法和用于治疗癌症的方法中的治疗剂。

公开(公告)号：US20140271463A1

公开(公告)日：2014-09-18

申请号：US14207396

申请日：2014-03-12

Applicant: Stichting VU-VUmc

Inventor： Marta DEL CAMPO MILAN ,  Cornelia Ramona Jimenez ,  Chrlott Elisabeth Teunissen

IPC: C07K16/28 ,  A61K51/10 ,  G01N33/569

CPC classification number: C07K16/28 ,  A61K51/1018 ,  A61K51/1027 ,  C07K14/4711 ,  G01N33/56966 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/50

Abstract: The disclosure relates to the use of altered BRI2 levels as a biomarker for the risk of developing Alzheimer's disease. Novel treatments based on altered BRI2 levels and anti-BRI2 antibodies are also provided.

Abstract translation: 本公开涉及使用改变的BRI2水平作为发展阿尔茨海默病的风险的生物标志物。 还提供了基于改变的BRI2水平和抗BRI2抗体的新型治疗。

公开(公告)号：US20240004312A1

公开(公告)日：2024-01-04

申请号：US18253734

申请日：2021-10-28

Applicant: ASML Netherlands B.V. ,  STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN ,  STICHTING VU ,  UNIVERSITEIT VAN AMSTERDAM

Inventor： Peter Michael KRAUS ,  Sylvianne Dorothea Christina ROSCAM ABBING ,  Filippo CAMPI ,  ZhuangYan ZHANG ,  Petrus Wilhelmus SMORENBURG ,  Nan LIN ,  Stefan Michiel WITTE ,  Arie Jeffrey DEN BOEF

IPC: G03F7/00 ,  G02F1/35 ,  H05G2/00

CPC classification number: G03F7/70641 ,  G03F7/706849 ,  G02F1/353 ,  G02F1/3505 ,  G02F1/3507 ,  H05G2/00

Abstract: Disclosed is a metrology apparatus for measurement of a target formed on a substrate by a lithographic process and associated method. The metrology apparatus comprises a radiation source operable to provide first radiation; a configured solid high harmonic generation medium being configured to receive and be excited by said first radiation to generate high harmonic second radiation from an output surface of the configured solid high harmonic generation medium; and a detection arrangement operable to detect said second radiation, at least a portion of which having been scattered by said target. The configured solid high harmonic generation medium is configured to shape the beam of said second radiation and/or separate said first and second radiation.

公开(公告)号：US20220280487A1

公开(公告)日：2022-09-08

申请号：US17638086

申请日：2020-08-26

Applicant: Stichting VUmc ,  Stichting VU

Inventor： Eelco RUIJTER ,  Mark Karsten RONG ,  Alexander SPEER ,  Wilhelmus BITTER ,  Stewart Thomas COLE

IPC: A61K31/433 ,  A61P31/06

Abstract: The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and/or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion.
The compounds have the following formula wherein Q and X are, respectively, CH and C, CR2 and C, CH and N, CR2 and N, or N and C; R1 is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms; R2 is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, and R3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl, or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

公开(公告)号：US20210032316A1

公开(公告)日：2021-02-04

申请号：US16967269

申请日：2019-02-05

Applicant: Stichting VU

Inventor： Martine Joyce Smit ,  Raimond Heukers ,  Timo Werner Marcella De Groof ,  Tian Shu Fan ,  Raymond Henry De Wit

IPC: C07K16/08 ,  C07K16/18 ,  G01N33/574 ,  A61K47/68 ,  A61K41/00

Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.

公开(公告)号：US20190310559A1

公开(公告)日：2019-10-10

申请号：US16376639

申请日：2019-04-05

Applicant: Stichting VU ,  Stichting Nederlandse Wetenschappelijk Onderzoek Instituten ,  Universiteit van Amsterdam ,  ASML Netherlands B.V.

Inventor： Johannes Fitzgerald DE BOER ,  Vasco Tomas TENNER ,  Arie Jeffrey DEN BOEF ,  Christos MESSINIS

IPC: G03F7/20 ,  G01N21/88

Abstract: Methods and apparatus are disclosed for determining a characteristic of a structure. In one arrangement, the structure is illuminated with first illumination radiation to generate first scattered radiation. A first interference pattern is formed by interference between a portion of the first scattered radiation reaching a sensor and first reference radiation. The structure is also illuminated with second illumination radiation from a different direction. A second interference pattern is formed using second reference radiation. The first and second interference patterns are used to determine the characteristic of the structure. Azimuthal angles of the first and second reference radiations onto the sensor are different.

公开(公告)号：US20180348145A1

公开(公告)日：2018-12-06

申请号：US15979990

申请日：2018-05-15

Applicant: ASML Netherlands B.V. ,  Stichting Nederlandse Wetenschappelijk Onderzoek Instituten ,  Stichting VU ,  Universiteit van Amsterdam

Inventor： Stefan Michiel WITTE ,  Gijsbert Simon Matthijs Jansen ,  Lars Christian Freisem ,  Kjeld Sijbrand Eduard Eikema ,  Simon Gijsbert Josephus Mathijssen

IPC: G01N21/88 ,  G01N21/95 ,  G01J1/42

CPC classification number: G03F7/706 ,  G01J9/00 ,  G03F7/70133 ,  G03F7/70141 ,  G03F7/70191

Abstract: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.

公开(公告)号：US09766180B2

公开(公告)日：2017-09-19

申请号：US14895477

申请日：2014-06-02

Applicant: Stichting VU-VUmc

Inventor： Gijs Jan Lodewijk Wuite ,  Erwin Johannes Gerard Peterman ,  Iddo Heller ,  Gerrit Sitters ,  Andrea Candelli ,  Stefan Walter Hell

IPC: G01N33/00 ,  G01N35/00 ,  G01N21/00 ,  C12Q1/68 ,  G01N21/64 ,  B01L3/00 ,  G02B21/00 ,  G02B21/16 ,  G02B21/32

CPC classification number: G01N21/6428 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0877 ,  B01L2400/0454 ,  C12Q1/6816 ,  G01N21/6458 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/32 ,  C12Q2565/629

Abstract: The present disclosure concerns a method and system for imaging a molecular strand (MS). The method comprises providing a sample volume (SV) comprising the strand (MS); providing an excitation beam (EB) having an excitation focus (EF) in the sample volume (SV); scanning the excitation focus (EF) in the sample volume (SV) along a one dimensional scanning line (SL); trapping an end of the strand (MS) in the sample volume (SV) and extending the strand (MS) along a one-dimensional trapping line (LL) parallel to the scanning line (SL); aligning the trapping line (LL) to coincide with the scanning line (SL) to have the scanning excitation focus (EF) coincide with the strand (MS); and recording the fluorescence response (FR) as a function of a plurality of distinct scanning positions (X0) of the excitation focus (EF) along the scanning line (SL).

公开(公告)号：US20170130277A1

公开(公告)日：2017-05-11

申请号：US15319452

申请日：2015-06-19

Applicant: STICHTING VU-VUMC ,  INTERNA TECHNOLOGIES B.V.

Inventor： Gerrit Albert MEIJER ,  Begoña DIOSDADO ,  Lisette M. TIMMER ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Francesco CERISOLI ,  Roeland Quirinus Jozef SCHAAPVELD

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.

公开(公告)号：EP4414783A1

公开(公告)日：2024-08-14

申请号：EP23155835.4

申请日：2023-02-09

Applicant: Stichting Nederlandse Wetenschappelijk Onderzoek Instituten ,  Stichting VU ,  Universiteit van Amsterdam ,  ASML Netherlands B.V.

Inventor： BIJLOO, Falco ,  KOENDERINK, Albert, Femius ,  KRAUS, Peter, Michael ,  DEN BOEF, Arie, Jeffrey

IPC: G03F7/00 ,  G01B11/02

CPC classification number: G03F7/70683 ,  G03F7/706843 ,  G03F7/70625 ,  G01B11/02

Abstract: A method for measuring a parameter of a substrate, comprises receiving pump radiation. A metrology target on the substrate is irradiated with the received radiation, thereby generating, through resonances, harmonic generated radiation. Using a metrology sensor, intensities are detected of at least two opposite radiation orders of the harmonic generated radiation diffracted by the metrology target. The parameter of the substrate is determined based on the intensities of the at least two opposite radiation orders and a peak wavelength of the harmonic generated radiation.